The prevalence and clinical characteristics of hypersexuality in patients with Parkinson's disease following dopaminergic therapy: A systematic literature review

Parkinsonism and Related Disorders

Volumn 25, Issue , 2016, Pages 10-16

  Nakum, Shivanee ^a   Cavanna, Andrea E ^a,b,c,d  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b BIRMINGHAM AND SOLIHULL MENTAL HEALTH NHS FOUNDATION TRUST   (United Kingdom)

^c ASTON UNIVERSITY   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Dopamine agonists; Dopamine replacement therapy; Hypersexuality; Impulse control disorders; Levodopa; Parkinson's disease

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; ANTIPARKINSON AGENT;

AGE; BEHAVIOR DISORDER; CLINICAL FEATURE; DISEASE ASSOCIATION; DRUG DOSE; EVIDENCE BASED MEDICINE; FEMALE; GENDER; HUMAN; HYPERSEXUALITY; MALE; MEDICAL HISTORY; ONSET AGE; PARKINSON DISEASE; PREVALENCE; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; CHEMICALLY INDUCED; DISRUPTIVE, IMPULSE CONTROL, AND CONDUCT DISORDERS; DRUG EFFECTS; SEXUAL BEHAVIOR;

ANTIPARKINSON AGENTS; DISRUPTIVE, IMPULSE CONTROL, AND CONDUCT DISORDERS; DOPAMINE AGONISTS; FEMALE; HUMANS; MALE; PARKINSON DISEASE; PREVALENCE; SEXUAL BEHAVIOR;

EID: 84975755401     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2016.02.017     Document Type: Review

References (52)

