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Volumn 18, Issue 7, 2016, Pages

Update on Current Evidence for Hepatitis C Therapeutic Options in HCV Mono-infected Patients

Author keywords

Direct acting antiviral agent; Hepatitis C; Sustained virologic response 12

Indexed keywords

BOCEPREVIR; DACLATASVIR; DASABUVIR; DASABUVIR PLUS OMBITASVIR PLUS PARITAPREVIR PLUS RITONAVIR; ELBASVIR; ELBASVIR PLUS GRAZOPREVIR; GRAZOPREVIR; LEDIPASVIR; LEDIPASVIR PLUS SOFOSBUVIR; NS3A PROTEASE; NS4 PROTEASE; NS5A PROTEAE; NS5B POLYMERASE; OMBITASVIR; PARITAPREVIR; PEGINTERFERON; PLACEBO; PROTEINASE; RIBAVIRIN; SIMEPREVIR; SOFOSBUVIR; SOFOSBUVIR PLUS VELPATASVIR; TELAPREVIR; UNCLASSIFIED DRUG;

EID: 84977487578     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-016-0527-8     Document Type: Review
Times cited : (15)

References (50)
  • 1
    • 84876149257 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence
    • Mohd Hanafiah K, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology (Baltimore, Md). 2013;57(4):1333–42.
    • (2013) Hepatology (Baltimore, Md) , vol.57 , Issue.4 , pp. 1333-1342
    • Mohd Hanafiah, K.1    Groeger, J.2    Flaxman, A.D.3    Wiersma, S.T.4
  • 2
    • 84921060015 scopus 로고    scopus 로고
    • Global distribution and prevalence of hepatitis C virus genotypes
    • Good review of over 1,000 studies tracking current global epidemiology of HCV with respect to distribution of genotypes
    • Messina JP, Humphreys I, Flaxman A, Brown A, Cooke GS, Pybus OG, et al. Global distribution and prevalence of hepatitis C virus genotypes. Hepatology (Baltimore, Md). 2015;61(1):77–87. Good review of over 1,000 studies tracking current global epidemiology of HCV with respect to distribution of genotypes.
    • (2015) Hepatology (Baltimore, Md) , vol.61 , Issue.1 , pp. 77-87
    • Messina, J.P.1    Humphreys, I.2    Flaxman, A.3    Brown, A.4    Cooke, G.S.5    Pybus, O.G.6
  • 3
    • 84857144025 scopus 로고    scopus 로고
    • The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007
    • PID: 22351712
    • Ly KN, Xing J, Klevens RM, Jiles RB, Ward JW, Holmberg SD. The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. Ann Intern Med. 2012;156(4):271–8.
    • (2012) Ann Intern Med , vol.156 , Issue.4 , pp. 271-278
    • Ly, K.N.1    Xing, J.2    Klevens, R.M.3    Jiles, R.B.4    Ward, J.W.5    Holmberg, S.D.6
  • 5
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • COI: 1:CAS:528:DC%2BC3MXkt1Chtrc%3D, PID: 21449783
    • Poordad F, McCone Jr J, Bacon BR, Bruno S, Manns MP, Sulkowski MS, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med. 2011;364(13):1195–206.
    • (2011) N Engl J Med , vol.364 , Issue.13 , pp. 1195-1206
    • Poordad, F.1    McCone, J.2    Bacon, B.R.3    Bruno, S.4    Manns, M.P.5    Sulkowski, M.S.6
  • 6
    • 84906053496 scopus 로고    scopus 로고
    • Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC2cXpslCnuro%3D, PID: 24907225
    • Jacobson IM, Dore GJ, Foster GR, Fried MW, Radu M, Rafalsky VV, et al. Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet. 2014;384(9941):403–13.
    • (2014) Lancet , vol.384 , Issue.9941 , pp. 403-413
    • Jacobson, I.M.1    Dore, G.J.2    Foster, G.R.3    Fried, M.W.4    Radu, M.5    Rafalsky, V.V.6
  • 7
    • 84899068302 scopus 로고    scopus 로고
    • Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin
    • COI: 1:CAS:528:DC%2BC2cXnt1Grsrg%3D, PID: 24720703, One of the key trials supporting current therapeutic options
    • Feld JJ, Kowdley KV, Coakley E, Sigal S, Nelson DR, Crawford D, et al. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370(17):1594–603. One of the key trials supporting current therapeutic options.
