Retinal Nerve Fiber Layer Thinning in Alzheimer's Disease: A Case-Control Study in Comparison to Normal Aging, Parkinsons Disease, and Non-Alzheimers Dementia

American Journal of Alzheimer's Disease and other Dementias

Volumn 31, Issue 5, 2016, Pages 430-436

  Pillai, Jagan A ^a,b   Bermel, Robert ^a,c   Bonner Jackson, Aaron ^a,b   Rae Grant, Alexander ^a,b,c   Fernandez, Hubert ^a,d   Bena, James ^e   Jones, Stephen E ^f   Ehlers, Justis P ^a   Leverenz, James B ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c Mellen Center for Multiple Sclerosis Treatment and Research   (United States)

^d Center for Neurological Restoration   (United States)

^e Quantitative Health Sciences   (United States)

^f Imaging Institute   (United States)

Author keywords

Alzheimer's disease; dementia; mild cognitive impairment; non Alzheimer's dementia; optical coherence tomography; Parkinson's disease; retinal nerve fiber thickness

Indexed keywords

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; COGNITION; CONTROLLED STUDY; DEMENTIA; FEMALE; GANGLION CELL LAYER THICKNESS; HUMAN; MACULAR VOLUME; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGY; NON ALZHEIMER DEMENTIA; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL COHERENCE TOMOGRAPHY DEVICE; PARKINSON DISEASE; RETINAL NERVE FIBER LAYER THICKNESS; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; VISUAL SYSTEM PARAMETERS; COGNITIVE DEFECT; COMPLICATION; CROSS-SECTIONAL STUDY; MIDDLE AGED; NERVE FIBER; OPTICAL COHERENCE TOMOGRAPHY; PATHOLOGY; PROCEDURES; RETINA;

AGED; AGING; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; COGNITIVE DYSFUNCTION; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; PARKINSON DISEASE; RETINA; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84978194184     PISSN: 15333175     EISSN: 19382731     Source Type: Journal    
DOI: 10.1177/1533317515628053     Document Type: Article

References (40)

