A multicenter, randomized, controlled Phase IIb trial of avoidance of hyperoxemia during cardiopulmonary bypass

Anesthesiology

Volumn 125, Issue 3, 2016, Pages 465-473

  McGuinness, Shay P ^a,b,c   Parke, Rachael L ^a,b,c   Drummond, Kate ^d   Willcox, Tim ^a,e   Bailey, Michael ^c  

^a AUCKLAND CITY HOSPITAL   (New Zealand)

^b MEDICAL RESEARCH INSTITUTE OF NEW ZEALAND   (New Zealand)

^c MONASH UNIVERSITY   (Australia)

^d ROYAL ADELAIDE HOSPITAL   (Australia)

^e UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CREATININE;

ABNORMALLY HIGH SUBSTRATE CONCENTRATION IN BLOOD; ACUTE KIDNEY FAILURE; ADULT; AGED; ARTERIAL HYPEROXEMIA; ARTICLE; ARTIFICIAL VENTILATION; AUSTRALIA; BLOOD FLOW; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CREATININE BLOOD LEVEL; DISEASE SEVERITY; FEMALE; HEART SURGERY; HEART VALVE SURGERY; HOSPITALIZATION; HUMAN; HYPEROXIA; INCIDENCE; INTENSIVE CARE UNIT; INTERVENTION STUDY; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; NEW ZEALAND; OPEN STUDY; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PARALLEL DESIGN; PEROPERATIVE COMPLICATION; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; URINE VOLUME; ACUTE KIDNEY INJURY; ADVERSE EFFECTS; BLOOD; CLINICAL TRIAL; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PREVENTION AND CONTROL; RISK FACTOR; SEVERITY OF ILLNESS INDEX; VERY ELDERLY; YOUNG ADULT;

ACUTE KIDNEY INJURY; ADULT; AGED; AGED, 80 AND OVER; AUSTRALIA; BIOMARKERS; CARDIOPULMONARY BYPASS; FEMALE; HUMANS; HYPEROXIA; INCIDENCE; LENGTH OF STAY; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; NEW ZEALAND; OXIDATIVE STRESS; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84978069601     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000001226     Document Type: Article

References (26)

