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Volumn 26, Issue 6, 2016, Pages 550-565

Does statin use cause memory decline in the elderly?

Author keywords

Brain; Brain volume; Cognition; Dementia; Diabetes; Heart; HMGCoA reductase inhibitors; Hypertension; Ischemic heart disease; Magnetic resonance; Memory; Statins; Stroke

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 84975140633     PISSN: 10501738     EISSN: 18732615     Source Type: Journal    
DOI: 10.1016/j.tcm.2016.03.009     Document Type: Review
Times cited : (23)

References (57)
  • 2
    • 84951268191 scopus 로고    scopus 로고
    • The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration
    • [2] Sachdev, P.S., Lipnicki, D.M., Kochan, N.A., Crawford, J.D., Thalamuthu, A., Andrews, G., et al. The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration. PloS one, 10, 2015, e0142388.
    • (2015) PloS one , vol.10 , pp. e0142388
    • Sachdev, P.S.1    Lipnicki, D.M.2    Kochan, N.A.3    Crawford, J.D.4    Thalamuthu, A.5    Andrews, G.6
  • 3
    • 73249119797 scopus 로고    scopus 로고
    • Outcome over seven years of healthy adults with and without subjective cognitive impairment
    • [3] Reisberg, B., Shulman, M.B., Torossian, C., Leng, L., Zhu, W., Outcome over seven years of healthy adults with and without subjective cognitive impairment. Alzheimers Dement 6 (2010), 11–24.
    • (2010) Alzheimers Dement , vol.6 , pp. 11-24
    • Reisberg, B.1    Shulman, M.B.2    Torossian, C.3    Leng, L.4    Zhu, W.5
  • 5
    • 84904264999 scopus 로고    scopus 로고
    • Potential for primary prevention of Alzheimer's disease: an analysis of population-based data
    • [5] Norton, S., Matthews, F.E., Barnes, D.E., Yaffe, K., Brayne, C., Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol 13 (2014), 788–794.
    • (2014) Lancet Neurol , vol.13 , pp. 788-794
    • Norton, S.1    Matthews, F.E.2    Barnes, D.E.3    Yaffe, K.4    Brayne, C.5
  • 6
    • 80052400687 scopus 로고    scopus 로고
    • Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association
    • [6] Gorelick, P.B., Scuteri, A., Black, S.E., Decarli, C., Greenberg, S.M., Iadecola, C., et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 42 (2011), 2672–2713.
    • (2011) Stroke , vol.42 , pp. 2672-2713
    • Gorelick, P.B.1    Scuteri, A.2    Black, S.E.3    Decarli, C.4    Greenberg, S.M.5    Iadecola, C.6
  • 7
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials
    • [7] Cholesterol Treatment Trialists Collaboraton, Baigent, C., Blackwell, L., Emberson, J., Holland, L.E., Reith, C., et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 376 (2010), 1670–1681.
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Cholesterol Treatment Trialists Collaboraton1    Baigent, C.2    Blackwell, L.3    Emberson, J.4    Holland, L.E.5    Reith, C.6
  • 8
    • 38049033935 scopus 로고    scopus 로고
    • Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis
    • [8] Cholesterol Treatment Trialists Collaboraton, Kearney, P.M., Blackwell, L., Collins, R., Keech, A., Simes, J., et al. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet 371 (2008), 117–125.
    • (2008) Lancet , vol.371 , pp. 117-125
    • Cholesterol Treatment Trialists Collaboraton1    Kearney, P.M.2    Blackwell, L.3    Collins, R.4    Keech, A.5    Simes, J.6
  • 9
    • 84864832599 scopus 로고    scopus 로고
    • The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials
    • [9] Cholesterol Treatment Trialists Collaboraton, Mihaylova, B., Emberson, J., Blackwell, L., Keech, A., Simes, J., et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 380 (2012), 581–590.
