An autonomous chemically fuelled small-molecule motor

Nature

Volumn 534, Issue 7606, 2016, Pages 235-240

  Wilson, Miriam R ^a   Solà, Jordi ^b   Carlone, Armando ^c   Goldup, Stephen M ^d   Lebrasseur, Nathalie ^e   Leigh, David A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^c Chirotech Technology Ltd   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

9 FLUORENYLMETHYL CHLOROFORMATE; CARBONIC ACID; CATENANE; DEUTERIUM; MACROCYCLIC COMPOUND; MOLECULAR MOTOR; PYRIDINE; ROTAXANE; TRIETHYLAMINE; 1-(9-FLUORENYL)METHYL CHLOROFORMATE; 9-FLUORENYLMETHOXYCARBONYL; FLUORENE DERIVATIVE; PYRIDINE DERIVATIVE;

CARBONATE; CATALYST; CHEMICAL COMPOUND; EQUIPMENT; HYDROLYSIS; MUSCLE; NANOTECHNOLOGY; PHOSPHATE;

ARTICLE; BINDING SITE; CATALYST; CHEMICAL REACTION; CONTROLLED STUDY; DERIVATIZATION; ELECTROSPRAY MASS SPECTROMETRY; HYDROLYSIS; NUCLEOPHILICITY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; CATALYSIS; CHEMISTRY; NANOTECHNOLOGY; ROTATION;

CATALYSIS; FLUORENES; MACROCYCLIC COMPOUNDS; NANOTECHNOLOGY; PYRIDINES; ROTATION;

EID: 84974577845     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature18013     Document Type: Article

References (33)

1. Schliwa, M. & Woehlke, G. Molecular motors. Nature 422, 759-765 (2003).
2. Erbas-Cakmak, S., Leigh, D. A., McTernan, C. T. & Nussbaumer, A. L. Artificial molecular machines. Chem. Rev. 115, 10081-10206 (2015).
3. Jiménez, M. C., Dietrich-Buchecker, C. & Sauvage, J.-P. Towards synthetic molecular muscles: contraction and stretching of a linear rotaxane dimer. Angew. Chem. Int. Ed. 39, 3284-3287 (2000).
4. Bruns, C. J. & Stoddart, J. F. Rotaxane-based molecular muscles. Acc. Chem. Res. 47, 2186-2199 (2014).
5. Thordarson, P., Bijsterveld, E. J. A., Rowan, A. E. & Nolte, R. J. M. Epoxidation of polybutadiene by a topologically linked catalyst. Nature 424, 915-918 (2003).
6. Lewandowski, B. et al. Sequence-specific peptide synthesis by an artificial small-molecule machine. Science 339, 189-193 (2013).
7. Serreli, V., Lee, C.-F., Kay, E. R. & Leigh, D. A. A molecular information ratchet. Nature 445, 523-527 (2007).
8. Ragazzon, G., Baroncini, M., Silvi, S., Venturi, M. & Credi, A. Light-powered autonomous and directional molecular motion of a dissipative self-assembling system. Nature Nanotechnol. 10, 70-75 (2014).
9. Cheng, C. et al. An artificial molecular pump. Nature Nanotechnol. 10, 547-553 (2015).
10. von Delius, M., Geertsema, E. M. & Leigh, D. A. A synthetic small molecule that can walk down a track. Nature Chem. 2, 96-101 (2010).
11. Kassem, S., Lee, A. T. L., Leigh, D. A., Markevicius, A. & Solà, J. Pick-up, transport and release of a molecular cargo using a small-molecule robotic arm. Nature Chem. 8, 138-143 (2016).
12. Koumura, N., Zijlstra, R. W. J., van Delden, R. A., Harada, N. & Feringa, B. L. Light-driven monodirectional molecular rotor. Nature 401, 152-155 (1999).
13. Eelkema, R. et al. Molecular machines: nanomotor rotates microscale objects. Nature 440, 163 (2006).
14. Greb, L. & Lehn, J.-M. Light-driven molecular motors: imines as four-step or two-step unidirectional rotors. J. Am. Chem. Soc. 136, 13114-13117 (2014).
15. Li, Q. et al. Macroscopic contraction of a gel induced by the integrated motion of light-driven molecular motors. Nature Nanotechnol. 10, 161-165 (2015).
16. Greb, L., Eichhöfer, A. & Lehn, J.-M. Synthetic molecular motors: thermal N inversion and directional photoinduced C=N bond rotation of camphorquinone imines. Angew. Chem. Int. Ed. 54, 14345-14348 (2015).
17. Tierney, H. L. et al. Experimental demonstration of a single-molecule electric motor. Nature Nanotechnol. 6, 625-629 (2011).
18. Perera, U. G. E. et al. Controlled clockwise and anticlockwise rotational switching of a molecular motor. Nature Nanotechnol. 8, 46-51 (2012).
19. Kay, E. R. & Leigh, D. A. Rise of the molecular machines. Angew. Chem. Int. Ed. 54, 10080-10088 (2015).
20. Astumian, R. D. Microscopic reversibility as the organizing principle of molecular machines. Nature Nanotechnol. 7, 684-688 (2012).
21. Feynman, R. P., Leighton, R. B. & Sands, M. The Feynman Lectures on Physics Vol. 1, Ch. 46 (Addison-Wesley, 1963).
22. Kelly, T. R., Tellitu, I. & Sestelo, J. P. In search of molecular ratchets. Angew. Chem. Int. Edn Engl. 36, 1866-1868 (1997).
23. Kelly, T. R., De Silva, H. & Silva, R. A. Unidirectional rotary motion in a molecular system. Nature 401, 150-152 (1999).
24. Kelly, T. R. et al. Progress toward a rationally designed, chemically powered rotary molecular motor. J. Am. Chem. Soc. 129, 376-386 (2007).
25. Leigh, D. A., Wong, J. K. Y., Dehez, F. & Zerbetto, F. Unidirectional rotation in a mechanically interlocked molecular rotor. Nature 424, 174-179 (2003).
26. Hernández, J. V., Kay, E. R. & Leigh, D. A. A reversible synthetic rotary molecular motor. Science 306, 1532-1537 (2004).
27. Fletcher, S. P., Dumur, F., Pollard, M. M. & Feringa, B. L. A reversible, unidirectional molecular rotary motor driven by chemical energy. Science 310, 80-82 (2005).
28. Haberhauer, G. A molecular four-stroke motor. Angew. Chem. Int. Ed. 50, 6415-6418 (2011).
29. Lu, C.-H., Cecconello, A., Elbaz, J., Credi, A. & Willner, I. A three-station DNA catenane rotary motor with controlled directionality. Nano Lett. 13, 2303-2308 (2013).
30. Davis, A. P. Tilting at windmills? The second law survives. Angew. Chem. Int. Ed. 37, 909-910 (1998).
31. Alvarez-Pérez, M., Goldup, S. M., Leigh, D. A. & Slawin, A. M. Z. A chemicallydriven molecular information ratchet. J. Am. Chem. Soc. 130, 1836-1838 (2008).
32. Carlone, A., Goldup, S. M., Lebrasseur, N., Leigh, D. A. & Wilson, A. A threecompartment chemically-driven molecular information ratchet. J. Am. Chem. Soc. 134, 8321-8323 (2012).
33. Cheng, C., McGonigal, P. R., Stoddart, J. F. & Astumian, R. D. Design and synthesis of nonequilibrium systems. ACS Nano 9, 8672-8688 (2015).