A framework for understanding the relationship between descending pain modulation, motor corticospinal, and neuroplasticity regulation systems in chronic myofascial pain

Frontiers in Human Neuroscience

Volumn 10, Issue , 2016, Pages

  Botelho, Leonardo M ^a,b   Morales Quezada, Leon ^c   Rozisky, Joanna R ^a,b   Brietzke, Aline P ^a,b   Torres, Iraci L S ^a   Deitos, Alicia ^a,b   Fregni, Felipe ^c   Caumo, Wolnei ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

BNDF; Chronic pain; Cortical excitability; CPM; MEP; QST; TMS

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FACILITATION; FEMALE; HUMAN; MOTOR CORTEX; MOTOR EVOKED POTENTIAL; MYOFASCIAL PAIN; NERVE CELL PLASTICITY; NEUROPATHOLOGY; PAIN ASSESSMENT; PAIN THRESHOLD; PROTEIN BLOOD LEVEL; PYRAMIDAL TRACT; TASK PERFORMANCE;

EID: 84978204092     PISSN: None     EISSN: 16625161     Source Type: Journal    
DOI: 10.3389/fnhum.2016.00308     Document Type: Article

References (53)

1. Arendt-Nielsen, L., Nie, H., Laursen, M. B., Laursen, B. S., Madeleine, P., Simonsen, O. H., et al. (2010). Sensitization in patients with painful knee osteoarthritis. Pain 149, 573-581. doi: 10.1016/j.pain.2010. 04.003
2. Bø, S. H., Davidsen, E. M., Gulbrandsen, P., Dietrichs, E., Bovim, G., Stovner, L. J., et al. (2009). Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache. Cephalalgia 29, 365-372. doi: 10.1111/j.1468-2982.2008.01727.x
3. Bouhassira, D., Attal, N., Alchaar, H., Boureau, F., Brochet, B., Bruxelle, J., et al. (2005). Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 114, 29-36. doi: 10.1016/j.pain.2004.12.010
4. Boyer, N., Dallel, R., Artola, A., and Monconduit, L. (2014). General trigeminospinal central sensitization and impaired descending pain inhibitory controls contribute to migraine progression. Pain 155, 1196-1205. doi: 10.1016/j.pain.2014.03.001
5. Bushnell, M. C., Ceko, M., and Low, L. A. (2013). Cognitive and emotional control of pain and its disruption in chronic pain. Nat. Rev. Neurosci. 14, 502-511. doi: 10.1038/nrn3516
6. Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., and Kupfer, D. J. (1989). The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res. 28, 193-213. doi: 10.1016/0165-1781(89)90047-4
7. Castillo Saavedra, L., Mendonca, M., and Fregni, F. (2014). Role of the primary motor cortex in the maintenance and treatment of pain in fibromyalgia. Med. Hypotheses 83, 332-336. doi: 10.1016/j.mehy.2014.06.007
8. Caumo, W., Ruehlman, L. S., Karoly, P., Sehn, F., Vidor, L. P., Dall-Âgnol, L., et al. (2013). Cross-cultural adaptation and validation of the profile of chronic pain: screen for a Brazilian population. Pain Med. 14, 52-61. doi: 10.1111526-4637.2012.01528.x
9. Chitour, D., Dickenson, A. H., and Le Bars, D. (1982). Pharmacological evidence for the involvement of serotonergic mechanisms in diffuse noxious inhibitory controls (DNIC). Brain Res. 236, 329-337. doi: 10.1016/0006-8993(82)90718-1
10. Dall’Agnol, L., Medeiros, L. F., Torres, I. L. S., Deitos, A., Brietzke, A., Laste, G.,et al. (2014). Repetitive transcranial magnetic stimulation increases the corticospinal inhibition and the brain-derived neurotrophic factor in chronic myofascial pain syndrome: an explanatorydouble-blinded, randomized, sham-controlled trial. J. Pain 15, 845-855. doi: 10.1016/j.jpain.2014.05.001
