-
1
-
-
84858702540
-
The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives
-
L. Chen, D.J. Magliano, and P.Z. Zimmet The worldwide epidemiology of type 2 diabetes mellitus-present and future perspectives Nat. Rev. Endocrinol. 8 4 2012 228 236
-
(2012)
Nat. Rev. Endocrinol.
, vol.8
, Issue.4
, pp. 228-236
-
-
Chen, L.1
Magliano, D.J.2
Zimmet, P.Z.3
-
2
-
-
19244365650
-
Thiazolidinediones
-
H. Yki-Jarvinen Thiazolidinediones N. Engl. J. Med. 351 11 2004 1106 1118
-
(2004)
N. Engl. J. Med.
, vol.351
, Issue.11
, pp. 1106-1118
-
-
Yki-Jarvinen, H.1
-
3
-
-
0020353926
-
Studies on antidiabetic agents II. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and its derivatives
-
T. Sohda, K. Mizuno, E. Imamiya, Y. Sugiyama, T. Fujita, and Y. Kawamatsu Studies on antidiabetic agents II. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and its derivatives Chem. Pharm. Bull. (Tokyo) 30 10 1982 3580 3600
-
(1982)
Chem. Pharm. Bull. (Tokyo)
, vol.30
, Issue.10
, pp. 3580-3600
-
-
Sohda, T.1
Mizuno, K.2
Imamiya, E.3
Sugiyama, Y.4
Fujita, T.5
Kawamatsu, Y.6
-
4
-
-
0020552510
-
Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent
-
T. Fujita, Y. Sugiyama, S. Taketomi, T. Sohda, Y. Kawamatsu, H. Iwatsuka, and Z. Suzuoki Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent Diabetes 32 9 1983 804 810
-
(1983)
Diabetes
, vol.32
, Issue.9
, pp. 804-810
-
-
Fujita, T.1
Sugiyama, Y.2
Taketomi, S.3
Sohda, T.4
Kawamatsu, Y.5
Iwatsuka, H.6
Suzuoki, Z.7
-
5
-
-
0024160854
-
Characterization of new oral antidiabetic agent CS-045: Studies in KK and ob/ob mice and Zucker fatty rats
-
T. Fujiwara, S. Yoshioka, T. Yoshioka, I. Ushiyama, and H. Horikoshi Characterization of new oral antidiabetic agent CS-045: studies in KK and ob/ob mice and Zucker fatty rats Diabetes 37 11 1988 1549 1558
-
(1988)
Diabetes
, vol.37
, Issue.11
, pp. 1549-1558
-
-
Fujiwara, T.1
Yoshioka, S.2
Yoshioka, T.3
Ushiyama, I.4
Horikoshi, H.5
-
6
-
-
0025055470
-
Studies on antidiabetic agents synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones
-
T. Sohda, Y. Momose, K. Meguro, Y. Kawamatsu, Y. Sugiyama, and H. Ikeda Studies on antidiabetic agents synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones Arzneimittelforschung 40 1 1990 37 42
-
(1990)
Arzneimittelforschung
, vol.40
, Issue.1
, pp. 37-42
-
-
Sohda, T.1
Momose, Y.2
Meguro, K.3
Kawamatsu, Y.4
Sugiyama, Y.5
Ikeda, H.6
-
7
-
-
0028076266
-
A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat
-
N.D. Oakes, C.J. Kennedy, A.B. Jenkins, D.R. Laybutt, D.J. Chisholm, and E.W. Kraegen A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat Diabetes 43 10 1994 1203 1210
-
(1994)
Diabetes
, vol.43
, Issue.10
, pp. 1203-1210
-
-
Oakes, N.D.1
Kennedy, C.J.2
Jenkins, A.B.3
Laybutt, D.R.4
Chisholm, D.J.5
Kraegen, E.W.6
-
8
-
-
0027988554
-
[Omega-(heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents
-
B.C. Cantello, M.A. Cawthorne, G.P. Cottam, P.T. Duff, D. Haigh, R.M. Hindley, C.A. Lister, S.A. Smith, and P.L. Thurlby [Omega-(heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents J. Med. Chem. 37 23 1994 3977 3985
-
(1994)
J. Med. Chem.
, vol.37
, Issue.23
, pp. 3977-3985
-
-
Cantello, B.C.1
Cawthorne, M.A.2
Cottam, G.P.3
Duff, P.T.4
Haigh, D.5
Hindley, R.M.6
Lister, C.A.7
Smith, S.A.8
Thurlby, P.L.9
-
9
-
-
0032568261
-
Hepatic dysfunction associated with troglitazone
-
P.B. Watkins, and R.W. Whitcomb Hepatic dysfunction associated with troglitazone N. Engl. J. Med. 338 13 1998 916 917
-
(1998)
N. Engl. J. Med.
, vol.338
, Issue.13
, pp. 916-917
-
-
Watkins, P.B.1
Whitcomb, R.W.2
-
10
-
-
77951457202
-
Fibrates, glitazones, and peroxisome proliferator-activated receptors
-
F. Lalloyer, and B. Staels Fibrates, glitazones, and peroxisome proliferator-activated receptors Arterioscler. Thromb. Vasc. Biol. 30 5 2010 894 899
-
(2010)
Arterioscler. Thromb. Vasc. Biol.
, vol.30
, Issue.5
, pp. 894-899
-
-
Lalloyer, F.1
Staels, B.2
-
11
-
-
84857719360
-
Update on cardiovascular safety of PPARgamma agonists and relevance to medicinal chemistry and clinical pharmacology
-
A. Ciudin, C. Hernandez, and R. Simo Update on cardiovascular safety of PPARgamma agonists and relevance to medicinal chemistry and clinical pharmacology Curr. Top. Med. Chem. 12 6 2012 585 604
-
(2012)
Curr. Top. Med. Chem.
, vol.12
, Issue.6
, pp. 585-604
-
-
Ciudin, A.1
Hernandez, C.2
Simo, R.3
-
12
-
-
34548580881
-
Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis
-
S. Singh, Y.K. Loke, and C.D. Furberg Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis JAMA 298 10 2007 1189 1195
-
(2007)
JAMA
, vol.298
, Issue.10
, pp. 1189-1195
-
-
Singh, S.1
Loke, Y.K.2
Furberg, C.D.3
-
13
-
-
77649144555
-
Pioglitazone: Side effect and safety profile
-
P. Shah, and S. Mudaliar Pioglitazone: side effect and safety profile Expert Opin. Drug Saf. 9 2 2010 347 354
-
(2010)
Expert Opin. Drug Saf.
, vol.9
, Issue.2
, pp. 347-354
-
-
Shah, P.1
Mudaliar, S.2
-
14
-
-
84938364689
-
Pioglitazone use and risk of bladder cancer and other common cancers in persons with diabetes
-
J.D. Lewis, L.A. Habel, C.P. Quesenberry, B.L. Strom, T. Peng, M.M. Hedderson, S.F. Ehrlich, R. Mamtani, W. Bilker, D.J. Vaughn, L. Nessel, S.K. Van Den Eeden, and A. Ferrara Pioglitazone use and risk of bladder cancer and other common cancers in persons with diabetes JAMA 314 3 2015 265 277
-
(2015)
JAMA
, vol.314
, Issue.3
, pp. 265-277
-
-
Lewis, J.D.1
Habel, L.A.2
Quesenberry, C.P.3
Strom, B.L.4
Peng, T.5
Hedderson, M.M.6
Ehrlich, S.F.7
Mamtani, R.8
Bilker, W.9
Vaughn, D.J.10
Nessel, L.11
Van Den Eeden, S.K.12
Ferrara, A.13
-
15
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
I. Issemann, and S. Green Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 347 6294 1990 645 650
-
(1990)
Nature
, vol.347
, Issue.6294
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
16
-
-
0026517010
-
Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors
-
C. Dreyer, G. Krey, H. Keller, F. Givel, G. Helftenbein, and W. Wahli Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors Cell 68 5 1992 879 887
-
(1992)
Cell
, vol.68
, Issue.5
, pp. 879-887
-
-
Dreyer, C.1
Krey, G.2
Keller, H.3
Givel, F.4
Helftenbein, G.5
Wahli, W.6
-
17
-
-
0027191040
-
CDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor
-
T. Sher, H.F. Yi, O.W. McBride, and F.J. Gonzalez cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor Biochemistry 32 21 1993 5598 5604
-
(1993)
Biochemistry
, vol.32
, Issue.21
, pp. 5598-5604
-
-
Sher, T.1
Yi, H.F.2
McBride, O.W.3
Gonzalez, F.J.4
-
18
-
-
0026785388
-
Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids
-
A. Schmidt, N. Endo, S.J. Rutledge, R. Vogel, D. Shinar, and G.A. Rodan Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids Mol. Endocrinol. 6 10 1992 1634 1641
-
(1992)
Mol. Endocrinol.
