Epidemiology of carbapenem resistant Klebsiella pneumoniae infections in Mediterranean countries

Mediterranean Journal of Hematology and Infectious Diseases

Volumn 8, Issue 1, 2016, Pages

  Girmenia, Corrado ^a   Serrao, Alessandra ^a   Canichella, Martina ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAPENEM; CARBAPENEM HYDROLYSING OXACILLINASE 48; CARBAPENEMASE; IMIPENEMASE; KLEBSIELLA PNEUMONIAE CARBAPENEMASE; NEW DELHI METALLO BETA LACTAMASE; UNCLASSIFIED DRUG; VERONA INTEGRON ENCODED METALLO BETA LACTAMASE;

ANTIBIOTIC RESISTANCE; BACTERIAL STRAIN; BACTERIUM ISOLATION; ENDEMIC DISEASE; ENZYME ACTIVITY; ENZYME SYNTHESIS; EPIDEMIC; GEOGRAPHIC DISTRIBUTION; GREECE; HUMAN; ITALY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MALTA; MEDITERRANEAN SEA; MIDDLE EAST; MIGRATION; MOLECULAR EPIDEMIOLOGY; NONHUMAN; NORTH AFRICA; PATIENT TRANSPORT; RESIDENTIAL CARE; REVIEW; TERTIARY HEALTH CARE;

EID: 84976497785     PISSN: None     EISSN: 20353006     Source Type: Journal    
DOI: 10.4084/mjhid.2016.032     Document Type: Review

References (113)

1. Munoz-Price LS, Poirel L, Bonomo RA, et al . Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis. 2013;13:785-96. http://dx.doi.org/10.1016/S1473-3099(13)70190-7
2. Tzouvelekis LS, Markogiannakis A, Psichogiou M, et al. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin Microbiol Rev. 2012 ;25:682-707. http://dx.doi.org/10.1128/CMR.05035-11 PMid:23034326 PMCid:PMC3485753
3. Cantón R, Akóva M, Carmeli Y, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect. 2012 ;18:413-31. http://dx.doi.org/10.1111/j.1469-0691.2012.03821.x PMid:22507109
4. Nordmann P, Poirel L. The difficult-to-control spread of carbapenemae producers in Enterobacteriaceae worldwide. Clin Microbiol Infect 2014;20:821-30 http://dx.doi.org/10.1111/1469-0691.12719 PMid:24930781
5. van Duin D, Doi Y. Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae: Are We at the End of the Road? J Clin Microbiol. 2015;53:3116-7. http://dx.doi.org/10.1128/JCM.01399-15 PMid:26202122 PMCid:PMC4572557
6. Monaco M, Giani T, Raffone M, et al. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014. Euro Surveill. 2014;19(42). http://dx.doi.org/10.2807/1560-7917.ES2014.19.42.20939 PMid:25358041
7. Syue LS, Chen YH, Ko WC, Hsueh PR. New drugs for the treatment of complicated intra-abdominal infections in the era of increasing antimicrobial resistance. Int J Antimicrob Agents. 2016 ;47:250-8. http://dx.doi.org/10.1016/j.ijantimicag.2015.12.021
8. Bergamasco MD, Barroso Barbosa M, de Oliveira Garcia D, et al. Infection with Klebsiella pneumoniae carbapenemase (KPC)- producing K. pneumoniae in solid organ transplantation. Transpl Infect Dis. 2012 ;14:198-205. http://dx.doi.org/10.1111/j.1399-3062.2011.00688.x
9. Taglietti F, Di Bella S, Galati V, et al. Carbapenemase-producing Klebsiella pneumoniae-related mortality among solid organ-transplanted patients: do we know enough? Transpl Infect Dis. 2013;15:E164-5. http://dx.doi.org/10.1111/tid.12085 PMid:23601113
10. Kalpoe JS, Sonnenberg E, Factor SH, et al. Mortality associated with carbapenem-resistant Klebsiella pneumoniae infections in liver transplant recipients. Liver Transpl. 2012 ;18:468-74. http://dx.doi.org/10.1002/lt.23374 PMid:22467548
11. Clancy CJ, Chen L, Shields RK, et al. Epidemiology and molecular characterization of bacteremia due to carbapenem-resistant Klebsiella pneumoniae in transplant recipients. Am J Transplant. 2013;13:2619-33. http://dx.doi.org/10.1111/ajt.12424 PMid:24011185 PMCid:PMC3955300
12. Satlin MJ, Jenkins SG, Walsh TJ. The Global Challenge of Carbapenem-Resistant Enterobacteriaceae in Transplant Recipients and Patients With Hematologic Malignancies. Clin Infect Dis. 2014 ;58:1274-83 http://dx.doi.org/10.1093/cid/ciu052 PMid:24463280 PMCid:PMC4038783
13. Pagano L, Caira M, Trecarichi EM, et al. Carbapenemase-producing Klebsiella pneumoniae and hematologic malignancies. Emerg Infect Dis. 2014;20:1235-6. http://dx.doi.org/10.3201/eid2007.130094 PMid:24960464 PMCid:PMC4073839
