Interaction of the LILRB1 inhibitory receptor with HLA class Ia dimers

European Journal of Immunology

Volumn 46, Issue 7, 2016, Pages 1681-1690

  Baía, Diogo ^a   Pou, Jordi ^b   Jones, Des ^c   Mandelboim, Ofer ^d   Trowsdale, John ^c   Muntasell, Aura ^b   López Botet, Miguel ^a,b  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b HOSPITAL DEL MAR   (Spain)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d HEBREW UNIVERSITY   (Israel)

Author keywords

HLA class I dimers; LILRB1; Macrophages; Type I interferon

Indexed keywords

DIMER; HLA ANTIGEN; HLA ANTIGEN CLASS 1A; INTERFERON; LEUKOCYTE IMMUNOGLOBULIN LIKE RECEPTOR SUBFAMILY B MEMBER 1; UNCLASSIFIED DRUG;

ARTICLE; CHIMERA; CONTROLLED STUDY; DIMERIZATION; EXOSOME; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION;

EID: 84978204145     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201546149     Document Type: Article

References (24)

1. Colonna, M., Navarro, F., Bellón, T., Llano, M., García, P., Samaridis, J., Angman, L. et al., A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 1997. 186: 1809–1818.
2. Cosman, D., Fanger, N., Borges, L., Kubin, M., Chin, W., Peterson, L. and Hsu, M. L., A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 1997. 7: 273–282.
3. Lamar, D. L., Weyand, C. M. and Goronzy, J. J., Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages. Blood 2010. 115: 3278–3286.
4. Navarro, F., Llano, M., Bellón, T., Colonna, M., Geraghty, D. E. and López-Botet, M., The ILT2(LIR1) and CD94/NKG2A NK cell receptors respectively recognize HLA-G1 and HLA-E molecules co-expressed on target cells. Eur. J. Immunol. 1999. 29: 277–283.
5. Morel, E. and Bellón, T., HLA class I molecules regulate IFN-gamma production induced in NK cells by target cells, viral products, or immature dendritic cells through the inhibitory receptor ILT2/CD85j. J. Immunol. 2008. 181: 2368–2381.
6. Saverino, D., Merlo, A., Bruno, S., Pistoia, V., Grossi, C. E. and Ciccone, E., Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells. J. Immunol. 2002. 168: 207–215.
7. Dietrich, J., Cella, M. and Colonna, M., Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization. J. Immunol. 2001. 166: 2514–2521
8. Fanger, N. A., Cosman, D., Peterson, L., Braddy, S. C., Maliszewski, C. R. and Borges, L., The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor- mediated signaling in monocytes. Eur. J. Immunol. 1998. 28: 3423–3434.
9. Young, N. T., Waller, E. C., Patel, R., Roghanian, A., Austyn, J. M. and Trowsdale, J., The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells. Blood 2008. 111: 3090–3096.
10. Mori, Y., Tsuji, S., Inui, M., Sakamoto, Y., Endo, S., Ito, Y., Fujimura, S. et al., Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. J. Immunol. 2008. 181: 4742–4751.
11. Jones, D. C., Kosmoliaptsis, V., Apps, R., Lapaque, N., Smith, I., Kono, A., Chang, C. et al., HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding. J. Immunol. 2011. 186: 2990–2997.
12. Chapman, T. L., Heikeman, A. P. and Bjorkman, P. J., The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity 1999. 11: 603–613.
13. Chapman, T. L., Heikema, A. P., West, A. P. and Bjorkman, P. J., Crystal structure and ligand binding properties of the D1D2 region of the inhibitory receptor LIR-1 (ILT2). Immunity 2000. 13: 727–736.
14. Willcox, B. E., Thomas, L. M. and Bjorkman, P. J., Crystal structure of HLA-A2bound to LIR-1, a host and viral major histocompatibility receptor. Nat. Immunol. 2002. 4: 913–919.
15. Shiroishi, M., Tsumoto, K., Amano, K., Shirakihara, Y., Colonna, M., Braud, V. M., Allan, D. S. et al., Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc. Natl. Acad. Sci. USA 2003. 100: 8856–8861.
16. Gonen-Gross, T., Achdout, H., Gazit, R., Hanna, J., Mizrahi, S., Markel, G., Goldman-Wohl, D. et al., Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. J. Immunol. 2003. 171: 1343–1351.
17. Apps, R., Gardner, L., Sharkey, A. M., Holmes, N. and Moffett, A., A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting cells via LILRB1. Eur. J. Immunol. 2007. 37: 1924–1937.
18. Giles, J., Shaw, J., Piper, C., Wong-Baeza, I., McHugh, K., Ridley, A., Li, D. et al., HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I. J. Immunol. 2012. 188: 6184–6193.
19. Gruda, R., Achdout, H., Stern-Ginossar, N., Gazit, R., Betser-Cohen, G., Manaster, I., Katz, G. et al., Intracellular cysteine residues in the tail of MHC class I proteins are crucial for extracellular recognition by leukocyte Ig-like receptor 1. J. Immunol. 2007. 179: 3655–3661.
20. Lynch, S., Santos, S. G., Campbell, E. C., Nimmo, A. M., Botting, C., Prescott, A., Antoniou, A. N. et al., Novel MHC class I structures on exosomes. J. Immunol. 2009. 183: 1884–1891.
21. Makhadiyeva, D., Lam, L., Moatari, M., Vallance, J., Zheng, Y., Campbell, E. C. and Powis, S. J., MHC class I dimer formation by alteration of the cellular redox environment and induction of apoptosis. Immunology 2012. 135: 133–139.
22. Grifoni, A., Montesano, C., Palma, P., Salerno, A., Colizzi, V. and Amicosante, M., Role of HLA-B alpha-3 domain amino acid position 194 in HIV disease progression. Mol. Immunol. 2013. 53: 410–413.
23. Li, N. L., Fu, L., Uchtenhagen, H., Achour, A. and Burshtyn, D. N., Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18. Eur. J. Immunol. 2013. 43: 1042–1052.
24. Brüne, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A. et al., Redox control of inflammation in macrophages. Antioxid. Redox. Signal. 2013. 20;19: 595–637.