, vol.6
, Issue.10
, pp. 1634-1641
-
-
Schmidt, A.1
Endo, N.2
Rutledge, S.J.3
Vogel, R.4
Shinar, D.5
Rodan, G.A.6
-
19
-
-
0028832067
-
The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation
-
J.S. Qi, V. Desai-Yajnik, M.E. Greene, B.M. Raaka, and H.H. Samuels The ligand-binding domains of the thyroid hormone/retinoid receptor gene subfamily function in vivo to mediate heterodimerization, gene silencing, and transactivation Mol. Cell. Biol. 15 3 1995 1817 1825
-
(1995)
Mol. Cell. Biol.
, vol.15
, Issue.3
, pp. 1817-1825
-
-
Qi, J.S.1
Desai-Yajnik, V.2
Greene, M.E.3
Raaka, B.M.4
Samuels, H.H.5
-
20
-
-
84877329207
-
PPAR gamma signaling and metabolism: The good, the bad and the future
-
M. Ahmadian, J.M. Suh, N. Hah, C. Liddle, A.R. Atkins, M. Downes, and R.M. Evans PPAR gamma signaling and metabolism: the good, the bad and the future Nat. Med. 19 5 2013 557 566
-
(2013)
Nat. Med.
, vol.19
, Issue.5
, pp. 557-566
-
-
Ahmadian, M.1
Suh, J.M.2
Hah, N.3
Liddle, C.4
Atkins, A.R.5
Downes, M.6
Evans, R.M.7
-
21
-
-
33847413743
-
Nitric oxide activation of peroxisome proliferator-activated receptor gamma through a p38 MAPK signaling pathway
-
A. Ptasinska, S. Wang, J. Zhang, R.A. Wesley, and R.L. Danner Nitric oxide activation of peroxisome proliferator-activated receptor gamma through a p38 MAPK signaling pathway FASEB J. 21 3 2007 950 961
-
(2007)
FASEB J.
, vol.21
, Issue.3
, pp. 950-961
-
-
Ptasinska, A.1
Wang, S.2
Zhang, J.3
Wesley, R.A.4
Danner, R.L.5
-
22
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
-
P. Tontonoz, E. Hu, and B.M. Spiegelman Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor Cell 79 7 1994 1147 1156
-
(1994)
Cell
, vol.79
, Issue.7
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
23
-
-
0029016829
-
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
-
J.M. Lehmann, L.B. Moore, T.A. Smith-Oliver, W.O. Wilkison, T.M. Willson, and S.A. Kliewer An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma) J. Biol. Chem. 270 22 1995 12953 12956
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.22
, pp. 12953-12956
-
-
Lehmann, J.M.1
Moore, L.B.2
Smith-Oliver, T.A.3
Wilkison, W.O.4
Willson, T.M.5
Kliewer, S.A.6
-
24
-
-
0028972025
-
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
-
B.M. Forman, P. Tontonoz, J. Chen, R.P. Brun, B.M. Spiegelman, and R.M. Evans 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma Cell 83 5 1995 803 812
-
(1995)
Cell
, vol.83
, Issue.5
, pp. 803-812
-
-
Forman, B.M.1
Tontonoz, P.2
Chen, J.3
Brun, R.P.4
Spiegelman, B.M.5
Evans, R.M.6
-
25
-
-
0032568310
-
Effect of troglitazone in insulin-treated patients with type II diabetes mellitus: Troglitazone and Exogenous Insulin Study Group
-
S. Schwartz, P. Raskin, V. Fonseca, and J.F. Graveline Effect of troglitazone in insulin-treated patients with type II diabetes mellitus: troglitazone and Exogenous Insulin Study Group N. Engl. J. Med. 338 13 1998 861 866
-
(1998)
N. Engl. J. Med.
, vol.338
, Issue.13
, pp. 861-866
-
-
Schwartz, S.1
Raskin, P.2
Fonseca, V.3
Graveline, J.F.4
-
26
-
-
0032568257
-
Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus
-
S.E. Inzucchi, D.G. Maggs, G.R. Spollett, S.L. Page, F.S. Rife, V. Walton, and G.I. Shulman Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus N. Engl. J. Med. 338 13 1998 867 872
-
(1998)
N. Engl. J. Med.
, vol.338
, Issue.13
, pp. 867-872
-
-
Inzucchi, S.E.1
Maggs, D.G.2
Spollett, G.R.3
Page, S.L.4
Rife, F.S.5
Walton, V.6
Shulman, G.I.7
-
27
-
-
0142186679
-
Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPAR gamma
-
L.C. Bell-Parikh, T. Ide, J.A. Lawson, P. McNamara, M. Reilly, and G.A. FitzGerald Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPAR gamma J. Clin. Invest. 112 6 2003 945 955
-
(2003)
J. Clin. Invest.
, vol.112
, Issue.6
, pp. 945-955
-
-
Bell-Parikh, L.C.1
Ide, T.2
Lawson, J.A.3
McNamara, P.4
Reilly, M.5
FitzGerald, G.A.6
-
28
-
-
0006132932
-
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
-
S.A. Kliewer, S.S. Sundseth, S.A. Jones, P.J. Brown, G.B. Wisely, C.S. Koble, P. Devchand, W. Wahli, T.M. Willson, J.M. Lenhard, and J.M. Lehmann Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma Proc. Natl. Acad. Sci. U.S.A. 94 9 1997 4318 4323
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, Issue.9
, pp. 4318-4323
-
-
Kliewer, S.A.1
Sundseth, S.S.2
Jones, S.A.3
Brown, P.J.4
Wisely, G.B.5
Koble, C.S.6
Devchand, P.7
Wahli, W.8
Willson, T.M.9
Lenhard, J.M.10
Lehmann, J.M.11
-
29
-
-
0037330414
-
PPAR gamma agonists in the treatment of type II diabetes: Is increased fatness commensurate with long-term efficacy?
-
T.M. Larsen, S. Toubro, and A. Astrup PPAR gamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy? Int. J. Obes. Relat. Metab. Disord. 27 2 2003 147 161
-
(2003)
Int. J. Obes. Relat. Metab. Disord.
, vol.27
, Issue.2
, pp. 147-161
-
-
Larsen, T.M.1
Toubro, S.2
Astrup, A.3
-
30
-
-
0032540325
-
Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR gamma
-
L. Nagy, P. Tontonoz, J.G. Alvarez, H. Chen, and R.M. Evans Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR gamma Cell 93 2 1998 229 240
-
(1998)
Cell
, vol.93
, Issue.2
, pp. 229-240
-
-
Nagy, L.1
Tontonoz, P.2
Alvarez, J.G.3
Chen, H.4
Evans, R.M.5
-
31
-
-
0035408779
-
A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes
-
P. Raskin, M. Rendell, M.C. Riddle, J.F. Dole, M.I. Freed, J. Rosenstock, and Rosiglitazone Clinical Trials Study Group A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin-treated type 2 diabetes Diabetes Care 24 7 2001 1226 1232
-
(2001)
Diabetes Care
, vol.24
, Issue.7
, pp. 1226-1232
-
-
Raskin, P.1
Rendell, M.2
Riddle, M.C.3
Dole, J.F.4
Freed, M.I.5
Rosenstock, J.6
Clinical Trials Study Group, R.7
-
32
-
-
0033754530
-
Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: A 6-month randomized placebo-controlled dose-response study. The Pioglitazone 001 Study Group
-
S. Aronoff, S. Rosenblatt, S. Braithwaite, J.W. Egan, A.L. Mathisen, and R.L. Schneider Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. The Pioglitazone 001 Study Group Diabetes Care 23 11 2000 1605 1611
-
(2000)
Diabetes Care
, vol.23
, Issue.11
, pp. 1605-1611
-
-
Aronoff, S.1
Rosenblatt, S.2
Braithwaite, S.3
Egan, J.W.4
Mathisen, A.L.5
Schneider, R.L.6
-
33
-
-
43249096938
-
Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: A randomized, placebo-controlled trial
-
D. Glintborg, M. Andersen, C. Hagen, L. Heickendorff, and A.P. Hermann Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: a randomized, placebo-controlled trial J. Clin. Endocrinol. Metab. 93 5 2008 1696 1701
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, Issue.5
, pp. 1696-1701
-
-
Glintborg, D.1
Andersen, M.2
Hagen, C.3
Heickendorff, L.4
Hermann, A.P.5
-
34
-
-
79955692835
-
A role for central nervous system PPAR-gamma in the regulation of energy balance
-
K.K. Ryan, B. Li, B.E. Grayson, E.K. Matter, S.C. Woods, and R.J. Seeley A role for central nervous system PPAR-gamma in the regulation of energy balance Nat. Med. 17 5 2011 623 626
-
(2011)
Nat. Med.
