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Volumn 23, Issue 12, 2017, Pages 3158-3167

PD-L2 expression in human tumors: Relevance to anti-PD-1 therapy in cancer

Author keywords

[No Author keywords available]

Indexed keywords

PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; PDCD1LG2 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84978223801     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-16-1761     Document Type: Article
Times cited : (454)

References (42)
  • 3
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.J.5    Kefford, R.6
  • 4
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
    • Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 2014;384:1109-17.
    • (2014) Lancet , vol.384 , pp. 1109-1117
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3    Hodi, F.S.4    Hamid, O.5    Kefford, R.6
  • 8
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014;32:1020-30.
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3    Kluger, H.M.4    Carvajal, R.D.5    Sharfman, W.H.6
  • 10
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 11
    • 84856818269 scopus 로고    scopus 로고
    • Antibodies to human programmed death receptor PD-1
    • Msd Oss B.V., assignee. United States patent US Jan 15
    • Carven GJ, Van Eenennaam H, Dulos GJ, inventors; Msd Oss B.V., assignee. Antibodies to human programmed death receptor PD-1. United States patent US8354509 B2. 2013 Jan 15.
    • (2013)
    • Carven, G.J.1    Van Eenennaam, H.2    Dulos, G.J.3
  • 12
    • 84947716066 scopus 로고    scopus 로고
    • Kenilworth, NJ: Merck & Co., Inc
    • Merck & Co. Keytruda (pembrolizumab) prescribing information. Kenilworth, NJ: Merck & Co., Inc; 2015. Available from: http://www.merck.com/product/usa/pi-circulars/k/keytruda/keytruda-pi.pdf.
    • (2015) Keytruda (Pembrolizumab) Prescribing Information
  • 13
    • 85020908157 scopus 로고    scopus 로고
    • Princeton, NJ USA: Bristol-Meyers Squibb
    • Bristol-Meyers Squibb. OPDIVO (nivolumab) prescribing information. Princeton, NJ USA: Bristol-Meyers Squibb; 2016. Available from: https://packageinserts.bms.com/pi/pi-opdivo.pdf.
    • (2016) OPDIVO (Nivolumab) Prescribing Information
  • 14
    • 85020901545 scopus 로고    scopus 로고
    • San Francisco, CA: Genentech
    • Genentech. TECENTRIQ (atezolizumab). San Francisco, CA: Genentech; 2016. Available from: https://www.gene.com/download/pdf/tecentriq-prescribing.pdf.
    • (2016) TECENTRIQ (Atezolizumab)
  • 15
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515:563-7.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.C.2    Kowanetz, M.3    Fine, G.D.4    Hamid, O.5    Gordon, M.S.6
  • 18
    • 0242559053 scopus 로고    scopus 로고
    • Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis
    • Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, et al. Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur J Immunol 2003;33:3117-26.
    • (2003) Eur J Immunol , vol.33 , pp. 3117-3126
    • Rodig, N.1    Ryan, T.2    Allen, J.A.3    Pang, H.4    Grabie, N.5    Chernova, T.6
  • 19
    • 82455167972 scopus 로고    scopus 로고
    • PD-L2 is predominantly expressed by Th2 cells
    • Lesterhuis WJ, Steer H, Lake RA. PD-L2 is predominantly expressed by Th2 cells. Mol Immunol 2011;49:1-3.
    • (2011) Mol Immunol , vol.49 , pp. 1-3
    • Lesterhuis, W.J.1    Steer, H.2    Lake, R.A.3
  • 20
    • 79961016549 scopus 로고    scopus 로고
    • Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice
    • Lesterhuis WJ, Punt CJ, Hato SV, Eleveld-Trancikova D, Jansen BJ, Nierkens S, et al. Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice. J Clin Invest 2011;121:3100-8.
    • (2011) J Clin Invest , vol.121 , pp. 3100-3108
    • Lesterhuis, W.J.1    Punt, C.J.2    Hato, S.V.3    Eleveld-Trancikova, D.4    Jansen, B.J.5    Nierkens, S.6
  • 21
    • 80051940011 scopus 로고    scopus 로고
    • PD-L2 is expressed on activated human T cells and regulates their function
    • Messal N, Serriari NE, Pastor S, Nunes JA, Olive D. PD-L2 is expressed on activated human T cells and regulates their function. Mol Immunol 2011;48:2214-9.
    • (2011) Mol Immunol , vol.48 , pp. 2214-2219
    • Messal, N.1    Serriari, N.E.2    Pastor, S.3    Nunes, J.A.4    Olive, D.5
  • 22
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 2014;20:5064-74.
    • (2014) Clin Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3    Xu, H.4    Pan, X.5    Kim, J.H.6
  • 24
    • 84995489253 scopus 로고    scopus 로고
    • Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results from the phase Ib KEYNOTE-012 expansion cohort
    • Sep 19. [Epub ahead of print]
    • Chow LQ, Haddad R, Gupta S, Mahipal A, Mehra R, Tahara M, et al. Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: results from the phase Ib KEYNOTE-012 expansion cohort. J Clin Oncol. 2016 Sep 19. [Epub ahead of print].
    • (2016) J Clin Oncol
    • Chow, L.Q.1    Haddad, R.2    Gupta, S.3    Mahipal, A.4    Mehra, R.5    Tahara, M.6
  • 25
    • 84969988424 scopus 로고    scopus 로고
    • Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): An open-label, multicentre, phase 1b trial
    • Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, et al. Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial. Lancet Oncol 2016;17:956-65.
    • (2016) Lancet Oncol , vol.17 , pp. 956-965
