How treatment affects the brain: meta-analysis evidence of neural substrates underpinning drug therapy and psychotherapy in major depression

Brain Imaging and Behavior

Volumn 10, Issue 2, 2016, Pages 619-627

  Boccia, Maddalena ^a,b   Piccardi, Laura ^b,c   Guariglia, Paola ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d KORE UNIVERSITY OF ENNA   (Italy)

Author keywords

ALE meta analysis; Cognitive behavioral therapy; Drug therapy; Insula; Major depression; Treatment effect

Indexed keywords

ANTIDEPRESSANT AGENT; CITALOPRAM; FLUOXETINE; NORTRIPTYLINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; VENLAFAXINE;

ANTERIOR CINGULATE; BASAL GANGLION; BEHAVIORAL ACTIVATION THERAPY; BRAIN REGION; CINGULATE GYRUS; COGNITIVE BEHAVIORAL THERAPY; FRONTAL GYRUS; HUMAN; INTERPERSONAL THERAPY; LEFT HEMISPHERE; LINGUAL GYRUS; MAJOR DEPRESSION; META ANALYSIS; MIDDLE FRONTAL GYRUS; MIDDLE TEMPORAL GYRUS; NEUROIMAGING; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PSYCHODYNAMIC PSYCHOTHERAPY; PSYCHOTHERAPY; REVIEW; ANATOMY AND HISTOLOGY; BRAIN; BRAIN CORTEX; DEPRESSIVE DISORDER, MAJOR; FRONTAL LOBE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; STATISTICAL MODEL; TREATMENT OUTCOME;

BRAIN; CEREBRAL CORTEX; DEPRESSIVE DISORDER, MAJOR; FRONTAL LOBE; GYRUS CINGULI; HUMANS; LIKELIHOOD FUNCTIONS; MAGNETIC RESONANCE IMAGING; PSYCHOTHERAPY; TREATMENT OUTCOME;

EID: 84975789724     PISSN: 19317557     EISSN: 19317565     Source Type: Journal    
DOI: 10.1007/s11682-015-9429-x     Document Type: Review

References (58)