, vol.17
, Issue.5
, pp. 623-626
-
-
Ryan, K.K.1
Li, B.2
Grayson, B.E.3
Matter, E.K.4
Woods, S.C.5
Seeley, R.J.6
-
35
-
-
79955694276
-
Brain PPAR-gamma promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones
-
M. Lu, D.A. Sarruf, S. Talukdar, S. Sharma, P. Li, G. Bandyopadhyay, S. Nalbandian, W. Fan, J.R. Gayen, S.K. Mahata, N.J. Webster, M.W. Schwartz, and J.M. Olefsky Brain PPAR-gamma promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones Nat. Med. 17 5 2011 618 622
-
(2011)
Nat. Med.
, vol.17
, Issue.5
, pp. 618-622
-
-
Lu, M.1
Sarruf, D.A.2
Talukdar, S.3
Sharma, S.4
Li, P.5
Bandyopadhyay, G.6
Nalbandian, S.7
Fan, W.8
Gayen, J.R.9
Mahata, S.K.10
Webster, N.J.11
Schwartz, M.W.12
Olefsky, J.M.13
-
36
-
-
23844472901
-
Thiazolidinediones expand body fluid volume through PPAR gamma stimulation of ENaC-mediated renal salt absorption
-
Y. Guan, C. Hao, D.R. Cha, R. Rao, W. Lu, D.E. Kohan, M.A. Magnuson, R. Redha, Y. Zhang, and M.D. Breyer Thiazolidinediones expand body fluid volume through PPAR gamma stimulation of ENaC-mediated renal salt absorption Nat. Med. 11 8 2005 861 866
-
(2005)
Nat. Med.
, vol.11
, Issue.8
, pp. 861-866
-
-
Guan, Y.1
Hao, C.2
Cha, D.R.3
Rao, R.4
Lu, W.5
Kohan, D.E.6
Magnuson, M.A.7
Redha, R.8
Zhang, Y.9
Breyer, M.D.10
-
37
-
-
84857714626
-
Peroxisome proliferator-activated receptor-gamma agonists repress epithelial sodium channel expression in the kidney
-
E. Borsting, V.P. Cheng, C.K. Glass, V. Vallon, and R. Cunard Peroxisome proliferator-activated receptor-gamma agonists repress epithelial sodium channel expression in the kidney Am. J. Physiol. Renal Physiol. 302 5 2012 F540 551
-
(2012)
Am. J. Physiol. Renal Physiol.
, vol.302
, Issue.5
, pp. F540-551
-
-
Borsting, E.1
Cheng, V.P.2
Glass, C.K.3
Vallon, V.4
Cunard, R.5
-
38
-
-
36849034568
-
PPAR-gamma regulates osteoclastogenesis in mice
-
Y. Wan, L.W. Chong, and R.M. Evans PPAR-gamma regulates osteoclastogenesis in mice Nat. Med. 13 12 2007 1496 1503
-
(2007)
Nat. Med.
, vol.13
, Issue.12
, pp. 1496-1503
-
-
Wan, Y.1
Chong, L.W.2
Evans, R.M.3
-
39
-
-
14244250617
-
Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation
-
A.A. Ali, R.S. Weinstein, S.A. Stewart, A.M. Parfitt, S.C. Manolagas, and R.L. Jilka Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation Endocrinology 146 3 2005 1226 1235
-
(2005)
Endocrinology
, vol.146
, Issue.3
, pp. 1226-1235
-
-
Ali, A.A.1
Weinstein, R.S.2
Stewart, S.A.3
Parfitt, A.M.4
Manolagas, S.C.5
Jilka, R.L.6
-
40
-
-
77956408841
-
PGC1 beta mediates PPAR gamma activation of osteoclastogenesis and rosiglitazone-induced bone loss
-
W. Wei, X. Wang, M. Yang, L.C. Smith, P.C. Dechow, J. Sonoda, R.M. Evans, and Y. Wan PGC1 beta mediates PPAR gamma activation of osteoclastogenesis and rosiglitazone-induced bone loss Cell Metab. 11 6 2010 503 516
-
(2010)
Cell Metab.
, vol.11
, Issue.6
, pp. 503-516
-
-
Wei, W.1
Wang, X.2
Yang, M.3
Smith, L.C.4
Dechow, P.C.5
Sonoda, J.6
Evans, R.M.7
Wan, Y.8
-
41
-
-
0031898610
-
PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
-
B.M. Spiegelman PPAR-gamma: adipogenic regulator and thiazolidinedione receptor Diabetes 47 4 1998 507 514
-
(1998)
Diabetes
, vol.47
, Issue.4
, pp. 507-514
-
-
Spiegelman, B.M.1
-
42
-
-
0034121698
-
Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene
-
M. Li, G. Pascual, and C.K. Glass Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene Mol. Cell. Biol. 20 13 2000 4699 4707
-
(2000)
Mol. Cell. Biol.
, vol.20
, Issue.13
, pp. 4699-4707
-
-
Li, M.1
Pascual, G.2
Glass, C.K.3
-
43
-
-
26444471700
-
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
-
G. Pascual, A.L. Fong, S. Ogawa, A. Gamliel, A.C. Li, V. Perissi, D.W. Rose, T.M. Willson, M.G. Rosenfeld, and C.K. Glass A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma Nature 437 7059 2005 759 763
-
(2005)
Nature
, vol.437
, Issue.7059
, pp. 759-763
-
-
Pascual, G.1
Fong, A.L.2
Ogawa, S.3
Gamliel, A.4
Li, A.C.5
Perissi, V.6
Rose, D.W.7
Willson, T.M.8
Rosenfeld, M.G.9
Glass, C.K.10
-
44
-
-
77951221502
-
Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature?
-
P. Ketsawatsomkron, C.J. Pelham, S. Groh, H.L. Keen, F.M. Faraci, and C.D. Sigmund Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature? J. Biol. Chem. 285 13 2010 9311 9316
-
(2010)
J. Biol. Chem.
, vol.285
, Issue.13
, pp. 9311-9316
-
-
Ketsawatsomkron, P.1
Pelham, C.J.2
Groh, S.3
Keen, H.L.4
Faraci, F.M.5
Sigmund, C.D.6
-
45
-
-
84875371292
-
Peroxisome proliferator-activated receptor-gamma mutations responsible for lipodystrophy with severe hypertension activate the cellular renin-angiotensin system
-
M. Auclair, C. Vigouroux, F. Boccara, E. Capel, C. Vigeral, B. Guerci, O. Lascols, J. Capeau, and M. Caron-Debarle Peroxisome proliferator-activated receptor-gamma mutations responsible for lipodystrophy with severe hypertension activate the cellular renin-angiotensin system Arterioscler. Thromb. Vasc. Biol. 33 4 2013 829 838
-
(2013)
Arterioscler. Thromb. Vasc. Biol.