    • Seiwert, T.Y.1    Burtness, B.2    Mehra, R.3    Weiss, J.4    Berger, R.5    Eder, J.P.6
  • 26
    • 84939227614 scopus 로고    scopus 로고
    • Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): Sensitivity analysis of trials in melanoma, lung and genitourinary cancers
    • Carbognin L, Pilotto S, Milella M, Vaccaro V, Brunelli M, Calio A, et al. Differential activity of nivolumab, pembrolizumab and MPDL3280A according to the tumor expression of programmed death-ligand-1 (PD-L1): sensitivity analysis of trials in melanoma, lung and genitourinary cancers. PLoS One 2015;10:e0130142.
    • (2015) PLoS One , vol.10
    • Carbognin, L.1    Pilotto, S.2    Milella, M.3    Vaccaro, V.4    Brunelli, M.5    Calio, A.6
  • 27
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
    • Herbst RS, Baas P, Kim DW, Felip E, Perez-Gracia JL, Han JY, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet 2016;387:1540-50.
    • (2016) Lancet , vol.387 , pp. 1540-1550
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3    Felip, E.4    Perez-Gracia, J.L.5    Han, J.Y.6
  • 28
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 2015;373:1627-39.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3    Spigel, D.R.4    Steins, M.5    Ready, N.E.6
  • 29
    • 84947267135 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) for advanced urothelial cancer: Updated results and biomarker analysis from KEYNOTE-012
    • Plimack ER, Bellmaunt J, Gupta S, Berger R, Montgomery B, Heath K, et al. Pembrolizumab (MK-3475) for advanced urothelial cancer: updated results and biomarker analysis from KEYNOTE-012. J Clin Oncol 2015;33Suppl 15:4502.
    • (2015) J Clin Oncol , vol.33 , pp. 4502
    • Plimack, E.R.1    Bellmaunt, J.2    Gupta, S.3    Berger, R.4    Montgomery, B.5    Heath, K.6
  • 30
    • 84923078390 scopus 로고    scopus 로고
    • MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
    • Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 2014;515:558-62.
    • (2014) Nature , vol.515 , pp. 558-562
    • Powles, T.1    Eder, J.P.2    Fine, G.D.3    Braiteh, F.S.4    Loriot, Y.5    Cruz, C.6
  • 31
    • 84959577118 scopus 로고    scopus 로고
    • Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial
    • Rosenberg JE, Hoffman-Censits J, Powles T, van der Heijden MS, Balar AV, Necchi A, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet 2016;387:1909-20.
    • (2016) Lancet , vol.387 , pp. 1909-1920
    • Rosenberg, J.E.1    Hoffman-Censits, J.2    Powles, T.3    Van Der Heijden, M.S.4    Balar, A.V.5    Necchi, A.6
  • 33
    • 84926678589 scopus 로고    scopus 로고
    • PD-L1 expression in melanoma shows marked heterogeneity within and between patients: Implications for anti-PD-1/PD-L1 clinical trials
    • Madore J, Vilain RE, Menzies AM, Kakavand H, Wilmott JS, Hyman J, et al. PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials. Pigment Cell Melanoma Res 2015;28:245-53.
    • (2015) Pigment Cell Melanoma Res , vol.28 , pp. 245-253
    • Madore, J.1    Vilain, R.E.2    Menzies, A.M.3    Kakavand, H.4    Wilmott, J.S.5    Hyman, J.6
  • 34
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127ra37.
    • (2012) Sci Transl Med , vol.4 , pp. 127ra37
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6
  • 36
    • 84871192340 scopus 로고    scopus 로고
    • Molecular pathways: Next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1
    • Chen DS, Irving BA, Hodi FS. Molecular pathways: next-generation immunotherapy-inhibiting programmed death-ligand 1 and programmed death-1. Clin Cancer Res 2012;18:6580-7.
    • (2012) Clin Cancer Res , vol.18 , pp. 6580-6587
    • Chen, D.S.1    Irving, B.A.2    Hodi, F.S.3
  • 37
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity 2013;39:1-10.
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 38
    • 84942567117 scopus 로고    scopus 로고
    • Targeting the programmed death-1/programmed death-ligand 1 axis in lymphoma
    • Cheah CY, Fowler NH, Neelapu SS. Targeting the programmed death-1/programmed death-ligand 1 axis in lymphoma. Curr Opin Oncol 2015;27:384-91.
    • (2015) Curr Opin Oncol , vol.27 , pp. 384-391
    • Cheah, C.Y.1    Fowler, N.H.2    Neelapu, S.S.3
  • 39
    • 84937759727 scopus 로고    scopus 로고
    • The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma
    • Mahoney KM, Freeman GJ, McDermott DF. The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma. Clin Ther 2015;37:764-82.
    • (2015) Clin Ther , vol.37 , pp. 764-782
    • Mahoney, K.M.1    Freeman, G.J.2    McDermott, D.F.3
  • 40
    • 1042268879 scopus 로고    scopus 로고
    • Gene expression profiling of diffuse large B-cell lymphoma
    • Rosenwald A, Staudt LM. Gene expression profiling of diffuse large B-cell lymphoma. Leuk Lymphoma 2003;44Suppl 3:S41-7.
    • (2003) Leuk Lymphoma , vol.44 , pp. S41-S47
    • Rosenwald, A.1    Staudt, L.M.2
  • 41
    • 84914695751 scopus 로고    scopus 로고
    • Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain
    • Shi M, Roemer MG, Chapuy B, Liao X, Sun H, Pinkus GS, et al. Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain. Am J Surg Pathol 2014;38:1715-23.
    • (2014) Am J Surg Pathol , vol.38 , pp. 1715-1723
    • Shi, M.1    Roemer, M.G.2    Chapuy, B.3    Liao, X.4    Sun, H.5    Pinkus, G.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.