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Volumn 102, Issue , 2016, Pages 187-197

Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy

Author keywords

Dendritic cells; Gemcitabine; Immunogenic cell death; Nanocarriers; Oxaliplatin; Pancreatic cancer

Indexed keywords

CELL DEATH; CYTOLOGY; DISEASES; ENZYME INHIBITION; IMMUNE SYSTEM; LYMPHOCYTES; MAMMALS; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; T-CELLS; TUMORS;

EID: 84975822161     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2016.06.032     Document Type: Article
Times cited : (220)

References (54)
  • 1
    • 84887610699 scopus 로고    scopus 로고
    • Nanooncology: the future of cancer diagnosis and therapy
    • [1] Thakor, A.S., Gambhir, S.S., Nanooncology: the future of cancer diagnosis and therapy. CA Cancer J. Clin. 63 (2013), 395–418.
    • (2013) CA Cancer J. Clin. , vol.63 , pp. 395-418
    • Thakor, A.S.1    Gambhir, S.S.2
  • 3
    • 85028172309 scopus 로고    scopus 로고
    • Multiple layer-by-layer lipid-polymer hybrid nanoparticles for improved FOLFIRINOX chemotherapy in pancreatic tumor models
    • [3] Li, F., Zhao, X., Wang, H., Zhao, R.F., Ji, T.J., Ren, H., et al. Multiple layer-by-layer lipid-polymer hybrid nanoparticles for improved FOLFIRINOX chemotherapy in pancreatic tumor models. Adv. Funct. Mater. 25 (2015), 788–798.
    • (2015) Adv. Funct. Mater. , vol.25 , pp. 788-798
    • Li, F.1    Zhao, X.2    Wang, H.3    Zhao, R.F.4    Ji, T.J.5    Ren, H.6
  • 4
    • 80052386569 scopus 로고    scopus 로고
    • Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles
    • [4] Wang, H., Zhao, Y., Wu, Y., Hu, Y.L., Nan, K., Nie, G., et al. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials 32 (2011), 8281–8290.
    • (2011) Biomaterials , vol.32 , pp. 8281-8290
    • Wang, H.1    Zhao, Y.2    Wu, Y.3    Hu, Y.L.4    Nan, K.5    Nie, G.6
  • 5
    • 84922827238 scopus 로고    scopus 로고
    • Co-delivery of HIF1alpha siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer
    • [5] Zhao, X., Li, F., Li, Y., Wang, H., Ren, H., Chen, J., et al. Co-delivery of HIF1alpha siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer. Biomaterials 46 (2015), 13–25.
    • (2015) Biomaterials , vol.46 , pp. 13-25
    • Zhao, X.1    Li, F.2    Li, Y.3    Wang, H.4    Ren, H.5    Chen, J.6
  • 6
    • 84875191130 scopus 로고    scopus 로고
    • Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy
    • [6] Wang, H., Wu, Y., Zhao, R., Nie, G., Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy. Adv. Mater. 25 (2013), 1616–1622.
    • (2013) Adv. Mater. , vol.25 , pp. 1616-1622
    • Wang, H.1    Wu, Y.2    Zhao, R.3    Nie, G.4
  • 7
    • 84892184138 scopus 로고    scopus 로고
    • Cationic polymer nanoparticles and nanogels: from synthesis to biotechnological applications
    • [7] Ramos, J., Forcada, J., Hidalgo-Alvarez, R., Cationic polymer nanoparticles and nanogels: from synthesis to biotechnological applications. Chem. Rev. 114 (2014), 367–428.
    • (2014) Chem. Rev. , vol.114 , pp. 367-428
    • Ramos, J.1    Forcada, J.2    Hidalgo-Alvarez, R.3
  • 8
    • 84858673601 scopus 로고    scopus 로고
    • Design of polymeric nanoparticles for biomedical delivery applications
    • [8] Elsabahy, M., Wooley, K.L., Design of polymeric nanoparticles for biomedical delivery applications. Chem. Soc. Rev. 41 (2012), 2545–2561.
    • (2012) Chem. Soc. Rev. , vol.41 , pp. 2545-2561
    • Elsabahy, M.1    Wooley, K.L.2
  • 9
    • 80054760652 scopus 로고    scopus 로고
    • Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine
    • [9] Al-Jamal, W.T., Kostarelos, K., Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. Acc. Chem. Res. 44 (2011), 1094–1104.
    • (2011) Acc. Chem. Res. , vol.44 , pp. 1094-1104
    • Al-Jamal, W.T.1    Kostarelos, K.2
  • 10
    • 84873252557 scopus 로고    scopus 로고
    • Liposomal drug delivery systems: from concept to clinical applications
    • [10] Allen, T.M., Cullis, P.R., Liposomal drug delivery systems: from concept to clinical applications. Adv. Drug Deliv. Rev. 65 (2013), 36–48.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 36-48
    • Allen, T.M.1    Cullis, P.R.2
  • 11