, vol.33
, Issue.4
, pp. 829-838
-
-
Auclair, M.1
Vigouroux, C.2
Boccara, F.3
Capel, E.4
Vigeral, C.5
Guerci, B.6
Lascols, O.7
Capeau, J.8
Caron-Debarle, M.9
-
46
-
-
21544466158
-
A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
-
R.B. Goldberg, D.M. Kendall, M.A. Deeg, J.B. Buse, A.J. Zagar, J.A. Pinaire, M.H. Tan, M.A. Khan, A.T. Perez, S.J. Jacober, and G.S. Investigators A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia Diabetes Care 28 7 2005 1547 1554
-
(2005)
Diabetes Care
, vol.28
, Issue.7
, pp. 1547-1554
-
-
Goldberg, R.B.1
Kendall, D.M.2
Deeg, M.A.3
Buse, J.B.4
Zagar, A.J.5
Pinaire, J.A.6
Tan, M.H.7
Khan, M.A.8
Perez, A.T.9
Jacober, S.J.10
-
47
-
-
84869754865
-
Endothelial cell peroxisome proliferator-activated receptor gamma reduces endotoxemic pulmonary inflammation and injury
-
A.T. Reddy, S.P. Lakshmi, J.M. Kleinhenz, R.L. Sutliff, C.M. Hart, and R.C. Reddy Endothelial cell peroxisome proliferator-activated receptor gamma reduces endotoxemic pulmonary inflammation and injury J. Immunol. 189 11 2012 5411 5420
-
(2012)
J. Immunol.
, vol.189
, Issue.11
, pp. 5411-5420
-
-
Reddy, A.T.1
Lakshmi, S.P.2
Kleinhenz, J.M.3
Sutliff, R.L.4
Hart, C.M.5
Reddy, R.C.6
-
48
-
-
83655167182
-
Disruption of endothelial peroxisome proliferator-activated receptor gamma accelerates diet-induced atherogenesis in LDL receptor-null mice
-
A. Qu, Y.M. Shah, S.K. Manna, and F.J. Gonzalez Disruption of endothelial peroxisome proliferator-activated receptor gamma accelerates diet-induced atherogenesis in LDL receptor-null mice Arterioscler. Thromb. Vasc. Biol. 32 1 2012 65 73
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, Issue.1
, pp. 65-73
-
-
Qu, A.1
Shah, Y.M.2
Manna, S.K.3
Gonzalez, F.J.4
-
49
-
-
80053930190
-
15-Deoxy-delta(1)(2),(1)(4) prostaglandin J(2) reduces the formation of atherosclerotic lesions in apolipoprotein e knockout mice
-
T. Seno, M. Hamaguchi, E. Ashihara, M. Kohno, H. Ishino, A. Yamamoto, M. Kadoya, K. Nakamura, K. Murakami, S. Matoba, T. Maekawa, and Y. Kawahito 15-Deoxy-delta(1)(2),(1)(4) prostaglandin J(2) reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice PLoS One 6 10 2011 e25541
-
(2011)
PLoS One
, vol.6
, Issue.10
, pp. e25541
-
-
Seno, T.1
Hamaguchi, M.2
Ashihara, E.3
Kohno, M.4
Ishino, H.5
Yamamoto, A.6
Kadoya, M.7
Nakamura, K.8
Murakami, K.9
Matoba, S.10
Maekawa, T.11
Kawahito, Y.12
-
50
-
-
43049092988
-
An antiproliferative BMP-2/PPAR gamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension
-
G. Hansmann, V.A. de Jesus Perez, T.P. Alastalo, C.M. Alvira, C. Guignabert, J.M. Bekker, S. Schellong, T. Urashima, L. Wang, N.W. Morrell, and M. Rabinovitch An antiproliferative BMP-2/PPAR gamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension J. Clin. Invest. 118 5 2008 1846 1857
-
(2008)
J. Clin. Invest.
, vol.118
, Issue.5
, pp. 1846-1857
-
-
Hansmann, G.1
De Jesus Perez, V.A.2
Alastalo, T.P.3
Alvira, C.M.4
Guignabert, C.5
Bekker, J.M.6
Schellong, S.7
Urashima, T.8
Wang, L.9
Morrell, N.W.10
Rabinovitch, M.11
-
51
-
-
84870253088
-
Peroxisome proliferator-activated receptor-gamma ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor
-
Y. Liu, X.Y. Tian, G. Mao, X. Fang, M.L. Fung, J.Y. Shyy, Y. Huang, and N. Wang Peroxisome proliferator-activated receptor-gamma ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor Hypertension 60 6 2012 1471 1478
-
(2012)
Hypertension
, vol.60
, Issue.6
, pp. 1471-1478
-
-
Liu, Y.1
Tian, X.Y.2
Mao, G.3
Fang, X.4
Fung, M.L.5
Shyy, J.Y.6
Huang, Y.7
Wang, N.8
-
52
-
-
0033599038
-
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
-
I. Barroso, M. Gurnell, V.E. Crowley, M. Agostini, J.W. Schwabe, M.A. Soos, G.L. Maslen, T.D. Williams, H. Lewis, A.J. Schafer, V.K. Chatterjee, and S. O'Rahilly Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension Nature 402 6764 1999 880 883
-
(1999)
Nature
, vol.402
, Issue.6764
, pp. 880-883
-
-
Barroso, I.1
Gurnell, M.2
Crowley, V.E.3
Agostini, M.4
Schwabe, J.W.5
Soos, M.A.6
Maslen, G.L.7
Williams, T.D.8
Lewis, H.9
Schafer, A.J.10
Chatterjee, V.K.11
O'Rahilly, S.12
-
53
-
-
79957945650
-
Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-gamma
-
M. Jain, G.R. Budinger, A. Lo, D. Urich, S.E. Rivera, A.K. Ghosh, A. Gonzalez, S.E. Chiarella, K. Marks, H.K. Donnelly, S. Soberanes, J. Varga, K.A. Radigan, N.S. Chandel, and G.M. Mutlu Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-gamma Am. J. Respir. Crit. Care Med. 183 11 2011 1490 1498
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.183
, Issue.11
, pp. 1490-1498
-
-
Jain, M.1
Budinger, G.R.2
Lo, A.3
Urich, D.4
Rivera, S.E.5
Ghosh, A.K.6
Gonzalez, A.7
Chiarella, S.E.8
Marks, K.9
Donnelly, H.K.10
Soberanes, S.11
Varga, J.12
Radigan, K.A.13
Chandel, N.S.14
Mutlu, G.M.15
-
54
-
-
21744458404
-
15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock
-
J.M. Kaplan, J.A. Cook, P.W. Hake, M. O'Connor, T.J. Burroughs, and B. Zingarelli 15-Deoxy-delta(12,14)-prostaglandin J(2) (15D-PGJ(2)), a peroxisome proliferator activated receptor gamma ligand, reduces tissue leukosequestration and mortality in endotoxic shock Shock 24 1 2005 59 65
-
(2005)
Shock
, vol.24
, Issue.1
, pp. 59-65
-
-
Kaplan, J.M.1
Cook, J.A.2
Hake, P.W.3
O'Connor, M.4
Burroughs, T.J.5
Zingarelli, B.6
-
55
-
-
78650781526
-
Rosiglitazone ameliorates endotoxin-induced organ damage in conscious rats
-
W.T. Wu, C.C. Lee, C.J. Lee, Y.M. Subeq, R.P. Lee, and B.G. Hsu Rosiglitazone ameliorates endotoxin-induced organ damage in conscious rats Biol. Res. Nurs. 13 1 2011 38 43
-
(2011)
Biol. Res. Nurs.
, vol.13
, Issue.1
, pp. 38-43
-
-
Wu, W.T.1
Lee, C.C.2
Lee, C.J.3
Subeq, Y.M.4
Lee, R.P.5
Hsu, B.G.6
-
56
-
-
63249107417
-
Convergence of nitric oxide and lipid signaling: Anti-inflammatory nitro-fatty acids
-
P.R. Baker, F.J. Schopfer, V.B. O'Donnell, and B.A. Freeman Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids Free Radic. Biol. Med. 46 8 2009 989 1003
-
(2009)
Free Radic. Biol. Med.
, vol.46
, Issue.8
, pp. 989-1003
-
-
Baker, P.R.1
Schopfer, F.J.2
O'Donnell, V.B.3
Freeman, B.A.4
-
57
-
-
29644433449
-
Fatty acid transduction of nitric oxide signaling: Multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands
-
P.R. Baker, Y. Lin, F.J. Schopfer, S.R. Woodcock, A.L. Groeger, C. Batthyany, S. Sweeney, M.H. Long, K.E. Iles, L.M. Baker, B.P. Branchaud, Y.E. Chen, and B.A. Freeman Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands J. Biol. Chem. 280 51 2005 42464 42475
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.51
, pp. 42464-42475
-
-
Baker, P.R.1
Lin, Y.2
Schopfer, F.J.3
Woodcock, S.R.4
Groeger, A.L.5
Batthyany, C.6
Sweeney, S.7
Long, M.H.8
Iles, K.E.9
Baker, L.M.10
Branchaud, B.P.11
Chen, Y.E.12
Freeman, B.A.13
-
58
-
-
14044275170
-
Nitrolinoleic acid: An endogenous peroxisome proliferator-activated receptor gamma ligand
-
F.J. Schopfer, Y. Lin, P.R. Baker, T. Cui, M. Garcia-Barrio, J. Zhang, K. Chen, Y.E. Chen, and B.A. Freeman Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand Proc. Natl. Acad. Sci. U.S.A. 102 7 2005 2340 2345
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, Issue.7
, pp. 2340-2345
-
-
Schopfer, F.J.1
Lin, Y.2
Baker, P.R.3
Cui, T.4
Garcia-Barrio, M.5
Zhang, J.6
Chen, K.7
Chen, Y.E.8
Freeman, B.A.9
-
59
-
-
77955391741
-
Effects of endogenous PPAR agonist nitro-oleic acid on metabolic syndrome in obese zucker rats
-
H. Wang, H. Liu, Z. Jia, G. Guan, and T. Yang Effects of endogenous PPAR agonist nitro-oleic acid on metabolic syndrome in obese zucker rats PPAR Res. 2010 2010 601562
-
(2010)
PPAR Res.