    • (2012) Lancet , vol.380 , pp. 581-590
    • Cholesterol Treatment Trialists Collaboraton1    Mihaylova, B.2    Emberson, J.3    Blackwell, L.4    Keech, A.5    Simes, J.6
  • 10
    • 84897970506 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • [10] Stone, N.J., Robinson, J.G., Lichtenstein, A.H., Bairey Merz, C.N., Blum, C.B., Eckel, R.H., et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 129:25 Suppl 2 (2014), S1–S45.
    • (2014) Circulation , vol.129 , Issue.25 , pp. S1-S45
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3    Bairey Merz, C.N.4    Blum, C.B.5    Eckel, R.H.6
  • 11
    • 34548058076 scopus 로고    scopus 로고
    • Physician response to patient reports of adverse drug effects: implications for patient-targeted adverse effect surveillance
    • [11] Golomb, B.A., McGraw, J.J., Evans, M.A., Dimsdale, J.E., Physician response to patient reports of adverse drug effects: implications for patient-targeted adverse effect surveillance. Drug Saf 30 (2007), 669–675.
    • (2007) Drug Saf , vol.30 , pp. 669-675
    • Golomb, B.A.1    McGraw, J.J.2    Evans, M.A.3    Dimsdale, J.E.4
  • 12
    • 84991404117 scopus 로고    scopus 로고
    • FDA. FDA Drug Safety Communication: Important Safety Label Changes to Cholesterol-Lowering Statin Drugs. 07.03.12. [accessed 22.04.14].
    • [12] FDA. FDA Drug Safety Communication: Important Safety Label Changes to Cholesterol-Lowering Statin Drugs. 07.03.12, 2014. http://www.fda.gov/Drugs/DrugSafety/ucm293101.htm [accessed 22.04.14].
    • (2014)
  • 13
    • 34548299453 scopus 로고    scopus 로고
    • Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease
    • [13] Wolozin, B., Wang, S.W., Li, N.C., Lee, A., Lee, T.A., Kazis, L.E., Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med, 5, 2007, 20.
    • (2007) BMC Med , vol.5 , pp. 20
    • Wolozin, B.1    Wang, S.W.2    Li, N.C.3    Lee, A.4    Lee, T.A.5    Kazis, L.E.6
  • 15
    • 67649252917 scopus 로고    scopus 로고
    • Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study
    • [15] Cramer, C., Haan, M.N., Galea, S., Langa, K.M., Kalbfleisch, J.D., Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study. Neurology 71 (2008), 344–350.
    • (2008) Neurology , vol.71 , pp. 344-350
    • Cramer, C.1    Haan, M.N.2    Galea, S.3    Langa, K.M.4    Kalbfleisch, J.D.5
  • 16
    • 58249089520 scopus 로고    scopus 로고
    • Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The rotterdam study
    • [16] Haag, M.D., Hofman, A., Koudstaal, P.J., Stricker, B.H., Breteler, M.M., Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The rotterdam study. J Neurol Neurosurg Psychiatry 80 (2009), 13–17.
    • (2009) J Neurol Neurosurg Psychiatry , vol.80 , pp. 13-17
    • Haag, M.D.1    Hofman, A.2    Koudstaal, P.J.3    Stricker, B.H.4    Breteler, M.M.5
  • 19
    • 43249094747 scopus 로고    scopus 로고
    • Statins, incident Alzheimer disease, change in cognitive function, and neuropathology
    • [19] Arvanitakis, Z., Schneider, J.A., Wilson, R.S., Bienias, J.L., Kelly, J.F., Evans, D.A., et al. Statins, incident Alzheimer disease, change in cognitive function, and neuropathology. Neurology 70:19 Pt 2 (2008), 1795–1802.
    • (2008) Neurology , vol.70 , Issue.19 , pp. 1795-1802
    • Arvanitakis, Z.1    Schneider, J.A.2    Wilson, R.S.3    Bienias, J.L.4    Kelly, J.F.5    Evans, D.A.6
  • 20
    • 84864147567 scopus 로고    scopus 로고
    • Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study
    • [20] Bettermann, K., Arnold, A.M., Williamson, J., Rapp, S., Sink, K., Toole, J.F., et al. Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study. J Stroke Cerebrovasc Dis 21 (2012), 436–444.