11. Defrin, R., Riabinin, M.,Feingold, Y., Schreiber, S., and Pick, C. G. (2015). Deficient pain modulatory systems in patients with mild traumatic brain and chronic post-traumatic headache: implications for its mechanism. J. Neurotrauma 32, 28-37. doi: 10.1089/neu.2014.3359
12. Deitos, A., Dussân-Sarria, J. A., de Souza, A., Medeiros, L., Tarragô Mda, G., Sehn, F., et al. (2015). Clinical value of serum neuroplasticity mediators in identifying the central sensitivity syndrome in patients with chronic pain with and without structural pathology. Clin. J. Pain 31, 959-967. doi: 10.1097/A.J.P.0000000000000194
13. de Zanette, S. A., Vercelino, R., Laste, G., Rozisky, J. R., Schwertner, A., Machado, C. B., et al. (2014). Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. BMC Pharmacol. Toxicol. 15:40. doi: 10.1186/2050-6511-15-40
14. Di Lazzaro, V., Oliviero, A., Meglio, M., Tamburrini, G., Tonali, P., Rothwell, J. C., et al. (2000). Direct demonstration of the effect of lorazepam on the excitability of the human motor cortex. Clin. Neurophysiol. 111, 794-799. doi: 10.1016/s1388-2457(99)00314-4
15. Fedi, M., Berkovic, S. F., Macdonell, R. A. L., Curatolo, J. M., Marini, C., and Reutens, D. C. (2008). Intracortical hyperexcitabilityin humans with a GABAA receptor mutation. Cereb. Cortex 18, 664-669. doi: 10.1093/cercor/bhm100
16. Graven-Nielsen, T., Wodehouse, T., Langford, R. M., Arendt-Nielsen, L., and Kidd, B. L. (2012). Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum. 64, 2907-2916. doi: 10.1002/art.34466
17. Iglesias, C., Nielsen, J. B., and Marchand-Pauvert, V. (2008). Corticospinal inhibition of transmission in propriospinal-like neurones during human walking. Eur. J. Neurosci. 28, 1351-1361. doi: 10.1111/j.1460-9568.2008.06414.x
18. Kaipper, M. B., Chachamovich, E., Hidalgo, M. P. L., Torres, I. L. D. S., and Caumo, W. (2010). Evaluation ofthe structure ofBrazilian State-Trait anxietyinventory using a Rasch psychometric approach. J. Psychosom. Res. 68, 223-233. doi: 10.1016/j.jpsychores.2009.09.013
19. King, C. D. (2014). Conditioned pain modulation and offset analgesia: different avenues to inhibit pain. Pain 155, 2444-2445. doi: 10.1016/j.pain.2014.08.017
20. King, C. D., Wong, F., Currie, T., Mauderli, A. P., Fillingim, R. B., and Riley, J. L. (2009). Deficiency in endogenous modulation of prolonged heat pain in patients with Irritable Bowel syndrome and temporomandibular disorder. Pain 143, 172-178. doi: 10.1016/j.pain.2008.12.027
21. Kwon, M., Altin, M., Duenas, H., and Alev, L. (2013). The Role of descending inhibitorypathways on chronic pain modulation and clinical implications. Pain Pract. 14, 656-667. doi: 10.1111/papr.12145
22. Le Bars, D. (2002). The whole body receptive field of dorsal horn multireceptive neurones. Brain Res. Rev. 40, 29-44. doi: 10.1016/S0165-0173(02)00186-8
23. Le Bars, D., Chitour, D., Kraus, E., Dickenson, A. H., and Besson, J. M. (1981). Effect of naloxone upon diffuse noxious inhibitory controls (DNIC) in the rat. Brain Res. 204, 387-402. doi: 10.1016/0006-8993(81)90597-7
24. Leffler, A.-S., Hansson, P., and Kosek, E. (2002b). Somatosensory perception in a remote pain-free area and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from long-term trapezius myalgia. Eur. J. Pain 6, 149-159. doi: 10.1053/eujp.2001.0312