, vol.2010
, pp. 601562
-
-
Wang, H.1
Liu, H.2
Jia, Z.3
Guan, G.4
Yang, T.5
-
60
-
-
47049101575
-
Nitro-fatty acid formation and signaling
-
B.A. Freeman, P.R. Baker, F.J. Schopfer, S.R. Woodcock, A. Napolitano, and M. d'Ischia Nitro-fatty acid formation and signaling J. Biol. Chem. 283 23 2008 15515 15519
-
(2008)
J. Biol. Chem.
, vol.283
, Issue.23
, pp. 15515-15519
-
-
Freeman, B.A.1
Baker, P.R.2
Schopfer, F.J.3
Woodcock, S.R.4
Napolitano, A.5
D'Ischia, M.6
-
61
-
-
77951242122
-
Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: Selective ligand activity and anti-diabetic signaling actions
-
F.J. Schopfer, M.P. Cole, A.L. Groeger, C.S. Chen, N.K. Khoo, S.R. Woodcock, F. Golin-Bisello, U.N. Motanya, Y. Li, J. Zhang, M.T. Garcia-Barrio, T.K. Rudolph, V. Rudolph, G. Bonacci, P.R. Baker, H.E. Xu, C.I. Batthyany, Y.E. Chen, T.M. Hallis, and B.A. Freeman Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actions J. Biol. Chem. 285 16 2010 12321 12333
-
(2010)
J. Biol. Chem.
, vol.285
, Issue.16
, pp. 12321-12333
-
-
Schopfer, F.J.1
Cole, M.P.2
Groeger, A.L.3
Chen, C.S.4
Khoo, N.K.5
Woodcock, S.R.6
Golin-Bisello, F.7
Motanya, U.N.8
Li, Y.9
Zhang, J.10
Garcia-Barrio, M.T.11
Rudolph, T.K.12
Rudolph, V.13
Bonacci, G.14
Baker, P.R.15
Xu, H.E.16
Batthyany, C.I.17
Chen, Y.E.18
Hallis, T.M.19
Freeman, B.A.20
more..
-
62
-
-
51349100657
-
Structural basis for the activation of PPAR gamma by oxidized fatty acids
-
T. Itoh, L. Fairall, K. Amin, Y. Inaba, A. Szanto, B.L. Balint, L. Nagy, K. Yamamoto, and J.W. Schwabe Structural basis for the activation of PPAR gamma by oxidized fatty acids Nat. Struct. Mol. Biol. 15 9 2008 924 931
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, Issue.9
, pp. 924-931
-
-
Itoh, T.1
Fairall, L.2
Amin, K.3
Inaba, Y.4
Szanto, A.5
Balint, B.L.6
Nagy, L.7
Yamamoto, K.8
Schwabe, J.W.9
-
63
-
-
84867386090
-
The nitrated fatty acid 10-nitro-oleate diminishes severity of LPS-induced acute lung injury in mice
-
A.T. Reddy, S.P. Lakshmi, and R.C. Reddy The nitrated fatty acid 10-nitro-oleate diminishes severity of LPS-induced acute lung injury in mice PPAR Res. 2012 2012 617063
-
(2012)
PPAR Res.
, vol.2012
, pp. 617063
-
-
Reddy, A.T.1
Lakshmi, S.P.2
Reddy, R.C.3
-
64
-
-
84883382596
-
The nitrated fatty acid 10-nitro-oleate attenuates allergic airway disease
-
A.T. Reddy, S.P. Lakshmi, S. Dornadula, S. Pinni, D.R. Rampa, and R.C. Reddy The nitrated fatty acid 10-nitro-oleate attenuates allergic airway disease J. Immunol. 191 5 2013 2053 2063
-
(2013)
J. Immunol.
, vol.191
, Issue.5
, pp. 2053-2063
-
-
Reddy, A.T.1
Lakshmi, S.P.2
Dornadula, S.3
Pinni, S.4
Rampa, D.R.5
Reddy, R.C.6
-
65
-
-
74149084013
-
Nitrated oleic acid up-regulates PPAR gamma and attenuates experimental inflammatory bowel disease
-
S. Borniquel, E.A. Jansson, M.P. Cole, B.A. Freeman, and J.O. Lundberg Nitrated oleic acid up-regulates PPAR gamma and attenuates experimental inflammatory bowel disease Free Radic. Biol. Med. 48 4 2010 499 505
-
(2010)
Free Radic. Biol. Med.
, vol.48
, Issue.4
, pp. 499-505
-
-
Borniquel, S.1
Jansson, E.A.2
Cole, M.P.3
Freeman, B.A.4
Lundberg, J.O.5
-
66
-
-
0036721606
-
Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst
-
A. Von Knethen, and B. Brune Activation of peroxisome proliferator-activated receptor gamma by nitric oxide in monocytes/macrophages down-regulates p47phox and attenuates the respiratory burst J. Immunol. 169 5 2002 2619 2626
-
(2002)
J. Immunol.
, vol.169
, Issue.5
, pp. 2619-2626
-
-
Von Knethen, A.1
Brune, B.2
-
67
-
-
0037323398
-
Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis
-
K. Hata, R. Nishimura, F. Ikeda, K. Yamashita, T. Matsubara, T. Nokubi, and T. Yoneda Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis Mol. Biol. Cell 14 2 2003 545 555
-
(2003)
Mol. Biol. Cell
, vol.14
, Issue.2
, pp. 545-555
-
-
Hata, K.1
Nishimura, R.2
Ikeda, F.3
Yamashita, K.4
Matsubara, T.5
Nokubi, T.6
Yoneda, T.7
-
68
-
-
75149173154
-
The role of ATF-2 family transcription factors in adipocyte differentiation: Antiobesity effects of p38 inhibitors
-
T. Maekawa, W. Jin, and S. Ishii The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors Mol. Cell. Biol. 30 3 2010 613 625
-
(2010)
Mol. Cell. Biol.
, vol.30
, Issue.3
, pp. 613-625
-
-
Maekawa, T.1
Jin, W.2
Ishii, S.3
-
69
-
-
36549069731
-
P38MAP Kinase activity is required for human primary adipocyte differentiation
-
M. Aouadi, J. Jager, K. Laurent, T. Gonzalez, M. Cormont, B. Binetruy, Y. Le Marchand-Brustel, J.F. Tanti, and F. Bost p38MAP Kinase activity is required for human primary adipocyte differentiation FEBS Lett. 581 29 2007 5591 5596
-
(2007)
FEBS Lett.
, vol.581
, Issue.29
, pp. 5591-5596
-
-
Aouadi, M.1
Jager, J.2
Laurent, K.3
Gonzalez, T.4
Cormont, M.5
Binetruy, B.6
Le Marchand-Brustel, Y.7
Tanti, J.F.8
Bost, F.9
-
70
-
-
0033544862
-
Constitutively active mitogen-activated protein kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis
-
J.A. Engelman, A.H. Berg, R.Y. Lewis, A. Lin, M.P. Lisanti, and P.E. Scherer Constitutively active mitogen-activated protein kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis J. Biol. Chem. 274 50 1999 35630 35638
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.50
, pp. 35630-35638
-
-
Engelman, J.A.1
Berg, A.H.2
Lewis, R.Y.3
Lin, A.4
Lisanti, M.P.5
Scherer, P.E.6
-
71
-
-
1642293248
-
P38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
-
W. Cao, K.W. Daniel, J. Robidoux, P. Puigserver, A.V. Medvedev, X. Bai, L.M. Floering, B.M. Spiegelman, and S. Collins p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene Mol. Cell. Biol. 24 7 2004 3057 3067
-
(2004)
Mol. Cell. Biol.