1. Herbertson M. Recombinant activated factor VII in cardiac surgery. Blood Coagul Fibrinolysis 2004; 15(suppl 1):S31-2
2. Bateman NT, Leach RM: ABC of oxygen. Acute oxygen therapy. BMJ 1998; 317:798-801
3. de Jonge E, Peelen L, Keijzers PJ, Joore H, de Lange D, van der Voort PH, Bosman RJ, de Waal RA, Wesselink R, de Keizer NF: Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients. Crit Care 2008; 12:R156
4. Thomson A, Webb D, Maxwell S, Grant I. Oxygen therapy in acute medical care: The potential dangers of hyperoxia need to be recognised. BMJ 2002; 324:1406-7
5. Capellier G, Beuret P, Clement G, Depardieu F, Ract C, Regnard J, Robert D, Barale F. Oxygen tolerance in patients with acute respiratory failure. Intensive Care Med 1998; 24:422-8
6. Rosner MH, Okusa MD: Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 2006; 1:19-32
7. Laffey JG, Boylan JF, Cheng DC: The systemic inflammatory response to cardiac surgery: Implications for the anesthesiologist. Anesthesiolog y 2002; 97:215-52
8. Elahi M, Asopa S, Pflueger A, Hakim N, Matata B. Acute kidney injury following cardiac surgery: Impact of early versus late haemofiltration on morbidity and mortality. Eur J Cardiothorac Surg 2009; 35:854-63
9. Rosner MH, Okusa MD: Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 2006; 1:19-32
10. Carlucci F, Tabucchi A, Biagioli B, Simeone F, Scolletta S, Rosi F, Marinello E. Cardiac surgery: Myocardial energy balance, antioxidant status and endothelial function after ischemia-reperfusion. Biomed Pharmacother 2002; 56:483-91
11. Haase M, Bellomo R, Haase-Fielitz A. Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury. J Am Coll Cardiol 2010; 55:2024-33
12. Bellomo R, Auriemma S, Fabbri A, D'Onofrio A, Katz N, McCullough PA, Ricci Z, Shaw A, Ronco C. The pathophysiology of cardiac surgery-associated acute kidney injury (CSA-AKI). Int J Artif Organs 2008; 31:166-78
13. Caputo M, Mokhtari A, Rogers CA, Panayiotou N, Chen Q, Ghorbel MT, Angelini GD, Parry AJ: The effects of normoxic versus hyperoxic cardiopulmonary bypass on oxidative stress and inflammatory response in cyanotic pediatric patients undergoing open cardiac surgery: A randomized controlled trial. J Thorac Cardiovasc Surg 2009; 138:206-14
14. Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S. Emergency Medicine Shock Research Network (EMShockNet) Investigators: Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010; 303:2165-71
15. Harten JM, Anderson KJ, Kinsella J, Higgins MJ: Normobaric hyperoxia reduces cardiac index in patients after coronary artery bypass surgery. J Cardiothorac Vasc Anesth 2005; 19:173-5
16. Thakar CV, Arrigain S, Worley S, Yared JP, Paganini EP: A clinical score to predict acute renal failure after cardiac surgery. J Am Soc Nephrol 2005; 16:162-8
17. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group: KDIGO Clinical Practice Guideline for acute kidney injury. Kidney Int 2012; 2:1-138
18. Haase M, Haase-Fielitz A, Bellomo R, Devarajan P, Story D, Matalanis G, Reade MC, Bagshaw SM, Seevanayagam N, Seevanayagam S, Doolan L, Buxton B, Dragun D. Sodium bicarbonate to prevent increases in serum creatinine after cardiac surgery: A pilot double-blind, randomized controlled trial. Crit Care Med 2009; 37:39-47
19. Haase M, Haase-Fielitz A, Plass M, Kuppe H, Hetzer R, Hannon C, Murray PT, Bailey MJ, Bellomo R, Bagshaw SM: Prophylactic perioperative sodium bicarbonate to prevent acute kidney injury following open heart surgery: A multicenter double-blinded randomized controlled trial. PLoS Med 2013; 10:e1001426
20. McGuinness SP, Parke RL, Bellomo R, Van Haren FM, Bailey M. Sodium bicarbonate infusion to reduce cardiac surgeryassociated acute kidney injury: A phase II multicenter double-blind randomized controlled trial. Crit Care Med 2013; 41:1599-607
21. Toraman F, Evrenkaya S, Senay S, Karabulut H, Alhan C. Adjusting oxygen fraction to avoid hyperoxemia during cardiopulmonary bypass. Asian Cardiovasc Thorac Ann 2007; 15:303-6
22. Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S. Emergency Medicine Shock Research Network (EMShockNet) Investigators: Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010; 303:2165-71
23. Kilgannon JH, Jones AE, Parrillo JE, Dellinger RP, Milcarek B, Hunter K, Shapiro NI, Trzeciak S. Emergency Medicine Shock Research Network (EMShockNet) Investigators: Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation 2011; 123:2717-22
24. Joachimsson P, Sjoberg F, Forsman M, Johansson M, Ahc H, Rutberg H. Adverse effects of hyperoxemia during cardiopulmonary bypass. J Thorac Cardiovasc Surg 1996; 112:812-9
25. Fontes MT, McDonagh DL, Phillips-Bute B, Welsby IJ, Podgoreanu MV, Fontes ML, Stafford-Smith M, Newman MF, Mathew JP. Neurologic Outcome Research Group (NORG) of the Duke Heart Center: Arterial hyperoxia during cardiopulmonary bypass and postoperative cognitive dysfunction. J Cardiothorac Vasc Anesth 2014; 28:462-6
26. de Somer F, Mulholland JW, Bryan MR, Aloisio T, Van Nooten GJ, Ranucci M. O2 delivery and CO2 production during cardiopulmonary bypass as determinants of acute kidney injury: Time for a goal-directed perfusion management?. Crit Care 2011; 15:R192