메뉴 건너뛰기




Volumn 2, Issue 2, 2013, Pages 111-122

Cobicistat: A Novel Pharmacoenhancer for Co-Formulation with HIV Protease and Integrase Inhibitors

Author keywords

Boosting; Cobicistat; eGFR; HIV; Infection; Pharmacology; Renal; Stribild; Virology

Indexed keywords

ATAZANAVIR; ATAZANAVIR PLUS RITONAVIR; CLARITHROMYCIN; COBICISTAT; COBICISTAT PLUS ELVITEGRAVIR PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; CYTOCHROME P450 3A4; DARUNAVIR; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; ELVITEGRAVIR; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; FLUTICASONE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INTEGRASE INHIBITOR; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; RITONAVIR; SIMVASTATIN; TENOFOVIR ALAFENAMIDE; TENOFOVIR DISOPROXIL;

EID: 84977139614     PISSN: 21938229     EISSN: 21936382     Source Type: Journal    
DOI: 10.1007/s40121-013-0013-7     Document Type: Review
Times cited : (32)

References (37)
  • 1
    • 84907817074 scopus 로고    scopus 로고
    • British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012
    • Williams I, Churchill D, Anderson J, Boffito M, Bower M, Cairns G, et al. British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2012. HIV Med. 2012;13(Suppl 2): 1-85.
    • (2012) HIV Med , vol.13 , Issue.SUPPL. 2 , pp. 1-85
    • Williams, I.1    Churchill, D.2    Anderson, J.3    Boffito, M.4    Bower, M.5    Cairns, G.6
  • 2
    • 84862777419 scopus 로고    scopus 로고
    • Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients: pooled results from the phase 3 double-blind randomized ECHO and THRIVE Trials
    • Cohen CJ, Molina JM, Cahn P, Clotet B, Fourie J, Grinsztejn B, et al. Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients: pooled results from the phase 3 double-blind randomized ECHO and THRIVE Trials. J Acquir Immune Defic Syndr. 2012;60(1): 33-42.
    • (2012) J Acquir Immune Defic Syndr , vol.60 , Issue.1 , pp. 33-42
    • Cohen, C.J.1    Molina, J.M.2    Cahn, P.3    Clotet, B.4    Fourie, J.5    Grinsztejn, B.6
  • 3
    • 77954183998 scopus 로고    scopus 로고
    • Suboptimal adherence to darunavir/ritonavir has minimal effect on efficacy compared with lopinavir/ritonavir in treatment-naive, HIV-infected patients: 96 week ARTEMIS data
    • Nelson M, Girard PM, Demasi R, Chen L, Smets E, Sekar V, et al. Suboptimal adherence to darunavir/ritonavir has minimal effect on efficacy compared with lopinavir/ritonavir in treatment-naive, HIV-infected patients: 96 week ARTEMIS data. J Antimicrob Chemother. 2010;65(7): 1505-9.
    • (2010) J Antimicrob Chemother , vol.65 , Issue.7 , pp. 1505-1509
    • Nelson, M.1    Girard, P.M.2    Demasi, R.3    Chen, L.4    Smets, E.5    Sekar, V.6
  • 4
    • 74549150032 scopus 로고    scopus 로고
    • Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008
    • Elzi L, Marzolini C, Furrer H, Ledergerber B, Cavassini M, Hirschel B, et al. Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008. Arch Intern Med. 2010;170(1): 57-65.
    • (2010) Arch Intern Med , vol.170 , Issue.1 , pp. 57-65
    • Elzi, L.1    Marzolini, C.2    Furrer, H.3    Ledergerber, B.4    Cavassini, M.5    Hirschel, B.6
  • 5
    • 79956332499 scopus 로고    scopus 로고
    • Beliefs about antiretroviral therapy, treatment adherence and quality of life in a 48-week randomised study of continuation of zidovudine/lamivudine or switch to tenofovir DF/emtricitabine, each with efavirenz
    • Cooper V, Moyle GJ, Fisher M, Reilly G, Ewan J, Liu HC, et al. Beliefs about antiretroviral therapy, treatment adherence and quality of life in a 48-week randomised study of continuation of zidovudine/lamivudine or switch to tenofovir DF/emtricitabine, each with efavirenz. AIDS Care. 2011;23(6): 705-13.
    • (2011) AIDS Care , vol.23 , Issue.6 , pp. 705-713
    • Cooper, V.1    Moyle, G.J.2    Fisher, M.3    Reilly, G.4    Ewan, J.5    Liu, H.C.6
