Cardiac Amyloid Load A Prognostic and Predictive Biomarker in Patients with Light-Chain Amyloidosis

Journal of the American College of Cardiology

Volumn 68, Issue 1, 2016, Pages 13-24

  Kristen, Arnt V ^a   Brokbals, Eva ^a   Aus Dem Siepen, Fabian ^a   Bauer, Ralf ^a   Hein, Selina ^a   Aurich, Matthias ^a   Riffel, Johannes ^a   Behrens, Hans Michael ^b   Krüger, Sandra ^b   Schirmacher, Peter ^a   Katus, Hugo A ^a,c   Röcken, Christoph ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Amyloidosis; Endomyocardial biopsy; Immunohistochemistry; Light chain amyloid; Survival; Transthyretin

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; MINERALOCORTICOID ANTAGONIST; AMYLOID; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; COHORT ANALYSIS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HEART AMYLOIDOSIS; HUMAN; KARNOFSKY PERFORMANCE STATUS; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEW YORK HEART ASSOCIATION CLASS; OVERALL SURVIVAL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SYSTOLIC BLOOD PRESSURE; TREATMENT RESPONSE; AMYLOIDOSIS; CARDIAC MUSCLE; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; MIDDLE AGED; PATHOLOGY; PREDICTIVE VALUE; PROGNOSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AMYLOID; AMYLOIDOSIS; BIOMARKERS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RETROSPECTIVE STUDIES;

EID: 84976354847     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2016.04.035     Document Type: Article

References (41)

