Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study

PLoS Medicine

Volumn 13, Issue 6, 2016, Pages

  Mogeni, Polycarp ^a   Williams, Thomas N ^a,b   Fegan, Gregory ^a,c   Nyundo, Christopher ^a   Bauni, Evasius ^a   Mwai, Kennedy ^a   Omedo, Irene ^a   Njuguna, Patricia ^a   Newton, Charles R ^a,c   Osier, Faith ^a   Berkley, James A ^a,c   Hammitt, Laura L ^a,d   Lowe, Brett ^a   Mwambingu, Gabriel ^a   Awuondo, Ken ^a   Mturi, Neema ^a   Peshu, Norbert ^a   Snow, Robert W ^a,c   Noor, Abdisalan ^a,c   Marsh, Kevin ^a,c   Bejon, Philip ^a,c   more..

^a KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; COMMUNITY CARE; CONTROLLED STUDY; DEMOGRAPHY; DISEASE SURVEILLANCE; DISEASE TRANSMISSION; FEMALE; GENETIC SUSCEPTIBILITY; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MALE; MICROSCOPY; MIDDLE AGED; OBSERVATIONAL STUDY; PARASITEMIA; PREVALENCE; SENSITIVITY ANALYSIS; SOIL MOISTURE; SPATIOTEMPORAL ANALYSIS; YOUNG ADULT; CHILD; HOSPITALIZATION; INFANT; INSECTICIDE TREATED NET; KENYA; LONGITUDINAL STUDY; MOSQUITO CONTROL; PARASITOLOGY; PRESCHOOL CHILD; RISK; STATISTICS AND NUMERICAL DATA; TRENDS; UTILIZATION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HOSPITALIZATION; HUMANS; INFANT; INSECTICIDE-TREATED BEDNETS; KENYA; LONGITUDINAL STUDIES; MALARIA; MALE; MOSQUITO CONTROL; PREVALENCE; RISK;

EID: 84978077014     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1002047     Document Type: Article

References (30)