  • 6
    • 0035119211 scopus 로고    scopus 로고
    • Self-reported symptoms after initiation of a protease inhibitor in HIV-infected patients and their impact on adherence to HAART
    • Duran S, Spire B, Raffi F, Walter V, Bouhour D, Journot V, et al. Self-reported symptoms after initiation of a protease inhibitor in HIV-infected patients and their impact on adherence to HAART. HIV Clin Trials. 2001;2(1): 38-45.
    • (2001) HIV Clin Trials , vol.2 , Issue.1 , pp. 38-45
    • Duran, S.1    Spire, B.2    Raffi, F.3    Walter, V.4    Bouhour, D.5    Journot, V.6
  • 7
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination
    • Lennox JL, DeJesus E, Lazzarin A, Pollard RB, Madruga JV, Berger DS, et al. Safety and efficacy of raltegravir-based versus efavirenz-based combination. Lancet. 2009;374(9692): 796-806.
    • (2009) Lancet , vol.374 , Issue.9692 , pp. 796-806
    • Lennox, J.L.1    DeJesus, E.2    Lazzarin, A.3    Pollard, R.B.4    Madruga, J.V.5    Berger, D.S.6
  • 8
  • 9
    • 37549003698 scopus 로고    scopus 로고
    • HIV-1 replication capacity and genotype changes in patients undergoing treatment
    • Gianotti N, Tiberi S, Menzo S, Danise A, Boeri E, Galli L, et al. HIV-1 replication capacity and genotype changes in patients undergoing treatment. J Med Virol. 2008;80(2): 201-8.
    • (2008) J Med Virol , vol.80 , Issue.2 , pp. 201-208
    • Gianotti, N.1    Tiberi, S.2    Menzo, S.3    Danise, A.4    Boeri, E.5    Galli, L.6
  • 11
    • 84878698505 scopus 로고    scopus 로고
    • Comparative study of tenofovir alafenamide vs tenofovir disoproxil fumarate, each with elvitegravir, cobicistat, and emtricitabine, for HIV treatment
    • Atlanta, USA; March 3-6
    • Zolopa A, Ortiz R, Sax P, et al. Comparative study of tenofovir alafenamide vs tenofovir disoproxil fumarate, each with elvitegravir, cobicistat, and emtricitabine, for HIV treatment. In: 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, USA; March 3-6, 2013.
    • (2013) 20th Conference on Retroviruses and Opportunistic Infections
    • Zolopa, A.1    Ortiz, R.2    Sax, P.3
  • 12
    • 79959359682 scopus 로고    scopus 로고
    • Ritonavir-boosted protease inhibitors in HIV therapy
    • Hull MW, Montaner JS. Ritonavir-boosted protease inhibitors in HIV therapy. Ann Med. 2011;43(5): 375-88.
    • (2011) Ann Med , vol.43 , Issue.5 , pp. 375-388
    • Hull, M.W.1    Montaner, J.S.2
  • 13
    • 84868678578 scopus 로고    scopus 로고
    • ARIES 144 week results: durable virologic suppression in HIV-infected patients simplified to unboosted atazanavir/abacavir/lamivudine
    • Squires KE, Young B, DeJesus E, Bellos N, Murphy D, Ward D, et al. ARIES 144 week results: durable virologic suppression in HIV-infected patients simplified to unboosted atazanavir/abacavir/lamivudine. HIV Clin Trials. 2012;13(5): 233-44.
    • (2012) HIV Clin Trials , vol.13 , Issue.5 , pp. 233-244
    • Squires, K.E.1    Young, B.2    DeJesus, E.3    Bellos, N.4    Murphy, D.5    Ward, D.6
  • 18
    • 84970026277 scopus 로고    scopus 로고
    • Elvitegravir/cobicistat/emtricitabine/tenofovir DF (STB) has durable efficacy and differentiated safety compared to atazanavir boosted by ritonavir plus emtricitabine/tenofovir DF in treatment-naïve HIV-1 infected patients: week 96 results
    • Glasgow, UK; November 11-16
    • Rockstroh JK, DeJesus E, Henry K, et al. Elvitegravir/cobicistat/emtricitabine/tenofovir DF (STB) has durable efficacy and differentiated safety compared to atazanavir boosted by ritonavir plus emtricitabine/tenofovir DF in treatment-naïve HIV-1 infected patients: week 96 results. In: 11th International Congress on Drug Therapy in HIV Infection. Glasgow, UK; November 11-16, 2012.
    • (2012) 11th International Congress on Drug Therapy in HIV Infection
    • Rockstroh, J.K.1    DeJesus, E.2    Henry, K.3