14. Girmenia C, Rossolini GM, Piciocchi A, et al Infections by carbapenem-resistant Klebsiella pneumoniae in stem cell transplant recipients: a nationwide retrospective survey from Italy. Bone Marrow Transplant, 2015;50:282-8 http://dx.doi.org/10.1038/bmt.2014.231 PMid:25310302
15. Girmenia C, Viscoli C, Piciocchi A, et al. Management of carbapenem resistant Klebsiella pneumoniae infections in stem cell transplant recipients: an Italian multidisciplinary consensus statement. Haematologica. 2015;100:e373-6. http://dx.doi.org/10.3324/haematol.2015.125484 PMid:25862702 PMCid:PMC4800687
16. Nordmann P. Carbapenemase-producing Enterobacteriaceae: overview of a major public health challenge. Med Mal Infect. 2014;44:51-6. http://dx.doi.org/10.1016/j.medmal.2013.11.007 PMid:24360201
17. Pitout JD, Nordmann P, Poirel L. Carbapenemase-Producing Klebsiella pneumoniae, a Key Pathogen Set for Global Nosocomial Dominance. Antimicrob Agents Chemother. 2015;59:5873-84. http://dx.doi.org/10.1128/AAC.01019-15 PMid:26169401 PMCid:PMC4576115
18. Walther-Rasmussen J, Hoiby N. Class A carbapenemases. J Antimicrob Chemother 2007;60:470-482. http://dx.doi.org/10.1093/jac/dkm226 PMid:17595289
19. Nordmann P, Naas T, Poirel L. Global spread of carbapenemase producing Enterobacteriaceae. Emerg Infect Dis 2011, 17:1791-1798 http://dx.doi.org/10.3201/eid1710.110655 PMid:22000347 PMCid:PMC3310682
20. Jean SS, Lee WS, Lam C, Hsu CW, Chen RJ, Hsueh PR. Carbapenemase-producing Gram-negative bacteria: current epidemics, antimicrobial susceptibility and treatment options. Future Microbiol. 2015;10:407-25. http://dx.doi.org/10.2217/fmb.14.135 PMid:25812463
21. Glasner C, Albiger B, Buist G, et al European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group. Carbapenemase-producing Enterobacteriaceae in Europe: a survey among national experts from 39 countries, February 2013. Euro Surveill. 2013;18(28). http://dx.doi.org/10.2807/1560-7917.ES2013.18.28.20525 PMid:23870096
22. Djahmi N, Dunyach-Remy C, Pantel A, Dekhil M, Sotto A, Lavigne JP. Epidemiology of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Mediterranean countries. Biomed Res Int. 2014;2014:305784. http://dx.doi.org/10.1155/2014/305784 PMid:24955354 PMCid:PMC4052623
23. Rasmussen BA, Bush K. Carbapenem-hydrolyzing ß-lactamases. Antimicrob Agents Chemother. 1997; 41:223-232. PMid:9021171 PMCid:PMC163693
24. Martínez-Martínez L, Pascual A, Hernández-Allés S, et al. Roles of ß-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae . Antimicrob Agents Chemother. 1999; 43:1669-1673. PMid:10390220 PMCid:PMC89341
25. Yigit H, Queenan AM, Anderson GJ, et al. Novel carbapenem-hydrolyzing ß-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae . Antimicrob Agents Chemother. 2001; 45:1151-1161. http://dx.doi.org/10.1128/AAC.45.4.1151-1161.2001 PMid:11257029 PMCid:PMC90438
26. Bradford PA, Bratu S, Urban C, et al. Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 ß-lactamases in New York City. Clin Infect Dis. 2004; 39:55-60. http://dx.doi.org/10.1086/421495 PMid:15206053
27. Bratu S, Landman D, Haag R, et al. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. Arch Intern Med. 2005; 165:1430-1435. http://dx.doi.org/10.1001/archinte.165.12.1430 PMid:15983294
28. Kitchel B, Rasheed JK, Patel JB, et al. Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258. Antimicrob Agents Chemother. 2009; 53:3365-3370. http://dx.doi.org/10.1128/AAC.00126-09 PMid:19506063 PMCid:PMC2715580
29. Gupta N, Limbago BM, Patel JB, Kallen AJ. Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis. 2011; 53:60-67. http://dx.doi.org/10.1093/cid/cir202 PMid:21653305
30. Samra Z, Ofir O, Lishtzinsky Y, Madar-Shapiro L, Bishara J. Outbreak of carbapenem-resistant Klebsiella pneumoniae producing KPC-3 in a tertiary medical centre in Israel, International Journal of Antimicrobial Agents, 2007;30:525-529. http://dx.doi.org/10.1016/j.ijantimicag.2007.07.024 PMid:17931835
31. Kitchel, Rasheed JK, J Patel JB et al., "Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258," Antimicrobial Agents and Chemotherapy, 2009;53:3365-3370.