1. Barsaglini, A., Sartori, G., Benetti, S., Pettersson-Yeo, W., & Mechelli, A. (2014). The effects of psychotherapy on brain function: a systematic and critical review. Progress in Neurobiology, 114, 1–14.
2. Baxter, L. R., Schwartz, J. M., Bergman, K. S., Szuba, M. P., Guze, B. H., Mazziotta, J. C., Alazraki, A., Selin, C. E., Ferng, H. K., Munford, P., & Phelps, M. E. (1992). Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive- compulsive disorder. Archives of General Psychiatry, 49, 681–689.
3. Bremner, J. D., Vythilingam, M., Vermetten, E., & Charney, D. S. (2007). Effects of antidepressant treatment on neutral correlates of emotional and neutral declarative verbal memory in depression. Journal of Affective Disorders, 101, 99–111.
4. Brockmann, H., Zobel, A., Joe, A., Biermann, K., Scheef, L., Schuhmacher, A., von Widdern, O., Metten, M., Biersack, H. J., Maier, W., & Boecker, H. (2009). The value of HMPAO SPECT in predicting treatment response to citalopram in patients with major depression. Psychiatry Research, 173(2), 107–112.
5. Brody, A. L., Saxena, S., Silverman, D. H., Alborzian, S., Fairbanks, L. A., Phelps, M. E., Huang, S. C., Wu, H. M., Maidment, K., & Baxter, L. R. (1999). Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine. Psychiatry Research, 91, 127–139.
6. Brody, A. L., Saxena, S., Stoessel, P., Gillies, L. A., Fairbanks, L. A., Alborzian, S., Phelps, M. E., Huang, S. C., Wu, H. M., Ho, M. L., Ho, M. K., Au, S. C., Maidment, K., & Baxter, L. R., Jr. (2001). Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Archives of General Psychiatry, 58(7), 631–640.
7. Buchheim, A., Viviani, R., Kessler, H., Kachele, H., Cierpka, M., Roth, G., George, C., Kernberg, O. F., Bruns, G., & Taubner, S. (2012). Changes in prefrontal-limbic function in major depression after 15 months of long- term psychotherapy. PLoS ONE, 7(3), e33745. doi:10.1371/journal.pone.0033745.
8. Cavanna, A. E., & Trimble, M. R. (2006). The precuneus: a review of its functional anatomy and behavioural correlates. Brain, 129(3), 564–583.
9. Chen, C. H., Ridler, K., Suckling, J., Williams, S., Fu, C. H. Y., Merlo-Pich, E., & Bullmore, E. (2007). Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment. Biological Psychiatry, 62, 407–414.
10. Clark, D. A., & Beck, A. T. (2010). Cognitive theory and therapy of anxiety and depression: convergence with neurobiological findings. Trends in Cognitive Sciences, 14(9), 418–424. doi:10.1016/j.tics.2010.06.007.
11. Costafreda, S. G., Khanna, A., Mourao-Miranda, J., & Fu, C. H. Y. (2009). Neural correlates of sad faces predict clinical remission to cognitive behavioural therapy in depression. Neuroreport, 20, 637–641.
12. Critchley, H. D., Wiens, S., Rotshtein, P., Ohman, A., & Dolan, R. J. (2004). Neural systems supporting interoceptive awareness. Nature Neuroscience, 7, 189–195.
13. Cuijpers, P., Berking, M., Andersson, G., Quigley, L., Kleiboer, A., & Dobson, K. S. (2013a). A meta-analysis of cognitive behavior therapy for adult depression, alone and in comparison to other treatments. Canadian Journal of Psychiatry, 58(7), 376–385.
14. Cuijpers, P., Hollon, S. D., van Straten, A., Bockting, C., Berking, M., & Andersson, G. (2013b). Does cognitive behaviour therapy have an enduring effect that is superior to keeping patients on continuation pharmacotherapy? A meta-analysis. BMJ Open, 26, 3(4). doi:10.1136/bmjopen-2012-002542.
15. Davidson, R. J., Irwin, W., Anderle, M. J., & Kalin, N. H. (2003). The neural substrates of affective processing in depressed patients treated with venlafaxine. American Journal of Psychiatry, 160, 64–75.
16. de Zubicaray, G. I., McMahon, K., Wilson, S. J., & Muthiah, S. (2001). Brain activity during the encoding, retention, and retrieval of stimulus representations. Learning and Memory, 8(5), 243–251.
17. Dichter, G. S., Felder, J. N., & Smoski, M. J. (2009). Affective context interferes with cognitive control in unipolar depression: an fMRI investigation. Journal of Affective Disorders, 114, 131–142.
18. Dichter, G. S., Felder, J. N., & Smoski, M. J. (2010). The effects of brief behavioral activation therapy for depression on cognitive control in affective contexts: an fMRI investigation. Journal of Affective Disorders, 126(1–2), 236–244.
19. Dougherty, D. D., & Rauch, S. L. (1997). Neuroimaging and clinical models of depression. Harvard Review of Psychiatry, 5, 138–159.