    • (2014) N Engl J Med , vol.370 , Issue.17 , pp. 1594-1603
    • Feld, J.J.1    Kowdley, K.V.2    Coakley, E.3    Sigal, S.4    Nelson, D.R.5    Crawford, D.6
  • 8
    • 84864387126 scopus 로고    scopus 로고
    • MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants
    • COI: 1:CAS:528:DC%2BC38XhtFajs7zF, PID: 22615282
    • Summa V, Ludmerer SW, McCauley JA, Fandozzi C, Burlein C, Claudio G, et al. MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012;56(8):4161–7.
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.8 , pp. 4161-4167
    • Summa, V.1    Ludmerer, S.W.2    McCauley, J.A.3    Fandozzi, C.4    Burlein, C.5    Claudio, G.6
  • 9
    • 84952883325 scopus 로고    scopus 로고
    • Feld JJ, Jacobson IM, Hezode C, Asselah T, Ruane PJ, Gruener N, et al. Sofosbuvir and velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection;373(27):2599–607. First large clinical trial data for a truly pan-genotypic all oral combination
    • Feld JJ, Jacobson IM, Hezode C, Asselah T, Ruane PJ, Gruener N, et al. Sofosbuvir and velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection. NEJM. 2015;373(27):2599–607. First large clinical trial data for a truly pan-genotypic all oral combination.
    • (2015) NEJM
  • 10
    • 84952909361 scopus 로고    scopus 로고
    • Foster GR, Afdhal N, Roberts SK, Brau N, Gane EJ, Pianko S, et al. Sofosbuvir and velpatasvir for HCV genotype 2 and 3 infection;373(27):2608–17. Companion trial to reference 9
    • Foster GR, Afdhal N, Roberts SK, Brau N, Gane EJ, Pianko S, et al. Sofosbuvir and velpatasvir for HCV genotype 2 and 3 infection. NEJM. 2015;373(27):2608–17. Companion trial to reference 9.
    • (2015) NEJM
  • 11
    • 84900339263 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
    • PID: 24725239, One of the key trials supporting current therapeutic options
    • Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014;370(20):1889–98. One of the key trials supporting current therapeutic options.
    • (2014) N Engl J Med , vol.370 , Issue.20 , pp. 1889-1898
    • Afdhal, N.1    Zeuzem, S.2    Kwo, P.3    Chojkier, M.4    Gitlin, N.5    Puoti, M.6
  • 12
    • 84900326091 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis
    • PID: 24720702
    • Kowdley KV, Gordon SC, Reddy KR, Rossaro L, Bernstein DE, Lawitz E, et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014;370(20):1879–88.
    • (2014) N Engl J Med , vol.370 , Issue.20 , pp. 1879-1888
    • Kowdley, K.V.1    Gordon, S.C.2    Reddy, K.R.3    Rossaro, L.4    Bernstein, D.E.5    Lawitz, E.6
  • 13
    • 84901044326 scopus 로고    scopus 로고
    • ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV
    • PID: 24795200
    • Ferenci P, Bernstein D, Lalezari J, Cohen D, Luo Y, Cooper C, et al. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med. 2014;370(21):1983–92.
    • (2014) N Engl J Med , vol.370 , Issue.21 , pp. 1983-1992
    • Ferenci, P.1    Bernstein, D.2    Lalezari, J.3    Cohen, D.4    Luo, Y.5    Cooper, C.6
  • 14
    • 84901036125 scopus 로고    scopus 로고
    • ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis
    • PID: 24725237
    • Poordad F, Hezode C, Trinh R, Kowdley KV, Zeuzem S, Agarwal K, et al. ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med. 2014;370(21):1973–82.
