Abnormal hippocampal-thalamic white matter tract development and positive symptom course in individuals at ultra-high risk for psychosis

npj Schizophrenia

Volumn 1, Issue 1, 2015, Pages

  Bernard, Jessica A ^a   Orr, Joseph M ^a   Mittal, Vijay A ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGE; ARTICLE; BRAIN DEVELOPMENT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; DISEASE SEVERITY; FEMALE; FOLLOW UP; FRACTIONAL ANISOTROPY; HIGH RISK PATIENT; HIPPOCAMPUS; HUMAN; LEFT HEMISPHERE; MALE; NEGATIVE SYNDROME; POSITIVE SYNDROME; PRIORITY JOURNAL; PSYCHOSIS; RIGHT HEMISPHERE; SYMPTOM ASSESSMENT; THALAMUS; TRACTOGRAPHY; WHITE MATTER;

EID: 84978079068     PISSN: None     EISSN: 2334265X     Source Type: Journal    
DOI: 10.1038/npjschz.2015.9     Document Type: Article

References (42)

1. Behrens TEJ, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CaM, Boulby Pa et al. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci 2003; 6: 750-757.
2. Qiu A, Zhong J, Graham S, Chia MY, Sim K. Combined analyses of thalamic volume, shape and white matter integrity in first-episode schizophrenia. Neuroimage 2009; 47: 1163-1171.
3. Rajarethinam R, DeQuardo JR, Miedler J, Arndt S, Kirbat R, Brunberg JA et al. Hippocampus and amygdala in schizophrenia: assessment of the relationship of neuroanatomy to psychopathology. Psychiatry Res Neuroimaging 2001; 108: 79-87.
4. Zierhut K, Bogerts B, Schott B, Fenker D, Walter M, Albrecht D et al. The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia. Psychiatry Res 2010; 183: 187-194.
5. Min SK, An SK, Jon D-I, Lee JD. Positive and negative symptoms and regional cerebral perfusion in antipsychotic-naive schizophrenic patients: a high-resolution SPECT study. Psychiatry Res Neuroimaging 1999; 90: 159-168.
6. Walker E, Mittal V, Tessner K. Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annu Rev Clin Psychol 2008; 4: 189-216.
7. Corson PW, Nopoulos P, Andreasen NC, Heckel D, Arndt S. Caudate size in firstepisode neuroleptic-naive schizophrenic patients measured using an artificial neural network. Biol Psychiatry 1999; 46: 712-720.
8. Andreasen NC, Pierson R. The role of the cerebellum in schizophrenia. Biol Psychiatry 2008; 64: 81-88.
9. Hao Y, Yan Q, Liu H, Xu L, Xue Z, Song X et al. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex. Schizophr Res 2009; 114: 128-135.
10. McIntosh AM, Muñoz Maniega S, Lymer GKS, McKirdy J, Hall J, Sussmann JED et al. White matter tractography in bipolar disorder and schizophrenia. Biol Psychiatry 2008; 64: 1088-1092.
11. Oh JS, Kubicki M, Rosenberger G, Bouix S, Levitt JJ, McCarley RW et al. Thalamofrontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography study. Hum Brain Mapp 2009; 30: 3812-3825.
12. Buchsbaum MS, Schoenknecht P, Torosjan Y, Newmark R, Chu K-W, Mitelman S et al. Diffusion tensor imaging of frontal lobe white matter tracts in schizophrenia. Ann Gen Psychiatry 2006; 5: 19.
13. Karlsgodt KH, Niendam Ta, Bearden CE, Cannon TD. White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis. Biol Psychiatry 2009; 66: 562-569.
14. Mittal VA, Dean DJ, Bernard JA, Orr JM, Pelletier-Baldelli A, Carol EE et al. Neurological Soft Signs Predict Abnormal Cerebellar-Thalamic Tract Development and Negative Symptoms in Adolescents at High Risk for Psychosis: A Longitudinal Perspective. Schizophr Bull 2014; 50: 1204-1215.
15. Ziermans TB, Schothorst PF, Sprong M, van Engeland H. Transition and remission in adolescents at ultra-high risk for psychosis. Schizophr Res 2011; 126: 58-64.
16. Cannon TD, Cadenhead K, Cornblatt B, Woods SW, Addington J, Walker E et al. Prediction of psychosis in youth at high clinical risk. Arch Gen Psychiatry 2008; 65: 28-37.
17. Fusar-Poli P, Crossley N, Woolley J, Carletti F, Perez-Iglesias R, Broome M et al. White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG study. J Psychiatry Neurosci 2011; 36: 239-248.
18. Wood SJ, Kennedy D, Phillips LJ, Seal ML, Yücel M, Nelson B et al. Hippocampal pathology in individuals at ultra-high risk for psychosis: a multi-modal magnetic resonance study. Neuroimage 2010; 52: 62-68.
19. Wood SJ, Yücel M, Velakoulis D, Phillips LJ, Yung AR, Brewer W et al. Hippocampal and anterior cingulate morphology in subjects at ultra-high-risk for psychosis: the role of family history of psychotic illness. Schizophr Res 2005; 75: 295-301.
