Underestimation of the true specificity of the urine lipoarabinomannan point-of-care diagnostic assay for HIV-associated tuberculosis

Journal of Acquired Immune Deficiency Syndromes

Volumn 69, Issue 4, 2015, Pages e144-e146

  Lawn, Stephen D ^a,b   Kerkhoff, Andrew D ^b,c,d   Nicol, Mark P ^e,f   Meintjes, Graeme ^e,g  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY OF CAPE TOWN   (South Africa)

^f UNIVERSITY OF CAPE TOWN   (South Africa)

^g IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOARABINOMANNAN; LIPOPOLYSACCHARIDE;

DIAGNOSTIC ACCURACY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS ASSOCIATED TUBERCULOSIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LETTER; LIPID URINE LEVEL; POINT OF CARE TESTING; PRACTICE GUIDELINE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SPUTUM ANALYSIS; TEST STRIP; TUBERCULOSIS; URINALYSIS; URINE LEVEL; AIDS-RELATED OPPORTUNISTIC INFECTIONS; COMPLICATION; DIAGNOSTIC TEST; FEMALE; MALE; MASS SCREENING; PROCEDURES; TUBERCULOSIS, PULMONARY; URINE;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; DIAGNOSTIC TESTS, ROUTINE; FEMALE; HIV INFECTIONS; HUMANS; LIPOPOLYSACCHARIDES; MALE; MASS SCREENING; TUBERCULOSIS, PULMONARY;

EID: 84975282776     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000000672     Document Type: Letter

References (15)

1. Drain PK, Losina E, Coleman SM, et al. Value of urine lipoarabinomannan grade and second test for optimizing clinic-based screening for HIV-associated pulmonary tuberculosis. J Ac-quir Immune Defic Syndr. 2015;68:274-280.
2. Lawn SD. Point-of-care detection of lipoar-abinomannan (LAM) in urine for diagnosis of HIV-associated tuberculosis: a state of the art review. BMC Infect Dis. 2012;12:103.
3. Lawn SD, Kerkhoff AD, Vogt M, et al. Clinical significance of lipoarabinomannan detection in urine using a low-cost point-of-care diagnostic assay for HIV-associated tuberculosis. AIDS. 2012;26:1635-1643.
4. Shah M, Ssengooba w, Armstrong D, et al. Comparative performance of urinary lipoarabinomannan assays and Xpert MTB/ RIF in HIV-infected individuals with suspected tuberculosis in Uganda. AIDS. 2014; 28:1307-1314.
5. Lemaire JF, Casenghi M. New diagnostics for tuberculosis: fulfilling patient needs first. J Int AIDS Soc. 2010;13:40.
6. McNerney R, Daley P. Towards a point-of-care test for active tuberculosis: obstacles and opportunities. Nat Rev Microbiol. 2011;9: 204-213.
7. Drain PK, Losina E, Coleman SM, et al. Diagnostic accuracy of a point-of-care urine test for tuberculosis screening among newly-diagnosed HIV-infected adults: a prospective, clinic-based study. BMC Infect Dis. 2014;14:110.
8. Lawn SD, Kerkhoff AD, Vogt M, et al. Diagnostic accuracy of a low-cost, urine antigen, point-of-care screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study. Lancet Infect Dis. 2012;12:201-209.
9. Peter JG, Theron G, Zyl-Smit R, et al. Diagnostic accuracy of a urine lipoarabinomannan strip-test for TB detection in HIV-infected hospitalised patients. Eur Respir J. 2012;40: 1211-1220.
10. Nakiyingi L, Moodley VM, Manabe YC, et al. Diagnostic accuracy of a rapid urine lipoar-abinomannan test for tuberculosis in HIV-infected adults. J Acquir Immune Defic Syndr. 2014;66:270-279.
11. Balcha TT, winqvist N, Sturegard E, et al. Detection of lipoarabinomannan in urine for identification of active tuberculosis among HIV-positive adults in Ethiopian health centres. Trop Med Int Health. 2014;19:734-742.
12. Lawn SD, Dheda K, Kerkhoff AD, et al. Determine TB-LAM lateral flow urine antigen assay for HIV-associated tuberculosis: recommendations on the design and reporting of clinical studies. BMC Infect Dis. 2013;13: 407.
13. Lawn SD, wood R. Tuberculosis in antiretro-viral treatment services in resource-limited settings: addressing the challenges of screening and diagnosis. J Infect Dis. 2011;204 Suppl 4:S1159-S1167.
14. Lawn SD, Edwards DJ, Kranzer K, et al. Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease. AIDS. 2009;23:1875-1880.
15. Lawn SD, Kerkhoff AD, Burton R, et al. Massive diagnostic yield of HIV-associated tuberculosis using rapid urine assays in South Africa. Program and Abstracts of the Conference on Retroviruses and Opportunistic Infections (CROI); March 3-6, 2014; Boston, MA. Abstract #2813.