    • (2014) N Engl J Med , vol.370 , Issue.21 , pp. 1973-1982
    • Poordad, F.1    Hezode, C.2    Trinh, R.3    Kowdley, K.V.4    Zeuzem, S.5    Agarwal, K.6
  • 15
    • 84937064772 scopus 로고    scopus 로고
    • Grazoprevir-elbasvir combination therapy for treatment-naive cirrhotic and noncirrhotic patients with chronic hepatitis C virus genotype 1, 4, or 6 infection: a randomized trial
    • PID: 25909356
    • Zeuzem S, Ghalib R, Reddy KR, Pockros PJ, Ari ZB, Zhao Y, et al. Grazoprevir-elbasvir combination therapy for treatment-naive cirrhotic and noncirrhotic patients with chronic hepatitis C virus genotype 1, 4, or 6 infection: a randomized trial. Ann Intern Med. 2015;163(1):1–13.
    • (2015) Ann Intern Med , vol.163 , Issue.1 , pp. 1-13
    • Zeuzem, S.1    Ghalib, R.2    Reddy, K.R.3    Pockros, P.J.4    Ari, Z.B.5    Zhao, Y.6
  • 16
    • 84920939338 scopus 로고    scopus 로고
    • Concordance of sustained virological response 4, 12, and 24 weeks post-treatment with sofosbuvir-containing regimens for hepatitis C virus
    • COI: 1:CAS:528:DC%2BC2MXks1Wm
    • Yoshida EM, Sulkowski MS, Gane EJ, Herring Jr RW, Ratziu V, Ding X, et al. Concordance of sustained virological response 4, 12, and 24 weeks post-treatment with sofosbuvir-containing regimens for hepatitis C virus. Hepatology (Baltimore, Md). 2015;61(1):41–5.
    • (2015) Hepatology (Baltimore, Md) , vol.61 , Issue.1 , pp. 41-45
    • Yoshida, E.M.1    Sulkowski, M.S.2    Gane, E.J.3    Herring, R.W.4    Ratziu, V.5    Ding, X.6
  • 17
    • 84977563793 scopus 로고    scopus 로고
    • Wyles D, Kwo P, Zeuzem S, et al. High efficacy and low relapse rates observed with 8 or 12 weeks of LDV/SOF STR in GT1 HCV infected treatment-naïve, non-cirrhotic patients with pretreatment HCV RNA < 6 million IU/mL. Vancouver, Canada, Abstract TUPEB249
    • Wyles D, Kwo P, Zeuzem S, et al. High efficacy and low relapse rates observed with 8 or 12 weeks of LDV/SOF STR in GT1 HCV infected treatment-naïve, non-cirrhotic patients with pretreatment HCV RNA < 6 million IU/mL. In Abstracts and Proceedings of the 2nd International HIV/Viral Hepatitis Co-infection Meeting. Vancouver, Canada. 2015. Abstract TUPEB249.
    • (2015) Abstracts and Proceedings of the 2nd International HIV/Viral Hepatitis Co-infection Meeting
  • 18
    • 84892619580 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection
    • COI: 1:CAS:528:DC%2BC2cXhtFymtb0%3D, PID: 24428467
    • Sulkowski MS, Gardiner DF, Rodriguez-Torres M, Reddy KR, Hassanein T, Jacobson I, et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med. 2014;370(3):211–21.
    • (2014) N Engl J Med , vol.370 , Issue.3 , pp. 211-221
    • Sulkowski, M.S.1    Gardiner, D.F.2    Rodriguez-Torres, M.3    Reddy, K.R.4    Hassanein, T.5    Jacobson, I.6
  • 19
    • 84939833091 scopus 로고    scopus 로고
    • Daclatasvir plus Sofosbuvir for HCV in patients coinfected with HIV-1
    • COI: 1:CAS:528:DC%2BC28XpslOltA%3D%3D, PID: 26196502, An important clinical trial for current therapeutic options
    • Wyles DL, Ruane PJ, Sulkowski MS, Dieterich D, Luetkemeyer A, Morgan TR, et al. Daclatasvir plus Sofosbuvir for HCV in patients coinfected with HIV-1. N Engl J Med. 2015;373(8):714–25. An important clinical trial for current therapeutic options.
