Three-Dimensional Cell Culture Assays: Are They More Predictive of in Vivo Efficacy than 2D Monolayer Cell-Based Assays?

Assay and Drug Development Technologies

Volumn 13, Issue 5, 2015, Pages 254-261

  Sittampalam, Sitta ^a   Eglen, Richard ^b   Ferguson, Stephen ^c   Maynes, Jason Thomas ^d   Olden, Kenneth ^e   Schrader, Laura ^f   Shelper, Todd ^g   Ferrer, Marc ^c  

^a Translational Sciences   (United States)

^b Corning Life Sciences ^*  (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^f 3D Biomatrix Inc   (United States)

^g GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DETERGENT;

ALZHEIMER DISEASE; ANESTHESIST; CELL ASSAY; CELL CULTURE; CELL INTERACTION; CELL LINE; CHEMICAL STRUCTURE; COCULTURE; COMPARATIVE EFFECTIVENESS; COST; CYTOARCHITECTURE; DISEASE MODEL; DRUG SCREENING; EXTRACELLULAR MATRIX; FOOD AND DRUG ADMINISTRATION; HEALTH CARE DELIVERY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; LABORATORY DEVICE; MANAGER; MOLECULE; NOTE; ONCOLOGY; PREDICTIVE VALUE; PRIMARY CELL; SCIENTIST; TECHNOLOGY; THREE DIMENSIONAL CELL CULTURE ASSAY; TWO DIMENSIONAL MONOLAYER CELL BASED ASSAY; BIOASSAY; CELL CULTURE TECHNIQUE; FORECASTING; GROUP PROCESS; HUMAN; PHARMACEUTICS; PROCEDURES; TRENDS;

BIOLOGICAL ASSAY; CELL CULTURE TECHNIQUES; FORECASTING; GROUP PROCESSES; HUMANS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84974660156     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2015.29001.rtd     Document Type: Note

References (0)