    • (2012) J Stroke Cerebrovasc Dis , vol.21 , pp. 436-444
    • Bettermann, K.1    Arnold, A.M.2    Williamson, J.3    Rapp, S.4    Sink, K.5    Toole, J.F.6
  • 21
    • 22844431778 scopus 로고    scopus 로고
    • Statin use and the risk of incident dementia: the cardiovascular health study
    • [21] Rea, T.D., Breitner, J.C., Psaty, B.M., Fitzpatrick, A.L., Lopez, O.L., Newman, A.B., et al. Statin use and the risk of incident dementia: the cardiovascular health study. Arch Neurol 62 (2005), 1047–1051.
    • (2005) Arch Neurol , vol.62 , pp. 1047-1051
    • Rea, T.D.1    Breitner, J.C.2    Psaty, B.M.3    Fitzpatrick, A.L.4    Lopez, O.L.5    Newman, A.B.6
  • 22
    • 35948977729 scopus 로고    scopus 로고
    • Association of statin use with cognitive decline in elderly African Americans
    • [22] Szwast, S.J., Hendrie, H.C., Lane, K.A., Gao, S., Taylor, S.E., Unverzagt, F., et al. Association of statin use with cognitive decline in elderly African Americans. Neurology 69 (2007), 1873–1880.
    • (2007) Neurology , vol.69 , pp. 1873-1880
    • Szwast, S.J.1    Hendrie, H.C.2    Lane, K.A.3    Gao, S.4    Taylor, S.E.5    Unverzagt, F.6
  • 24
    • 70349334173 scopus 로고    scopus 로고
    • Treatment of vascular risk factors is associated with slower decline in Alzheimer disease
    • [24] Deschaintre, Y., Richard, F., Leys, D., Pasquier, F., Treatment of vascular risk factors is associated with slower decline in Alzheimer disease. Neurology 73 (2009), 674–680.
    • (2009) Neurology , vol.73 , pp. 674-680
    • Deschaintre, Y.1    Richard, F.2    Leys, D.3    Pasquier, F.4
  • 25
    • 0036305918 scopus 로고    scopus 로고
    • The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment
    • [25] Hajjar, I., Schumpert, J., Hirth, V., Wieland, D., Eleazer, G.P., The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment. J Gerontol A Biol Sci Med Sci 57 (2002), M414–M418.
    • (2002) J Gerontol A Biol Sci Med Sci , vol.57 , pp. M414-M418
    • Hajjar, I.1    Schumpert, J.2    Hirth, V.3    Wieland, D.4    Eleazer, G.P.5
  • 26
  • 28
    • 33846461149 scopus 로고    scopus 로고
    • Effects of statins on cognitive function in patients with Alzheimer's disease in galantamine clinical trials
    • [28] Winblad, B., Jelic, V., Kershaw, P., Amatniek, J., Effects of statins on cognitive function in patients with Alzheimer's disease in galantamine clinical trials. Drugs Aging 24 (2007), 57–61.
    • (2007) Drugs Aging , vol.24 , pp. 57-61
    • Winblad, B.1    Jelic, V.2    Kershaw, P.3    Amatniek, J.4
  • 29
    • 0037031061 scopus 로고    scopus 로고
    • MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial
    • [29] Heart Protection Study Collaborative Group, MRC/BHF heart protection study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360 (2002), 7–22.
    • (2002) Lancet , vol.360 , pp. 7-22
    • Heart Protection Study Collaborative Group1
  • 30
    • 74849094929 scopus 로고    scopus 로고
    • Pravastatin and cognitive function in the elderly. Results of the PROSPER study
    • [30] Trompet, S., van Vliet, P., de Craen, A.J., Jolles, J., Buckley, B.M., Murphy, M.B., et al. Pravastatin and cognitive function in the elderly. Results of the PROSPER study. J Neurol 257 (2010), 85–90.