32. Schwaber MJ, Lev B, Israeli A, et al. Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention. Clin Infect Dis. 2011;52:848-55 http://dx.doi.org/10.1093/cid/cir025 PMid:21317398
33. Cuzon G, Naas T, Demachy MC, Nordmann P. Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in Klebsiella pneumoniae isolate from Greece. Antimicrob Agents Chemother. 2008; 52:796-97 http://dx.doi.org/10.1128/AAC.01180-07 PMid:18056283 PMCid:PMC2224780
34. Tegmark WK, Haeggman S, Gezelius L, et al. Identification of Klebsiella pneumoniae carbapenemase in Sweden. Euro Surveill. 2007; 12:E071220. http://ecdc.europa.eu/en/publications/Publications/antimicrobial-resistance-europe-2014.pdf
35. Maltezou HC, Giakkoupi P, Maragos A, et al. Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece). J Infect. 2009; 58:213-19. http://dx.doi.org/10.1016/j.jinf.2009.01.010 PMid:19246099
36. Pournaras S, Protonotariou E, Voulgari E, et al. Clonal spread of KPC-2 carbapenemase-producing Klebsiella pneumoniae strains in Greece. J Antimicrob Chemother. 2009; 64:348-52. http://dx.doi.org/10.1093/jac/dkp207 PMid:19525514
37. Souli M, Galani I, Antoniadou A, et al. An outbreak of infection due to beta-lactamase Klebsiella pneumoniae carbapenemase 2-producing K pneumoniae in a Greek University Hospital: molecular characterization, epidemiology, and outcomes. Clin Infect Dis. 2010; 50:364-73. http://dx.doi.org/10.1086/649865 PMid:20041768
38. Kontopoulou K, Protonotariou E, Vasilakos K, et al. Hospital outbreak caused by Klebsiella pneumoniae producing KPC-2 beta-lactamase resistant to colistin. J Hosp Infect. 2010; 76:70-73. http://dx.doi.org/10.1016/j.jhin.2010.03.021 PMid:20705205
39. Zarkotou O, Pournaras S, Tselioti P, et al. Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect. 2011; 17:1798-803. http://dx.doi.org/10.1111/j.1469-0691.2011.03514.x PMid:21595793
40. Bathoorn E, Tsioutis C, da Silva Voorham JM, et al. Emergence of pan-resistance in KPC-2 carbapenemase-producing Klebsiella pneumoniae in Crete, Greece: a close call. J Antimicrob Chemother. 2016;71:1207-12. http://dx.doi.org/10.1093/jac/dkv467 PMid:26817488
41. Spyropoulou A, Papadimitriou-Olivgeris M, Bartzavali C, et al. A ten-year surveillance study of carbapenemase-producing Klebsiella pneumoniae in a tertiary care Greek university hospital: predominance of KPC- over VIM- or NDM-producing isolates. J Med Microbiol. 2016;65:240-6. http://dx.doi.org/10.1099/jmm.0.000217 PMid:26698320
42. Giani T, D'Andrea MM, Pecile P, et al. Emergence in Italy of Klebsiella pneumoniae sequence type 258 producing KPC-3 carbapenemase. J Clin Microbiol. 2009; 47:3793-94. http://dx.doi.org/10.1128/JCM.01773-09 PMid:19759220 PMCid:PMC2772625
43. Fontana C, Favaro M, Sarmati L, et al. Emergence of KPC-producing Klebsiella pneumoniae in Italy. BMC Res Notes. 2010; 3:40. http://dx.doi.org/10.1186/1756-0500-3-40 PMid:20178590 PMCid:PMC2844393
44. Giani T, Pini B, Arena F, et al. Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011. Euro Surveill. 2013;18 (22). PMid:23787077
45. Tumbarello M, Viale P, Viscoli C, et al. Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy. Clin Infect Dis. 2012; 55:943-50. http://dx.doi.org/10.1093/cid/cis588 PMid:22752516
46. Giannella M, Trecarichi EM, De Rosa FG, et al. Risk factors for carbapenem-resistant Klebsiella pneumoniae bloodstream infection among rectal carriers: a prospective observational multicentre study. Clin Microbiol Infect. 2014;20: 1357-62 http://dx.doi.org/10.1111/1469-0691.12747 PMid:24980276
47. Giacobbe DR, Del Bono V, Trecarichi EM, et al. Risk factors for bloodstream infections due to colistin-resistant KPC-producing Klebsiella pneumoniae: results from a multicenter case-control-control study. Clin Microbiol Infect. 2015;21:1106.e1-8. http://dx.doi.org/10.1016/j.cmi.2015.08.001 PMid:26278669
