Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells

European Urology

Volumn 71, Issue 1, 2017, Pages 8-12

  Yang, Zhao ^a   Li, Chong ^a   Fan, Zusen ^a   Liu, Hongjie ^b   Zhang, Xiaolong ^c   Cai, Zhiming ^d   Xu, Liqin ^e   Luo, Jian ^e   Huang, Yi ^c   He, Luyun ^a   Liu, Chunxiao ^f   Wu, Song ^c  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c Shenzhen University   (China)

^d THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^e BGI SHENZHEN   (China)

^f SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

bladder cancer; bladder cancer stem cells; genetic alteration; self renewal; single cell sequencing; tumor evolution

Indexed keywords

ATM PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR PITX2; TRANSCRIPTION FACTOR SIN3A; XERODERMA PIGMENTOSUM GROUP D PROTEIN; ARID1A PROTEIN, HUMAN; DNA BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; GPRC5A PROTEIN, HUMAN; MLL2 PROTEIN, HUMAN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ARIDA1 GENE; ARTICLE; BLADDER CANCER; BLADDER CANCER NON STEM CELL; BLADDER EPITHELIAL NON STEM CELL; BLADDER EPITHELIAL STEM CELL; BRF1 GENE; CANCER GENETICS; CANCER STEM CELL; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL ISOLATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CREBBP GENE; CRISPR CAS SYSTEM; FAT4 GENE; GENE EXPRESSION; GENE MUTATION; GPRC5A GENE; HUMAN; HUMAN BLADDER CANCER STEM CELL; MKL1 GENE; MLL2 GENE; MOUSE; MUTATION RATE; MUTATOR GENE; NOD SCID MOUSE; NONHUMAN; PAWR GENE; PHYLOGENY; PRIORITY JOURNAL; RGS9BP GENE; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; SINGLE CELL SEQUENCING; SOMATIC MUTATION; STAG2 GENE; STEM CELL; STEM CELL SELF-RENEWAL; TRANSCRIPTION REGULATION; TRANSPLANTATION; TUMOR XENOGRAFT; BLADDER TUMOR; EPITHELIUM CELL; GENETICS; METABOLISM; MUTATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; WHOLE EXOME SEQUENCING;

DNA-BINDING PROTEINS; EPITHELIAL CELLS; HUMANS; MUTATION; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED; TRANSCRIPTION FACTORS; URINARY BLADDER NEOPLASMS; WHOLE EXOME SEQUENCING;

EID: 84977072596     PISSN: 03022838     EISSN: 18737560     Source Type: Journal    
DOI: 10.1016/j.eururo.2016.06.025     Document Type: Article

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