    • (2010) J Neurol , vol.257 , pp. 85-90
    • Trompet, S.1    van Vliet, P.2    de Craen, A.J.3    Jolles, J.4    Buckley, B.M.5    Murphy, M.B.6
  • 31
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial
    • [31] Shepherd, J., Blauw, G.J., Murphy, M.B., Bollen, E.L., Buckley, B.M., Cobbe, S.M., et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 360 (2002), 1623–1630.
    • (2002) Lancet , vol.360 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3    Bollen, E.L.4    Buckley, B.M.5    Cobbe, S.M.6
  • 32
    • 0036714243 scopus 로고    scopus 로고
    • Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26-week randomized, placebo-controlled, double-blind trial
    • [32] Simons, M., Schwarzler, F., Lutjohann, D., von Bergmann, K., Beyreuther, K., Dichgans, J., et al. Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: a 26-week randomized, placebo-controlled, double-blind trial. Ann Neurol 52 (2002), 346–350.
    • (2002) Ann Neurol , vol.52 , pp. 346-350
    • Simons, M.1    Schwarzler, F.2    Lutjohann, D.3    von Bergmann, K.4    Beyreuther, K.5    Dichgans, J.6
  • 33
    • 77949908687 scopus 로고    scopus 로고
    • Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
    • [33] Feldman, H.H., Doody, R.S., Kivipelto, M., Sparks, D.L., Waters, D.D., Jones, R.W., et al. Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe. Neurology 74 (2010), 956–964.
    • (2010) Neurology , vol.74 , pp. 956-964
    • Feldman, H.H.1    Doody, R.S.2    Kivipelto, M.3    Sparks, D.L.4    Waters, D.D.5    Jones, R.W.6
  • 34
    • 80053336026 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
    • [34] Sano, M., Bell, K.L., Galasko, D., Galvin, J.E., Thomas, R.G., van Dyck, C.H., et al. A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease. Neurology 77 (2011), 556–563.
    • (2011) Neurology , vol.77 , pp. 556-563
    • Sano, M.1    Bell, K.L.2    Galasko, D.3    Galvin, J.E.4    Thomas, R.G.5    van Dyck, C.H.6
  • 35
    • 33846846591 scopus 로고    scopus 로고
    • Effect of atorvastatin on cognitive function in patients from the Lipid Lowering and Onset of Renal Disease (LORD) trial
    • [35] Summers, M.J., Oliver, K.R., Coombes, J.S., Fassett, R.G., Effect of atorvastatin on cognitive function in patients from the Lipid Lowering and Onset of Renal Disease (LORD) trial. Pharmacotherapy 27 (2007), 183–190.
    • (2007) Pharmacotherapy , vol.27 , pp. 183-190
    • Summers, M.J.1    Oliver, K.R.2    Coombes, J.S.3    Fassett, R.G.4
  • 36
    • 3843148550 scopus 로고    scopus 로고
    • Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults
    • [36] Muldoon, M.F., Ryan, C.M., Sereika, S.M., Flory, J.D., Manuck, S.B., Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults. Am J Med 117 (2004), 823–829.
    • (2004) Am J Med , vol.117 , pp. 823-829
    • Muldoon, M.F.1    Ryan, C.M.2    Sereika, S.M.3    Flory, J.D.4    Manuck, S.B.5
  • 38
    • 84859001212 scopus 로고    scopus 로고
    • The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
    • [38] Higgins, J.P., Altman, D.G., Gotzsche, P.C., Jüni, P., Moher, D., Oxman, A.D., et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. Br Med J, 343, 2011, d5928.
    • (2011) Br Med J , vol.343 , pp. d5928
    • Higgins, J.P.1    Altman, D.G.2    Gotzsche, P.C.3    Jüni, P.4    Moher, D.5    Oxman, A.D.6
  • 39
    • 0035021115 scopus 로고    scopus 로고
    • The double-blind, randomized, placebo-controlled trial: gold standard or golden calf?
    • [39] Kaptchuk, T.J., The double-blind, randomized, placebo-controlled trial: gold standard or golden calf?. J Clin Epidemiol 54 (2001), 541–549.