20. Eickhoff, S. B., Laird, A. R., Grefkes, C., Wang, L. E., Zilles, K., & Fox, P. T. (2009). Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Human Brain Mapping, 30(9), 2907–2926.
21. Fava, G. A., Rafanelli, C., Grandi, S., Canestrari, R., & Morphy, M. A. (1998). Six-year outcome for cognitive behavioral treatment of residual symptoms in major depression. The American Journal of Psychiatry, 155(10), 1443–1445.
22. Freud, S. (1895). Project for a scientific psychology. in Vintage, THP, 1950.
23. Fu, C. H. Y., Williams, S. C. R., Cleare, A. J., Brammer, M. J., Walsh, N. D., Kim, J., Andrew, C. M., Pich, E. M., Williams, P. M., & Reed, L. J. (2004). Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study. Archives of General Psychiatry, 61, 877–889.
24. Fu, C. H. Y., Williams, S., Cleare, A. J., Scott, J., Mitterschiffthaler, M. T., Walsh, N. D., Donaldson, C., Suckling, J., Andrew, C., Steiner, H., & Murray, R. M. (2008). Neural responses to sad facial expressions in major depression following cognitive behavioral therapy. Biological Psychiatry, 64, 505–512.
25. Fu, C. H. Y., Steiner, H., & Costafreda, S. G. (2013). Predictive neural biomarkers of clinical response in depression: a meta-analysis of functional and structural neuroimaging studies of pharmacological and psychological therapies. Neurobiology of Disease, 52, 75–83.
26. Gelenberg, A. J. (2010). Depression symptomatology and neurobiology. The Journal of Clinical Psychiatry, 71, e02.
27. Goldapple, K., Segal, Z. V., Garson, C., Lau, M., Bieling, P., Kennedy, S. H., & Mayberg, H. S. (2004). Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy. Archives of General Psychiatry, 61, 34–41.
28. Grossi, D., Di Vita, A., Palermo, L., Sabatini, U., Trojano, L., & Guariglia, C. (2014). The brain network for self-feeling: a symptom-lesion mapping study. Neuropsychologia, 63, 92–98. doi:10.1016/j.neuropsychologia.2014.08.004.
29. Gusnard, D. A., Raichle, M. E., & Raichle, M. E. (2001). Searching for a baseline: functional imaging and the resting human brain. Nature Reviews Neuroscience, 2(10), 685–694.
30. Haldane, M., Jogia, J., Cobb, A., Kozuch, E., Kumari, V., & Frangou, S. (2008). Changes in brain activation during working memory and facial recognition tasks in patients with bipolar disorder with Lamotrigine monotherapy. European Neuropsychopharmacology, 18, 48–54.
31. Jogia, J., Haldane, M., Cobb, A., Kumari, V., & Frangou, S. (2008). Pilot investigation of the changes in cortical activation during facial affect recognition with lamotrigine monotherapy in bipolar disorder. British Journal of Psychiatry, 192, 197–201.
32. Kalani, M. Y., Kalani, M. A., Gwinn, R., Keogh, B., & Tse, V. C. (2009). Embryological development of the human insula and its implications for the spread and resection of insular gliomas. Neurosurgical Focus, 27, E2.
33. Kalin, N. H., Davidson, R. J., Irwin, W., Warner, G., Orendi, J. L., Sutton, S. K., Mock, B. J., Sorenson, J. A., Lowe, M., & Turski, P. A. (1997). Functional magnetic resonance imaging studies of emotional processing in normal and depressed patients: effects of venlafaxine. Journal of Clinical Psychiatry, 58, 32–39.
34. Kandel, E. R. (1998). A new intellectual framework for psychiatry. The American Journal of Psychiatry, 155(4), 457–469.
35. Kelley, W. M., Macrae, C. N., Wyland, C. L., Caglar, S., Inati, S., & Heatherton, T. F. (2002). Finding the self? An event-related fMRI study. Journal of Cognitive Neuroscience, 14(5), 785–794.
36. Kennedy, S. H., Evans, K. R., Kruger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001). Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. American Journal of Psychiatry, 158, 899–905.
37. Kong, L., Wu, F., Tang, Y., Ren, L., & Kong, D. (2014). Frontal-subcortical volumetric deficits in single episode, medication-naive depressed patients and the effects of 8 weeks fluoxetine treatment: a VBM-DARTEL study. PLoS ONE, 9(1), e79055.
38. Linden, D. E. (2006). How psychotherapy changes the brain-the contribution of functional neuroimaging. Molecular Psychiatry, 11(6), 528–538.
39. Mayberg, H. S. (1997). Limbic-cortical dysregulation: a proposed model of depression. Journal of Neuropsychiatry and Clinical Neurosciences, 9, 471–481.
40. Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000). Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biological Psychiatry, 48, 830–843.