    • 84864141021 scopus 로고    scopus 로고
    • Materials for drug delivery: innovative solutions to address complex biological hurdles
    • [11] Mitragotri, S., Lahann, J., Materials for drug delivery: innovative solutions to address complex biological hurdles. Adv. Mater. 24 (2012), 3717–3723.
    • (2012) Adv. Mater. , vol.24 , pp. 3717-3723
    • Mitragotri, S.1    Lahann, J.2
  • 12
    • 79955007145 scopus 로고    scopus 로고
    • The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers
    • [12] Ashley, C.E., Carnes, E.C., Phillips, G.K., Padilla, D., Durfee, P.N., Brown, P.A., et al. The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers. Nat. Mater. 10 (2011), 389–397.
    • (2011) Nat. Mater. , vol.10 , pp. 389-397
    • Ashley, C.E.1    Carnes, E.C.2    Phillips, G.K.3    Padilla, D.4    Durfee, P.N.5    Brown, P.A.6
  • 13
    • 70350292588 scopus 로고    scopus 로고
    • Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer
    • [13] Malam, Y., Loizidou, M., Seifalian, A.M., Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol. Sci. 30 (2009), 592–599.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 592-599
    • Malam, Y.1    Loizidou, M.2    Seifalian, A.M.3
  • 15
    • 39749182234 scopus 로고    scopus 로고
    • Apoptosis: controlled demolition at the cellular level
    • [15] Taylor, R.C., Cullen, S.P., Martin, S.J., Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 9 (2008), 231–241.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 231-241
    • Taylor, R.C.1    Cullen, S.P.2    Martin, S.J.3
  • 20
    • 84913586780 scopus 로고    scopus 로고
    • Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
    • [20] Sistigu, A., Yamazaki, T., Vacchelli, E., Chaba, K., Enot, D.P., Adam, J., et al. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat. Med. 20 (2014), 1301–1309.
    • (2014) Nat. Med. , vol.20 , pp. 1301-1309
    • Sistigu, A.1    Yamazaki, T.2    Vacchelli, E.3    Chaba, K.4    Enot, D.P.5    Adam, J.6
  • 22
    • 79952390627 scopus 로고    scopus 로고
    • Immune parameters affecting the efficacy of chemotherapeutic regimens
    • [22] Zitvogel, L., Kepp, O., Kroemer, G., Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat. Rev. Clin. Oncol. 8 (2011), 151–160.
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 151-160
    • Zitvogel, L.1    Kepp, O.2    Kroemer, G.3
  • 24
    • 73949092850 scopus 로고    scopus 로고
    • Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
    • [24] Denkert, C., Loibl, S., Noske, A., Roller, M., Muller, B.M., Komor, M., et al. Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J. Clin. Oncol. 28 (2010), 105–113.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 105-113
    • Denkert, C.1    Loibl, S.2    Noske, A.3    Roller, M.4    Muller, B.M.5    Komor, M.6
  • 25
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • [25] DeNardo, D.G., Brennan, D.J., Rexhepaj, E., Ruffell, B., Shiao, S.L., Madden, S.F., et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 1 (2011), 54–67.
    • (2011) Cancer Discov. , vol.1 , pp. 54-67
    • DeNardo, D.G.1    Brennan, D.J.2    Rexhepaj, E.3    Ruffell, B.4    Shiao, S.L.5    Madden, S.F.6
  • 26
    • 80052227854 scopus 로고    scopus 로고
    • Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy
    • [26] Halama, N., Michel, S., Kloor, M., Zoernig, I., Benner, A., Spille, A., et al. Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy. Cancer Res. 71 (2011), 5670–5677.
    • (2011) Cancer Res. , vol.71 , pp. 5670-5677
    • Halama, N.1    Michel, S.2    Kloor, M.3    Zoernig, I.4    Benner, A.5    Spille, A.6
  • 27
    • 82955217260 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer
    • [27] West, N.R., Milne, K., Truong, P.T., Macpherson, N., Nelson, B.H., Watson, P.H., Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer. Breast Cancer Res., 13, 2011, R126.
    • (2011) Breast Cancer Res. , vol.13 , pp. R126
    • West, N.R.1    Milne, K.2    Truong, P.T.3    Macpherson, N.4    Nelson, B.H.5    Watson, P.H.6
  • 28
    • 34948820602 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
    • [28] Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat. Med. 13 (2007), 1050–1059.