    • (2015) N Engl J Med , vol.373 , Issue.8 , pp. 714-725
    • Wyles, D.L.1    Ruane, P.J.2    Sulkowski, M.S.3    Dieterich, D.4    Luetkemeyer, A.5    Morgan, T.R.6
  • 20
    • 84898669547 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
    • COI: 1:CAS:528:DC%2BC2cXmvFShtLk%3D, PID: 24725238
    • Afdhal N, Reddy KR, Nelson DR, Lawitz E, Gordon SC, Schiff E, et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014;370(16):1483–93.
    • (2014) N Engl J Med , vol.370 , Issue.16 , pp. 1483-1493
    • Afdhal, N.1    Reddy, K.R.2    Nelson, D.R.3    Lawitz, E.4    Gordon, S.C.5    Schiff, E.6
  • 21
    • 84946098188 scopus 로고    scopus 로고
    • AASLD, IDSA, IAS–USA. Accessed 10 Nov 2015. Main online HCV guidelines for the management of HCV infection in the United States
    • AASLD, IDSA, IAS–USA. HCV guidance: recommendations for testing, managing, and treating hepatitis C. http://www.hcvguidelines.org. Accessed 10 Nov 2015. Main online HCV guidelines for the management of HCV infection in the United States.
    • HCV guidance: recommendations for testing, managing, and treating hepatitis C
  • 22
    • 84925362379 scopus 로고    scopus 로고
    • Ledipasvir-sofosbuvir with or without ribavirin to treat patients with HCV genotype 1 infection and cirrhosis non-responsive to previous protease-inhibitor therapy: a randomised, double-blind, phase 2 trial (SIRIUS)
    • COI: 1:CAS:528:DC%2BC2MXksV2gsLs%3D, PID: 25773757
    • Bourliere M, Bronowicki JP, de Ledinghen V, Hezode C, Zoulim F, Mathurin P, et al. Ledipasvir-sofosbuvir with or without ribavirin to treat patients with HCV genotype 1 infection and cirrhosis non-responsive to previous protease-inhibitor therapy: a randomised, double-blind, phase 2 trial (SIRIUS). Lancet Infect Dis. 2015;15(4):397–404.
    • (2015) Lancet Infect Dis , vol.15 , Issue.4 , pp. 397-404
    • Bourliere, M.1    Bronowicki, J.P.2    de Ledinghen, V.3    Hezode, C.4    Zoulim, F.5    Mathurin, P.6
  • 23
    • 84933181270 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir in patients with genotype 1 hepatitis C virus infection and compensated cirrhosis: an integrated safety and efficacy analysis
    • COI: 1:CAS:528:DC%2BC2MXhtVOktL%2FI
    • Reddy KR, Bourliere M, Sulkowski M, Omata M, Zeuzem S, Feld JJ, et al. Ledipasvir and sofosbuvir in patients with genotype 1 hepatitis C virus infection and compensated cirrhosis: an integrated safety and efficacy analysis. Hepatology (Baltimore, Md). 2015;62(1):79–86.
    • (2015) Hepatology (Baltimore, Md) , vol.62 , Issue.1 , pp. 79-86
    • Reddy, K.R.1    Bourliere, M.2    Sulkowski, M.3    Omata, M.4    Zeuzem, S.5    Feld, J.J.6
  • 24
    • 84899106124 scopus 로고    scopus 로고
    • Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin
    • COI: 1:CAS:528:DC%2BC2cXnt1Grsrk%3D, PID: 24720679
    • Zeuzem S, Jacobson IM, Baykal T, Marinho RT, Poordad F, Bourliere M, et al. Retreatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014;370(17):1604–14.
    • (2014) N Engl J Med , vol.370 , Issue.17 , pp. 1604-1614
    • Zeuzem, S.1    Jacobson, I.M.2    Baykal, T.3    Marinho, R.T.4    Poordad, F.5    Bourliere, M.6
  • 25
    • 84904647749 scopus 로고    scopus 로고
    • ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection
    • COI: 1:CAS:528:DC%2BC2cXhtFyhur3K, PID: 24818763, e1
    • Andreone P, Colombo MG, Enejosa JV, Koksal I, Ferenci P, Maieron A, et al. ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection. Gastroenterology. 2014;147(2):359–65. e1.