48. Monaco M, Giani T, Raffone M, Arena F, Garcia-Fernandez A, Pollini S; Network EuSCAPE-Italy, Grundmann H, Pantosti A, Rossolini GM. Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014. Euro Surveill. 2014;19(42). http://dx.doi.org/10.2807/1560-7917.ES2014.19.42.20939 PMid:25358041
49. Aschbacher R, Giani T, Corda D, et al. Carbapenemase-producing Enterobacteriaceae during 2011-12 in the Bolzano area (Northern Italy): increasing diversity in a low-endemicity setting. Diagn Microbiol Infect Dis. 2013;77:354-6. http://dx.doi.org/10.1016/j.diagmicrobio.2013.08.029 PMid:24125922
50. Tumbarello M, Trecarichi EM, De Rosa FG, et al. Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study. J Antimicrob Chemother. 2015;70:2133-43. http://dx.doi.org/10.1093/jac/dkv200
51. Naas T, Nordmann P, Vedel G, Poyart C. Plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC in a Klebsiella pneumoniae isolate from France. Antimicrob Agents Chemother. 2005; 49:4423-24. http://dx.doi.org/10.1128/AAC.49.10.4423-4424.2005 PMid:16189140 PMCid:PMC1251528
52. Dortet L, Radu I, Gautier V, Blot F, Chachaty E, Arlet G. Intercontinental travels of patients and dissemination of plasmid-mediated carbapenemase KPC-3 associated with OXA-9 and TEM-1. J Antimicrob Chemother. 2008; 61:455-57 http://dx.doi.org/10.1093/jac/dkm455 PMid:18032422
53. Cuzon G, Naas T, Demachy MC, Nordmann P. Nosocomial outbreak of Klebsiella pneumoniae harbouring bla(KPC-3) in France subsequent to a patient transfer from Italy. Int J Antimicrob Agents. 2012; 39:448-49. http://dx.doi.org/10.1016/j.ijantimicag.2012.01.008 PMid:22421327
54. Naas T, Cuzon G, Babics A, et al. Endoscopy-associated transmission of carbapenem-resistant Klebsiella pneumoniae producing KPC-2 beta-lactamase. J Antimicrob Chemother. 2010; 65:1305-06. http://dx.doi.org/10.1093/jac/dkq117 PMid:20382724
55. Albiger B, Glasner C, Struelens MJ, Grundmann H, Monnet DL; European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) working group. Carbapenemase-producing Enterobacteriaceae in Europe: assessment by national experts from 38 countries, May 2015. Euro Surveill. 2015;20(45). http://dx.doi.org/10.2807/1560-7917.ES.2015.20.45.30062 PMid:26675038
56. Curiao T, Morosini MI, Ruiz-Garbajosa P, et al. Emergence of bla KPC-3-Tn4401a associated with a pKPN3/4-like plasmid within ST384 and ST388 Klebsiella pneumoniae clones in Spain. J Antimicrob Chemother. 2010; 65:1608-14. http://dx.doi.org/10.1093/jac/dkq174 PMid:20513703
57. Oteo J, Ortega A, Bartolomé R, et al. Prospective multicenter study of carbapenemase-producing Enterobacteriaceae from 83 hospitals in Spain reveals high in vitro susceptibility to colistin and meropenem. Antimicrob Agents Chemother. 2015;59:3406-12. http://dx.doi.org/10.1128/AAC.00086-15 PMid:25824224 PMCid:PMC4432182
58. Palacios-Baena ZR, Oteo J, Conejo C, et al. Comprehensive clinical and epidemiological assessment of colonisation and infection due to carbapenemase-producing Enterobacteriaceae in Spain. J Infect. 2016;72:152-60. http://dx.doi.org/10.1016/j.jinf.2015.10.008 PMid:26546855
59. Bedenic B, Mazzariol A, Plecko V, Bošnjak Z, Barl P, Vraneš J, Cornaglia G. First report of KPC-producing Klebsiella pneumoniae in Croatia. J Chemother. 2012;24:237-9. http://dx.doi.org/10.1179/1973947812Y.0000000017 PMid:23040691
60. Jelic M, Butic I, Plecko V, et al. KPC-Producing Klebsiella pneumoniae Isolates in Croatia: A Nationwide Survey. Microb Drug Resist. 2015 Dec 28. http://dx.doi.org/10.1089/mdr.2015.0150 PMid:26709956
61. Kostyanev T, Tafaj S, Skenduli I, et al. First detection of KPC-3-producing Klebsiella pneumoniae in Albania New Microbes New Infect. 2015 ;4:11-2.
