Zonulin Regulates Intestinal Permeability and Facilitates Enteric Bacteria Permeation in Coronary Artery Disease

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Li, Chuanwei ^a   Gao, Min ^b   Zhang, Wen ^b   Chen, Caiyu ^a   Zhou, Faying ^a   Hu, Zhangxu ^a   Zeng, Chunyu ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; RNA 16S; ZONULIN;

BACTERIUM; BLOOD; CACO-2 CELL LINE; CELL SHAPE; CORONARY ARTERY DISEASE; DEMOGRAPHY; DRUG EFFECT; FEMALE; GENETICS; HUMAN; INTESTINE; INTESTINE ABSORPTION; INTRACELLULAR SPACE; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PSEUDOMONAS; REAL TIME POLYMERASE CHAIN REACTION;

BACTERIA; BASE SEQUENCE; CACO-2 CELLS; CELL SHAPE; CHOLERA TOXIN; CORONARY ARTERY DISEASE; DEMOGRAPHY; FEMALE; HUMANS; INTESTINAL ABSORPTION; INTESTINES; INTRACELLULAR SPACE; MALE; MIDDLE AGED; PSEUDOMONAS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL, 16S;

EID: 84976645635     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep29142     Document Type: Article

References (30)

1. Mozaffarian, D. et al. Heart disease and stroke statistics-2015 update: a report from the American Heart Association. Circulation. 131, e29-322 (2015).
2. Hansson, G. K. Inflammation, Atherosclerosis, and Coronary Artery Disease. N Engl J Med. 352, 1685-95 (2005).
3. Chen, S. et al. IL-17A is proatherogenic in high-fat diet-induced and Chlamydia pneumoniae infection-acceleratedatherosclerosis in mice. J Immunol. 185, 5619-27 (2010).
4. Kalayoglu, M. V1., Libby, P., Byrne, G. I. Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease. JAMA. 288, 2724-31 (2002).
5. Koren, O. et al. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci USA 108, Suppl 1, 4592-8 (2011).
6. Wang, Z. et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 472, 57-63 (2011).
7. Koeth, R. A. et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 19,576-85(2013).
8. Armingohar, Z., Jorgensen, J. J., Kristoffersen, A. K., Abesha-Belay, E., Olsen, I. Bacteria and bacterial DNA in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis. J Oral Microbiol. 6, doi: 10.3402/jom.v6.23408. eCollection 2014 (2014).
9. Tripathi, A. et al. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci USA 106, 16799-804 (2009).
10. Zhang, D. et al. Circulating zonulin levels in newly diagnosed Chinese type 2 diabetes patients. Diabetes Res Clin Pract. 106, 312-8 (2014).
11. Zhang, D., Zhang, L., Yue, F., Zheng, Y., Russell, R. Serum zonulin is elevated in women with polycystic ovary syndrome and correlates with insulin resistance and severity of anovulation. Eur J Endocrinol. 172, 29-36 (2015).
12. Moreno-Navarrete, J. M., Sabater, M., Ortega, F., Ricart, W., Fernandez-Real, J. M. Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance. PLoS One 7, e37160 (2012).
13. El Asmar, R. et al. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology. 123, 1607-15 (2002).
14. Neves, A. L., Coelho, J., Couto, L., Leite-Moreira, A., Roncon-Albuquerque, R., Jr. Metabolic endotoxemia: a molecular link between obesity and cardiovascular risk. J Mol Endocrinol. 51, R51-64 (2013).
15. Koeth, R. A. et al. ?-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 20, 799-812 (2014).
16. Reina, J., Lopez, A. Clinical and microbiological characteristics of Rahnella aquatilis strains isolated from children. J Infect. 33, 135-7 (1996).
17. Gaitan, J. I., Bronze, M. S. Infection caused by Rahnella aquatilis. Am J Med Sci. 339, 577-9 (2010).
18. Alballaa, S. R., Qadri, S. M., al-Furayh, O., al-Qatary, K. Urinary tract infection due to Rahnella aquatilis in a renal transplant patient. J Clin Microbiol. 30, 2948-50 (1992).
19. Wagner Mackenzie, B. et al. Evaluating variation in human gut microbiota profiles due to DNA extraction method and inter-subject differences. Front Microbiol. 6, 130 (2015).
20. Hietbrink, F. et al. Systemic inflammation increases intestinal permeability during experimental human endotoxemia. Shock. 32, 374-8 (2009).
21. Han, X., Fink, M. P., Delude, R. L. Proinflammatory cytokines cause NO-dependent and-independent changes in expression and localization of tight junction proteins in intestinal epithelial cells. Shock. 19, 229-37 (2003).
22. Klaus, D. A. et al. Increased plasma zonulin in patients with sepsis. Biochem Med (Zagreb) 23, 107-11 (2013).
23. Wang, W., Uzzau, S., Goldblum, S. E., Fasano, A. Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci. 113, 4435-40 (2000).
24. Grayston, J. T. et al. Azithromycin for the secondary prevention of coronary events. N Engl J Med. 352, 1637-45 (2005).
25. Cannon, C. P. et al. Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome. N Engl J Med. 352, 1646-54 (2005).
26. Gregory, J. C. et al. Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem. 290, 5647-60 (2015).
27. Duffin, R. et al. Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis. Science 351, 1333-8 (2016).
28. Pu, J. et al. In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy. Eur Heart J. 3, 372-83 (2012).
29. Margulies, M. et al. Genome sequencing in microfabricated high-density picolitre reactors. Nature 437, 376-80 (2005).
30. Roosa, S. et al. The Pseudomonas community in metal-contaminated sediments as revealed by quantitative PCR: a link with metal bioavailability. Res Microbiol. 165, 647-56 (2014).