41. McGuire, P. K., Bench, C. J., Frith, C. D., Marks, I. M., Frackowiak, R. S. J., & Dolan, R. J. (1994). Functional anatomy of obsessive- compulsive phenomena. British Journal of Psychiatry, 164, 459–468.
42. Nagai, M., Kishi, K., & Kato, S. (2007). Insular cortex and neuropsychiatric disorders: a review of recent literature. European Psychiatry: The Journal of the Association of European Psychiatrists, 22(6), 387–394.
43. Pampallona, S., Bollini, P., Tibaldi, G., Kupelnick, B., & Munizza, C. (2004). Combined pharmacotherapy and psychological treatment for depression: a systematic review. Archives of General Psychiatry, 61(7), 714–719.
44. Paykel, E. S., Scott, J., Teasdale, J. D., Johnson, A. L., Garland, A., Moore, R., Jenaway, A., Cornwall, P. L., Hayhurst, H., & Abbott, R. (1999). Prevention of relapse in residual depression by cognitive therapy: a controlled trial. Archives of General Psychiatry, 56(9), 829–835.
45. Petersen, T. J. (2006). Enhancing the efficacy of antidepressants with psychotherapy. Journal of Psychopharmacology, 20(3), 19–28.
46. Pizzagalli, D., Pascual-Marqui, R. D., Nitschke, J. B., Oakes, T. R., Larson, C. L., Abercrombie, H. C., Schaefer, S. M., Koger, J. V., Benca, R. M., & Davidson, R. J. (2001). Anterior cingulate activity as a predictor or degree of treatment response in major depression: evidence from brain electrical tomography analysis. American Journal of Psychiatry, 158, 405–415.
47. Quidé, Y., Witteveen, A. B., El-Hage, W., Veltman, D. J., & Olff, M. (2012). Differences between effects of psychological versus pharmacological treatments on functional and morphological brain alterations in anxiety disorders and major depressive disorder: a systematic review. Neuroscience and Biobehavioral Reviews, 36(1), 626–644.
48. Rauch, S. L., Savage, C. R., Alpert, N. M., Miguel, E. C., Baer, L., Breiter, H. C., Fischman, A. J., Manzo, P. A., Moretti, C., & Jenike, M. A. (1995). A positron emission tomographic study of simple phobic symptom provocation. Archives of General Psychiatry, 52, 20–28.
49. Roffman, J. L., Marci, C. D., Glick, D. M., Dougherty, D. D., & Rauch, S. L. (2005). Neuroimaging and the functional neuroanatomy of psychotherapy. Psychological Medicine, 35(10), 1385–1398.
50. Saxena, S., Brody, A., Ho, M. L., Zohrabi, N., Maidment, K., & Baxter, L. R. (2003). Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. American Journal of Psychiatry, 160, 522–532.
51. Schienle, A., Schäfer, A., Stark, R., & Vaitl, D. (2009). Long-term effects of cognitive behavior therapy on brain activation in spider phobia. Psychiatry Research: Neuroimaging, 172(2), 99–102,
52. Schnell, K., & Herpertz, S. C. (2007). Effects of dialectic-behavioral-therapy on the neural correlates of affective hyperarousal in borderline personality disorder. Journal of Psychiatric Research, 41, 837–847.
53. Schwartz, J. M., Stoessel, P. W., Baxter, L. R., Martin, K. M., & Phelps, M. E. (1996). Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder. Archives of General Psychiatry, 53, 109–113.
54. Teasdale, J. D., Scott, J., Moore, R. G., Hayhurst, H., Pope, M., & Paykel, E. S. (2001). How does cognitive therapy prevent relapse in residual depression? Evidence from a controlled trial. Journal of Consulting and Clinical Psychology, 69(3), 347–357.
55. Thase, M. E., Greenhouse, J. B., Frank, E., Reynolds, C. F., Pilkonis, P. A., Hurley, K., Grochocinski, V., & Kupfer, D. J. (1997). Treatment of major depression with psychotherapy or psychotherapy-pharmacotherapy combinations. Archives of General Psychiatry, 54(11), 1009–1015.
56. Vlassenko, A., Sheline, Y. I., Fischer, K., & Mintun, M. A. (2004). Cerebral perfusion response to successful treatment of depression with different serotoninergic agents. Journal of Neuropsychiatry and Clinical Neurosciences, 16, 360–363.
57. Weingarten, C. P., & Strauman, T. J. (2014). Neuroimaging for psychotherapy research: current trends. Psychotherapy Research: Journal of the Society for Psychotherapy Research. doi:10.1080/10503307.2014.883088.
58. Yoshimura, S., Okamoto, Y., Onoda, K., Matsunaga, M., Okada, G., Kunisato, Y., Yoshino, A., Ueda, K., Suzuki, S., & Yamawaki, S. (2014). Cognitive behavioral therapy for depression changes medial prefrontal and ventral anterior cingulate cortex activity associated with self-referential processing. Social Cognition and Affective Neuroscience, 9(4), 487–493.