62. Bakour S, Sahli F, Touati A, Rolain JM. Emergence of KPC-producing Klebsiella pneumoniae ST512 isolated from cerebrospinal fluid of a child in Algeria. New Microbes New Infect. 2014;8:34-6.
63. Metwally L, Gomaa N, Attallah M, Kamel N. High prevalence of Klebsiella pneumoniae carbapenemase-mediated resistance in K. pneumoniae isolates from Egypt. East Mediterr Health J. 2013;19:947-52. PMid:24673086
64. Helal SF, El-Rachidi NG, AbdulRahman EM, Hassan DM. The presence of blaKPC-mediated resistance in Enterobacteriaceae in Cairo University hospitals in Egypt and its correlation with in vitro carbapenem susceptibility. J Chemother 2014;26:125-8. http://dx.doi.org/10.1179/1973947813Y.0000000099 PMid:24592883
65. Abdulall AK, El-Mahallawy HA, Abdo sa, Aly NK. Emergence of Klebsiella pneumoniae clinical isolates harboring Klebsiella pneumoniaecarbapenemase and metallo-ß-lactamase in two hospitals in Egypt. New Egyptian Journal of Microbiology 2014; 39:
66. Walsh TR, Toleman MA, Poirel L, and Nordmann P., Metallo-β-lactamases: the quiet before the storm? Clin Microbiol Rev 2005;18:306-325.
67. Vatopoulos A, High rates of metallo-??-lactamase-producingpneumoniae in Greece-a review of the current evidence. Euro Surveillance, vol. 13, no. 4, 2008. PMid:18445397
68. Luzzaro F, Docquier JD, Colinon C, Endimiani A, Lombardi G, Amicosante G, Rossolini GM, Toniolo A. Emergence in Klebsiella pneumoniae and Enterobacter cloacae clinical isolates of the VIM-4 metallo-beta-lactamase encoded by a conjugative plasmid. Antimicrob Agents Chemother. 2004;48:648-50. http://dx.doi.org/10.1128/AAC.48.2.648-650.2004 PMid:14742229 PMCid:PMC321512
69. Aschbacher R, Doumith M, Livermore DM, Larcher C, Woodford N. Linkage of acquired quinolone resistance (qnrS1) and metallo-beta-lactamase (blaVIM-1) genes in multiple species of Enterobacteriaceae from Bolzano, Italy. J Antimicrob Chemother. 2008 ;61:515-23. http://dx.doi.org/10.1093/jac/dkm508 PMid:18184647
70. Aschbacher R, Pagani L, Doumith M, et al. Metallo-β-lactamases among Enterobacteriaceae from routine samples in an Italian tertiary-care hospital and long-term care facilities during 2008.Clin Microbiol Infect. 2011;17:181-9. http://dx.doi.org/10.1111/j.1469-0691.2010.03225.x PMid:20345467
71. Cantón R, Akóva M, Carmeli Y, et al. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect. 2012 ;18:413-31. http://dx.doi.org/10.1111/j.1469-0691.2012.03821.x PMid:22507109
72. M.-F. Lartigue, L. Poirel, and P. Nordmann, "First detection of a carbapenem-hydrolyzing metalloenzyme in an Enterobacteriaceae isolate in France," Antimicrob Agents Chemother, 2004; 48:4929-4930. http://dx.doi.org/10.1128/AAC.48.12.4929-4930.2004 PMid:15561885 PMCid:PMC529240
73. Barguigua A, El Otmani F, El Yaagoubi FL, Talmi M, Zerouali K, Timinouni M, First report of a Klebsiella pneumoniae strain coproducing NDM-1, VIM-1 and OXA-48 carbapenemases isolated inMorocco, APMIS, 2013:121:675-677. http://dx.doi.org/10.1111/apm.12034 PMid:23278254
74. Poirel L, Abdelaziz MO, Bernabeu S, Nordmann P., Occurrence of OXA-48 and VIM-1 carbapenemase-producing Enterobacteriaceae in Egypt, Intern J Antimicrob Agents, 2013;41:90-91. http://dx.doi.org/10.1016/j.ijantimicag.2012.08.015 PMid:23040010
75. Robin F, Aggoune-Khinache N, Delmas J. Naim M, Bonnet R., Novel VIM metallo-??-lactamase variant from clinical isolates of Enterobacteriaceae from Algeria, Antimicrob Agents Chemother, 2010;54:466-470. http://dx.doi.org/10.1128/AAC.00017-09 PMid:19901092 PMCid:PMC2798476