    • (2007) Nat. Med. , vol.13 , pp. 1050-1059
    • Apetoh, L.1    Ghiringhelli, F.2    Tesniere, A.3    Obeid, M.4    Ortiz, C.5    Criollo, A.6
  • 29
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    • [29] Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat. Med. 15 (2009), 1170–1178.
    • (2009) Nat. Med. , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1    Apetoh, L.2    Tesniere, A.3    Aymeric, L.4    Ma, Y.5    Ortiz, C.6
  • 30
    • 1942422743 scopus 로고    scopus 로고
    • Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development
    • [30] Kelland, L.R., Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur. J. Cancer 40 (2004), 827–836.
    • (2004) Eur. J. Cancer , vol.40 , pp. 827-836
    • Kelland, L.R.1
  • 33
    • 84947763610 scopus 로고    scopus 로고
    • Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
    • [33] Vacchelli, E., Ma, Y., Baracco, E.E., Sistigu, A., Enot, D.P., Pietrocola, F., et al. Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science 350 (2015), 972–978.
    • (2015) Science , vol.350 , pp. 972-978
    • Vacchelli, E.1    Ma, Y.2    Baracco, E.E.3    Sistigu, A.4    Enot, D.P.5    Pietrocola, F.6
  • 35
    • 79551523389 scopus 로고    scopus 로고
    • Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis
    • [35] Schiavoni, G., Sistigu, A., Valentini, M., Mattei, F., Sestili, P., Spadaro, F., et al. Cyclophosphamide synergizes with type I interferons through systemic dendritic cell reactivation and induction of immunogenic tumor apoptosis. Cancer Res. 71 (2011), 768–778.
    • (2011) Cancer Res. , vol.71 , pp. 768-778
    • Schiavoni, G.1    Sistigu, A.2    Valentini, M.3    Mattei, F.4    Sestili, P.5    Spadaro, F.6
  • 36
    • 84890283544 scopus 로고    scopus 로고
    • The Janus face of cyclophosphamide: a sterile inflammatory response that potentiates cancer immunotherapy
    • [36] Ziccheddu, G., Proietti, E., Moschella, F., The Janus face of cyclophosphamide: a sterile inflammatory response that potentiates cancer immunotherapy. Oncoimmunology, 2, 2013, e25789.
    • (2013) Oncoimmunology , vol.2 , pp. e25789
    • Ziccheddu, G.1    Proietti, E.2    Moschella, F.3
  • 37
    • 34249650184 scopus 로고    scopus 로고
    • Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications
    • [37] Spisek, R., Charalambous, A., Mazumder, A., Vesole, D.H., Jagannath, S., Dhodapkar, M.V., Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood 109 (2007), 4839–4845.
    • (2007) Blood , vol.109 , pp. 4839-4845
    • Spisek, R.1    Charalambous, A.2    Mazumder, A.3    Vesole, D.H.4    Jagannath, S.5    Dhodapkar, M.V.6
  • 38
    • 84923061042 scopus 로고    scopus 로고
    • Inhibition of HIF-1alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
    • [38] Zhao, T., Ren, H., Jia, L., Chen, J., Xin, W., Yan, F., et al. Inhibition of HIF-1alpha by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget 6 (2015), 2250–2262.
    • (2015) Oncotarget , vol.6 , pp. 2250-2262
    • Zhao, T.1    Ren, H.2    Jia, L.3    Chen, J.4    Xin, W.5    Yan, F.6
  • 39
    • 4644359855 scopus 로고    scopus 로고
    • Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study
    • [39] Andre, T., Tournigand, C., Rosmorduc, O., Provent, S., Maindrault-Goebel, F., Avenin, D., et al. Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. Ann. Oncol. 15 (2004), 1339–1343.
    • (2004) Ann. Oncol. , vol.15 , pp. 1339-1343
    • Andre, T.1    Tournigand, C.2    Rosmorduc, O.3    Provent, S.4    Maindrault-Goebel, F.5    Avenin, D.6
  • 41
    • 69049106405 scopus 로고    scopus 로고
    • In vivo activity of gemcitabine-loaded PEGylated small unilamellar liposomes against pancreatic cancer
    • [41] Cosco, D., Bulotta, A., Ventura, M., Celia, C., Calimeri, T., Perri, G., et al. In vivo activity of gemcitabine-loaded PEGylated small unilamellar liposomes against pancreatic cancer. Cancer Chemother. Pharmacol. 64 (2009), 1009–1020.
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , pp. 1009-1020
    • Cosco, D.1    Bulotta, A.2    Ventura, M.3    Celia, C.4    Calimeri, T.5    Perri, G.6
  • 42
    • 82255175232 scopus 로고    scopus 로고
    • Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer
    • [42] Rejiba, S., Reddy, L.H., Bigand, C., Parmentier, C., Couvreur, P., Hajri, A., Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer. Nanomedicine 7 (2011), 841–849.
    • (2011) Nanomedicine , vol.7 , pp. 841-849
    • Rejiba, S.1    Reddy, L.H.2    Bigand, C.3    Parmentier, C.4    Couvreur, P.5    Hajri, A.6
  • 44
    • 84857997683 scopus 로고    scopus 로고
    • A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death
    • [44] Garg, A.D., Krysko, D.V., Verfaillie, T., Kaczmarek, A., Ferreira, G.B., Marysael, T., et al. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J. 31 (2012), 1062–1079.
    • (2012) EMBO J. , vol.31 , pp. 1062-1079
    • Garg, A.D.1    Krysko, D.V.2    Verfaillie, T.3    Kaczmarek, A.4    Ferreira, G.B.5    Marysael, T.6
  • 45
    • 46749136790 scopus 로고    scopus 로고
    • Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein
    • [45] Kazama, H., Ricci, J.E., Herndon, J.M., Hoppe, G., Green, D.R., Ferguson, T.A., Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 29 (2008), 21–32.
    • (2008) Immunity , vol.29 , pp. 21-32
    • Kazama, H.1    Ricci, J.E.2    Herndon, J.M.3    Hoppe, G.4    Green, D.R.5    Ferguson, T.A.6
  • 46
    • 68249137289 scopus 로고    scopus 로고
    • Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases
    • [46] Luthi, A.U., Cullen, S.P., McNeela, E.A., Duriez, P.J., Afonina, I.S., Sheridan, C., et al. Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity 31 (2009), 84–98.
    • (2009) Immunity , vol.31 , pp. 84-98
    • Luthi, A.U.1    Cullen, S.P.2    McNeela, E.A.3    Duriez, P.J.4    Afonina, I.S.5    Sheridan, C.6
  • 47
    • 70849115361 scopus 로고    scopus 로고
    • Regular dose of gemcitabine induces an increase in CD14+ monocytes and CD11c+ dendritic cells in patients with advanced pancreatic cancer
    • [47] Soeda, A., Morita-Hoshi, Y., Makiyama, H., Morizane, C., Ueno, H., Ikeda, M., et al. Regular dose of gemcitabine induces an increase in CD14+ monocytes and CD11c+ dendritic cells in patients with advanced pancreatic cancer. Jpn. J. Clin. Oncol. 39 (2009), 797–808.
    • (2009) Jpn. J. Clin. Oncol. , vol.39 , pp. 797-808
    • Soeda, A.1    Morita-Hoshi, Y.2    Makiyama, H.3    Morizane, C.4    Ueno, H.5    Ikeda, M.6
  • 49
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • [49] Brahmer, J.R., Tykodi, S.S., Chow, L.Q., Hwu, W.J., Topalian, S.L., Hwu, P., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 366 (2012), 2455–2465.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 51
    • 77958050577 scopus 로고    scopus 로고
    • Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma
    • [51] Royal, R.E., Levy, C., Turner, K., Mathur, A., Hughes, M., Kammula, U.S., et al. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma. J. Immunother. 33 (2010), 828–833.
    • (2010) J. Immunother. , vol.33 , pp. 828-833
    • Royal, R.E.1    Levy, C.2    Turner, K.3    Mathur, A.4    Hughes, M.5    Kammula, U.S.6
  • 52
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • [52] Taube, J.M., Klein, A., Brahmer, J.R., Xu, H., Pan, X., Kim, J.H., et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin. Cancer Res. 20 (2014), 5064–5074.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3    Xu, H.4    Pan, X.5    Kim, J.H.6
  • 53
    • 84876807399 scopus 로고    scopus 로고
    • Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma
    • [53] Zheng, L., Xue, J., Jaffee, E.M., Habtezion, A., Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma. Gastroenterology 144 (2013), 1230–1240.
    • (2013) Gastroenterology , vol.144 , pp. 1230-1240
    • Zheng, L.1    Xue, J.2    Jaffee, E.M.3    Habtezion, A.4
  • 54
    • 84883207410 scopus 로고    scopus 로고
    • Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
    • [54] Le, D.T., Lutz, E., Uram, J.N., Sugar, E.A., Onners, B., Solt, S., et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J. Immunother. 36 (2013), 382–389.
    • (2013) J. Immunother. , vol.36 , pp. 382-389
    • Le, D.T.1    Lutz, E.2    Uram, J.N.3    Sugar, E.A.4    Onners, B.5    Solt, S.6


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