Outpatient antibiotic prescription: A population-based study on regional age-related use of cephalosporins and fluoroquinolones in Germany;Antibiotikaverordnung in der ambulanten Versorgung: Eine bevölkerungsbezogene Untersuchung in Deutschland zum regionalen, altersgruppenbezogenen Verbrauch von Cephalosporinen und Fluorchinolonen

Deutsches Arzteblatt International

Volumn 113, Issue 26, 2016, Pages 454-459

  Bätzing Feigenbaum, Jörg ^a   Schulz, Maike ^a   Schulz, Mandy ^a   Hering, Ramona ^a   Kern, Winfried V ^b  

^a Fachbereich regionalisierte Versorgungsanalysen und Versorgungsatlas   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CEPHALOSPORIN DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE;

AGE; ANTIBIOTIC THERAPY; ARTICLE; GERMANY; HUMAN; OUTPATIENT; POPULATION RESEARCH; PRESCRIPTION; ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; BACTERIAL INFECTION; CLINICAL PRACTICE; FEMALE; INFANT; MALE; MIDDLE AGED; NEWBORN; PRESCHOOL CHILD; STATISTICS AND NUMERICAL DATA; TRENDS; UTILIZATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CEPHALOSPORINS; CHILD, PRESCHOOL; DRUG PRESCRIPTIONS; FEMALE; FLUOROQUINOLONES; GERMANY; HUMANS; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; PRACTICE PATTERNS, PHYSICIANS'; YOUNG ADULT;

EID: 84978174418     PISSN: 18660452     EISSN: None     Source Type: Journal    
DOI: 10.3238/arztebl.2016.0454     Document Type: Article

References (40)

