Identification of BRAF kinase domain duplications across multiple tumor types and response to RAF inhibitor therapy

JAMA Oncology

Volumn 2, Issue 2, 2016, Pages 272-274

  Klempner, Samuel J ^a   Bordoni, Rodolfo ^b,c   Gowen, Kyle ^d   Kaplan, Henry ^e   Stephens, Philip J ^d,f   Ou, Sai Hong Ignatius ^a   Ali, Siraj M ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Georgia Cancer Specialists ^*  (United States)

^c NORTHSIDE HOSPITAL   (United States)

^d FOUNDATION MEDICINE   (United States)

^e SWEDISH MEDICAL CENTER   (United States)

^f ALBANY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; B RAF KINASE; BRAF PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

ADULT; ANTAGONISTS AND INHIBITORS; CARCINOMA, ACINAR CELL; CASE REPORT; DNA MUTATIONAL ANALYSIS; ENZYMOLOGY; FEMALE; GENE DUPLICATION; GENE EXPRESSION PROFILING; GENETICS; HUMAN; METABOLISM; MUTATION; PAROTID NEOPLASMS; PATHOLOGY; PERSONALIZED MEDICINE; PREDICTIVE VALUE; PROTEIN TERTIARY STRUCTURE; REMISSION; TREATMENT OUTCOME;

ADULT; ANTINEOPLASTIC AGENTS; CARCINOMA, ACINAR CELL; DNA MUTATIONAL ANALYSIS; FEMALE; GENE DUPLICATION; GENE EXPRESSION PROFILING; HUMANS; MUTATION; PAROTID NEOPLASMS; PRECISION MEDICINE; PREDICTIVE VALUE OF TESTS; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS B-RAF; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 84976579873     PISSN: 23742437     EISSN: 23742445     Source Type: Journal    
DOI: 10.1001/jamaoncol.2015.4437     Document Type: Article

References (6)

1. Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949-954.
2. Rodriguez FJ, Ligon AH, Horkayne-Szakaly I, et al. BRAF duplications and MAPK pathway activation are frequent in gliomas of the optic nerve proper. J Neuropathol Exp Neurol. 2012;71(9):789-794.
3. Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. A dimerization-dependent mechanism drives RAF catalytic activation. Nature. 2009;461(7263):542-545.
4. Poulikakos PI, Persaud Y, Janakiraman M, et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011;480(7377):387-390.
5. Pfister S, Janzarik WG, Remke M, et al. BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. J Clin Invest. 2008;118(5):1739-1749.
6. Palanisamy N, Ateeq B, Kalyana-Sundaram S, et al. Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nat Med. 2010;16(7):793-798.