    • (2001) J Clin Epidemiol , vol.54 , pp. 541-549
    • Kaptchuk, T.J.1
  • 40
    • 84940596408 scopus 로고    scopus 로고
    • Hard-wired bias: how even double-blind, randomized controlled trials can be skewed from the start
    • [40] Prasad, V., Berger, V.W., Hard-wired bias: how even double-blind, randomized controlled trials can be skewed from the start. Mayo Clin Proc 90 (2015), 1171–1175.
    • (2015) Mayo Clin Proc , vol.90 , pp. 1171-1175
    • Prasad, V.1    Berger, V.W.2
  • 41
    • 20844440894 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results
    • [41] Sparks, D.L., Sabbagh, M.N., Connor, D.J., Lopez, J., Launer, L.J., Browne, P., et al. Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. Arch Neurol 62 (2005), 753–757.
    • (2005) Arch Neurol , vol.62 , pp. 753-757
    • Sparks, D.L.1    Sabbagh, M.N.2    Connor, D.J.3    Lopez, J.4    Launer, L.J.5    Browne, P.6
  • 47
    • 0002175349 scopus 로고
    • Problems of test construction in the field of aphasia
    • [47] Benton, A., Problems of test construction in the field of aphasia. Cortex 3 (1967), 32–58.
    • (1967) Cortex , vol.3 , pp. 32-58
    • Benton, A.1
  • 51
    • 84965055942 scopus 로고    scopus 로고
    • Lippincott Williams & Wilkins Philadelphia
    • [51] Kaplan, E., The Boston Naming Test, 2001, Lippincott Williams & Wilkins, Philadelphia.
    • (2001) The Boston Naming Test
    • Kaplan, E.1
  • 53
    • 77953711938 scopus 로고    scopus 로고
    • Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database
    • [53] Hippisley-Cox, J., Coupland, C., Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database. Br Med J, 340, 2010, c2197.
    • (2010) Br Med J , vol.340 , pp. c2197
    • Hippisley-Cox, J.1    Coupland, C.2
  • 54
    • 58149123594 scopus 로고    scopus 로고
    • Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials
    • [54] Smeeth, L., Douglas, I., Hall, A.J., Hubbard, R., Evans, S., Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials. Br J Clin Pharmacol 67 (2009), 99–109.
    • (2009) Br J Clin Pharmacol , vol.67 , pp. 99-109
    • Smeeth, L.1    Douglas, I.2    Hall, A.J.3    Hubbard, R.4    Evans, S.5
  • 55
    • 77954317961 scopus 로고    scopus 로고
    • Age-varying association between statin use and incident Alzheimer's disease
    • [55] Li, G., Shofer, J.B., Rhew, I.C., Kukull, W.A., Peskind, E.R., McCormick, W., et al. Age-varying association between statin use and incident Alzheimer's disease. J Am Geriatr Soc 58 (2010), 1311–1317.
    • (2010) J Am Geriatr Soc , vol.58 , pp. 1311-1317
    • Li, G.1    Shofer, J.B.2    Rhew, I.C.3    Kukull, W.A.4    Peskind, E.R.5    McCormick, W.6
  • 56
    • 0036186663 scopus 로고    scopus 로고
    • Serum lipoprotein levels, statin use, and cognitive function in older women
    • [56] Yaffe, K., Barrett-Connor, E., Lin, F., Grady, D., Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol 59 (2002), 378–384.
    • (2002) Arch Neurol , vol.59 , pp. 378-384
    • Yaffe, K.1    Barrett-Connor, E.2    Lin, F.3    Grady, D.4
  • 57
    • 84855222091 scopus 로고    scopus 로고
    • An evaluation of the effect of atorvastatin on memory and psychomotor functions in hypertensive patients
    • [57] Prajapati, S., Desai, C.K., Dikshit, R.K., An evaluation of the effect of atorvastatin on memory and psychomotor functions in hypertensive patients. J Postgrad Med 57 (2011), 291–297.
    • (2011) J Postgrad Med , vol.57 , pp. 291-297
    • Prajapati, S.1    Desai, C.K.2    Dikshit, R.K.3


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