    • (2014) Gastroenterology , vol.147 , Issue.2 , pp. 359-365
    • Andreone, P.1    Colombo, M.G.2    Enejosa, J.V.3    Koksal, I.4    Ferenci, P.5    Maieron, A.6
  • 26
    • 84954286001 scopus 로고    scopus 로고
    • Sustained virologic response of 100% in HCV genotype 1b patients with cirrhosis receiving ombitasvir/Paritaprevir/r and Dasabuvir for 12 Weeks
    • Feld JJ, Moreno C, Trinh R, Tam E, Bourgeois S, Horsmans Y, et al. Sustained virologic response of 100% in HCV genotype 1b patients with cirrhosis receiving ombitasvir/Paritaprevir/r and Dasabuvir for 12 Weeks. J Hepatol. 2016;64:301–7.
    • (2016) J Hepatol , vol.64 , pp. 301-307
    • Feld, J.J.1    Moreno, C.2    Trinh, R.3    Tam, E.4    Bourgeois, S.5    Horsmans, Y.6
  • 27
    • 84977476214 scopus 로고    scopus 로고
    • Kwo P, Gane E, Peng CY, et al. Efficacy and safety of grazoprevir/elbasvir +/− RBV for 12 or 16 weeks in patients with HCV G1, G4, or G6 infection who previously failed peginterferon/RBV: C-EDGE treatment-experienced; Vienna, Austria. Abstract P0886
    • Kwo P, Gane E, Peng CY, et al. Efficacy and safety of grazoprevir/elbasvir +/− RBV for 12 or 16 weeks in patients with HCV G1, G4, or G6 infection who previously failed peginterferon/RBV: C-EDGE treatment-experienced. Program and abstracts of the 50th Annual Meeting of the European Association for the Study of the Liver. 2015; Vienna, Austria. Abstract P0886.
    • (2015) Program and abstracts of the 50th Annual Meeting of the European Association for the Study of the Liver
  • 28
    • 84947338288 scopus 로고    scopus 로고
    • Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study
    • COI: 1:CAS:528:DC%2BC2MXhs1Wjs77N, PID: 26456905
    • Roth D, Nelson DR, Bruchfeld A, Liapakis A, Silva M, Monsour Jr H, et al. Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4–5 chronic kidney disease (the C-SURFER study): a combination phase 3 study. Lancet. 2015;386(10003):1537–45.
    • (2015) Lancet , vol.386 , Issue.10003 , pp. 1537-1545
    • Roth, D.1    Nelson, D.R.2    Bruchfeld, A.3    Liapakis, A.4    Silva, M.5    Monsour, H.6
  • 29
    • 84948662474 scopus 로고    scopus 로고
    • Sofosbuvir plus velpatasvir combination therapy for treatment-experienced patients with genotype 1 or 3 hepatitis C virus infection: a randomized trial
    • Pianko S, Flamm SL, Shiffman ML, Kumar S, Strasser SI, Dore GJ, et al. Sofosbuvir plus velpatasvir combination therapy for treatment-experienced patients with genotype 1 or 3 hepatitis C virus infection: a randomized trial. Ann Intern Med. 2015;163(11):809–17.
    • (2015) Ann Intern Med , vol.163 , Issue.11 , pp. 809-817
    • Pianko, S.1    Flamm, S.L.2    Shiffman, M.L.3    Kumar, S.4    Strasser, S.I.5    Dore, G.J.6
  • 30
    • 84877730954 scopus 로고    scopus 로고
    • Sofosbuvir for previously untreated chronic hepatitis C infection
    • COI: 1:CAS:528:DC%2BC3sXnsl2gsrY%3D, PID: 23607594
    • Lawitz E, Mangia A, Wyles D, Rodriguez-Torres M, Hassanein T, Gordon SC, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med. 2013;368(20):1878–87.
