IL-17F promotes tissue injury in autoimmune kidney diseases

Journal of the American Society of Nephrology

Volumn 27, Issue 12, 2016, Pages 3666-3677

  Riedel, Jan Hendrik ^a   Paust, Hans Joachim ^a   Krohn, Sonja ^a   Turner, Jan Eric ^a   Kluger, Malte A ^a   Steinmetz, Oliver M ^a   Krebs, Christian F ^a   Stahl, Rolf A K ^a   Panzer, Ulf ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERLEUKIN 17; INTERLEUKIN 17F;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CELL ISOLATION; CELL STIMULATION; CELL TRANSFER; COMPARATIVE STUDY; CONTROLLED STUDY; FLOW CYTOMETRY; GAMMA DELTA T LYMPHOCYTE; IMMUNE COMPLEX NEPHRITIS; IMMUNE RESPONSE; KIDNEY DISEASE; KIDNEY INJURY; KIDNEY TUBULE CELL; MESANGIUM CELL; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; TH17 CELL; TISSUE INJURY; ANIMAL; AUTOIMMUNE DISEASES; GLOMERULONEPHRITIS; IMMUNOLOGY; MALE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; AUTOIMMUNE DISEASES; GLOMERULONEPHRITIS; INTERLEUKIN-17; MALE; MICE; NEUTROPHILS;

EID: 84978074195     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2015101077     Document Type: Article

References (35)

