Inherent Risk Factors for Nosocomial Infection in the Long Stay Critically Ill Child Without Known Baseline Immunocompromise: A Post Hoc Analysis of the CRISIS Trial

Pediatric Infectious Disease Journal

Volumn 35, Issue 11, 2016, Pages 1182-1186

  Carcillo, Joseph A ^a   Dean, J Michael ^b   Holubkov, Richard ^b   Berger, John ^c   Meert, Kathleen L ^d   Anand, Kanwaljeet J S ^e   Zimmerman, Jerry ^f   Newth, Christopher J ^g   Harrison, Rick ^h   Burr, Jeri ^b   Willson, Douglas F ⁱ   Nicholson, Carol ^j   Bell, Michael J ^a   Berg, Robert A ^k   Shanley, Thomas P ^l   Heidemann, Sabrina M ^d   Dalton, Heidi ^m   Jenkins, Tammara L ^j   Doctor, Allan ⁿ   Webster, Angie ^b  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ARKANSAS   (United States)

^f UNIVERSITY OF WASHINGTON   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ UNIVERSITY OF VIRGINIA   (United States)

^j Eunice Kennedy Shriver National Institute of Child Health and Development   (United States)

^k UNIVERSITY OF PENNSYLVANIA   (United States)

^l UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^m UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

ⁿ WASHINGTON UNIVERSITY   (United States)

more..

Author keywords

immune competent host; nosocomial infection; pediatric intensive care unit

Indexed keywords

ACINETOBACTER; ACINETOBACTER BAUMANNII; ADOLESCENT; ALPHA HEMOLYTIC STREPTOCOCCUS; ARTICLE; ASPERGILLUS NIGER; BACTERIUM IDENTIFICATION; BLOODSTREAM INFECTION; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CHILD; CHILDHOOD DISEASE; CITROBACTER FREUNDII; COAGULASE NEGATIVE STAPHYLOCOCCUS; COHORT ANALYSIS; CONTROLLED STUDY; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; EIKENELLA; ENTEROBACTER; ENTEROBACTER CLOACAE; ENTEROBACTERAEROGENES; ENTEROCOCCUS; ENTEROCOCCUS AEROGENES; ENTEROCOCCUS CLOACAE; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ENTEROCOCCUS RAFFINOSIS; ESCHERICHIA COLI; FEMALE; FILOBASIDIELLA; FUNGUS IDENTIFICATION; GRAM POSITIVE COCCI; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS PARAINFLUENZAE; HEART ARREST; HOSPITAL ADMISSION; HOSPITAL INFECTION; HUMAN; IMMUNOCOMPROMISED PATIENT; INFECTION PREVENTION; INFECTION RISK; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; LENGTH OF STAY; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROCOCCUS; MIXED INFECTION; MORAXELLA CATARRHALIS; NEUTROPENIA; NONHUMAN; PANTOEA AGGLOMERANS; PEDIATRIC INTENSIVE CARE UNIT; PEPTOCLOSTRIDIUM DIFFICILE; POST HOC ANALYSIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; SERRATIA MARCESCENS; SKIN INFECTION; SOFT TISSUE INFECTION; SPECIES IDENTIFICATION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STENOTROPHOMONAS MALTOPHILIA; STREPTOCOCCUS PNEUMONIAE; URINARY TRACT INFECTION; VANCOMYCIN RESISTANT ENTEROCOCCUS FAECIUM; YEAST; CROSS INFECTION; INFANT; PRESCHOOL CHILD; RISK FACTOR;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; CROSS INFECTION; FEMALE; HUMANS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; MALE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84977100891     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000001286     Document Type: Article

References (21)

1. Gravel D, Matlow A, Ofner-Agostini M, et al; Canadian Nosocomial Infection Surveillance Program. A point prevalence survey of health careassociated infections in pediatric populations in major Canadian acute care hospitals. Am J Infect Control. 2007;35:157-162.
2. Leclerc F, Leteurtre S, Duhamel A, et al. Cumulative influence of organ dysfunctions and septic state on mortality of critically ill children. Am J Respir Crit Care Med. 2005;171:348-353.
3. Carcillo JA, Dean JM, Holubkov R, et al. The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial. Pediatr Crit Care Med. 2012;13:165-173.
4. Leteurtre S, Martinot A, Duhamel A, et al. Development of a pediatric multiple organ dysfunction score: use of two strategies. Med Decis Making. 1999;19:399-410.
5. Pollack MM, Patel KM, Ruttimann UE. The Pediatric Risk of Mortality III-Acute Physiology Score (PRISM III-APS): a method of assessing physiologic instability for pediatric intensive care unit patients. J Pediatr. 1997;131:575-581.
6. Doughty LA, Kaplan SS, Carcillo JA. Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. Crit Care Med. 1996;24:1137-1143.
7. Virkkunen I, Ryynänen S, Kujala S, et al. Incidence of regurgitation and pulmonary aspiration of gastric contents in survivors from out-of-hospital cardiac arrest. Acta Anaesthesiol Scand. 2007;51:202-205.
8. Tsai MS, Chiang WC, Lee CC, et al. Infections in the survivors of out-ofhospital cardiac arrest in the first 7 days. Intensive Care Med. 2005;31:621-626.
9. Gajic O, Festic E, Afessa B. Infectious complications in survivors of cardiac arrest admitted to the medical intensive care unit. Resuscitation. 2004;60:65-69.
10. Taira BR, Fenton KE, Lee TK, et al. Ventilator-associated pneumonia in pediatric trauma patients. Pediatr Crit Care Med. 2009;10:491-494.
11. Upperman JS, Sheridan RL. Pediatric trauma susceptibility to sepsis. Pediatr Crit Care Med. 2005;6(3 Suppl):S108-S111.
12. Urrea M, Torner F, Pons M, et al. Incidence study of nosocomial infection in pediatric trauma patients. J Pediatr Orthop B. 2005;14:371-374.
13. Brook I. Infectious complications following trauma in children. Adv Pediatr. 1997;44:429-451.
14. Meert KL, Ofenstein JP, Sarnaik AP. Altered T cell cytokine production following mechanical trauma. Ann Clin Lab Sci. 1998;28:283-288.
15. Meert KL, Long M, Kaplan J, et al. Alterations in immune function following head injury in children. Crit Care Med. 1995;23:822-828.
16. Heffernan DS, Monaghan SF, Thakkar RK, et al. Failure to normalize lymphopenia following trauma is associated with increased mortality, independent of the leukocytosis pattern. Crit Care. 2012;16:R12.
17. Lucin KM, Sanders VM, Popovich PG. Stress hormones collaborate to induce lymphocyte apoptosis after high level spinal cord injury. J Neurochem. 2009;110:1409-1421.
18. Felmet KA, Hall MW, Clark RS, et al. Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol. 2005;174:3765-3772.
19. Shi Z, Xie H, Wang P, et al. Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev. 2013; 8:CD008367.
20. Hall MW, Knatz NL, Vetterly C, et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med. 2011;37:525-532.
21. Drewry AM, Samra N, Skrupky LP, et al. Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock. 2014;42:383-391.