    • (2013) N Engl J Med , vol.368 , Issue.20 , pp. 1878-1887
    • Lawitz, E.1    Mangia, A.2    Wyles, D.3    Rodriguez-Torres, M.4    Hassanein, T.5    Gordon, S.C.6
  • 31
    • 84877739274 scopus 로고    scopus 로고
    • Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options
    • COI: 1:CAS:528:DC%2BC3sXnsl2gsrk%3D, PID: 23607593
    • Jacobson IM, Gordon SC, Kowdley KV, Yoshida EM, Rodriguez-Torres M, Sulkowski MS, et al. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med. 2013;368(20):1867–77.
    • (2013) N Engl J Med , vol.368 , Issue.20 , pp. 1867-1877
    • Jacobson, I.M.1    Gordon, S.C.2    Kowdley, K.V.3    Yoshida, E.M.4    Rodriguez-Torres, M.5    Sulkowski, M.S.6
  • 33
    • 84943558459 scopus 로고    scopus 로고
    • Efficacy of sofosbuvir plus ribavirin with or without peginterferon-alfa in patients with hepatitis C virus genotype 3 infection and treatment-experienced patients with cirrhosis and hepatitis C virus genotype 2 infection
    • COI: 1:CAS:528:DC%2BC2MXhslamsrbP, PID: 26248087, An interesting trial highlighting that there may still be a role for interferon-based therapy in treating genotype 3 cirrhotic patients who have been shown to have poor response to DAA combinations
    • Foster GR, Pianko S, Brown A, Forton D, Nahass RG, George J, et al. Efficacy of sofosbuvir plus ribavirin with or without peginterferon-alfa in patients with hepatitis C virus genotype 3 infection and treatment-experienced patients with cirrhosis and hepatitis C virus genotype 2 infection. Gastroenterology. 2015;149(6):1462–70. An interesting trial highlighting that there may still be a role for interferon-based therapy in treating genotype 3 cirrhotic patients who have been shown to have poor response to DAA combinations.
    • (2015) Gastroenterology , vol.149 , Issue.6 , pp. 1462-1470
    • Foster, G.R.1    Pianko, S.2    Brown, A.3    Forton, D.4    Nahass, R.G.5    George, J.6
  • 34
    • 84925364974 scopus 로고    scopus 로고
    • All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III study
    • COI: 1:CAS:528:DC%2BC2MXlt1WktLw%3D
    • Nelson DR, Cooper JN, Lalezari JP, Lawitz E, Pockros PJ, Gitlin N, et al. All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: ALLY-3 phase III study. Hepatology (Baltimore, Md). 2015;61(4):1127–35.
    • (2015) Hepatology (Baltimore, Md) , vol.61 , Issue.4 , pp. 1127-1135
    • Nelson, D.R.1    Cooper, J.N.2    Lalezari, J.P.3    Lawitz, E.4    Pockros, P.J.5    Gitlin, N.6
  • 35
    • 84948705255 scopus 로고    scopus 로고
    • Sofosbuvir with velpatasvir in treatment-naive noncirrhotic patients with genotype 1 to 6 hepatitis C virus infection: a randomized trial
    • Everson GT, Towner WJ, Davis MN, Wyles DL, Nahass RG, Thuluvath PJ, et al. Sofosbuvir with velpatasvir in treatment-naive noncirrhotic patients with genotype 1 to 6 hepatitis C virus infection: a randomized trial. Ann Intern Med. 2015;163:818–26.
    • (2015) Ann Intern Med , vol.163 , pp. 818-826
    • Everson, G.T.1    Towner, W.J.2    Davis, M.N.3    Wyles, D.L.4    Nahass, R.G.5    Thuluvath, P.J.6
  • 36
    • 84939815619 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for hepatitis C genotype 4: a proof-of-concept, single-centre, open-label phase 2a cohort study
    • COI: 1:CAS:528:DC%2BC2MXhtF2itbnI, PID: 26187031
    • Kohli A, Kapoor R, Sims Z, Nelson A, Sidharthan S, Lam B, et al. Ledipasvir and sofosbuvir for hepatitis C genotype 4: a proof-of-concept, single-centre, open-label phase 2a cohort study. Lancet Infect Dis. 2015;15(9):1049–54.
