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Volumn 73, Issue 7, 2016, Pages 651-652

What are we learning from early-phase clinical trials with glutamate targeting medications for the treatment of major depressive disorder

Author keywords

[No Author keywords available]

Indexed keywords

BASIMGLURANT; GLUTAMATE RECEPTOR 5; GLUTAMIC ACID; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; ANTIDEPRESSANT AGENT;

EID: 84978100390     PISSN: 2168622X     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapsychiatry.2016.0780     Document Type: Editorial
Times cited : (10)

References (11)
  • 2
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    • Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discov. 2008;7(5):426-437.
    • (2008) Nat Rev Drug Discov. , vol.7 , Issue.5 , pp. 426-437
    • Sanacora, G.1    Zarate, C.A.2    Krystal, J.H.3    Manji, H.K.4
  • 4
    • 84978143703 scopus 로고    scopus 로고
    • Efficacy and safety of basimglurant as adjunctive therapy for major depression: A randomized clinical trial [published online June 15, 2016]
    • Quiroz JA, Tamburri P, Deptula D, et al. Efficacy and safety of basimglurant as adjunctive therapy for major depression: a randomized clinical trial [published online June 15, 2016]. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2016.0838.
    • JAMA Psychiatry
    • Quiroz, J.A.1    Tamburri, P.2    Deptula, D.3
  • 5
    • 28244486818 scopus 로고    scopus 로고
    • Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: A possible key mechanism in the modulation of N-methyl-D-aspartate effects
    • Tebano MT, Martire A, Rebola N, et al. Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects. J Neurochem. 2005;95(4):1188-1200.
    • (2005) J Neurochem. , vol.95 , Issue.4 , pp. 1188-1200
    • Tebano, M.T.1    Martire, A.2    Rebola, N.3
  • 7
    • 59049098262 scopus 로고    scopus 로고
    • An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101, 606, in patients with treatment-refractory major depressive disorder
    • Preskorn SH, Baker B, Kolluri S, Menniti FS, Krams M, Landen JW. An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101, 606, in patients with treatment-refractory major depressive disorder. J Clin Psychopharmacol. 2008;28(6):631-637.
    • (2008) J Clin Psychopharmacol. , vol.28 , Issue.6 , pp. 631-637
    • Preskorn, S.H.1    Baker, B.2    Kolluri, S.3    Menniti, F.S.4    Krams, M.5    Landen, J.W.6
  • 8
    • 84908572031 scopus 로고    scopus 로고
    • Lanicemine: A low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects
    • Sanacora G, Smith MA, Pathak S, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Mol Psychiatry. 2014;19(9):978-985.
    • (2014) Mol Psychiatry , vol.19 , Issue.9 , pp. 978-985
    • Sanacora, G.1    Smith, M.A.2    Pathak, S.3
  • 9
    • 84929617020 scopus 로고    scopus 로고
    • Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent
    • Preskorn S, Macaluso M, Mehra DO, Zammit G, Moskal JR, Burch RM; GLYX-13 Clinical Study Group. Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent. J Psychiatr Pract. 2015;21(2):140-149.
    • (2015) J Psychiatr Pract. , vol.21 , Issue.2 , pp. 140-149
    • Preskorn, S.1    Macaluso, M.2    Mehra, D.O.3    Zammit, G.4    Moskal, J.R.5    Burch, R.M.6
  • 11
    • 84978105554 scopus 로고    scopus 로고
    • Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: Post-hoc analyses of a randomized, placebo-controlled study (PURSUIT)
    • June 16-19, Hollywood, Florida
    • Pathak S, Su H-L, Posener J. et al. Adjunctive lanicemine (AZD6765) in patients with major depressive disorder and a history of inadequate response to antidepressants: post-hoc analyses of a randomized, placebo-controlled study (PURSUIT). Poster presented at the American Society of Clinical Psychiatry Annual Meeting; June 16-19, 2014; Hollywood, Florida.
    • (2014) The American Society of Clinical Psychiatry Annual Meeting
    • Pathak, S.1    Su, H.-L.2    Posener, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.