1. [1] Voon, V., Potenza, M.N., Thomsen, T., Medication-related impulse control and repetitive behaviors in Parkinson's disease. Curr. Opin. Neurol. 20, 2007, 484–492.
2. [2] Barns Neurauter, M.P., Rickards, H., Cavanna, A.E., The prevalence and clinical characteristics of pathological gambling in Parkinson's disease: an evidence-based review. Funct. Neurol. 25 (2010), 9–13.
3. [3] Leroi, I., Ahearn, D.J., Andrews, M., McDonald, K.R., Byrne, E.J., Burns, A., Behavioural disorders, disability and quality of life in Parkinson's disease. Age Ageing 40 (2011), 614–621.
4. [4] Raggi, A., Leonardi, M., Carella, F., Soliveri, P., Albanese, A., Romito, L.M., Impact of nonmotor symptoms on disability in patients with Parkinson's disease. Int. J. Rehabil. Res. 34 (2011), 316–320.
5. [5] Aarsland, D., Marsh, L., Schrag, A., Neuropsychiatric symptoms in Parkinson's disease. Mov. Disord. 24 (2009), 2175–2186.
6. [6] Spencer, A.H., Rickards, H., Fasano, A., Cavanna, A.E., The prevalence and clinical characteristics of punding in Parkinson's disease. Mov. Disord. 26 (2011), 578–586.
7. [7] Voon, V., Hassan, K., Zurowski, M., de Souza, M., Thomsen, T., Fox, S., Lang, A.E., Miyasaki, J., Prevalence of repetitive and reward-seeking behaviors in Parkinson disease. Neurology 67 (2006), 1254–1257.
8. [8] Weintraub, D., Koester, J., Potenza, M.N., Siderowf, A.D., Stacy, M., Voon, V., Whetteckey, J., Wunderlich, G.R., Lang, A.E., Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Arch. Neurol. 67 (2010), 589–595.
9. [9] Evans, A.H., Katzenschlager, R., Paviour, D., O'Sullivan, J.D., Appel, S., Lawrence, A.D., Lees, A.J., Punding in Parkinson's disease: its relation to the dopamine dysregulation syndrome. Mov. Disord. 19 (2004), 397–405.
10. [10] Vogel, H.P., Schiffter, R., Hypersexuality: a complication of dopaminergic therapy in Parkinson's disease. Pharmacopsychiatria 16 (1983), 107–110.
11. [11] American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders. 4th Ed., 2000, American Psychiatric Association, Washington, DC Text Revision (DSM-IV-TR).
12. [12] Leroi, I., Harbishettar, V., Andrews, M., McDonald, K.R., Byrne, E.J., Burns, A., Carer burden in apathy and impulse control disorders in Parkinson's disease. Int. J. Geriatr. Psychiatry 27 (2012), 160–166.
13. [13] Kuzma, J.M., Black, D.W., Epidemiology, prevalence, and natural history of compulsive sexual behavior. Psychiatr. Clin. North Am. 31 (2008), 603–611.
14. [14] Giladi, N., Weitzman, N., Schreiber, S., Shabtai, H., Peretz, C., New onset heightened interest or drive for gambling, shopping, eating or sexual activity in patients with Parkinson's disease: the role of dopamine agonist treatment and age at motor symptoms onset. J. Psychopharmacol. 21 (2007), 501–506.
15. [15] Bostwick, J.M., Hecksel, K.A., Stevens, S.R., Bower, J.H., Ahlskog, J.E., Frequency of new onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson disease. Mayo Clin. Proc. 84 (2009), 310–316.
16. [16] Cooper, C.A., Jadidian, A., Paggi, M., Romrell, J., Okun, M.S., Rodriguez, R.L., Fernandez, H.H., Prevalence of hypersexual behavior in Parkinson's disease patients: not restricted to males and dopamine agonist use. Int. J. Gen. Med. 30 (2009), 57–61.
17. [17] de Chazeron, I., Llorca, P.M., Chéreau-Boudet, I., Blanc, O., Perriot, J., Ouchchane, L., Ulla, M., Debilly, B., Derost, P., Durif, F., Hypersexuality and pathological gambling in Parkinson's disease: a cross-sectional case-control study. Mov. Disord. 26 (2011), 2127–2130.
18. [18] Klos, K.J., Bower, J.H., Josephs, K.A., Matsumoto, J.Y., Ahlskog, J.E., Pathological hypersexuality predominantly linked to adjuvant dopamine agonist therapy in Parkinson's disease and multiple system atrophy. Park. Relat. Disord. 11 (2005), 381–386.
19. [19] Sachdeva, J., Harbishettar, V., Barraclough, M., McDonald, K., Leroi, I., Clinical profile of compulsive sexual behaviour and paraphilia in Parkinson's disease. J. Park. Dis. 4 (2014), 665–670.
20. [20] Munhoz, R.P., Fabiani, G., Becker, N., Teive, H.A., Increased frequency and range of sexual behavior in a patient with Parkinson's disease after use of pramipexole: a case report. J. Sex. Med. 6 (2009), 1177–1180.
21. [21] Shapiro, M.A., Chang, Y.L., Munson, S.K., Okun, M.S., Fernandez, H.H., Hypersexuality and paraphilia induced by selegiline in Parkinson's disease: report of 2 cases. Park. Relat. Disord. 12 (2006), 392–395.
22. [22] Singh, A., Kandimala, G., Dewey, R.B. Jr., O'Suilleabhain, P., Risk factors for pathologic gambling and other compulsions among Parkinson's disease patients taking dopamine agonists. J. Clin. Neurosci. 14 (2007), 1178–1181.
23. [23] van Deelen, R.A., Rommers, M.K., Eerenberg, J.G., Egberts, A.C., Hypersexuality during use of levodopa. Ned. Tijdschr. Geneeskd. 146 (2002), 2095–2098.
24. [24] Weintraub, D., Siderowf, A.D., Potenza, M.N., Goveas, J., Morales, K.H., Duda, J.E., Moberg, P.J., M.B. Stern M, Association of dopamine agonist use with impulse control disorders in Parkinson disease. Arch. Neurol. 63 (2006), 969–973.
25. [25] Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J. Clin. Epidemiol. 62 (2009), 1006–1012.
26. [26] Joutsa, J., Martikainen, K., Vahlberg, T., Voon, V., Kaasinen, V., Impulse control disorders and depression in Finnish patients with Parkinson's disease. Park. Relat. Disord. 18 (2012), 155–160.