76. Ktari S, Arlet G, Mnif B et al., "Emergence of multidrugresistant Klebsiella pneumoniae isolates producing VIM-4 metallo-??-lactamase, CTX-M-15 extended-spectrum ??-lactamase, and CMY-4 AmpC ??-lactamase in a Tunisian University Hospital," Antimicrob Agents Chemother, 2006;50: 4198-4201. http://dx.doi.org/10.1128/AAC.00663-06 PMid:17015633 PMCid:PMC1694011
77. Nordmann P, Poirel L, Toleman MA, Walsh TR. Does broad-spectrum ??-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria? J Antimicrob Chemother, 2011; 66:689-692. http://dx.doi.org/10.1093/jac/dkq520 PMid:21393184
78. Kumarasamy KK, Toleman MA, Walsh TR et al., Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect Dis, 2010;10:597-602. http://dx.doi.org/10.1016/S1473-3099(10)70143-2
79. Birgy A, Doit C, Mariani-Kurkdjian P et al., Early detection of colonization by VIM-1-producing Klebsiella pneumoniae and NDM-1-producing Escherichia coli in two children returning to France. J Clin Microbiol. 2011;49:3085-3087. http://dx.doi.org/10.1128/JCM.00540-11 PMid:21653781 PMCid:PMC3147713
80. Giani T, Pini B, Arena F et al., Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey. Eurosurveillance, 2013;18:22.
81. Gil-Romero Y, Sanz-Rodriguez N, Almagro-Molto M, and Gomez-Garces GM., New description of a NDM-1 carbapenemase producing Klebsiella pneumoniae carrier in Spain, Enferm Infec Microb Clin, 2013;31: 418-419. http://dx.doi.org/10.1016/j.eimc.2012.10.009 PMid:23218738
82. Oteo J, Domingo-Garcia D, Fernandez-Romero S et al.,Abdominal abscess due to NDM-1-producing Klebsiella pneumoniae in Spain. J Med Microbiol 2012; 61:864-867. http://dx.doi.org/10.1099/jmm.0.043190-0 PMid:22383442
83. Poirel L, Benouda A, Hays C, Nordmann P., Emergence of NDM-1-producing Klebsiella pneumoniae in Morocco. J Antimicrob Chemother. 2011;66: 2781-2783. http://dx.doi.org/10.1093/jac/dkr384 PMid:21930570
84. Nasr AB, Decre D, Compain F, Genel N, Barguellil F, Arlet G. Emergence of NDM-1 in association with OXA- 48 in Klebsiella pneumoniae from Tunisia. Antimicrob Agents Chemother, 2013; 57: 4089-4090. http://dx.doi.org/10.1128/AAC.00536-13 PMid:23752514 PMCid:PMC3719753
85. Abdelaziz MO, Bonura C, Aleo A, Fasciana T, Mammina C. NDM-1-and OXA-163-producing Klebsiella pneumoniae isolates in Cairo, Egypt, 2012. J Glob Antimicrob Resist 2013;1:213-5. http://dx.doi.org/10.1016/j.jgar.2013.06.003
86. Poirel L, Ozdamar M, Ocampo-Sosa AA, Turkoglu S, Ozer UG, Nordmann P. NDM-1-producing Klebsiella pneumoniae now in Turkey. Antimicrob Agents Chemother 2012;56: 2784-2785. http://dx.doi.org/10.1128/AAC.00150-12 PMid:22391536 PMCid:PMC3346671
87. Alp E, Percin D, Colakoglu S et al., Molecular characterization of carbapenem-resistant Klebsiella pneumoniae in a tertiary university hospital in Turkey. J Hosp Infect, 2013; 84:178-180. http://dx.doi.org/10.1016/j.jhin.2013.03.002 PMid:23623803
88. Giakkoupi P, Tryfinopoulou K, Kontopidou F et al., Emergence of NDM-producing Klebsiella pneumonia in Greece. Diagn Microbiol Infect Dise 2013; 77:382-384. http://dx.doi.org/10.1016/j.diagmicrobio.2013.09.001 PMid:24135413
89. Psichogiou M, Tassios PT, Avlamis A et al. Ongoing epidemic of blaVIM-1-positive Klebsiella pneumoniae in Athens, Greece: a prospective survey. J Antimicrob Chemother 2008; 61: 59-63. http://dx.doi.org/10.1093/jac/dkm443 PMid:17999975