, vol.24
, Issue.7
, pp. 3057-3067
-
-
Cao, W.1
Daniel, K.W.2
Robidoux, J.3
Puigserver, P.4
Medvedev, A.V.5
Bai, X.6
Floering, L.M.7
Spiegelman, B.M.8
Collins, S.9
-
72
-
-
84905844118
-
Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism
-
Y. Zhang, H. Guo, J.A. Deis, M.G. Mashek, M. Zhao, D. Ariyakumar, A.G. Armien, D.A. Bernlohr, D.G. Mashek, and X. Chen Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism J. Biol. Chem. 289 32 2014 22063 22077
-
(2014)
J. Biol. Chem.
, vol.289
, Issue.32
, pp. 22063-22077
-
-
Zhang, Y.1
Guo, H.2
Deis, J.A.3
Mashek, M.G.4
Zhao, M.5
Ariyakumar, D.6
Armien, A.G.7
Bernlohr, D.A.8
Mashek, D.G.9
Chen, X.10
-
73
-
-
18244399631
-
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPAR gamma coactivator-1
-
P. Puigserver, J. Rhee, J. Lin, Z. Wu, J.C. Yoon, C.Y. Zhang, S. Krauss, V.K. Mootha, B.B. Lowell, and B.M. Spiegelman Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPAR gamma coactivator-1 Mol. Cell 8 5 2001 971 982
-
(2001)
Mol. Cell
, vol.8
, Issue.5
, pp. 971-982
-
-
Puigserver, P.1
Rhee, J.2
Lin, J.3
Wu, Z.4
Yoon, J.C.5
Zhang, C.Y.6
Krauss, S.7
Mootha, V.K.8
Lowell, B.B.9
Spiegelman, B.M.10
-
74
-
-
10744222588
-
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: Modulation by p38 MAPK
-
M. Fan, J. Rhee, J. St-Pierre, C. Handschin, P. Puigserver, J. Lin, S. Jaeger, H. Erdjument-Bromage, P. Tempst, and B.M. Spiegelman Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK Genes Dev. 18 3 2004 278 289
-
(2004)
Genes Dev.
, vol.18
, Issue.3
, pp. 278-289
-
-
Fan, M.1
Rhee, J.2
St-Pierre, J.3
Handschin, C.4
Puigserver, P.5
Lin, J.6
Jaeger, S.7
Erdjument-Bromage, H.8
Tempst, P.9
Spiegelman, B.M.10
-
75
-
-
0037414826
-
Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes
-
T. Teruel, R. Hernandez, M. Benito, and M. Lorenzo Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes J. Biol. Chem. 278 1 2003 263 269
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.1
, pp. 263-269
-
-
Teruel, T.1
Hernandez, R.2
Benito, M.3
Lorenzo, M.4
-
76
-
-
58949098466
-
Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase
-
M.R. Bratton, D.E. Frigo, K.A. Vigh-Conrad, D. Fan, S. Wadsworth, J.A. McLachlan, and M.E. Burow Organochlorine-mediated potentiation of the general coactivator p300 through p38 mitogen-activated protein kinase Carcinogenesis 30 1 2009 106 113
-
(2009)
Carcinogenesis
, vol.30
, Issue.1
, pp. 106-113
-
-
Bratton, M.R.1
Frigo, D.E.2
Vigh-Conrad, K.A.3
Fan, D.4
Wadsworth, S.5
McLachlan, J.A.6
Burow, M.E.7
-
77
-
-
77949519323
-
Carbon monoxide blocks lipopolysaccharide-induced gene expression by interfering with proximal TLR4 to NF-kappaB signal transduction in human monocytes
-
M. Chhikara, S. Wang, S.J. Kern, G.A. Ferreyra, J.J. Barb, P.J. Munson, and R.L. Danner Carbon monoxide blocks lipopolysaccharide-induced gene expression by interfering with proximal TLR4 to NF-kappaB signal transduction in human monocytes PLoS One 4 12 2009 e8139
-
(2009)
PLoS One
, vol.4
, Issue.12
, pp. e8139
-
-
Chhikara, M.1
Wang, S.2
Kern, S.J.3
Ferreyra, G.A.4
Barb, J.J.5
Munson, P.J.6
Danner, R.L.7
-
78
-
-
80055033765
-
Carbon monoxide induced PPAR gamma SUMOylation and UCP2 block inflammatory gene expression in macrophages
-
A. Haschemi, B.Y. Chin, M. Jeitler, H. Esterbauer, O. Wagner, M. Bilban, and L.E. Otterbein Carbon monoxide induced PPAR gamma SUMOylation and UCP2 block inflammatory gene expression in macrophages PLoS One 6 10 2011 e26376
-
(2011)
PLoS One
, vol.6
, Issue.10
, pp. e26376
-
-
Haschemi, A.1
Chin, B.Y.2
Jeitler, M.3
Esterbauer, H.4
Wagner, O.5
Bilban, M.6
Otterbein, L.E.7
-
79
-
-
33646579079
-
Carbon monoxide orchestrates a protective response through PPAR gamma
-
M. Bilban, F.H. Bach, S.L. Otterbein, E. Ifedigbo, J.C. d'Avila, H. Esterbauer, B.Y. Chin, A. Usheva, S.C. Robson, O. Wagner, and L.E. Otterbein Carbon monoxide orchestrates a protective response through PPAR gamma Immunity 24 5 2006 601 610
-
(2006)
Immunity
, vol.24
, Issue.5
, pp. 601-610
-
-
Bilban, M.1
Bach, F.H.2
Otterbein, S.L.3
Ifedigbo, E.4
D'Avila, J.C.5
Esterbauer, H.6
Chin, B.Y.7
Usheva, A.8
Robson, S.C.9
Wagner, O.10
Otterbein, L.E.11
-
80
-
-
0037119433
-
12,14-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species
-
12,14-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species J. Biol. Chem. 277 33 2002 29681 29685
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.33
, pp. 29681-29685
-
-
Lennon, A.M.1
Ramauge, M.2
Dessouroux, A.3
Pierre, M.4
-
81
-
-
24044476859
-
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice
-
S.Z. Duan, C.Y. Ivashchenko, M.W. Russell, D.S. Milstone, and R.M. Mortensen Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice Circ. Res. 97 4 2005 372 379
-
(2005)
Circ. Res.
