Multiple Plasmids Contribute to Antibiotic Resistance and Macrophage Survival in Vitro in CMY2-Bearing Salmonella enterica

Foodborne Pathogens and Disease

Volumn 13, Issue 7, 2016, Pages 398-404

  Kempf, Allen J ^a   Hulsebus, Holly J ^a   Akbar, Samina ^a,b  

^a Des Moines University College of Osteopathic Medicine   (United States)

^b Marian University College of Osteopathic Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; CEFOXITIN; CEFTIOFUR; CEFTRIAXONE; CHLORAMPHENICOL; CIPROFLOXACIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; KANAMYCIN; NALIDIXIC ACID; SULFAFURAZOLE; TETRACYCLINE; BETA LACTAMASE; BETA-LACTAMASE CMY-2;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; CELL SURVIVAL; CMY2 GENE; CONTROLLED STUDY; ESCHERICHIA COLI; HEP 2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MOLECULAR MECHANICS; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; PLASMID; PRIORITY JOURNAL; REPLICON; SALMONELLA ENTERICA; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; ANIMAL; BACTERIUM CONJUGATION; CELL LINE; GENETICS; INTEGRON; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOUSE; MULTIDRUG RESISTANCE; SALMONELLOSIS;

ANIMALS; BETA-LACTAMASES; CELL LINE; CONJUGATION, GENETIC; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; HUMANS; INTEGRONS; MACROPHAGES; MICE; PLASMIDS; REPLICON; SALMONELLA ENTERICA; SALMONELLA INFECTIONS;

EID: 84978128513     PISSN: 15353141     EISSN: 15567125     Source Type: Journal    
DOI: 10.1089/fpd.2015.2067     Document Type: Article

References (25)

1. Arlet G, Barrett TJ, Butaye P, Cloeckaert A, Mulvey MR, White DG. Salmonella resistant to extended-spectrum cephalosporins: Prevalence and epidemiology. Microbes Infect 2006;8:1945-1954
2. Bauernfeind A, Stemplinger I, Junwirth R, Giamarellu H. Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance. Antimicrob Agents Chemother 1996;40:221-224
3. Beutlich J, Guerra B, Schroeter A, Arvand M, Szabo I, Helmuth R. [Highly ciprofloxacin resistant Salmonella enterica serovar Kentucky isolates in turkey meat and a human patient]. Berl Munch Tierarztl Wochenschr 2012;125:89-95
4. Brunelle BW, Bearson BL, Bearson SM. Chloramphenicol and tetracycline decrease motility and increase invasion and attachment gene expression in specific isolates of multidrugresistant Salmonella enterica serovar Typhimurium. Front Microbiol 2015;5:801
5. Brunelle BW, Bearson SM, Bearson BL. Tetracycline accelerates the temporally-regulated invasion response in specific isolates of multidrug-resistant Salmonella enterica serovar Typhimurium. BMC Microbiol 2013;13:202
6. Call DR, Singer RS, Meng D, Broschat SL, Orfe LH, Anderson JM, Herndon DR, Kappmeyer LS, Daniels JB, Besser TE. blaCMY-2-positive IncA/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids. Antimicrob Agents Chemother 2010; 54:590-596
7. Carattoli A, Tosini F, Giles WP, Rupp ME, Hinrichs SH, Angulo FJ, Barrett TJ, Fey PD. Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporinresistant Salmonella strains isolated in the United States between 1996 and 1998. Antimicrob Agents Chemother 2002; 46:1269-1272
8. Douce GR, Amin II, Stephen J. Invasion of HEp-2 cells by strains of Salmonella typhimurium of different virulence in relation to gastroenteritis. 1991. J Med Microbiol 1991;35: 349-357
9. Gebreyes WA, Altier C. Molecular characterization of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhimurium isolates from swine. J Clin Microbiol 2002; 40:2813-2822
10. Gebreyes WA, Thakur S, Morrow WE. Comparison of prevalence, antimicrobial resistance, and occurrence of multidrugresistant Salmonella in antimicrobial-free and conventional pig production. J Food Prot 2006;69:743-748
11. Giles WP, Benson AK, Olson ME, Hutkins RW, Whichard JM, Winokur PL, Fey PD. DNA sequence analysis of regions surrounding blaCMY-2 from multiple Salmonella plasmid backbones. Antimicrob Agents Chemother 2004;48:2845-2852
12. Green MaSJ. Molecular Cloning: A Laboratory Manual. 4th ed. New York: Cold Spring Harbor Laboratory Press, 2012
13. Guo YF, Zhang WH, Ren SQ, Yang L, Lu DH, Zeng ZL, Liu YH, Jiang HX. IncA/C plasmid-mediated spread of CMY-2 in multidrug-resistant Escherichia coli from food animals in China. PLoS One 2014;9:e96738
14. Holmes AH, Moore LS, Sundsfjord A, Steinbakk M, Regmi S, Karkey A, Guerin PJ, Piddock LJ. Understanding the mechanisms and drivers of antimicrobial resistance. Lancet 2016; 387:176-187
15. Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev 2009;22:161-182, Table of Contents
16. Johnson TJ, Lang KS. IncA/C plasmids: An emerging threat to human and animal health?Mob Genet Elements 2012;2:55-58
17. Johnson TJ, Nolan LK. Plasmid replicon typing. Methods Mol Biol 2009;551:27-35
18. Johnson TJ, Wannemuehler YM, Johnson SJ, Logue CM, White DG, Doekott C, Nolan LK. Plasmid replicon typing of commensal and pathogenic Escherichia coli isolates. Appl Environ Microbiol 2007;73:1976-1983
19. Lang KS, Danzeisen JL, Xu W, Johnson TJ. Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-hostrange IncA/C plasmid. Appl Environ Microbiol 2012;78: 3379-3386
20. Lindsey RL, Fedorka-Cray PJ, Frye JG, Meinersmann RJ. Inc A/ C plasmids are prevalent in multidrug-resistant Salmonella enterica isolates. Appl Environ Microbiol 2009;75:1908-1915
21. Pistorio M, Del Papa MF, Balague LJ, Lagares A. Identification of a transmissible plasmid from an Argentine Sinorhizobium meliloti strain which can be mobilised by conjugative helper functions of the European strain S. meliloti GR4. FEMS Microbiol Lett 2003;225:15-21
22. Pitout JD. Multiresistant Enterobacteriaceae: New threat of an old problem. Expert Rev Anti Infect Ther 2008;6:657-669
23. Poole TL, Edrington TS, Brichta-Harhay DM, Carattoli A, Anderson RC, Nisbet DJ. Conjugative transferability of the A/C plasmids from Salmonella enterica isolates that possess or lack bla(CMY) in the A/C plasmid backbone. Foodborne Pathog Dis 2009;6:1185-1194
24. Subbiah M, Top EM, Shah DH, Call DR. Selection pressure required for long-term persistence of blaCMY-2-positive IncA/ C plasmids. Appl Environ Microbiol 2011;77:4486-4493
25. Zhao S, White DG, McDermott PF, Friedman S, English L, Ayers S, Meng J, Maurer JJ, Holland R, Walker RD. Identification and expression of cephamycinase bla(CMY) genes in Escherichia coli and Salmonella isolates from food animals and ground meat. Antimicrob Agents Chemother 2001;45:3647-3650