    • (2015) Lancet Infect Dis , vol.15 , Issue.9 , pp. 1049-1054
    • Kohli, A.1    Kapoor, R.2    Sims, Z.3    Nelson, A.4    Sidharthan, S.5    Lam, B.6
  • 37
    • 84931569160 scopus 로고    scopus 로고
    • Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial
    • COI: 1:CAS:528:DC%2BC2MXls1Grt7k%3D, PID: 25837829
    • Hezode C, Asselah T, Reddy KR, Hassanein T, Berenguer M, Fleischer-Stepniewska K, et al. Ombitasvir plus paritaprevir plus ritonavir with or without ribavirin in treatment-naive and treatment-experienced patients with genotype 4 chronic hepatitis C virus infection (PEARL-I): a randomised, open-label trial. Lancet. 2015;385(9986):2502–9.
    • (2015) Lancet , vol.385 , Issue.9986 , pp. 2502-2509
    • Hezode, C.1    Asselah, T.2    Reddy, K.R.3    Hassanein, T.4    Berenguer, M.5    Fleischer-Stepniewska, K.6
  • 38
    • 84933671704 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and drug-interaction profile of the hepatitis C virus NS5B polymerase inhibitor sofosbuvir
    • COI: 1:CAS:528:DC%2BC2MXhtFCgsb3M, PID: 25822283
    • Kirby BJ, Symonds WT, Kearney BP, Mathias AA. Pharmacokinetic, pharmacodynamic, and drug-interaction profile of the hepatitis C virus NS5B polymerase inhibitor sofosbuvir. Clin Pharmacokinet. 2015;54(7):677–90.
    • (2015) Clin Pharmacokinet , vol.54 , Issue.7 , pp. 677-690
    • Kirby, B.J.1    Symonds, W.T.2    Kearney, B.P.3    Mathias, A.A.4
  • 39
    • 84928569640 scopus 로고    scopus 로고
    • Drug-drug interaction profile of the all-oral anti-hepatitis C virus regimen of paritaprevir/ritonavir, ombitasvir, and dasabuvir
    • COI: 1:CAS:528:DC%2BC2MXmvFakt74%3D, PID: 25646891
    • Menon RM, Badri PS, Wang T, Polepally AR, Zha J, Khatri A, et al. Drug-drug interaction profile of the all-oral anti-hepatitis C virus regimen of paritaprevir/ritonavir, ombitasvir, and dasabuvir. J Hepatol. 2015;63(1):20–9.
    • (2015) J Hepatol , vol.63 , Issue.1 , pp. 20-29
    • Menon, R.M.1    Badri, P.S.2    Wang, T.3    Polepally, A.R.4    Zha, J.5    Khatri, A.6
  • 41
    • 84879683134 scopus 로고    scopus 로고
    • Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials
    • COI: 1:CAS:528:DC%2BC3sXhtVeisLbP, PID: 23575197
    • Sullivan JC, De Meyer S, Bartels DJ, Dierynck I, Zhang EZ, Spanks J, et al. Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials. Clin Infect Dis. 2013;57(2):221–9.
    • (2013) Clin Infect Dis , vol.57 , Issue.2 , pp. 221-229
    • Sullivan, J.C.1    De Meyer, S.2    Bartels, D.J.3    Dierynck, I.4    Zhang, E.Z.5    Spanks, J.6
  • 42
    • 84977526976 scopus 로고    scopus 로고
    • Sarrazin C, Dvory-Sobol H, Svarovskaia E, Doehle B, McCarville J. Baseline and post-baseline resistance analyses of phase 2/3 studies of ledipasvir/sofosbuvir ± RBV. [Abstract 1926]. November 7–11; Boston, MA2014
    • Sarrazin C, Dvory-Sobol H, Svarovskaia E, Doehle B, McCarville J. Baseline and post-baseline resistance analyses of phase 2/3 studies of ledipasvir/sofosbuvir ± RBV. [Abstract 1926]. 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD); November 7–11; Boston, MA2014.