90. Baroud M, Dandache I, Araj GF et al., Underlying mechanisms of carbapenem resistance in extended-spectrum ??-lactamase-producing Klebsiella pneumoniae and Escherichia coli isolates at a tertiary care centre in Lebanon: role of OXA-48 and NDM-1 carbapenemases. Intern J Antimicrob Agents. 2013;41:75-79. http://dx.doi.org/10.1016/j.ijantimicag.2012.08.010 PMid:23142087
91. Bialvaei AZ, Kafil HS, Leylabadlo HE, Asgharzadeh M, Aghazadeh M. Dissemination of carbapenemases producing Gram negative bacteria in the Middle East. Iran J Microbiol 2015;7:226-246
92. Gefen-Halevi S, Hindiyeh MY, Ben-David D, Smollan G, Gal-Mor O, Azar R, et al. Isolation of genetically unrelated bla(NDM-1)- positive Providencia rettgeri strains in Israel. J Clin Microbiol.2013;51:1642-3. http://dx.doi.org/10.1128/JCM.00381-13 PMid:23486709 PMCid:PMC3647926
93. Poirel L, H'eritier C, Tolun V, Nordmann P., Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae," Antimicrob Agents Chemother, 2004;48:15-22 http://dx.doi.org/10.1128/AAC.48.1.15-22.2004 PMid:14693513 PMCid:PMC310167
94. Carrer A, Poirel L, Eraksoy H, Cagatay AA, Badur S, Nordmann P. Spread of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey. Antimicrob Agents Chemother 2008;52:2950-4. http://dx.doi.org/10.1128/AAC.01672-07 PMid:18519712 PMCid:PMC2493117
95. Aktas Z, Kayacan CB, Schneider I, Can B, Midilli K, Bauernfeind A. Carbapenem-hydrolyzing oxacillinase, OXA-48, persists in Klebsiella pneumoniae in Istanbul, Turkey. Chemother 2008;54:101-6. http://dx.doi.org/10.1159/000118661 PMid:18303258
96. Cuzon G, Ouanich J, Gondret R, Naas T, Nordmann P., Outbreak of OXA-48-positive carbapenem-resistant Klebsiella pneumoniae isolates in France. Antimicrob Agents Chemother. 2011;55: 2420-2423. http://dx.doi.org/10.1128/AAC.01452-10 PMid:21343451 PMCid:PMC3088266
97. Potron A, Poirel L, Rondinaud E, Nordmann P., Intercontinental spread ofOXA-48 beta-lactamase-producing Enterobacteriaceae over a 11-year period, 2001 to 2011. Eurosurveillance, 2013; 18:31. http://dx.doi.org/10.2807/1560-7917.ES2013.18.31.20549
98. Benouda A, Touzani O, Khairallah MT, Araj GF, Matar GM., First detection of oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Morocco. Ann Trop Med Parasitol 2010;104:327- 330. http://dx.doi.org/10.1179/136485910X12743554760108 PMid:20659393
99. Voulgari E, Zarkotou O, Ranellou K et al., Outbreak of OXA-48 carbapenemase-producing Klebsiella pneumoniae in Greece involving an ST11 clone. J Antimicrob Chemother. 2013; 68:84-88. http://dx.doi.org/10.1093/jac/dks356 PMid:22945916
100. Adler A, Shklyar M, Schwaber MJ et al., Introduction of OXA-48-producing enterobacteriaceae to israeli hospitals by medical tourism. J Antimicrob Chemother. 2011; 66:2763-2766. http://dx.doi.org/10.1093/jac/dkr382 PMid:22191089
101. Matar GM, Dandache I, Carrer A et al., Spread of OXA-48-mediated resistance to carbapenems in Lebanese Klebsiella pneumoniae and Escherichia coli that produce extended spectrum ??-lactamase. Ann Tropic Med Parasitol 2010;104:271-274. http://dx.doi.org/10.1179/136485910X12647085215651 PMid:20507701
102. Matar GM, Cuzon G, Araj GF et al., "Oxacillinase mediated resistance to carbapenems in Klebsiella pneumoniae from Lebanon," Clin Microbiol Infect 2008;14:887-888. http://dx.doi.org/10.1111/j.1469-0691.2008.02059.x PMid:18844693
103. Pirs M, Andlovic A, Cerar T et al., A case of OXA-48 carbapenemase-producing Klebsiella pneumoniae in a patient transferred to Slovenia from Libya, November 2011. Euro Surveillance, 2011;16:50.