27. [27] Callesen, M.B., Weintraub, D., Damholdt, M.F., Moller, A., Impulsive and compulsive behaviors among Danish patients with Parkinson's disease: prevalence, depression, and personality. Park. Relat. Disord. 20 (2014), 22–26.
28. [28] Fan, W., Ding, H., Ma, J., Chan, P., Impulse control disorders in Parkinson's disease in a Chinese population. Neurosci. Lett. 465 (2009), 6–9.
29. [29] Hassan, A., Bower, J.H., Kumar, N., Matsumoto, J.Y., Fealey, R.D., Josephs, K.A., Ahlskog, J.E., Dopamine agonist-triggered pathological behaviors: surveillance in the PD clinic reveals high frequencies. Park. Relat. Disord. 17 (2011), 260–264.
30. [30] Chiang, H.L., Huang, Y.S., Chen, S.T., Wu, Y.R., Are there ethnic differences in impulsive/compulsive behaviors in Parkinson's disease?. Eur. J. Neurol. 19 (2011), 494–500.
31. [31] Poletti, M., Logi, C., Lucetti, C., Del Dotto, P., Baldacci, F., Vergallo, A., Ulivi, M., Del Sarto, S., Rossi, G., Ceravolo, R., Bonuccelli, U., A single-center, cross-sectional prevalence study of impulsive control disorders in Parkinson disease. J. Clin. Psychopharmacol. 33 (2013), 691–694.
32. [32] Rodríguez-Violante, M., González-Latapi, P., Cervantes-Arriaga, A., Camacho-Ordoñez, A., Weintraub, D., Impulse control and related disorders in Mexican Parkinson's disease patients. Park. Relat. Disord. 20 (2014), 907–910.
33. [33] Weintraub, D., Stewart, S., Shea, J.A., Lyons, K.E., Pahwa, R., Driver-Dunckley, E.D., Adler, C.H., Potenza, M.N., Miyasaki, J., Siderowf, A.D., Duda, J.E., Hurtig, H.I., Colcher, A., Horn, S.S., Stern, M.B., Voon, V., Validation of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP). Mov. Disord. 24 (2009), 1461–1467.
34. [34] Cannas, A., Solla, P., Floris, G., Tacconi, P., Loi, D., Marcia, E., Marrosu, M.G., Hypersexual behaviour, frotteurism and delusional jealousy in a young parkinsonian patient during dopaminergic therapy with pergolide: a rare case of iatrogenic paraphilia. Prog. Neuropsychopharmacol. Biol. Psychiatry 30 (2006), 1539–1541.
35. [35] Fernandez, F.M., Gonzalez, T.M., Pathological gambling and hypersexuality due to dopaminergic treatment in Parkinson's disease. Actas Esp. Psiquiatr. 37 (2009), 118–122.
36. [36] Wingo, T.S., Evatt, M., Scott, B., Freeman, A., Stacy, M., Impulse control disorders arising in 3 patients treated with rotigotine. Clin. Neuropharmacol. 32 (2009), 59–62.
37. [37] Solla, P., Bortolato, M., Cannas, A., Mulas, C.S., Marrosu, F., Paraphilias and paraphilic disorders in Parkinson's disease: a systematic review of the literature. Mov. Disord. 30 (2015), 604–613.
38. [38] Ondo, W.G., Lai, D., Predictors of impulsivity and reward seeking behavior with dopamine agonists. Park. Relat. Disord. 14 (2008), 28–32.
39. [39] Singh, A., Kandimala, G., Dewey, R.B. Jr., O'Suilleabhain, P., Risk factors for pathological gambling and other compulsions among Parkinson's disease patients taking dopamine agonists. J. Clin. Neurosci. 14 (2007), 1178–1181.
40. [40] Voon, V., Thomsen, T., Miyasaki, J.M., de Souza, M., Shafro, A., Fox, S.H., Duff-Canning, S., Lang, A.E., Zurowski, M., Factors associated with dopaminergic drug-related pathological gambling in Parkinson disease. Arch. Neurol. 64 (2007), 212–216.
41. [41] Gurevich, E.V., Joyce, J.N., Distribution of dopamine D3 receptor expression neurons in the human forebrain: comparison with D2 receptor expressing neurons. Neuropsychopharmacology 20 (1999), 60–80.
42. [42] Holden, C., ‘Behavioral’ addictions: do they exist?. Science 294 (2001), 980–982.
43. [43] Brewer, J.A., Potenza, M.N., The neurobiology and genetics of impulse control disorders: relationships to drug addictions. Biochem. Pharmacol. 75 (2008), 63–75.
44. [44] Gerlach, M., Double, K., Arzberger, T., Leblhuber, F., Tatschner, T., Riederer, P., Dopamine receptor agonists in current clinical use: comparative dopamine receptor binding profiles defined in the human striatum. J. Neural Transm. 110 (2003), 1119–1127.
45. [45] Balarajah, S., Cavanna, A.E., The pathophysiology of impulse control disorders in Parkinson disease. Behav. Neurol. 26 (2013), 237–244.
46. [46] Martinez-Martin, P., Leentjens, A.F., de Pedro-Cuesta, J., Chaudhuri, K.R., Schrag, A.E., Weintraub, D., Accuracy of screening instruments for detection of neuropsychiatric syndromes in Parkinson's disease. Mov. Disord., 2016 (in press).
47. [47] Pereira, B., Llorca, P.M., Durif, F., Brousse, G., Blanc, O., Rieu, I., Derost, P., Ulla, M., Debilly, B., de Chazeron, I., Screening hypersexuality in Parkinson's disease in everyday practice. Park. Relat. Disord. 19 (2013), 242–246.
48. [48] Driver-Dunckley, E., Samanta, J., Stacy, M., Pathological gambling associated with dopamine agonist therapy in Parkinson's disease. Neurology 61 (2003), 422–423.
49. [49] Pontone, G., Williams, J.R., Bassett, S.S., Marsh, L., Clinical features associated with impulse control disorders in Parkinson disease. Neurology 67 (2006), 1258–1261.
50. [50] Baumann-Vogel, H., Valko, P.O., Eisele, G., Baumann, C.R., Impulse control disorders in Parkinson's disease: don't set your mind at rest by self-assessments. Eur. J. Neurol. 22 (2015), 603–609.
51. [51] Bronner, G., Vodusek, D.B., Management of sexual dysfunction in Parkinson's disease. Ther. Adv. Neurol. Disord. 4 (2011), 375–383.
52. [52] Demetriades, P., Rickards, H., Cavanna, A.E., Impulse control disorders following deep brain stimulation of the subthalamic nucleus in Parkinson's disease: clinical aspects. Parkinson's Dis., 2011, 658415.