1. J.D. Sipe, M.D. Benson, J.N. Buxbaum, and et al. Nomenclature 2014: amyloid fibril proteins and clinical classification of the amyloidosis Amyloid 21 2014 221 224
2. G. Merlini, and V. Bellotti Molecular mechanisms of amyloidosis N Engl J Med 349 2003 583 596
3. A.V. Kristen, E. Giannitsis, S. Lehrke, and et al. Assessment of disease severity and outcome in patients with systemic light-chain amyloidosis by the high-sensitivity troponin T assay Blood 116 2010 2455 2461
4. V. Plante-Bordeneuve Update in the diagnosis and management of transthyretin familial amyloid polyneuropathy J Neurol 261 2014 1227 1233
5. Y. Ando, T. Coelho, J.L. Berk, and et al. Guideline of transthyretin-related hereditary amyloidosis for clinicians Orphanet J Rare Dis 8 2013 1 18
6. S. Dubrey, E. Ackermann, and J. Gillmore The transthyretin amyloidoses: advances in therapy Postgrad Med J 91 2015 439 448
7. C. Rapezzi, G. Merlini, C.C. Quarta, and et al. Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types Circulation 120 2009 1203 1212
8. A.V. Kristen, J.B. Perz, S.O. Schonland, and et al. Rapid progression of left ventricular wall thickness predicts mortality in cardiac light-chain amyloidosis J Heart Lung Transplant 26 2007 1313 1319
9. R. Mussinelli, F. Salinaro, A. Alogna, and et al. Diagnostic and prognostic value of low QRS voltages in cardiac AL amyloidosis Ann Noninvasive Electrocardiol 18 2013 271 280
10. S.J. Buss, M. Emami, D. Mereles, and et al. Longitudinal left ventricular function for prediction of survival in systemic light-chain amyloidosis: incremental value compared with clinical and biochemical markers J Am Coll Cardiol 60 2012 1067 1076
11. 1 mapping in transthyretin amyloidosis J Am Coll Cardiol Img 7 2014 157 165
12. E. Perugini, P.L. Guidalotti, F. Salvi, and et al. Noninvasive etiologic diagnosis of cardiac amyloidosis using 99mtc-3,3-diphosphono-1,2-propanodicarboxylic acid scintigraphy J Am Coll Cardiol 46 2005 1076 1084
13. A. Castaño, A. DeLuca, R. Weinberg, and et al. Serial scanning with technetium pyrophosphate (99mTc-PYP) in advanced ATTR cardiac amyloidosis J Nucl Cardiol 2015 Oct 9 [E-pub ahead of print]
14. A. Dispenzieri, R.A. Kyle, M.A. Gertz, and et al. Survival in patients with primary systemic amyloidosis and raised serum cardiac troponins Lancet 361 2003 1787 1789
15. G. Palladini Serum N-terminal pro-brain natriuretic peptide is a sensitive marker of myocardial dysfunction in AL amyloidosis Circulation 107 2003 2440 2445
16. J.E. Rahman, E.F. Helou, R. Gelzer-Bell, and et al. Noninvasive diagnosis of biopsy-proven cardiac amyloidosis J Am Coll Cardiol 43 2004 410 415
17. M.A. Gertz, R. Comenzo, R.H. Falk, and et al. Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis Am J Hematol 79 2005 319 328
18. G. Palladini, A. Dispenzieri, M.A. Gertz, and et al. New criteria for response to treatment in immunoglobulin light chain amyloidosis based on free light chain measurement and cardiac biomarkers: impact on survival outcomes J Clin Oncol 30 2012 4541 4549
19. G. de Simone, R.B. Devereux, A. Ganau, and et al. Estimation of left ventricular chamber Am J Cardiol 78 1996 801 807
20. D.L. King, L. El-Khoury Coffin, and M.S. Maurer Myocardial contraction fraction: a volumetric index of myocardial shorteningby freehand three-dimensional echocardiography J Am Coll Cardiol 40 2002 325 329
21. Z. Gioeva, P. Urban, R. Rüdiger Meliss, and et al. ATTR amyloid in the carpal tunnel ligament is frequently of wildtype transthyretin origin Amyloid 20 2013 1 6
22. S.O. Schonland, U. Hegenbart, T. Bochtler, and et al. Immunohistochemistry in the classification of systemic forms of amyloidosis: a systematic investigation of 117 patients Blood 119 2012 488 493
23. A. Kebbel, and C. Röcken Immunohistochemical classification of amyloid in surgical pathology revisited Am J Surg Pathol 30 2006 673 683
24. Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J Royal Stat Soc 57 1995 289 300
25. B.T. Larsen, O.M. Mereuta, S. Dasari, and et al. Correlation of histomorphological pattern of cardiac amyloid deposition with amyloid type: a histological and proteomic analysis of 108 cases Histopathology 68 2016 648 656
26. D. Mohty, T. Damy, P. Cosnay, and et al. Cardiac amyloidosis: updates in diagnosis and management Arch Cardiovasc Dis 106 2013 528 540
27. R. Liao, M. Jain, P. Teller, and et al. Infusion of light chains from patients with cardiac amyloidosis causes diastolic dysfunction in isolated mouse hearts Circulation 104 2001 1594 1597
28. A.V. Kristen, F.A.D. Siepen, K. Scherer, and et al. Comparison of different types of cardiac amyloidosis by cardiac magnetic resonance imaging Amyloid 22 2015 132 141
29. A.W.J.M. Glaudemans, R.W.J. van Rheenen, M.P. van den Berg, and et al. Bone scintigraphy with 99mtechnetium-hydroxymethylene diphosphonate allows early diagnosis of cardiac involvement in patients with transthyretin-derived systemic amyloidosis Amyloid 21 2014 35 44
30. A.V. Kristen, T.J. Dengler, and H.A. Katus Suspected cardiac amyloidosis: endomyocardial biopsy remains the diagnostic gold-standard Am J Hematol 82 2007 328
31. H.J. Lachmann, B. Chir, D.R. Booth, and et al. Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis N Engl J Med 346 2002 1786 1791
32. C. Chimenti, and A. Frustaci Contribution and risks of left ventricular endomyocardial biopsy in patients with cardiomyopathies: a retrospective study over a 28-year period Circulation 128 2013 1531 1541
33. C. Röcken, B. Peters, G. Juenemann, and et al. Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation Circulation 106 2002 2091 2097
34. O. Leone, S. Longhi, C.C. Quarta, and et al. New pathological insights into cardiac amyloidosis: implications for non-invasive diagnosis Amyloid 19 2012 99 105
35. F.L. Ruberg, E. Appelbaum, R. Davidoff, and et al. Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in light-chain cardiac amyloidosis Am J Cardiol 103 2009 544 549
36. A.M. Maceira, S.K. Prasad, P.N. Hawkins, M. Roughton, and D.J. Pennell Cardiovascular magnetic resonance and prognosis in cardiac amyloidosis J Cardiovasc Magn Reson 10 2008 1 11
37. W. Hosch, A.V. Kristen, M. Libicher, and et al. Late enhancement in cardiac amyloidosis: correlation of MRI enhancement pattern with histopathological findings Amyloid 15 2008 196 204
38. C. Rapezzi, C.C. Quarta, L. Obici, and et al. Disease profile and differential diagnosis of hereditary transthyretin-related amyloidosis with exclusively cardiac phenotype: an Italian perspective Eur Heart J 34 2013 520 528
39. R.C. Givens, C. Russo, P. Green, and M.S. Maurer Comparison of cardiac amyloidosis due to wild-type and V122I transthyretin in older adults referred to an academic medical center Aging Health 9 2013 229 235
40. F.L. Ruberg, M.S. Maurer, D.P. Judge, and et al. Prospective evaluation of the morbidity and mortality of wild-type and V122I mutant transthyretin amyloid cardiomyopathy: the Transthyretin Amyloidosis Cardiac Study (TRACS) Am Heart J 164 2012 222 228
41. A.V. Kristen, F.U. Sack, S.O. Schonland, and et al. Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosis Eur J Heart Fail 11 2009 1014 1020