Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature

Science

Volumn 352, Issue 6291, 2016, Pages 1341-1344

  Grimes, D T ^a   Boswell, C W ^b,c   Morante, N F C ^a   Henkelman, R M ^b,c   Burdine, R D ^a   Ciruna, B ^b,c  

^a PRINCETON UNIVERSITY   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE 7; UNCLASSIFIED DRUG; PTK7 PROTEIN, ZEBRAFISH;

ABNORMALITY; BIOLOGICAL DEVELOPMENT; BODY FLUID; CELLS AND CELL COMPONENTS; CYPRINID; FLUID FLOW; GENE EXPRESSION; MOTILITY; MUTATION; PHENOTYPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEVELOPMENT; CELL MOTILITY; CEREBROSPINAL FLUID FLOW; EPENDYMA CELL; EUKARYOTIC FLAGELLUM; IDIOPATHIC SCOLIOSIS; MORPHOGENESIS; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ZEBRA FISH; ANIMAL; CEREBROSPINAL FLUID; CONGENITAL MALFORMATION; DISEASE MODEL; EPENDYMA; GENETICS; HYDROCEPHALUS; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SCOLIOSIS; SPINE; TRANSGENIC ANIMAL;

DANIO RERIO;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CEREBROSPINAL FLUID; CILIA; DISEASE MODELS, ANIMAL; EPENDYMA; HYDROCEPHALUS; MUTATION; RECEPTOR PROTEIN-TYROSINE KINASES; SCOLIOSIS; SPINE; ZEBRAFISH;

EID: 84975153575     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf6419     Document Type: Article

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