Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

Diabetologia

Volumn 59, Issue 10, 2016, Pages 2156-2165

  Adriaenssens, Alice E ^a   Svendsen, Berit ^b,c   Lam, Brian Y H ^a   Yeo, Giles S H ^a   Holst, Jens J ^b,c   Reimann, Frank ^a   Gribble, Fiona M ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b Capital Region   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Alpha cells; Beta cells; Delta cells; Ghrelin; Glucagon; Insulin; RNA sequencing; Somatostatin

Indexed keywords

CALCIUM; G PROTEIN COUPLED RECEPTOR; GHRELIN RECEPTOR; PANCRELIPASE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; GHRELIN; GLUCAGON; INSULIN; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CELL POPULATION; CONTROLLED STUDY; GENE EXPRESSION; GLUCAGON RELEASE; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET DELTA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA SEQUENCE; TRANSCRIPTOMICS; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PANCREAS ISLET; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOMATOSTATIN CELL; TRANSGENIC MOUSE;

ANIMALS; CALCIUM; GHRELIN; GLUCAGON; GLUCAGON-SECRETING CELLS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOMATOSTATIN-SECRETING CELLS; TRANSCRIPTOME;

EID: 84978149797     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4033-1     Document Type: Article

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