1. Gaffen SL, Jain R, Garg AV, Cua DJ: The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol 14: 585-600, 2014
2. Langley RG, Elewski BE, LebwohlM, Reich K, Griffiths CE, Papp K, Puig L, Nakagawa H, Spelman L, Sigurgeirsson B, Rivas E, Tsai TF, Wasel N, Tyring S, Salko T, Hampele I, NotterM, Karpov A, Helou S, Papavassilis C; ERASURE Study Group; FIXTURE Study Group: Secukinumab in plaque psoriasis-results of two phase 3 trials. N Engl J Med 371: 326-338, 2014
3. Kitching AR, Holdsworth SR: The emergence of TH17 cells as effectors of renal injury. J Am Soc Nephrol 22: 235-238, 2011
4. Turner JE, Paust HJ, Steinmetz OM, Panzer U: The Th17 immune response in renal inflammation. Kidney Int 77: 1070-1075, 2010
5. Couser WG: Basic and translational concepts of immune-mediated glomerular diseases. J Am Soc Nephrol 23: 381-399, 2012
6. Kurts C, Panzer U, Anders HJ, Rees AJ: The immune system and kidney disease: basic concepts and clinical implications. Nat Rev Immunol 13: 738-753, 2013
7. Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA: IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 20: 5332-5341, 2001
8. Chang SH, Dong C: IL-17F: regulation, signaling and function in inflammation. Cytokine 46: 7-11, 2009
9. Kolls JK, Lindén A: Interleukin-17 family members and inflammation. Immunity 21: 467-476, 2004
10. Cua DJ, Tato CM: Innate IL-17-producing cells: The sentinels of the immune system. Nat Rev Immunol 10: 479-489, 2010
11. Pantelyushin S, Haak S, Ingold B, Kulig P, Heppner FL, Navarini AA, Becher B: Rorgt+innate lymphocytes and gd T cells initiate psoriasiform plaque formation in mice. J Clin Invest 122: 2252-2256, 2012
12. Toy D, Kugler D,WolfsonM, Vanden Bos T, Gurgel J, Derry J, Tocker J, Peschon J: Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol 177: 36-39, 2006
13. Aujla SJ, Chan YR, Zheng M, FeiM, Askew DJ, Pociask DA, Reinhart TA, McAllister F, Edeal J, Gaus K, Husain S, Kreindler JL, Dubin PJ, Pilewski JM, Myerburg MM, Mason CA, Iwakura Y, Kolls JK: IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med 14: 275-281, 2008
14. Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K,Nakae S, Sasakawa C, Iwakura Y: Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30: 108-119, 2009
15. Haak S, Croxford AL, Kreymborg K, Heppner FL, Pouly S, Becher B, Waisman A: IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest 119: 61-69, 2009
16. Sarkar S, Justa S, Brucks M, Endres J, Fox DA, Zhou X, Alnaimat F, Whitaker B, Wheeler JC, Jones BH, Bommireddy SR: Interleukin (IL)-17A, F and AF in inflammation: A study in collagen-induced arthritis and rheumatoid arthritis. Clin Exp Immunol 177: 652-661, 2014
17. Disteldorf EM, Krebs CF, Paust HJ, Turner JE, Nouailles G, Tittel A, Meyer-Schwesinger C, StegeG, Brix S, Velden J,Wiech T, Helmchen U, Steinmetz OM, Peters A, Bennstein SB, Kaffke A, Llanto C, Lira SA, Mittrücker HW, Stahl RA, Kurts C, Kaufmann SH, Panzer U: CXCL5 drives neutrophil recruitment in TH17-mediatedGN. J AmSocNephrol 26: 55-66, 2015
18. Summers SA, Odobasic D, Khouri MB, Steinmetz OM, Yang Y, Holdsworth SR, Kitching AR: Endogenous interleukin (IL)-17A promotes pristane-induced systemic autoimmunity and lupus nephritis induced by pristane. Clin Exp Immunol 176: 341-350, 2014
19. Mease PJ, Genovese MC, Greenwald MW, Ritchlin CT, Beaulieu AD, Deodhar A, Newmark R, Feng J, Erondu N, Nirula A: Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis. N Engl J Med 370: 2295-2306, 2014
20. Leonardi C,Matheson R, Zachariae C, Cameron G, Li L, Edson-Heredia E, BraunD, Banerjee S:Anti-interleukin-17monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med 366: 1190-1199, 2012
21. Genovese MC, Greenwald M, Cho CS, Berman A, Jin L, Cameron GS, Benichou O, Xie L, Braun D, Berclaz PY, Banerjee S: A phase II randomized study of subcutaneous ixekizumab, an anti-interleukin-17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic agents or had an inadequate response to tumor necrosis factor inhibitors. Arthritis Rheumatol 66: 1693-1704, 2014
22. SandbornWJ, Gasink C, Gao LL, BlankMA, Johanns J, Guzzo C, Sands BE, Hanauer SB, Targan S, Rutgeerts P, Ghosh S, de Villiers WJ, Panaccione R, Greenberg G, Schreiber S, Lichtiger S, Feagan BG; CERTIFI Study Group: Ustekinumab induction and maintenance therapy in refractory Crohn's disease. NEngl JMed 367: 1519-1528, 2012
23. Paust HJ, Turner JE, Steinmetz OM, Peters A, Heymann F, Hölscher C, WolfG, Kurts C,MittrückerHW, Stahl RA, Panzer U: The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J Am Soc Nephrol 20: 969-979, 2009
24. Steinmetz OM, Summers SA, Gan PY, Semple T, Holdsworth SR, Kitching AR: The Th17-defining transcription factor RORgt promotes glomerulonephritis. J Am Soc Nephrol 22: 472-483, 2011
25. Tulone C, Giorgini A, Freeley S, Coughlan A, Robson MG: Transferred antigen-specific T(H)17 but not T(H)1 cells induce crescentic glomerulonephritis in mice. Am J Pathol 179: 2683-2690, 2011
26. Ramani K, Pawaria S, Maers K, Huppler AR, Gaffen SL, Biswas PS: An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis. J Leukoc Biol 96: 463-472, 2014
27. Kluger MA, Melderis S, Nosko A, Goerke B, Luig M, Meyer MC, Turner JE, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl RA, Panzer U, Steinmetz OM: Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus [published online ahead of print October 14, 2015]. Kidney Int doi:10.1038/ki.2015.296
28. Gaffen SL: Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 9: 556-567, 2009
29. Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C: Regulation of inflammatory responses by IL-17F. J ExpMed 205: 1063-1075, 2008
30. Panzer U, Steinmetz OM, Paust HJ, Meyer-Schwesinger C, Peters A, Turner JE, ZahnerG, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl RA: Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice. J AmSoc Nephrol 18: 2071-2084, 2007
31. Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker HW, Tiegs G, Stahl RA, Panzer U: CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. J AmSoc Nephrol 21: 974-985, 2010
32. Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Wegscheid C, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U: Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN. J Am Soc Nephrol 23: 1987-2000, 2012
33. Paust HJ, Ostmann A, Erhardt A, Turner JE, Velden J, Mittrücker HW, Sparwasser T, Panzer U, Tiegs G: Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis. Kidney Int 80: 154-164, 2011
34. Wolf G, Mueller E, Stahl RA, Ziyadeh FN: Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. J Clin Invest 92: 1366-1372, 1993
35. Wolf G, Haberstroh U, Neilson EG: Angiotensin II stimulates the proliferation and biosynthesis of type I collagen in cultured murine mesangial cells. Am J Pathol 140: 95-107, 1992