Individual differences in depression are associated with abnormal function of the limbic system in multiple sclerosis patients

Multiple Sclerosis

Volumn 22, Issue 8, 2016, Pages 1094-1105

  Riccelli, Roberta ^a   Passamonti, Luca ^b,c   Cerasa, Antonio ^b   Nigro, Salvatore ^a   Cavalli, Salvatore Maria ^a   Chiriaco, Carmelina ^b   Valentino, Paola ^a   Nisticò, Rita ^b   Quattrone, Aldo ^a,b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Depression; functional connectivity; limbic system; multiple sclerosis; prefrontal cortex

Indexed keywords

ADULT; AMYGDALA; ARTICLE; BECK DEPRESSION INVENTORY; CINGULATE GYRUS; CONNECTOME; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DISEASE ASSOCIATION; DISEASE SEVERITY; DORSOLATERAL PREFRONTAL CORTEX; EMOTION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; INDIVIDUALITY; LIMBIC SYSTEM; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; ORBITAL CORTEX; PATHOPHYSIOLOGY; AGED; EMOTIONAL PROCESSING TASK; EXPERIMENTAL BEHAVIORAL TEST; FATIGUE SEVERITY SCALE; FUNCTIONAL CONNECTIVITY; INTERVIEW; PREFRONTAL CORTEX; SCORING SYSTEM; VERY ELDERLY; AFFECT; BRAIN MAPPING; CASE CONTROL STUDY; COMPLICATION; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; MIDDLE AGED; NERVE TRACT; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PROCEDURES; PSYCHOLOGY; RISK FACTOR; YOUNG ADULT;

ADULT; AFFECT; BRAIN MAPPING; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DEPRESSION; EMOTIONS; FEMALE; HUMANS; LIMBIC SYSTEM; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS; YOUNG ADULT;

EID: 84978121066     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458515606987     Document Type: Article

References (33)