20. Lawrie SM, Whalley HC, Abukmeil SS, Kestelman JN, Donnelly L, Miller P et al. Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia. Biol Psychiatry 2001; 49: 811-823.
21. Keshavan M, Dick E, Mankowski I, Harenski K, Montrose D, Diwadkar V et al. Decreased left amygdala and hippocampal volumes in young offspring at risk for schizophrenia. Schizophr Res 2002; 58: 173-183.
22. Lunsford-Avery JR, Orr JM, Gupta T, Pelletier-Baldelli A, Dean DJ, Smith AK et al. Sleep dysfunction and thalamic abnormalities in adolescents at ultra high-risk for psychosis. Schizophr Res 2013; 151: 148-153.
23. Mittal Va, Gupta T, Orr JM, Pelletier-Baldelli A, Dean DJ, Lunsford-Avery JR et al. Physical activity level and medial temporal health in youth at ultra high-risk for psychosis. J Abnorm Psychol 2013; 122: 1101-1110.
24. Pantelis C, Velakoulis D, Wood SJ, Yücel M, Yung aR, Phillips LJ et al. Neuroimaging and emerging psychotic disorders: the Melbourne ultra-high risk studies. Int Rev Psychiatry 2007; 19: 371-381.
25. Jacobson S, Kelleher I, Harley M, Murtagh A, Clarke M, Blanchard M et al. Structural and functional brain correlates of subclinical psychotic symptoms in 11-13 year old schoolchildren. Neuroimage 2010; 49: 1875-1885.
26. Boos HBM, Mandl RCW, van Haren NEM, Cahn W, van Baal GCM, Kahn RS et al. Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings. Eur Neuropsychopharmacol 2013; 23: 295-304.
27. Walterfang M, McGuire PK, Yung AR, Phillips LJ, Velakoulis D, Wood SJ et al. White matter volume changes in people who develop psychosis. Br J Psychiatry 2008; 193: 210-215.
28. Buehlmann E, Berger GE, Aston J, Gschwandtner U, Pflueger MO, Borgwardt SJ et al. Hippocampus abnormalities in at risk mental states for psychosis? A crosssectional high resolution region of interest magnetic resonance imaging study. J Psychiatr Res 2010; 44: 447-453.
29. First M, Spitzer R, Gibbon M, Williams J. Structured Clinical Interview for the DSM-IV Axis I Disorders (SCID-I), Patient Edition. American Psychiatric Press: Washington, DC, USA, 1995.
30. Miller TJ, Mcglashan TH, Woods SW, Stein K, Driesen N, Corcoran CM et al. Symptom assessment in schizophrenic prodromal states. Psychiatr Q 1999; 70: 273-287.
31. Johansen-Berg H, Behrens TEJ, Sillery E, Ciccarelli O, Thompson AJ, Smith SM et al. Functional-Anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus. Cereb Cortex 2005; 15: 31-39.
32. Behrens TEJ, Johansen-Berg H, Jbabdi S, Rushworth MFS, Woolrich MW. Probabilistic diffusion tractography with multiple fibre orientations: what can we gain? Neuroimage 2007; 34: 144-155.
33. Yung AR, Yuen HP, Berger G, Francey S, Hung T-C, Nelson B et al. Declining transition rate in ultra high risk (prodromal) services: dilution or reduction of risk? Schizophr Bull 2007; 33: 673-681.
34. Bernard JA, Dean DJ, Kent JS, Orr JM, Pelletier-Baldelli A, Lunsford-Avery J et al. Cerebellar networks in individuals at ultra high-risk of psychosis: impact on postural sway and symptom severity. Hum Brain Mapp 2014; 35: 4064-4078.
35. Bloemen OJN, de Koning MB, Schmitz N, Nieman DH, Becker HE, de Haan L et al. White-matter markers for psychosis in a prospective ultra-high-risk cohort. Psychol Med 2010; 40: 1297-1304.
36. Clemm von Hohenberg C, Pasternak O, Kubicki M, Ballinger T, Vu M-A, Swisher T et al. White matter microstructure in individuals at clinical high risk of psychosis: a Whole-Brain Diffusion Tensor Imaging Study. Schizophr Bull 2013; 40: 895-903.
37. Kubicki M, McCarley R, Westin C-F, Park H-J, Maier S, Kikinis R et al. A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res 2007; 41: 15-30.
38. Kubicki M, Park H, Westin CF, Nestor PG, Mulkern RV, Maier SE et al. DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity. Neuroimage 2005; 26: 1109-1118.
39. Kubicki M, Westin C-F, McCarley RW, Shenton ME. The application of DTI to investigate white matter abnormalities in schizophrenia. Ann N Y Acad Sci 2005; 1064: 134-148.
40. Phillips LJ, Velakoulis D, Pantelis C, Wood S, Pan H, Yung AR et al. Non-reduction in hippocampal volume is associated with higher risk of psychosis. Schizophr Res 2002; 58: 145-158.
41. Peters BD, Karlsgodt KH. White matter development in the early stages of psychosis. Schizophr Res 2015; 161: 61-69.
42. Thomas C, Ye FQ, Irfanoglu MO, Modi P, Saleem KS, Leopold Da et al. Anatomical accuracy of brain connections derived from diffusion MRI tractography is inherently limited. Proc Natl Acad Sci USA 2014; 111: 16574-16579.