25. Leffler, A.-S., Kosek, E., Lerndal, T., Nordmark, B., and Hansson, P. (2002a). Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis. Eur. J. Pain 6, 161-176. doi: 10.1053/eujp.2001.0313
26. Ma, X., Shi, T.-F., Zhang, M., Lu, X. Y., Yang, C. X., Zhu, D., et al. (2012). Modulatory role of glutamic acid on the electrical activities of pain-related neurons in the hippocampal CA3 region. Neurosci. Lett. 513, 67-71. doi: 10.1016/j.neulet.2012.02.009
27. Makino, K., Kohase, H., Sanada, T., and Umino, M. (2010). Phenylephrine suppresses the pain modulation of diffuse noxious inhibitory control in rats. Anesth. Analg. 110, 1215-1221. doi: 10.1213/ANE.0b013e3181d2a768
28. Marchand-Pauvert, V., Simonetta-Moreau, M., and Pierrot-Deseilligny, E. (1999). Cortical control of spinal pathways mediating group II excitation to human thigh motoneurones. J. Physiol. 517, 301-313. doi: 10.1111/j.1469-7793.1999.0301z.x
29. Nijs, J., Van Houdenhove, B., and Oostendorp, R. A. B. (2010). Recognition of central sensitization in patients with musculoskeletal pain: application of pain neurophysiology in manual therapy practice. Man. Ther. 15: 135e141. doi: 10.1016/j.math.2009.12.001
30. Olesen, S. S., Brock, C., Krarup, A. L., Funch-Jensen, P., Arendt-Nielsen, L., Wilder-Smith, O. H., et al. (2010). Descending inhibitory pain modulation is impaired in patients with chronic pancreatitis. Clin. Gastroenterol. Hepatol. 8, 724-730. doi: 10.1016/j.cgh.2010.03.005
31. Palos, G. R., Mendoza, T. R., Mobley, G. M., Cantor, S. B., and Cleeland, C. S. (2006). Asking the community about cutpoints used to describe mild, moderate, and severe pain. J. Pain 7, 49-56. doi: 10.1016/j.jpain.2005.07.012
32. Pascual-Leone, A., Valls-Solé, J., Wassermann, E. M., and Hallett, M. (1994). Responses to rapid-rate transcranial magnetic stimulation ofthe human motor cortex. Brain 117, 847-858. doi: 10.1093/brain/117.4.847
33. Pessoa, L. (2008). On the relationship between emotion and cognition. Nat. Rev. Neurosci. 9, 148-158. doi: 10.1038/nrn2317
34. Pielsticker, A., Haag, G., Zaudig, M., and Lautenbacher, S. (2005). Impairment of pain inhibition in chronic tension-type headache. Pain 118, 215-223. doi: 10.1016/j.pain.2005.08.019
35. Pierrot-Deseilligny, E., and Burke, D. (2005). The Circuity of the Human Spinal Cord: its Role in Motor Control and Movement Disorders. 1st Edn. Cambridge: Cambridge University Press.
36. Ren, K., and Dubner, R. (2007). Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors. Mol. Neurobiol. 35, 224-235. doi: 10.1007/s12035-007-0028-8
37. Sanada, T., Kohase, H., Makino, K., and Umino, M. (2009). Effects of alpha-adrenergic agonists on pain modulation in diffuse noxious inhibitory control. J. Med. Dent. Sci. 56, 17-24. doi: 10.1016/s1090-3801(09)60308-6
38. Schestatsky, P., Stefani, L. C., Sanches, P. R., Silva Junior, D. P., Torres, I. L., Dall-Agnol, L., et al. (2011). Validation of a Brazilian quantitative sensory testing (QST) device for the diagnosis of small fiber neuropathies. Arq. Neuropsiquiatr. 69, 943-948. doi: 10.1590/S0004-282X2011000700019
39. Schwenkreis, P., Janssen, F., Rommel, O., Pleger, B., Völker, B., Hosbach, I., et al. (2003). Bilateral motor córtex disinhibition in complex regional pain syndrome (CRPS) type I of the hand. Neurology 61, 515-519. doi: 10.1212/wnl.62. 9.1654