104. Oteo J, Hern'andez JM, Espasa M et al., Emergence of OXA-48-producing Klebsiella pneumoniae and the novel carbapenemases OXA-244 and OXA-245 in Spain. J Antimicrob Chemother,2013;68:317-321. http://dx.doi.org/10.1093/jac/dks383 PMid:23034714
105. Ktari S, Mnif B, Louati F et al., Spread of Klebsiella pneumoniae isolates producing OXA-48 ??-lactamase in a Tunisian university hospital. J Antimicrob Chemother 2011; 66: 1644-1646. http://dx.doi.org/10.1093/jac/dkr181 PMid:21565807
106. Hays C, Benouda A, Poirel L, Elouennass M, and Nordmann P., Nosocomial occurrence of OXA-48-producing enterobacterial isolates in a Moroccan hospital, Intern J Antimicrob Ag, 2012;39:545-547. http://dx.doi.org/10.1016/j.ijantimicag.2012.03.002 PMid:22521525
107. Barguigua A, ElOtmani E, Talmi M, Zerouali K, and Timinouni M. Emergence of carbapenem-resistant Enterobacteriaceae isolates in the Moroccan community. Diagn Microbiol Infect Dis, 2012;73: 290-291. http://dx.doi.org/10.1016/j.diagmicrobio.2012.03.011 PMid:22521054
108. Kraiem AG, Zorgani A, Elahmer O, Hammami A, Chaaben BM, Ghenghesh KS. New Delhi metallo-ß-lactamase and OXA-48 carbapenemases in Gram-negative bacilli isolates in Libya. Libyan J Med. 2015;10:29206. http://dx.doi.org/10.3402/ljm.v10.29206 PMid:26294290 PMCid:PMC4543448
109. Lafeuille E, Decré D, Mahjoub-Messai F, Bidet P, Arlet G, Bingen E. OXA-48 carbapenemase-producing Klebsiella pneumoniae isolated from Libyan patients. Microb Drug Resist. 2013 ;19:491-7. http://dx.doi.org/10.1089/mdr.2012.0219 PMid:23808959
110. Kocsis E, Savio C, Piccoli M, Cornaglia G, Mazzariol A. Klebsiella pneumoniae harbouring OXA-48 carbapenemase in a Libyan refugee in Italy. Clin Microbiol Infect. 2013;19:E409-11. Pirš M, Andlovic A, Cerar T, Žohar-Cretnik T, Kobola L, Kolman J, Frelih T,Prešern-Štrukelj M, Ružic-Sabljic E, Seme K. A case of OXA-48 carbapenemase-producing Klebsiella pneumoniae in a patient transferred to Slovenia from Libya, November 2011. Euro Surveill. 2011;16:20042
111. Pirš M, Andlovic A, Cerar T, Žohar-Cretnik T, Kobola L, Kolman J, Frelih T,Prešern-Štrukelj M, Ružic-Sabljic E, Seme K. A case of OXA-48 carbapenemase-producing Klebsiella pneumoniae in a patient transferred to Slovenia from Libya, November 2011. Euro Surveill. 2011;16:20042.
112. Hammerum AM, Larsen AR, Hansen F, Justesen US, Friis-Møller A, Lemming LE, Fuursted K, Littauer P, Schønning K, Gahrn-Hansen B, Ellermann-Eriksen S,Kristensen B. Patients transferred from Libya to Denmark carried OXA-48-producing Klebsiella pneumoniae, NDM-1-producing Acinetobacter baumannii and meticillin-resistant Staphylococcus aureus. Int J Antimicrob Agents. 2012 ;40:191-2. http://dx.doi.org/10.1016/j.ijantimicag.2012.05.003 PMid:22743013
113. Pirš M, Andlovic A, Cerar T, Žohar-Cretnik T, Kobola L, Kolman J, Frelih T,Prešern-Štrukelj M, Ružic-Sabljic E, Seme K. A case of OXA-48 carbapenemase-producing Klebsiella pneumoniae in a patient transferred to Slovenia from Libya, November 2011. Euro Surveill. 2011;16:20042