    • 65th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • 44
    • 84964762303 scopus 로고    scopus 로고
    • Long-term follow-up of treatment-emergent resistance-associated variants in NS3, NS5A and NS5B with paritaprevir/r, ombitasvir- and dasabuvir-based regimens. [0057]. 50th Annual Meeting of the European Association for the Study of the Liver; April 22–26; Vienna
    • Krishnan P, Tripathi R, Schnell G, Reisch T, Beyer J, Dekhtyar T, et al. Long-term follow-up of treatment-emergent resistance-associated variants in NS3, NS5A and NS5B with paritaprevir/r, ombitasvir- and dasabuvir-based regimens. [0057]. 50th Annual Meeting of the European Association for the Study of the Liver; April 22–26; Vienna, Austria: Journal of Hepatology. 2015. p. S220.
    • (2015) Austria: Journal of Hepatology , pp. S220
    • Krishnan, P.1    Tripathi, R.2    Schnell, G.3    Reisch, T.4    Beyer, J.5    Dekhtyar, T.6
  • 45
    • 84954399628 scopus 로고    scopus 로고
    • Sarrazin C. The importance of resistance to direct antiviral drugs in HCV infection in clinical practice;64:486–504. A good review of concepts regarding HCV DAA resistance
    • Sarrazin C. The importance of resistance to direct antiviral drugs in HCV infection in clinical practice. J Hepatol. 2016;64:486–504. A good review of concepts regarding HCV DAA resistance.
    • (2016) J Hepatol.
  • 47
    • 84903795463 scopus 로고    scopus 로고
    • The treatment cascade for chronic hepatitis C virus infection in the United States: a systematic review and meta-analysis
    • PID: 24988388
    • Yehia BR, Schranz AJ, Umscheid CA, Lo Re 3rd V. The treatment cascade for chronic hepatitis C virus infection in the United States: a systematic review and meta-analysis. PLoS One. 2014;9(7), e101554.
    • (2014) PLoS One , vol.9 , Issue.7
    • Yehia, B.R.1    Schranz, A.J.2    Umscheid, C.A.3    Lo Re, V.4
  • 48
    • 84898634396 scopus 로고    scopus 로고
    • Therapy for hepatitis C—the costs of success
    • COI: 1:CAS:528:DC%2BC2cXmvFShtbo%3D, PID: 24725236
    • Hoofnagle JH, Sherker AH. Therapy for hepatitis C—the costs of success. N Engl J Med. 2014;370(16):1552–3.
    • (2014) N Engl J Med , vol.370 , Issue.16 , pp. 1552-1553
    • Hoofnagle, J.H.1    Sherker, A.H.2
  • 49
    • 84938795806 scopus 로고    scopus 로고
    • Restrictions for medicaid reimbursement of sofosbuvir for the treatment of hepatitis C Virus infection in the United States
    • PID: 26120969, An important paper highlighting current Medicaid restrictions on access to HCV therapies
    • Barua S, Greenwald R, Grebely J, Dore GJ, Swan T, Taylor LE. Restrictions for medicaid reimbursement of sofosbuvir for the treatment of hepatitis C Virus infection in the United States. Ann Intern Med. 2015;163(3):215–23. An important paper highlighting current Medicaid restrictions on access to HCV therapies.
    • (2015) Ann Intern Med , vol.163 , Issue.3 , pp. 215-223
    • Barua, S.1    Greenwald, R.2    Grebely, J.3    Dore, G.J.4    Swan, T.5    Taylor, L.E.6
  • 50
    • 84887020007 scopus 로고    scopus 로고
    • Hepatitis C virus treatment for prevention among people who inject drugs: modeling treatment scale-up in the age of direct-acting antivirals
    • Martin NK, Vickerman P, Grebely J, Hellard M, Hutchinson SJ, Lima VD, et al. Hepatitis C virus treatment for prevention among people who inject drugs: modeling treatment scale-up in the age of direct-acting antivirals. Hepatology. 2013;58:1598–601.
    • (2013) Hepatology , vol.58 , pp. 1598-1601
    • Martin, N.K.1    Vickerman, P.2    Grebely, J.3    Hellard, M.4    Hutchinson, S.J.5    Lima, V.D.6


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