1. Austin DJ, Kristinsson KG, Anderson RM: The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance. Proc Natl Acad Sci USA 1999; 96: 1152-6.
2. Bronzwaer SL, Cars O, Buchholz U, et al.: European Antimicrobial Resistance Surveillance System-a European study on the relationship be - tween antimicrobial use and antimicrobial resistance. Emerg Infect Dis 2002; 8: 278-82.
3. Goossens H, Ferech M, van der Stichele R, et al.: Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 2005; 365: 579-87.
4. Bundesministerium für Gesundheit (BMG), Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz (BMELV), Bundesministerium für Bildung und Forschung (BMBF): DART - Deutsche Antibiotika-Resistenzstrategie. Berlin 2011. http://mobile.bundesgesundheitsminis terium.de/fileadmin/dateien/Publikationen/Gesundheit/Broschueren/Deutsche-Antibiotika-Resistenzstrategie-DART-110331.pdf (last accessed on 28 July 2015).
5. Bundesministerium für Gesundheit (BMG), Bundesministerium für Er - nährung und Landwirtschaft BMEL), Bundesministerium für Bildung und Forschung (BMBF): DART 2020 - Antibiotika-Resistenzen bekämpfen zum Wohl von Mensch und Tier. Berlin 2015. www.bundesgesundheitsministe rium.de/fileadmin/dateien/Publikationen/Ministerium/Broschueren/BMG-DART-2020-Bericht-dt.pdf (last accessed on 22 December 2015).
6. Behnke M, Hansen S, Leistner R, et al.: Nosocomial infection and antibiotic use: a second national prevalence study in Germany. Dtsch Arztebl Int 2013; 110: 627-33.
7. Gastmeier P, Weitzel-Kage D, Behnke M, et al.: Surveillance of Clostridium difficile-associated diarrhoea with the German nosocomial infection surveillance system KISS (CDAD-KISS). Int J Antimicrob Agents 2009; 33 (Suppl 1): S19-23.
8. Lübbert C, John E, von Müller L: Clostridium difficile infection-guideline-based diagnosis and treatment. Dtsch Arztebl Int 2014; 111: 723-31.
9. Garg S, Mirza YR, Girotra M, et al.: Epidemiology of Clostridium difficileassociated disease (CDAD): a shift from hospital-acquired infection to long-term care facility-based infection. Dig Dis Sci 2013; 58: 3407-12.
10. de With K, Schröder H, Meyer E, et al.: Antibiotic use in Germany and European comparison. Dtsch Med Wochenschr 2004; 129: 1987-92.
11. Kern WV, de With K, Nink K, et al.: Regional variation in outpatient antibiotic prescribing in Germany. Infection 2006; 34: 269-73.
12. Koller D, Hoffmann F, Maier W, et al.: Variation in antibiotic prescriptions: is area deprivation an explanation? Analysis of 1.2 million children in Germany. Infection 2013; 41: 121-7.
13. Augustin J, Mangiapane S, Kern WV: A regional analysis of outpatient antibiotic prescribing in Germany in 2010. Eur J Public Health 2015; 25: 397-9.
14. Gallini A, Taboulet F, Bourrel R: Regional variations in quinolone use in France and associated factors. Eur J Clin Microbiol Infect Dis 2012; 31: 2911-8.
15. van Eldere J, Mera RM, Miller LA, et al.: Risk factors for development of multiple-class resistance to Streptococcus pneumoniae strains in Belgium over a 10-year period: antimicrobial consumption, population density, and geographic location. Antimicrob Agents Chemother 2007; 51: 3491-7.
16. Achermann R, Suter K, Kronenberg A, et al.: Antibiotic use in adult outpatients in Switzerland in relation to regions, seasonality and point of care tests. Clin Microbiol Infect 2011; 17: 855-61.
17. Clavenna A, Berti A, Gualandi L, et al.: Drug utilisation profile in the Italian paediatric population. Eur J Pediatr 2009; 168: 173-80.
18. Sachverständigenrat zur Begutachtung der Entwicklung im Gesundheitswesen: Bedarfsgerechte Versorgung - Perspektiven für ländliche Regionen und ausgewählte Leistungsbereiche. Berlin 2014. www.svrgesundheit. de/fileadmin/user-upload/Gutachten/2014/SVR-Gutachten- 2014-Langfassung.pdf (last accessed on 28 July 2015).
19. Kern WV, de With K: Rationale Antibiotikaverordnung - mehr Herausforderungen als Erfolge. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2012; 55: 1418-26.
20. Höffken G, Lorenz J, Kern WV, et al.: Diagnostik, antimikrobielle Therapie und Management von erwachsenen Patienten mit ambulant erworbenen unteren Atemwegsinfektionen sowie ambulant erworbener Pneumonie - Update 2009. Pneumologie 2009; 63: e1-68.
21. Woodhead M, Blasi F, Ewig S, et al.: Guidelines for the management of adult lower respiratory tract infections-full version. Clin Microbiol Infect 2011; 17 (Suppl 6): E1-59.
22. Macy E: Penicillin allergy: optimizing diagnostic protocols, public health implications, and future research needs. Curr Opin Allergy Clin Immunol 2015; 15: 308-13.
23. Finn AL, Straughn A, Meyer M, et al.: Effect of dose and food on the bio - availability of cefuroxime axetil. Biopharm Drug Dispos 1987; 8: 519-26.
24. Søes L, Mølbak K, Strøbaek S, et al.: The emergence of Clostridium difficile PCR ribotype 027 in Denmark-a possible link with the increased consumption of fluoroquinolones and cephalosporins? Euro Surveill 2009; 14: 1917.
25. Hernandez-Santiago V, Marwick CA, Patton A, et al.: Time series analysis of the impact of an intervention in Tayside, Scotland to reduce primary care broad-spectrum antimicrobial use. J Antimicrob Chemother 2015; 70: 2397-404.
26. Deshpande A, Pasupuleti V, Thota P, et al.: Community-associated Clostridium difficile infection and antibiotics: a meta-analysis. J Antimicrob Chemother 2013; 68: 1951-61.
27. Brown KA, Khanafer N, Daneman N, et al.: Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection. Antimicrob Agents Chemother 2013; 57: 2326-3.
28. Hammerum AM, Larsen J, Andersen VD, et al.: Characterization of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli obtained from Danish pigs, pig farmers and their families from farms with high or no consumption of third- or fourth-generation cephalosporins. J Antimicrob Chemother 2014; 69: 2650-7.
29. Knudsen JD, Andersen SE: A multidisciplinary intervention to reduce infections of ESBL- and AmpC-producing, gram-negative bacteria at a University Hospital. PLoS One 2014; 9: e86457.
30. Han JH, Bilker WB, Nachamkin I, et al.: Impact of antibiotic use during hospitalization on the development of gastrointestinal colonization with Escherichia coli with reduced fluoroquinolone susceptibility. Infect Control Hosp Epidemiol 2013; 34: 1070-6.
31. Vibet MA, Roux J, Montassier E, et al.: Systematic analysis of the relationship between antibiotic use and extended-spectrum betalactamase resistance in Enterobacteriaceae in a French hospital: a time series analysis. Eur J Clin Microbiol Infect Dis 2015; 34: 1957-63.
32. Gefenaite G, Bijlsma MJ, Bos HJ, et al.: Did introduction of pneumococcal vaccines in the Netherlands decrease the need for respiratory antibiotics in children? Analysis of 2002 to 2013 data. Euro Surveill 2014; 19: 20948.
33. Rückinger S, van der Linden M, Reinert RR, et al: Reduction in the incidence of invasive pneumococcal disease after general vaccination with 7-valent pneumococcal conjugate vaccine in Germany. Vaccine 2009; 27: 4136-41.
34. Weiss S, Falkenhorst G, van der Linden M, et al.: Impact of 10- and 13-valent pneumococcal conjugate vaccines on incidence of invasive pneumococcal disease in children aged under 16 years in Germany, 2009 to 2012. Euro Surveill 2015; 20: 21057.
35. Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin (DEGAM): Brennen beim Wasserlassen. DEGAM-Leitlinie Nr. 1. Anwenderversion der S3-Leitlinie Harnwegsinfekt. omikron publishing Düsseldorf 2009. www.degam.de/files/Inhalte/Leitlinien-Inhalte/Dokumente/DEGAM-S3-Leitlinien/LL-01-Langfassung-mit-KV-ZD.pdf (last accessed on 28 July 2015).
36. Wagenlehner FME, Hoyme UB, Kaase M, et al.: Clinical Practice Guide lines: Uncomplicated urinary tract infections. Dtsch Arztebl Int 2011; 108: 415-23.
37. Petursson P: GPs' reasons for "non-pharmacological" prescribing of antibiotics. A phenomenological study. Scand J Prim Health Care 2005; 23: 120-5.
38. Cals JW, Boumans D, Lardinois RJ, et al.: Public beliefs on antibiotics and respiratory tract infections: an internet-based questionnaire study. Br J Gen Pract 2007; 57: 942-7.
39. Briel M, Schuetz P, Mueller B, et al: Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care. Arch Intern Med 2008; 168: 2000-7.
40. Stucker F, Herrmann F, Graf JD, et al.: Procalcitonin and infection in the elderly. J Am Geriatr Soc 2005; 53: 1392-5.