Linear extrapolation of missing radiographic change scores in clinical trials does not spuriously overestimate group radiographic changes in rheumatoid arthritis

Rheumatology (United Kingdom)

Volumn 55, Issue 7, 2016, Pages 1295-1300

  Markusse, Iris M ^a   Landewé, Robert ^b,c   Wolterbeek, Ron ^a   Ho, Meilien ^d   Jenkins, Martin ^d   van der Heijde, Désirée ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c Zuyderland Medical Centre   (Netherlands)

^d ASTRAZENECA   (United Kingdom)

Author keywords

Imputation; Missing data; Radiographic progression; Rheumatoid arthritis

Indexed keywords

FOSTAMATINIB; METHOTREXATE; ANTIRHEUMATIC AGENT; OXAZINE DERIVATIVE; PYRIDINE DERIVATIVE;

ADULT; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE DURATION; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; INTERMETHOD COMPARISON; JOINT RADIOGRAPHY; LAST OBSERVATION CARRIED FORWARD; LINEAR EXTRAPOLATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; ARTHRITIS, RHEUMATOID; CLINICAL TRIAL; DIAGNOSTIC IMAGING; DISEASE COURSE; MIDDLE AGED; PHASE 3 CLINICAL TRIAL; RADIOGRAPHY; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

ADULT; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; OXAZINES; PYRIDINES; RADIOGRAPHY; TREATMENT OUTCOME;

EID: 84977142279     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kew030     Document Type: Article

References (9)

1. Sharp JT, Lidsky MD, Collins LC, et al. Methods of scoring the progression of radiologic changes in rheumatoid arthritis. Correlation of radiologic, clinical and laboratory abnormalities. Arthritis Rheum 1971;14:706-20. doi: 10.1002/art.1780140605
2. Sharp JT, Young DY, Bluhm GB, et al. How many joints in the hands and wrists should be included in a score of radiologic abnormalities used to assess rheumatoid arthritis? Arthritis Rheum 1985;28:1326-35
3. Van der Heijde D. How to read radiographs according to the Sharp/van der Heijde method. J Rheumatol 1999;26:743-5.
4. LandewéR, Strand V, van der Heijde D. From inhibition of radiographic progression to maintaining structural integrity: a methodological framework for radiographic progression in rheumatoid arthritis and psoriatic arthritis clinical trials. Ann Rheum Dis 2013;72:1113-7. doi: 10.1136/annrheumdis-2012-203159
5. Van der Heijde D, LandewéR, Klareskog L, et al. Presentation and analysis of data on radiographic outcome in clinical trials: experience from the TEMPO study. Arthritis Rheum 2005;52:49-60. doi: 10.1002/art.20775
6. LandewéR, van der Heijde D. Presentation and analysis of radiographic data in clinical trials and observational studies. Ann Rheum Dis 2005;64:iv48-51. doi: 10.1136/ ard.2005.042572
7. Hulsmans HMJ, Jacobs JWG, van der Heijde DMFM, et al. The course of radiologic damage during the first six years of rheumatoid arthritis. Arthritis Rheum 2000;43:1927-40. doi: 10.1002/1529-0131(200009)43:9<1927::AIDANR3> 3.0.CO;2-B
8. Wolfe F, Sharp JT. Radiographic outcome of recent-onset rheumatoid arthritis: a 19-year study of radiographic progression. Arthritis Rheum 1998;41:1571-82. doi: 10.1002/ 1529-0131(199809)41:9<1571::AID-ART7>3.0.CO;2-R
9. Weinblatt ME, Genovese MC, Ho M, et al. Effects of fostamatinib, an oral spleen tyrosine kinase inhibitor, in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a Phase III, multicenter, randomized, double-blind, placebo-controlled, parallelgroup study. Arthritis Rheumatol 2014;66:3255-64. doi: 10.1002/art.38851