Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice

Aging

Volumn 8, Issue 5, 2016, Pages 1049-1063

  Crapser, Joshua ^a   Ritzel, Rodney ^a   Verma, Rajkumar ^a   Venna, Venugopal R ^a   Liu, Fudong ^a   Chauhan, Anjali ^a   Koellhoffer, Edward ^a   Patel, Anita ^b   Ricker, Austin ^c   Maas, Kendra ^c   Graf, Joerg ^c   McCullough, Louise D ^a,d  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Aging; Experimental stroke; Infection; Inflammation; Middle cerebral artery occlusion

Indexed keywords

ADAPTIVE IMMUNITY; AGING; ANIMAL; BACTERIAL TRANSLOCATION; BRAIN ISCHEMIA; C57BL MOUSE; CEREBROVASCULAR ACCIDENT; COMPLICATION; DISEASE MODEL; INNATE IMMUNITY; METABOLISM; MICROBIOLOGY; MOUSE; PERMEABILITY; PHYSIOLOGY; SEPSIS; STOMACH MUCOSA;

ADAPTIVE IMMUNITY; AGING; ANIMALS; BACTERIAL TRANSLOCATION; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; GASTRIC MUCOSA; IMMUNITY, INNATE; MICE; MICE, INBRED C57BL; PERMEABILITY; SEPSIS; STROKE;

EID: 84976439921     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100952     Document Type: Article

References (2)

1. McCullough L, Wu L, Haughey N, Liang X, Hand T, Wang Q, Breyer RM, Andreasson K. Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J Neurosci. 2004; 24:257-268.
2. Ritzel RM, Patel AR, Grenier JM, Crapser J, Verma R, Jellison ER, McCullough LD. Functional differences between microglia and monocytes after ischemic stroke. J Neuroinflammation. 2015; 12:106-015-0329-1.