High prevalence of antimicrobial-resistant gram-negative colonization in hospitalized cambodian infants

Pediatric Infectious Disease Journal

Volumn 35, Issue 8, 2016, Pages 856-861

  Turner, Paul ^a,b,c   Pol, Sreymom ^a,b   Soeng, Sona ^a   Sar, Poda ^a   Neou, Leakhena ^a   Chea, Phal ^a   Day, Nicholas PJ ^a,b   Cooper, Ben S ^a,b   Turner, Claudia ^a,b,c  

^a Angkor Hospital for Children   (Cambodia)

^b MAHIDOL UNIVERSITY   (Thailand)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

antimicrobial resistance; colonization; Gram negative; infant; neonate

Indexed keywords

AMPICILLIN; CARBAPENEM; CEPHALOSPORIN; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; PROBIOTIC AGENT; ANTIINFECTIVE AGENT;

ACINETOBACTER INFECTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BLOOD CULTURE; CAMBODIAN; ESCHERICHIA COLI INFECTION; FEMALE; GRAM NEGATIVE INFECTION; GRAM NEGATIVE SEPSIS; HOSPITALIZATION; HOSPITALIZED INFANT; HUMAN; INFANT; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE INFECTION; LACTOBACILLUS ACIDOPHILUS; MAJOR CLINICAL STUDY; MALE; NECROTIZING ENTEROCOLITIS; NEWBORN; NEWBORN INTENSIVE CARE; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; CAMBODIA; CROSS INFECTION; DRUG EFFECT; GRAM NEGATIVE BACTERIUM; HETEROZYGOTE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PREVALENCE; TIME FACTOR;

ANTI-BACTERIAL AGENTS; CAMBODIA; CARRIER STATE; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; MALE; MICROBIAL SENSITIVITY TESTS; PREVALENCE; TIME FACTORS;

EID: 84973924472     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000001187     Document Type: Article

References (26)

1. Laxminarayan R, Duse A, Wattal C, et al. Antibiotic resistance-The need for global solutions. Lancet Infect Dis. 2013; 13: 1057-1098.
2. Zaidi AK, Huskins WC, Thaver D, et al. Hospital-Acquired neonatal infections in developing countries. Lancet. 2005; 365: 1175-1188.
3. Zaidi AK, Thaver D, Ali SA, et al. Pathogens associated with sepsis in newborns and young infants in developing countries. Pediatr Infect Dis J. 2009; 28(1 suppl): S10-S18.
4. Bizzarro MJ, Gallagher PG. Antibiotic-resistant organisms in the neonatal intensive care unit. Semin Perinatol. 2007; 31: 26-32.
5. Lubell Y, Ashley EA, Turner C, et al. Susceptibility of community-Acquired pathogens to antibiotics in Africa and Asia in neonates-An alarmingly short review. Trop Med InThealth. 2011; 16: 145-151.
6. Stoesser N, Moore CE, Pocock JM, et al. Pediatric bloodstream infections in Cambodia, 2007 to 2011. Pediatr Infect Dis J. 2013; 32: e272-e276.
7. Al-Taiar A, Hammoud MS, Cuiqing L, et al. Neonatal infections in China, Malaysia, Hong Kong and Thailand. Arch Dis Child Fetal Neonatal Ed. 2013; 98: F249-F255.
8. Tran HT, Doyle LW, Lee KJ, et al. A high burden of late-onset sepsis among newborns admitted to the largest neonatal unit in central Vietnam. J Perinatol. 2015; 35: 846-851.
9. Emary KR, Carter MJ, Pol S, et al. Urinary antibiotic activity in paediatric patients attending an outpatient department in north-western Cambodia. Trop Med InThealth. 2015; 20: 24-28.
10. Singh N, Patel KM, Léger MM, et al. Risk of resistant infections with Enterobacteriaceae in hospitalized neonates. Pediatr Infect Dis J. 2002; 21: 1029-1033.
11. Donskey CJ. The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens. Clin Infect Dis. 2004; 39: 219-226.
12. Mammina C, Di Carlo P, Cipolla D, et al. Surveillance of multidrug-resistant Gram-negative bacilli in a neonatal intensive care unit: prominent role of cross transmission. Am J Infect Control. 2007; 35: 222-230.
13. Das P, Singh AK, Pal T, et al. Colonization of the gut with Gram-negative bacilli, its association with neonatal sepsis and its clinical relevance in a developing country. J Med Microbiol. 2011; 60(pt 11): 1651-1660.
14. Shakil S, Akram M, Ali SM, et al. Acquisition of extended-spectrum betalactamase producing Escherichia coli strains in male and female infants admitted to a neonatal intensive care unit: molecular epidemiology and analysis of risk factors. J Med Microbiol. 2010; 59(pt 8): 948-954.
15. Parm U, Metsvaht T, Sepp E, et al. Risk factors associated with gut and nasopharyngeal colonization by common Gram-negative species and yeasts in neonatal intensive care units patients. Early Hum Dev. 2011; 87: 391-399.
16. Seale J, Millar M. Perinatal vertical transmission of antibiotic-resistant bacteria: a systematic review and proposed research strategy. BJOG. 2014; 121: 923-928.
17. Cambodia: Key Demographic Indicators. Available at: http://data.unicef. org/countries/KHM. Accessed August 12, 2015.
18. CLSI. Performance Standards for Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement. CLSI Document M100-S23. Wayne, PA: Clinical and Laboratory Standards Institute; 2013.
19. Macnow T, Otoole D, DeLaMora P, et al. Utility of surveillance cultures for antimicrobial resistant organisms in infants transferred to the neonatal intensive care unit. Pediatr Infect Dis J. 2013; 32: e443-e450.
20. Benenson S, Levin PD, Block C, et al. Continuous surveillance to reduce extended-spectrum β-lactamase Klebsiella pneumoniae colonization in the neonatal intensive care unit. Neonatology. 2013; 103: 155-160.
21. Rastogi S, Shah R, Perlman J, et al. Pattern of bacterial colonization in a new neonatal intensive care unit and its association with infections in infants. Am J Infect Control. 2012; 40: 512-515.
22. Hickey L, Jacobs SE, Garland SM; ProPrems Study Group. Probiotics in neonatology. J Paediatr Child Health. 2012; 48: 777-783.
23. Reuman PD, Duckworth DH, Smith KL, et al. Lack of effect of Lactobacillus on gastrointestinal bacterial colonization in premature infants. Pediatr Infect Dis. 1986; 5: 663-668.
24. Sung V, Hiscock H, Tang ML, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ. 2014; 348: g2107.
25. Anthony M, Bedford-Russell A, Cooper T, et al. Managing and preventing outbreaks of Gram-negative infections in UK neonatal units. Arch Dis Child Fetal Neonatal Ed. 2013; 98: F549-F553.
26. Stoesser N, Xayaheuang S, Vongsouvath M, et al. Colonization with Enterobacteriaceae producing ESBLs in children attending pre-school childcare facilities in the Lao People?s Democratic Republic. J Antimicrob Chemother. 2015; 70: 1893-1897.