, vol.97
, Issue.4
, pp. 372-379
-
-
Duan, S.Z.1
Ivashchenko, C.Y.2
Russell, M.W.3
Milstone, D.S.4
Mortensen, R.M.5
-
82
-
-
15444369845
-
Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: Correlation with endoplasmic reticulum stress
-
O.S. Gardner, C.W. Shiau, C.S. Chen, and L.M. Graves Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress J. Biol. Chem. 280 11 2005 10109 10118
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.11
, pp. 10109-10118
-
-
Gardner, O.S.1
Shiau, C.W.2
Chen, C.S.3
Graves, L.M.4
-
83
-
-
84906882822
-
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013
-
M. Ng, T. Fleming, M. Robinson, B. Thomson, N. Graetz, C. Margono, E.C. Mullany, S. Biryukov, C. Abbafati, S.F. Abera, J.P. Abraham, N.M. Abu-Rmeileh, T. Achoki, F.S. AlBuhairan, Z.A. Alemu, R. Alfonso, M.K. Ali, R. Ali, N.A. Guzman, W. Ammar, P. Anwari, A. Banerjee, S. Barquera, S. Basu, D.A. Bennett, Z. Bhutta, J. Blore, N. Cabral, I.C. Nonato, J.C. Chang, R. Chowdhury, K.J. Courville, M.H. Criqui, D.K. Cundiff, K.C. Dabhadkar, L. Dandona, A. Davis, A. Dayama, S.D. Dharmaratne, E.L. Ding, A.M. Durrani, A. Esteghamati, F. Farzadfar, D.F. Fay, V.L. Feigin, A. Flaxman, M.H. Forouzanfar, A. Goto, M.A. Green, R. Gupta, N. Hafezi-Nejad, G.J. Hankey, H.C. Harewood, R. Havmoeller, S. Hay, L. Hernandez, A. Husseini, B.T. Idrisov, N. Ikeda, F. Islami, E. Jahangir, S.K. Jassal, S.H. Jee, M. Jeffreys, J.B. Jonas, E.K. Kabagambe, S.E. Khalifa, A.P. Kengne, Y.S. Khader, Y.H. Khang, D. Kim, R.W. Kimokoti, J.M. Kinge, Y. Kokubo, S. Kosen, G. Kwan, T. Lai, M. Leinsalu, Y. Li, X. Liang, S. Liu, G. Logroscino, P.A. Lotufo, Y. Lu, J. Ma, N.K. Mainoo, G.A. Mensah, T.R. Merriman, A.H. Mokdad, J. Moschandreas, M. Naghavi, A. Naheed, D. Nand, K.M. Narayan, E.L. Nelson, M.L. Neuhouser, M.I. Nisar, T. Ohkubo, S.O. Oti, A. Pedroza, D. Prabhakaran, N. Roy, U. Sampson, H. Seo, S.G. Sepanlou, K. Shibuya, R. Shiri, I. Shiue, G.M. Singh, J.A. Singh, V. Skirbekk, N.J. Stapelberg, L. Sturua, B.L. Sykes, M. Tobias, B.X. Tran, L. Trasande, H. Toyoshima, S. van de Vijver, T.J. Vasankari, J.L. Veerman, G. Velasquez-Melendez, V.V. Vlassov, S.E. Vollset, T. Vos, C. Wang, X. Wang, E. Weiderpass, A. Werdecker, J.L. Wright, Y.C. Yang, H. Yatsuya, J. Yoon, S.J. Yoon, Y. Zhao, M. Zhou, S. Zhu, A.D. Lopez, C.J. Murray, and E. Gakidou Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013 Lancet 384 9945 2014 766 781
-
(2014)
Lancet
, vol.384
, Issue.9945
, pp. 766-781
-
-
Ng, M.1
Fleming, T.2
Robinson, M.3
Thomson, B.4
Graetz, N.5
Margono, C.6
Mullany, E.C.7
Biryukov, S.8
Abbafati, C.9
Abera, S.F.10
Abraham, J.P.11
Abu-Rmeileh, N.M.12
Achoki, T.13
AlBuhairan, F.S.14
Alemu, Z.A.15
Alfonso, R.16
Ali, M.K.17
Ali, R.18
Guzman, N.A.19
Ammar, W.20
Anwari, P.21
Banerjee, A.22
Barquera, S.23
Basu, S.24
Bennett, D.A.25
Bhutta, Z.26
Blore, J.27
Cabral, N.28
Nonato, I.C.29
Chang, J.C.30
Chowdhury, R.31
Courville, K.J.32
Criqui, M.H.33
Cundiff, D.K.34
Dabhadkar, K.C.35
Dandona, L.36
Davis, A.37
Dayama, A.38
Dharmaratne, S.D.39
Ding, E.L.40
Durrani, A.M.41
Esteghamati, A.42
Farzadfar, F.43
Fay, D.F.44
Feigin, V.L.45
Flaxman, A.46
Forouzanfar, M.H.47
Goto, A.48
Green, M.A.49
Gupta, R.50
Hafezi-Nejad, N.51
Hankey, G.J.52
Harewood, H.C.53
Havmoeller, R.54
Hay, S.55
Hernandez, L.56
Husseini, A.57
Idrisov, B.T.58
Ikeda, N.59
Islami, F.60
Jahangir, E.61
Jassal, S.K.62
Jee, S.H.63
Jeffreys, M.64
Jonas, J.B.65
Kabagambe, E.K.66
Khalifa, S.E.67
Kengne, A.P.68
Khader, Y.S.69
Khang, Y.H.70
Kim, D.71
Kimokoti, R.W.72
Kinge, J.M.73
Kokubo, Y.74
Kosen, S.75
Kwan, G.76
Lai, T.77
Leinsalu, M.78
Li, Y.79
Liang, X.80
Liu, S.81
Logroscino, G.82
Lotufo, P.A.83
Lu, Y.84
Ma, J.85
Mainoo, N.K.86
Mensah, G.A.87
Merriman, T.R.88
Mokdad, A.H.89
Moschandreas, J.90
Naghavi, M.91
Naheed, A.92
Nand, D.93
Narayan, K.M.94
Nelson, E.L.95
Neuhouser, M.L.96
Nisar, M.I.97
Ohkubo, T.98
Oti, S.O.99
more..
-
84
-
-
84923124525
-
An ERK/Cdk5 axis controls the diabetogenic actions of PPAR gamma
-
A.S. Banks, F.E. McAllister, J.P. Camporez, P.J. Zushin, M.J. Jurczak, D. Laznik-Bogoslavski, G.I. Shulman, S.P. Gygi, and B.M. Spiegelman An ERK/Cdk5 axis controls the diabetogenic actions of PPAR gamma Nature 517 7534 2015 391 395
-
(2015)
Nature
, vol.517
, Issue.7534
, pp. 391-395
-
-
Banks, A.S.1
McAllister, F.E.2
Camporez, J.P.3
Zushin, P.J.4
Jurczak, M.J.5
Laznik-Bogoslavski, D.6
Shulman, G.I.7
Gygi, S.P.8
Spiegelman, B.M.9
-
85
-
-
84880122195
-
Adiposity and insulin resistance in humans: The role of the different tissue and cellular lipid depots
-
S. Hocking, D. Samocha-Bonet, K.L. Milner, J.R. Greenfield, and D.J. Chisholm Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots Endocr. Rev. 34 4 2013 463 500
-
(2013)
Endocr. Rev.
, vol.34
, Issue.4
, pp. 463-500
-
-
Hocking, S.1
Samocha-Bonet, D.2
Milner, K.L.3
Greenfield, J.R.4
Chisholm, D.J.5
-
86
-
-
84926632412
-
Control of adipocyte differentiation in different fat depots; Implications for pathophysiology or therapy
-
X. Ma, P. Lee, D.J. Chisholm, and D.E. James Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy Front. Endocrinol. (Lausanne) 6 2015 1
-
(2015)
Front. Endocrinol. (Lausanne)
, vol.6
, pp. 1
-
-
Ma, X.1
Lee, P.2
Chisholm, D.J.3
James, D.E.4
-
87
-
-
41949114990
-
Role of mitochondrial dysfunction in insulin resistance
-
J.A. Kim, Y. Wei, and J.R. Sowers Role of mitochondrial dysfunction in insulin resistance Circ. Res. 102 4 2008 401 414
-
(2008)
Circ. Res.
, vol.102
, Issue.4
, pp. 401-414
-
-
Kim, J.A.1
Wei, Y.2
Sowers, J.R.3
-
88
-
-
0036776903
-
Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients [corrected]
-
D.G. Carey, G.J. Cowin, G.J. Galloway, N.P. Jones, J.C. Richards, N. Biswas, and D.M. Doddrell Effect of rosiglitazone on insulin sensitivity and body composition in type 2 diabetic patients [corrected] Obes. Res. 10 10 2002 1008 1015
-
(2002)
Obes. Res.
, vol.10
, Issue.10
, pp. 1008-1015
-
-
Carey, D.G.1
Cowin, G.J.2
Galloway, G.J.3
Jones, N.P.4
Richards, J.C.5
Biswas, N.6
Doddrell, D.M.7
-
89
-
-
0036072223
-
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients
-
Y. Miyazaki, A. Mahankali, M. Matsuda, S. Mahankali, J. Hardies, K. Cusi, L.J. Mandarino, and R.A. DeFronzo Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients J. Clin. Endocrinol. Metab. 87 6 2002 2784 2791
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, Issue.6
, pp. 2784-2791
-
-
Miyazaki, Y.1
Mahankali, A.2
Matsuda, M.3
Mahankali, S.4
Hardies, J.5
Cusi, K.6
Mandarino, L.J.7
DeFronzo, R.A.8
-
90
-
-
17544396164
-
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation
-
M. Adams, C.T. Montague, J.B. Prins, J.C. Holder, S.A. Smith, L. Sanders, J.E. Digby, C.P. Sewter, M.A. Lazar, V.K. Chatterjee, and S. O'Rahilly Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation J. Clin. Invest. 100 12 1997 3149 3153
-
(1997)