  • 19
    • 84977129158 scopus 로고    scopus 로고
    • Elvitegravir/cobicistat/emtricitabine/tenofovir DF (STB) has durable efficacy and differentiated safety compared to efavirenz/emtricitabine/tenofovir DF (ATR) in treatment-naïve HIV-1 infected patients: week 96 results
    • Glasgow, UK; November 11-15
    • Zolopa A, Gallant J, Cohen C, et al. Elvitegravir/cobicistat/emtricitabine/tenofovir DF (STB) has durable efficacy and differentiated safety compared to efavirenz/emtricitabine/tenofovir DF (ATR) in treatment-naïve HIV-1 infected patients: week 96 results. In: 11th International Congress on Drug Therapy in HIV Infection. Glasgow, UK; November 11-15, 2012.
    • (2012) 11th International Congress on Drug Therapy in HIV Infection
    • Zolopa, A.1    Gallant, J.2    Cohen, C.3
  • 20
    • 80052917901 scopus 로고    scopus 로고
    • Phase 2 study of cobicistat versus ritonavir each with once-daily atazanavir and fixed-dose emtricitabine/tenofovir df in the initial treatment of HIV infection
    • Elion R, Cohen C, Gathe J, Shalit P, Hawkins T, Liu HC, et al. Phase 2 study of cobicistat versus ritonavir each with once-daily atazanavir and fixed-dose emtricitabine/tenofovir df in the initial treatment of HIV infection. AIDS. 2011;25(15): 1881-6.
    • (2011) Aids , vol.25 , Issue.15 , pp. 1881-1886
    • Elion, R.1    Cohen, C.2    Gathe, J.3    Shalit, P.4    Hawkins, T.5    Liu, H.C.6
  • 22
    • 84952805309 scopus 로고    scopus 로고
    • Safety/tolerability, pharmacokinetics, and boosting of twice-daily cobicistat administered alone or in combination with darunavir or tipranavir
    • Barcelona, Spain; April 16-18
    • Ramanathan S, Wang H, Szwarcberg J, Kearney BP. Safety/tolerability, pharmacokinetics, and boosting of twice-daily cobicistat administered alone or in combination with darunavir or tipranavir. In: 13th International Workshop on Clinical Pharmacology of HIV Therapy. Barcelona, Spain; April 16-18, 2012.
    • (2012) 13th International Workshop on Clinical Pharmacology of HIV Therapy
    • Ramanathan, S.1    Wang, H.2    Szwarcberg, J.3    Kearney, B.P.4
  • 23
    • 84898609803 scopus 로고    scopus 로고
    • Effect of food on pharmacokinetics of elvitegravir, emtricitabine, tenofovir DF and the pharmacoenhancer GS-9350 as a fixed-dose combination tablet
    • San Francisco, USA; September 12-15
    • German P, Warren D, Wei L, Zhong L, Hui J, Kearney BP. Effect of food on pharmacokinetics of elvitegravir, emtricitabine, tenofovir DF and the pharmacoenhancer GS-9350 as a fixed-dose combination tablet. In: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). San Francisco, USA; September 12-15, 2009.
    • (2009) 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
    • German, P.1    Warren, D.2    Wei, L.3    Zhong, L.4    Hui, J.5    Kearney, B.P.6
  • 28
    • 79952993719 scopus 로고    scopus 로고
    • Last accessed 20 Aug 2013
    • HIV Drug Interactions webpage. http://www. HIV-druginteractions. org. Last accessed 20 Aug 2013.
    • HIV Drug Interactions webpage
  • 29
    • 84862876886 scopus 로고    scopus 로고
    • Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks
    • Sax PE, DeJesus E, Mills A, Zolopa A, Cohen C, Wohl D, et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet. 2012;379(9835): 2439-48.
    • (2012) Lancet , vol.379 , Issue.9835 , pp. 2439-2448
    • Sax, P.E.1    DeJesus, E.2    Mills, A.3    Zolopa, A.4    Cohen, C.5    Wohl, D.6
  • 30
    • 84862843404 scopus 로고    scopus 로고
    • Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial
    • DeJesus E, Rockstroh JK, Henry K, Molina JM, Gathe J, Ramanathan S, et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet. 2012;379(9835): 2429-38.
    • (2012) Lancet , vol.379 , Issue.9835 , pp. 2429-2438
    • DeJesus, E.1    Rockstroh, J.K.2    Henry, K.3    Molina, J.M.4    Gathe, J.5    Ramanathan, S.6