1. Feinstein A, Magalhaes S, Richard JF, et al. The link between multiple sclerosis and depression. Nat Rev Neurol 2014; 10: 507-517.
2. McIvor GP, Riklan M, Reznikoff M., Depression in multiple sclerosis as a function of length and severity of illness, age, remission and perceived social support. J Clin Psychol 1984; 40: 1028-1033.
3. Millefiorini E, Padovani A, Pozzilli C, et al. Depression in the early phase of MS: Influence of functional disability, cognitive impairment and brain abnormalities. Acta Neurol Scand 1992; 86: 354-358.
4. Minden SL, Orav J, Reich P., Depression in multiple sclerosis. Gen Hosp Psychiatriy 1987; 9: 426-434.
5. Pokryszko-Dragan A, Frydecka I, Kosmaczewska A, et al. Stimulated peripheral production of interferon-gamma is related to fatigue and depression in multiple sclerosis. Clin Neurol Neurosurg 2012; 114: 1153-1158.
6. Zorzon M, de Masi R, Nasuelli D, et al. Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects. J Neurol 2001; 248: 416-421.
7. Feinstein A, Roy P, Lobaugh N, et al. Structural brain abnormalities in multiple sclerosis patients with major depression. Neurology 2004; 62: 586-590.
8. Feinstein A, O'Connor P, Akbar N, et al. Diffusion tensor imaging abnormalities in depressed multiple sclerosis patients. Mult Scler 2010; 16: 189-196.
9. Rocca MA, Valsasina P, Martinelli V, et al. Large-scale neuronal network dysfunction in relapsing-remitting multiple sclerosis. Neurology 2012; 79: 1449-1457.
10. Nigro S, Passamonti L, Riccelli R, et al. Structural 'connectomic' alterations in the limbic system of multiple sclerosis patients with major depression. Mult Scler 2015; 21: 1003-1012.
11. Pelletier J, Audoin B, Reuter F, et al. Plasticity in MS: From functional imaging to rehabilitation. Int MS J 2009; 16: 26-31.
12. Fusar-Poli P, Placentino A, Carletti F, et al. Functional atlas of emotional faces processing: A voxel-based meta-analysis of 105 functional magnetic resonance imaging studies. J Psychiatry Neurosci 2009; 34: 418-432.
13. Davis M,. The role of the amygdala in fear and anxiety. Annu Rev Neurosci 1992; 15: 353-375.
14. Herman JP, Schafer MK, Young EA, et al. Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis. J Neurosci 1989; 9: 3072-3082.
15. Stuhrmann A, Suslow T, Dannlowski U,. Facial emotion processing in major depression: A systematic review of neuroimaging findings. Biol Mood Anxiety Disord 2011; 1: 10.
16. Drevets WC, Price JL, Furey ML,. Brain structural and functional abnormalities in mood disorders: Implications for neurocircuitry models of depression. Brain Struct Funct 2008; 213: 93-118.
17. Staffen W, Mair A, Zauner H, et al. Cognitive function and fMRI in patients with multiple sclerosis: Evidence for compensatory cortical activation during an attention task. Brain 2002; 125: 1275-1282.
18. Passamonti L, Cerasa A, Liguori M, et al. Neurobiological mechanisms underlying emotional processing in relapsing-remitting multiple sclerosis. Brain 2009; 132: 3380-3391.
19. Rocca MA, Filippi M,. Functional MRI in multiple sclerosis. J Neuroimaging 2007; 17 (Suppl. 1): 36S-41S.
20. Mayberg HS,. Limbic-cortical dysregulation: A proposed model of depression. J Neuropsychiatry Clin Neurosci 1997; 9: 471-481.
21. Korgaonkar MS, Fornito A, Williams LM, et al. Abnormal structural networks characterize major depressive disorder: A connectome analysis. Biol Psychiatry 2014; 76: 567-574.
22. Berney A, Nishikawa M, Benkelfat C, et al. An index of 5-HT synthesis changes during early antidepressant treatment: alpha-[11C]methyl-L-tryptophan PET study. Neurochem Int 2008; 52: 701-708.
23. Beck AT, Steer RA, Brown GK,. Manual for the BDI-Fast Screen for medical patients. San Antonio, TX: Psychological Corporation, 2000.
24. Benedict RH, Fishman I, McClellan MM, et al. Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosis. Mult Scler 2003; 9: 393-396.
25. Friston KJ,. Testing for anatomically specified regional effects. Hum Brain Mapp 1997; 5: 133-136.
26. Desikan RS, Segonne F, Fischl B, et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 2006; 31: 968-980.
27. Friston KJ, Buechel C, Fink GR, et al. Psychophysiological and modulatory interactions in neuroimaging. Neuroimage 1997; 6: 218-229.
28. Beiske AG, Svensson E, Sandanger I, et al. Depression and anxiety amongst multiple sclerosis patients. Eur J Neurol 2008; 15: 239-245.
29. Gold SM, O'Connor MF, Gill R, et al. Detection of altered hippocampal morphology in multiple sclerosis-associated depression using automated surface mesh modeling. Hum Brain Mapp 2014; 35: 30-37.
30. Gold SM, Kern KC, O'Connor MF, et al. Smaller cornu ammonis 2-3/dentate gyrus volumes and elevated cortisol in multiple sclerosis patients with depressive symptoms. Biol Psychiatry 2010; 68: 553-559.
31. Gotlib IH, Sivers H, Gabrieli JD, et al. Subgenual anterior cingulate activation to valenced emotional stimuli in major depression. Neuroreport 2005; 16: 1731-1734.
32. Phillips ML, Ladouceur CD, Drevets WC,. A neural model of voluntary and automatic emotion regulation: Implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 2008; 13: 829, 33-57.
33. Leppanen JM, Milders M, Bell JS, et al. Depression biases the recognition of emotionally neutral faces. Psychiatry Res 2004; 128: 123-133.