40. Sehn, F., Chachamovich, E., Vidor, L. P., Dall-Agnol, L., de Souza, I. C., Torres, I. L., et al. (2012). Cross-cultural adaptation and validation of the Brazilian Portuguese version of the pain catastrophizing scale. PainMed. 13, 1425-1435. doi: 10.1111/j. 1526-4637.2012.01492.x
41. Simons, D. G., Travell, J. G., and Simons, L. S. (1999). Travell and Simons’ Myofascial Pain and Dysfunction: The Trigger Point Manual. Volume 1 Upper Half of Body, 2nd Edn. Baltimore, MD: Williams & Wilkins.
42. Spezia Adachi, L. N., Quevedo, A. S., de Souza, A., Scarabelot, V. L., Rozisky, J. R., de Oliveira, C., et al. (2015). Exogenouslyinduced brain activation regulates neuronal activitybytop-down modulation: conceptualized model for electrical brain stimulation. Exp. Brain Res. 233, 1377-1389. doi: 10.1007/s00221-015-4212-1
43. Staud, R., Robinson, M. E., Vierck, C. J., and Price, D. D. (2003). Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients. Pain 101, 167-174. doi: 10.1016/S0304-3959(02)00325-1
44. Tao, W., Chen, Q., Zhou, W., Wang, Y., Wang, L., and Zhang, Z. (2014). Persistent inflammation-induced up-regulation of brain-derived neurotrophic factor (BDNF) promotes synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 subunits in descending pain modulatory circuits. J. Biol. Chem. 289, 22196-22204. doi: 10.1074/jbc.M114.580381
45. Vidor, L. P., Torres, I. L. S., Medeiros, L. F., Dussân-Sarria, J. A., DallÄgnol, L., Deitos, A., et al. (2014). Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome. BMC Neurosci. 15:42. doi: 10.1186/1471-2202-15-42
46. Volz, M. S., Medeiros, L. F., Tarragô, M. D. G., Vidor, L. P., Dall’Agnol, L., Deitos, A., et al. (2013a). The relationship between cortical excitability and pain catastrophizing in myofascial pain. J. Pain 14, 1140-1147. doi: 10.1016/j.jpain.2013.04.013
47. Volz, M. S., Suarez-Contreras, V., Mendonca, M. E., Pinheiro, F. S., Merabet, L. B., and Fregni, F. (2013b). Effects of sensory behavioral tasks on pain threshold and cortical excitability. PLoS ONE 8:e52968. doi: 10.1371/journal.pone.0052968
48. Warmenhoven, F., van Rijswijk, E., Engels, Y., Kan, C., Prins, J., van Weel, C., et al. (2012). The Beck Depression Inventory (BDI-II) and a single screening question as screening tools for depressive disorder in Dutch advanced cancer patients. Support Care Cancer 20, 319-324. doi: 10.1007/s00520-010-1082-8
49. Willer, J. C., Bouhassira, D., and Le Bars, D. (1999). Neurophysiological bases of the counterirritation phenomenon: diffuse control inhibitors induced by nociceptive stimulation. Neurophysiol. Clin. 29, 379-400. doi: 10.1016/s0987-7053(00)87263-9
50. Willer, J. C., Le Bars, D., and De Broucker, T. (1990). Diffuse noxious inhibitory controls in man: involvement of an opioidergic link. Eur. J. Pharmacol. 182, 347-355. doi: 10.1016/0014-2999(90)90293-F
51. Yarnitsky, D. (2010). Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states. Curr. Opin. Anaesthesiol. 23, 611-615. doi: 10.1097/ACO.0b013e32833c348b
52. Yarnitsky, D., Granot, M., Nahman-Averbuch, H., Khamaisi, M., and Granovsky, Y. (2012). Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy. Pain 153, 1193-1198. doi: 10.1016/j.pain.2012.02.021
53. Zanette, S. A., Dussân-Sarria, J. A., Souza, A., Deitos, A., Torres, I. L. S., and Caumo, W. (2014). Higher serum S100B and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia. Mol. Pain 10:46. doi: 10.1186/1744-8069-10-46