1. Ceesay SJ, Casals-Pascual C, Nwakanma DC, Walther M, Gomez-Escobar N, Fulford AJ, et al. Continued decline of malaria in The Gambia with implications for elimination. PLoS ONE. 2010;5(8):e12242. Epub 2010/09/02. doi: 10.1371/journal.pone.001224220805878; PubMed Central PMCID: PMCPmc2923605.
2. O'Meara WP, Mangeni JN, Steketee R, Greenwood B, Changes in the burden of malaria in sub-Saharan Africa. The Lancet Infectious Diseases. 2010;10(8):545–55. doi: 10.1016/S1473-3099(10)70096-720637696
3. Noor AM, Kinyoki DK, Mundia CW, Kabaria CW, Mutua JW, Alegana VA, et al. The changing risk of Plasmodium falciparum malaria infection in Africa: 2000–10: a spatial and temporal analysis of transmission intensity. Lancet. 2014;383(9930):1739–47. Epub 2014/02/25. doi: 10.1016/s0140-6736(13)62566-024559537; PubMed Central PMCID: PMCPmc4030588.
4. Snow RW, Omumbo JA, Lowe B, Molyneux CS, Obiero JO, Palmer A, et al. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet. 1997;349(9066):1650–4. Epub 1997/06/07. doi: 10.1016/s0140-6736(97)02038-29186382.
5. Woolhouse ME, Patterns in parasite epidemiology: the peak shift. Parasitol Today. 1998;14(10):428–34. Epub 2006/10/17. 17040835.
6. Okiro EA, Al-Taiar A, Reyburn H, Idro R, Berkley JA, Snow RW, Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity. Malaria journal. 2009;8:4. Epub 2009/01/09. doi: 10.1186/1475-2875-8-419128453; PubMed Central PMCID: PMCPmc2630996.
7. Karema C, Aregawi MW, Rukundo A, Kabayiza A, Mulindahabi M, Fall IS, et al. Trends in malaria cases, hospital admissions and deaths following scale-up of anti-malarial interventions, 2000–2010, Rwanda. Malaria journal. 2012;11:236. Epub 2012/07/25. doi: 10.1186/1475-2875-11-23622823945; PubMed Central PMCID: PMCPmc3502144.
8. Trape JF, Tall A, Diagne N, Ndiath O, Ly AB, Faye J, et al. Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study. Lancet Infect Dis. 2011;11(12):925–32. Epub 2011/08/23. doi: 10.1016/s1473-3099(11)70194-321856232.
9. Pemberton-Ross P, Smith TA, Hodel EM, Kay K, Penny MA, Age-shifting in malaria incidence as a result of induced immunological deficit: a simulation study. Malaria journal. 2015;14:287. Epub 2015/07/25. doi: 10.1186/s12936-015-0805-126206255; PubMed Central PMCID: PMCPmc4513612.
10. Midekisa A, Senay G, Henebry GM, Semuniguse P, Wimberly MC, Remote sensing-based time series models for malaria early warning in the highlands of Ethiopia. Malaria journal. 2012;11:165. Epub 2012/05/16. doi: 10.1186/1475-2875-11-16522583705; PubMed Central PMCID: PMCPmc3493314.
11. Scott JA, Bauni E, Moisi JC, Ojal J, Gatakaa H, Nyundo C, et al. Profile: The Kilifi Health and Demographic Surveillance System (KHDSS). Int J Epidemiol. 2012;41(3):650–7. Epub 2012/05/01. doi: 10.1093/ije/dys06222544844; PubMed Central PMCID: PMCPmc3396317.
12. Bejon P, Berkley JA, Mwangi T, Ogada E, Mwangi I, Maitland K, et al. Defining childhood severe falciparum malaria for intervention studies. PLoS Med. 2007;4(8):e251. Epub 2007/08/24. doi: 10.1371/journal.pmed.004025117713980; PubMed Central PMCID: PMCPmc1949845.
13. Mwangi TW, Ross A, Snow RW, Marsh K, Case definitions of clinical malaria under different transmission conditions in Kilifi District, Kenya. J Infect Dis. 2005;191(11):1932–9. 15871128.
14. Smith DL, Guerra CA, Snow RW, Hay SI, Standardizing estimates of the Plasmodium falciparum parasite rate. Malaria journal. 2007;6:131. Epub 2007/09/27. doi: 10.1186/1475-2875-6-13117894879; PubMed Central PMCID: PMCPmc2072953.
15. Tatem AJ, Goetz SJ, Hay SI, Terra and Aqua: new data for epidemiology and public health. Int J Appl Earth Obs Geoinf. 2004;6(1):33–46. Epub 2004/11/01. 22545030; PubMed Central PMCID: PMCPmc3337546.
16. Team RCR: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2013.
17. Bejon P, Williams TN, Nyundo C, Hay SI, Benz D, Gething PW, et al. A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots. Elife. 2014;3:e02130. Epub 2014/05/21. doi: 10.7554/eLife.0213024843017; PubMed Central PMCID: PMCPmc3999589.
18. Snow RW, Molyneux C, Warn P, Omumbo J, Nevill C, Gupta S, et al. Infant parasite rates and immunoglobulin M seroprevalence as a measure of exposure to Plasmodium falciparum during a randomized controlled trial of insecticide-treated bed nets on the Kenyan coast. Am J Trop Med Hyg. 1996;55(2):144–9. 8780451
19. O'Meara WP, Bejon P, Mwangi TW, Okiro EA, Peshu N, Snow RW, et al. Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya. Lancet. 2008;372(9649):1555–62. Epub 2008/11/06. doi: 10.1016/s0140-6736(08)61655-418984188; PubMed Central PMCID: PMCPmc2607008.
20. Snow RW, Kibuchi E, Karuri SW, Sang G, Gitonga CW, Mwandawiro C, et al. Changing Malaria Prevalence on the Kenyan Coast since 1974: Climate, Drugs and Vector Control. PLoS ONE. 2015;10(6):e0128792. Epub 2015/06/25. doi: 10.1371/journal.pone.012879226107772.
21. Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V, et al. Indicators of life-threatening malaria in African children. The New England journal of medicine. 1995;332(21):1399–404. Epub 1995/05/25. doi: 10.1056/nejm1995052533221027723795.
22. Goncalves BP, Huang CY, Morrison R, Holte S, Kabyemela E, Prevots DR, et al. Parasite burden and severity of malaria in Tanzanian children. The New England journal of medicine. 2014;370(19):1799–808. Epub 2014/05/09. doi: 10.1056/NEJMoa130394424806160; PubMed Central PMCID: PMCPmc4091983.
23. Reyburn H, Mbatia R, Drakeley C, Bruce J, Carneiro I, Olomi R, et al. Association of transmission intensity and age with clinical manifestations and case fatality of severe Plasmodium falciparum malaria. Jama. 2005;293(12):1461–70. 15784869.
24. Smith T, Killeen G, Lengeler C, Tanner M, Relationships between the outcome of Plasmodium falciparum infection and the intensity of transmission in Africa. The American journal of tropical medicine and hygiene. 2004;71(2 Suppl):80–6. Epub 2004/08/28. 15331822.
25. Dondorp AM, Lee SJ, Faiz MA, Mishra S, Price R, Tjitra E, et al. The relationship between age and the manifestations of and mortality associated with severe malaria. Clin Infect Dis. 2008;47(2):151–7. doi: 10.1086/58928718533842.
26. von Seidlein L, Olaosebikan R, Hendriksen IC, Lee SJ, Adedoyin OT, Agbenyega T, et al. Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. Clin Infect Dis. 2012;54(8):1080–90. doi: 10.1093/cid/cis03422412067; PubMed Central PMCID: PMC3309889.
27. Maitland K, Kiguli S, Opoka RO, Engoru C, Olupot-Olupot P, Akech SO, et al. Mortality after fluid bolus in African children with severe infection. The New England journal of medicine. 2011;364(26):2483–95. Epub 2011/05/28. doi: 10.1056/NEJMoa110154921615299.
28. Dondorp AM, Fanello CI, Hendriksen IC, Gomes E, Seni A, Chhaganlal KD, et al. Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet. 2010;376(9753):1647–57. Epub 2010/11/11. doi: 10.1016/s0140-6736(10)61924-121062666; PubMed Central PMCID: PMCPmc3033534.
29. Lim SS, Fullman N, Stokes A, Ravishankar N, Masiye F, Murray CJ, et al. Net benefits: a multicountry analysis of observational data examining associations between insecticide-treated mosquito nets and health outcomes. PLoS Med. 2011;8(9):e1001091. Epub 2011/09/13. doi: 10.1371/journal.pmed.100109121909249; PubMed Central PMCID: PMCPmc3167799.
30. Noor AM, Kirui VC, Brooker SJ, Snow RW, The use of insecticide treated nets by age: implications for universal coverage in Africa. BMC Public Health. 2009;9:369. Epub 2009/10/03. 1471-2458-9-369 [pii] doi: 10.1186/1471-2458-9-36919796380; PubMed Central PMCID: PMC2761895.