Comparison of Pharmacokinetics of Vardenafil Administered Using an Ultrasonic Nebulizer for Inhalation vs a Single 10-mg Oral Tablet

Journal of Sexual Medicine

Volumn 13, Issue 7, 2016, Pages 1111-1118

  Berry, Brooke ^a   Altman, Phillip ^b   Rowe, James ^c   Vaisman, Jack ^d  

^a Altman Biomedical Consulting ^*  (Australia)

^b Altman Biomedical Consulting   (Australia)

^c NxGen Pharmaceuticals Pty Ltd   (Australia)

^d Qual med Pty Ltd   (Australia)

Author keywords

Comparative; Inhalation; PDE5 Inhibitor; Pharmacokinetics; Vardenafil

Indexed keywords

VARDENAFIL; TABLET; VASODILATOR AGENT;

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; COUGHING; DIZZINESS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY DEVICE; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HEADACHE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOT FLUSH; HUMAN; HUMAN EXPERIMENT; HYPOTENSION; MALE; MAXIMUM PLASMA CONCENTRATION; NAUSEA; NEBULIZER; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SOMNOLENCE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRASONIC NEBULIZER; ADULT; CLINICAL TRIAL; CROSSOVER PROCEDURE; ERECTILE DYSFUNCTION; FEMALE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; REPRODUCIBILITY; TABLET; ULTRASOUND; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; CROSS-OVER STUDIES; ERECTILE DYSFUNCTION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEBULIZERS AND VAPORIZERS; REPRODUCIBILITY OF RESULTS; TABLETS; ULTRASONICS; VARDENAFIL DIHYDROCHLORIDE; VASODILATOR AGENTS; YOUNG ADULT;

EID: 84974623512     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2009.01403.x     Document Type: Article

References (4)

1. Patient Information Sheet. Vardenafil hydrochloride (marketed as Levitra). Available at: (accessed June 22, 2009). http://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021400s011lbl.pdf.
2. Francis S.H., Morris G.Z., Corbin J.D. Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function. Int J Impot Res 2008, 20:333-342.
3. Stark S., Sachse R., Liedl T., Hensen J., Rohde G., Wensing G., Horstmann R., Schrott K.M. Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose. Eur Urol 2001, 40:181-190.
4. Rajagopalan P., Mazzu A., Xia C., Dawkins R., Sundaresan P. Effect of high-fat breakfast and moderate-fat evening meal on the pharmacokinetics of vardenafil, an oral phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction. Int J Clin Pharmacol 2003, 43:260-267.