  • 31
    • 84876283495 scopus 로고    scopus 로고
    • A randomized double-blind comparison of coformulated elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate for Initial treatment of HIV-1 infection: analysis of week 96 results
    • Zolopa A, Sax PE, Dejesus E, Mills A, Cohen C, Wohl D, et al. A randomized double-blind comparison of coformulated elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate for Initial treatment of HIV-1 infection: analysis of week 96 results. J Acquir Immune Defic Syndr. 2013;63(1): 96-100.
    • (2013) J Acquir Immune Defic Syndr , vol.63 , Issue.1 , pp. 96-100
    • Zolopa, A.1    Sax, P.E.2    Dejesus, E.3    Mills, A.4    Cohen, C.5    Wohl, D.6
  • 32
    • 84876409173 scopus 로고    scopus 로고
    • A randomized, double-blind comparison of co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir DF for initial treatment of HIV-1 infection: analysis of week 96 results
    • Rockstroh JK, Dejesus E, Henry K, Molina JM, Gathe J, Ramanathan S, et al. A randomized, double-blind comparison of co-formulated elvitegravir/cobicistat/emtricitabine/tenofovir versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir DF for initial treatment of HIV-1 infection: analysis of week 96 results. J Acquir Immune Defic Syndr. 2013;62(5): 483-6.
    • (2013) J Acquir Immune Defic Syndr , vol.62 , Issue.5 , pp. 483-486
    • Rockstroh, J.K.1    Dejesus, E.2    Henry, K.3    Molina, J.M.4    Gathe, J.5    Ramanathan, S.6
  • 33
    • 84878525908 scopus 로고    scopus 로고
    • Cobicistat versus ritonavir as a pharmacoenhancer of atazanavir plus emtricitabine/tenofovir disoproxil fumarate in treatment-naive HIV type 1-infected patients: week 48 results
    • Gallant JE, Koenig E, Andrade-Villanueva J, Chetchotisakd P, Dejesus E, Antunes F, et al. Cobicistat versus ritonavir as a pharmacoenhancer of atazanavir plus emtricitabine/tenofovir disoproxil fumarate in treatment-naive HIV type 1-infected patients: week 48 results. J Infect Dis. 2013;208(1): 32-9.
    • (2013) J Infect Dis , vol.208 , Issue.1 , pp. 32-39
    • Gallant, J.E.1    Koenig, E.2    Andrade-Villanueva, J.3    Chetchotisakd, P.4    Dejesus, E.5    Antunes, F.6
  • 35
    • 84865714929 scopus 로고    scopus 로고
    • Effect of cobicistat on glomerular filtration rate in subjects with normal and impaired renal function
    • German P, Liu HC, Szwarcberg J, Hepner M, Andrews J, Kearney BP, et al. Effect of cobicistat on glomerular filtration rate in subjects with normal and impaired renal function. J Acquir Immune Defic Syndr. 2012;61(1): 32-40.
    • (2012) J Acquir Immune Defic Syndr , vol.61 , Issue.1 , pp. 32-40
    • German, P.1    Liu, H.C.2    Szwarcberg, J.3    Hepner, M.4    Andrews, J.5    Kearney, B.P.6
  • 36
    • 84977132825 scopus 로고    scopus 로고
    • Elvitegravir/cobicistat/tenofovir DF/emtricitabine (STB) and cobicistat (COBI) in HIV infected patients with mild to moderate renal impairment
    • Kuala Lumpur, Malaysia; 30 June-03 July 2013
    • Post F, Winston J, Andrade-Villanueva J, Fisher M, Liu Y, Zhong L, et al. Elvitegravir/cobicistat/tenofovir DF/emtricitabine (STB) and cobicistat (COBI) in HIV infected patients with mild to moderate renal impairment. In: 7th IAS Conference on HIV Pathogenesis, Treatment, and Prevention. Kuala Lumpur, Malaysia; 30 June-03 July 2013.
    • 7th IAS Conference on HIV Pathogenesis, Treatment, and Prevention
    • Post, F.1    Winston, J.2    Andrade-Villanueva, J.3    Fisher, M.4    Liu, Y.5    Zhong, L.6
  • 37
    • 58849154620 scopus 로고    scopus 로고
    • Recent developments in HIV and the kidney
    • Post FA, Holt SG. Recent developments in HIV and the kidney. Curr Opin Infect Dis. 2009;22(1): 43-8.
    • (2009) Curr Opin Infect Dis. , vol.22 , Issue.1 , pp. 43-48
    • Post, F.A.1    Holt, S.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.