BCR signaling inhibitors differ in their ability to overcome Mcl-1-mediated resistance of CLL B cells to ABT-199

Blood

Volumn 127, Issue 25, 2016, Pages 3192-3201

  Bojarczuk, Kamil ^a,b   Sasi, Binu K ^a   Gobessi, Stefania ^a   Innocenti, Idanna ^c   Pozzato, Gabriele ^d   Laurenti, Luca ^c   Efremov, Dimitar G ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^d UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; BIM PROTEIN; BRUTON TYROSINE KINASE; ENTOSPLETINIB; FOSTAMATINIB; GLYCOGEN SYNTHASE KINASE 3; IBRUTINIB; IDELALISIB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE SYK; PROTEIN MCL 1; VENETOCLAX; ANTINEOPLASTIC AGENT; FUSED HETEROCYCLIC RINGS; LYMPHOCYTE ANTIGEN RECEPTOR; MCL1 PROTEIN, HUMAN; N4-(2,2-DIMETHYL-3-OXO-4H-PYRID(1,4)OXAZIN-6-YL)-5-FLUORO-N2-(3,4,5-TRIMETHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE; OXAZINE DERIVATIVE; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; SULFONAMIDE;

ARTICLE; B LYMPHOCYTE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG POTENCY; ENZYME INACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; APOPTOSIS; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BRIDGED BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; OXAZINES; PURINES; PYRAZOLES; PYRIDINES; PYRIMIDINES; QUINAZOLINONES; RECEPTORS, ANTIGEN, B-CELL; SULFONAMIDES;

EID: 84977272170     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-10-675009     Document Type: Article

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