1. Jack CR Jr, Albert MS, Knopman DS, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011; 7 (3): 257-262.
2. Thompson KL, Yeo JM, Waddell B, et al. A systematic review and meta-analysis of retinal nerve fiber layer change in dementia, using optical coherence tomography. Alzheimers Dement Diagn Asses Dis Moni. 2015; 1 (2): 136-143.
3. Ikram MK, Cheung CY, Wong TY, Chen CP,. Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2012; 83 (9): 917-922.
4. Blanks JC, Torigoe Y, Hinton DR, Blanks RH,. Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina. Neurobiol Aging. 1996; 17 (3): 377-384.
5. Blanks JC, Schmidt SY, Torigoe Y, Porrello KV, Hinton DR, Blanks RH,. Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL. Neurobiol Aging. 1996; 17 (3): 385-395.
6. Hinton DR, Sadun AA, Blanks JC, Miller CA,. Optic nerve degeneration in Alzheimer's disease. N Engl J Med. 1986; 315 (8): 485-487.
7. Curcio CA, Drucker DN,. Retinal ganglion cells in Alzheimer's disease and aging. Ann Neurol. 1993; 33 (3): 248-257.
8. Davies DC, McCoubrie P, McDonald B, Jobst KA,. Myelinated axon number in the optic nerve is unaffected by Alzheimer's disease. Br J Ophthalmol. 1995; 79 (6): 596-600.
9. Hedges TR, Perez Galves R, Speigelman D, Barbas NR, Peli E, Yardley CJ,. Retinal nerve fiber layer abnormalities in Alzheimer's disease. Acta Ophthalmol Scand. 1996; 74 (3): 271-275.
10. Tsai CS, Ritch R, Schwartz B, et al. Optic nerve head and nerve fiber layer in Alzheimer's disease. Arch Ophthalmol. 1991; 109 (2): 199-204.
11. Katz B, Rimmer S, Iragui V, Katzman R,. Abnormal pattern electroretinogram in Alzheimer's disease: evidence for retinal ganglion cell degeneration? Ann Neurol. 1989; 26 (2): 221-225.
12. Trick GL, Barris MC, Bickler-Bluth M,. Abnormal pattern electroretinograms in patients with senile dementia of the Alzheimer's type. Ann Neurol. 1989; 26 (2): 226-231.
13. Danesh-Meyer HV, Birch H, Ku JY, Carroll S, Gamble G,. Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging. Neurology. 2006; 67 (10): 1852-1854.
14. Krasodomska K, Lubi.,ski W, Potemkowski A, Honczarenko K,. Pattern electroretinogram (PERG) and pattern visual evoked potential (PVEP) in the early stages of Alzheimer's disease. Doc Ophthalmol. 2010; 121 (2): 111-121.
15. Paquet C, Boissonnot M, Roger F, Dighiero P, Gil R, Hugon J,. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2007; 420 (2): 97-99.
16. Lu Y, Li Z, Zhang X, Ming B, et al. Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: evidence in optical coherence tomography. Neurosci Lett. 2010; 480 (1): 69-72.
17. Kesler A, Vakhapova V, Korczyn AD, Naftaliev E, Neudorfer M,. Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Clin Neurol Neurosurg. 2011; 113 (7): 523-526.
18. Ascaso FJ, Cruz N, Modrego PJ, et al. Retinal alterations in mild cognitive impairment and Alzheimer's disease: an optical coherence tomography study. J Neurol. 2014; 261 (8): 1522-1530.
19. Berisha F, Feke GT, Trempe CL, McMeel JW, Schepens CL,. Retinal abnormalities in early Alzheimer's disease. Invest Ophthalmol Vis Sci. 2007; 48 (5): 2285-2289.
20. Kesler A, Vakhapova V, Korczyn AD, Naftaliev E, Neudorfer M,. Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Clin Neurol Neurosurg. 2011; 113 (7): 523-526.
21. Iseri PK, Altinaş O, Tokay T, Yüksel N,. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease. J Neuroophthalmol. 2006; 26 (1): 18-24.
22. Kergoat H, Kergoat MJ, Justino L, Chertkow H, Robillard A, Bergman H,. An evaluation of the retinal nerve fiber layer thickness by scanning laser polarimetry in individuals with dementia of the Alzheimer type. Acta Ophthalmol Scand. 2001; 79 (2): 187-191.
23. Justino L, Kergoat M, Bergman H, Chertkow H, Robillard A, Kergoat H,. Neuroretinal function is normal in early dementia of the Alzheimer type. Neurobiol Aging. 2001; 22 (4): 691-695.
24. Sadun AA, Borchert M, DeVita E, Hinton DR, Bassi CJ,. Assessment of visual impairments in patients with Alzheimer's disease. Am J Ophthalmol. 1987; 104 (2): 113-120.
25. Galetta KM, Calabresi PA, Frohman EM, Balcer LJ,. Optical coherence tomography (OCT): imaging the visual pathway as a model for neurodegeneration. Neurotherapeutics. 2011; 8 (1): 117-132.
26. Inzelberg R, Ramirez JA, Nisipeanu P, Ophir A,. Retinal nerve fiber layer thinning in Parkinson disease. Vision Res. 2004; 44 (24): 2793-2797.
27. Bodis-Wollner I,. Retinopathy in Parkinson disease. J Neural Transm. 2009; 116 (11): 1493-1501.
28. Yu JC, Feng IF, Xiang Y, et al. Retinal fiber nerve layer thickness changes in Parkinson disease: a meta-analysis. PLoS One. 2014; 9 (1): e85718
29. Moreno-Ramos T, Benito-León J, Villarejo A, Bermejo-Pareja F,. Retinal nerve fiber layer thinning in dementia associated with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease. J Alzheimers Dis. 2013; 34 (3): 659-664.
30. Albert MS, DeKosky ST, Dickson D, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011; 7 (3): 270-279.
31. McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011; 7 (3): 263-269.
32. Gibb WR, Lees AJ,. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry. 1988; 51 (6): 745-752.
33. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005; 53 (4): 695-699.
34. Wechsler D., Wechsler Memory Scale-Fourth Edition. San Antonio, TX: Pearson; 2009.
35. Benedict RHB, Schretlen DG, Groninger L, et al. Hopkins Verbal Learning Test-Revised: normative data and analysis of inter-form and test-retest reliability. Clin Neuropsychol. 1998; 12 (1): 43-55.
36. Tombaugh TN, Kozak J, Rees L,. Normative data stratified by age and education for two measures of verbal fluency: FAS and Animal naming. Arch Clin Neuropsychol. 1999; 14 (2): 167-177.
37. Army Individual Test Battery. Manual of Directions and Scoring. Washington, DC: War Department, Adjutant General's Office; 1944.
38. Alasil T, Wang K, Keane PA, et al. Analysis of normal retinal nerve fiber layer thickness by age, sex, and race using spectral domain optical coherence tomography. J Glaucoma. 2013; 22 (7): 532-541.
39. Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, et al. Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage. 2011; 54 (suppl 1): s204-s217.
40. Cheung CY, Ong YT, Ikram MK, et al. Microvascular network alterations in the retina of patients with Alzheimer's disease. Alzheimers Dement. 2014; 10 (2): 135-142.