Human platelets utilize cycloxygenase-1 to generate dioxolane A3, a neutrophil-activating eicosanoid

Journal of Biological Chemistry

Volumn 291, Issue 26, 2016, Pages 13448-13464

  Hinz, Christine ^a   Aldrovandi, Maceler ^a   Uhlson, Charis ^b   Marnett, Lawrence J ^c   Longhurst, Hilary J ^d   Warner, Timothy D ^d   Alam, Saydul ^a   Slatter, David A ^a   Lauder, Sarah N ^a   Allen Redpath, Keith ^a   Collins, Peter W ^a   Murphy, Robert C ^b   Thomas, Christopher P ^a   O'Donnell, Valerie B ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c VANDERBILT INGRAM CANCER CENTER   (United States)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL SIGNALING; CHEMICAL ACTIVATION; ENDOTHELIAL CELLS; ENZYMES; PATHOLOGY; PLANTS (BOTANY); REACTION INTERMEDIATES;

ACTIVATING PLATELETS; CHEMICAL OXIDATION; CHRONIC DISEASE; CYTOSOLIC PHOSPHOLIPASE; GENETIC STUDIES; HUMAN NEUTROPHIL; INTRACELLULAR CALCIUM; PROTEASE ACTIVATED RECEPTORS;

PLATELETS;

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CALCIUM; CD11B ANTIGEN; CYCLOOXYGENASE 1; CYTOSOLIC PHOSPHOLIPASE A2; DIOXOLANE A3; FORMYLMETHIONYLLEUCYLPHENYLALANINE; ICOSANOID; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 4; THROMBIN; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; FORMAL GLYCOL; MEMBRANE PROTEIN; PTGS1 PROTEIN, HUMAN; PTGS1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPIDOMICS; MOUSE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE; THROMBOCYTE ACTIVATION; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; IMMUNOLOGY; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; MALE; METABOLISM; NEUTROPHIL; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ASPIRIN; BLOOD PLATELETS; CYCLOOXYGENASE 1; DIOXOLANES; IMMUNITY, INNATE; MACROPHAGE-1 ANTIGEN; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; NEUTROPHIL ACTIVATION; NEUTROPHILS; PLATELET ACTIVATION;

EID: 84976426732     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.700609     Document Type: Article

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