J. Clin. Invest.
, vol.100
, Issue.12
, pp. 3149-3153
-
-
Adams, M.1
Montague, C.T.2
Prins, J.B.3
Holder, J.C.4
Smith, S.A.5
Sanders, L.6
Digby, J.E.7
Sewter, C.P.8
Lazar, M.A.9
Chatterjee, V.K.10
O'Rahilly, S.11
-
91
-
-
0036125944
-
Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
-
H. Hirose, T. Kawai, Y. Yamamoto, M. Taniyama, M. Tomita, K. Matsubara, Y. Okazaki, T. Ishii, Y. Oguma, I. Takei, and T. Saruta Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes Metabolism 51 3 2002 314 317
-
(2002)
Metabolism
, vol.51
, Issue.3
, pp. 314-317
-
-
Hirose, H.1
Kawai, T.2
Yamamoto, Y.3
Taniyama, M.4
Tomita, M.5
Matsubara, K.6
Okazaki, Y.7
Ishii, T.8
Oguma, Y.9
Takei, I.10
Saruta, T.11
-
92
-
-
58149473706
-
TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis
-
K. Fujisawa, T. Nishikawa, D. Kukidome, K. Imoto, T. Yamashiro, H. Motoshima, T. Matsumura, and E. Araki TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis Biochem. Biophys. Res. Commun. 379 1 2009 43 48
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.379
, Issue.1
, pp. 43-48
-
-
Fujisawa, K.1
Nishikawa, T.2
Kukidome, D.3
Imoto, K.4
Yamashiro, T.5
Motoshima, H.6
Matsumura, T.7
Araki, E.8
-
93
-
-
0031057517
-
Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
-
M. Adams, M.J. Reginato, D. Shao, M.A. Lazar, and V.K. Chatterjee Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site J. Biol. Chem. 272 8 1997 5128 5132
-
(1997)
J. Biol. Chem.
, vol.272
, Issue.8
, pp. 5128-5132
-
-
Adams, M.1
Reginato, M.J.2
Shao, D.3
Lazar, M.A.4
Chatterjee, V.K.5
-
94
-
-
0038776380
-
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR gamma
-
E. Hu, J.B. Kim, P. Sarraf, and B.M. Spiegelman Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR gamma Science 274 5295 1996 2100 2103
-
(1996)
Science
, vol.274
, Issue.5295
, pp. 2100-2103
-
-
Hu, E.1
Kim, J.B.2
Sarraf, P.3
Spiegelman, B.M.4
-
95
-
-
0032894240
-
C-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity
-
H.S. Camp, S.R. Tafuri, and T. Leff c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity Endocrinology 140 1 1999 392 397
-
(1999)
Endocrinology
, vol.140
, Issue.1
, pp. 392-397
-
-
Camp, H.S.1
Tafuri, S.R.2
Leff, T.3
-
96
-
-
0141920726
-
Genetic modulation of PPAR gamma phosphorylation regulates insulin sensitivity
-
S.M. Rangwala, B. Rhoades, J.S. Shapiro, A.S. Rich, J.K. Kim, G.I. Shulman, K.H. Kaestner, and M.A. Lazar Genetic modulation of PPAR gamma phosphorylation regulates insulin sensitivity Dev. Cell 5 4 2003 657 663
-
(2003)
Dev. Cell
, vol.5
, Issue.4
, pp. 657-663
-
-
Rangwala, S.M.1
Rhoades, B.2
Shapiro, J.S.3
Rich, A.S.4
Kim, J.K.5
Shulman, G.I.6
Kaestner, K.H.7
Lazar, M.A.8
-
97
-
-
58249112308
-
Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation
-
K. Helenius, Y. Yang, J. Alasaari, and T.P. Makela Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation Mol. Cell. Biol. 29 2 2009 315 323
-
(2009)
Mol. Cell. Biol.
, vol.29
, Issue.2
, pp. 315-323
-
-
Helenius, K.1
Yang, Y.2
Alasaari, J.3
Makela, T.P.4
-
98
-
-
77954941113
-
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5
-
J.H. Choi, A.S. Banks, J.L. Estall, S. Kajimura, P. Bostrom, D. Laznik, J.L. Ruas, M.J. Chalmers, T.M. Kamenecka, M. Bluher, P.R. Griffin, and B.M. Spiegelman Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5 Nature 466 7305 2010 451 456
-
(2010)
Nature
, vol.466
, Issue.7305
, pp. 451-456
-
-
Choi, J.H.1
Banks, A.S.2
Estall, J.L.3
Kajimura, S.4
Bostrom, P.5
Laznik, D.6
Ruas, J.L.7
Chalmers, M.J.8
Kamenecka, T.M.9
Bluher, M.10
Griffin, P.R.11
Spiegelman, B.M.12
-
99
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
F. Picard, M. Kurtev, N. Chung, A. Topark-Ngarm, T. Senawong, R. Machado De Oliveira, M. Leid, M.W. McBurney, and L. Guarente Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma Nature 429 6993 2004 771 776
-
(2004)
Nature
, vol.429
, Issue.6993
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
Machado De Oliveira, R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
100
-
-
41549153833
-
The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma
-
O. van Beekum, A.B. Brenkman, L. Grontved, N. Hamers, N.J. van den Broek, R. Berger, S. Mandrup, and E. Kalkhoven The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma Endocrinology 149 4 2008 1840 1849
-
(2008)
Endocrinology
, vol.149
, Issue.4
, pp. 1840-1849
-
-
Van Beekum, O.1
Brenkman, A.B.2
Grontved, L.3
Hamers, N.4
Van Den Broek, N.J.5
Berger, R.6
Mandrup, S.7
Kalkhoven, E.8
-
101
-
-
78649852533
-
SIRT1 is regulated by a PPAR{gamma}-SIRT1 negative feedback loop associated with senescence
-
L. Han, R. Zhou, J. Niu, M.A. McNutt, P. Wang, and T. Tong SIRT1 is regulated by a PPAR{gamma}-SIRT1 negative feedback loop associated with senescence Nucleic Acids Res. 38 21 2010 7458 7471
-
(2010)
Nucleic Acids Res.
, vol.38
, Issue.21
, pp. 7458-7471
-
-
Han, L.1
Zhou, R.2
Niu, J.3
McNutt, M.A.4
Wang, P.5
Tong, T.6
-
102
-
-
84864615516
-
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma
-
L. Qiang, L. Wang, N. Kon, W. Zhao, S. Lee, Y. Zhang, M. Rosenbaum, Y. Zhao, W. Gu, S.R. Farmer, and D. Accili Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma Cell 150 3 2012 620 632
-
(2012)
Cell
, vol.150
, Issue.3
, pp. 620-632
-
-
Qiang, L.1
Wang, L.2
Kon, N.3
Zhao, W.4
Lee, S.5
Zhang, Y.6
Rosenbaum, M.7
Zhao, Y.8
Gu, W.9
Farmer, S.R.10
Accili, D.11
-
103
-
-
7944236265
-
The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain
-
D. Yamashita, T. Yamaguchi, M. Shimizu, N. Nakata, F. Hirose, and T. Osumi The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain Genes Cells 9 11 2004 1017 1029
-
(2004)
Genes Cells
, vol.9
, Issue.11
, pp. 1017-1029
-
-
Yamashita, D.1
Yamaguchi, T.2
Shimizu, M.3
Nakata, N.4
Hirose, F.5
Osumi, T.6
-
104
-
-
4644257496
-
Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation
-
Z.E. Floyd, and J.M. Stephens Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation Obes. Res. 12 6 2004 921 928
-
(2004)
Obes. Res.
, vol.12
, Issue.6
, pp. 921-928
-
-
Floyd, Z.E.1
Stephens, J.M.2
-
105
-
-
84863012459
-
Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
-
P.A. Dutchak, T. Katafuchi, A.L. Bookout, J.H. Choi, R.T. Yu, D.J. Mangelsdorf, and S.A. Kliewer Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones Cell 148 3 2012 556 567
-
(2012)
Cell
, vol.148
, Issue.3
, pp. 556-567
-
-
Dutchak, P.A.1
Katafuchi, T.2
Bookout, A.L.3
Choi, J.H.4
Yu, R.T.5
Mangelsdorf, D.J.6
Kliewer, S.A.7
-
106
-
-
33748416853
-
A recurrent phospho-sumoyl switch in transcriptional repression and beyond
-
X.J. Yang, and S. Gregoire A recurrent phospho-sumoyl switch in transcriptional repression and beyond Mol. Cell 23 6 2006 779 786
-
(2006)
Mol. Cell
, vol.23
, Issue.6
, pp. 779-786
-
-
Yang, X.J.1
Gregoire, S.2
-
107
-
-
63049133308
-
PPAR-gamma AF-2 domain functions as a component of a ubiquitin-dependent degradation signal
-
G.E. Kilroy, X. Zhang, and Z.E. Floyd PPAR-gamma AF-2 domain functions as a component of a ubiquitin-dependent degradation signal Obesity (Silver Spring) 17 4 2009 665 673
-
(2009)
Obesity (Silver Spring)
, vol.17
, Issue.4
, pp. 665-673
-
-
Kilroy, G.E.1
Zhang, X.2
Floyd, Z.E.3
-
108
-
-
0037838892
-
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
-
C.P. Briscoe, M. Tadayyon, J.L. Andrews, W.G. Benson, J.K. Chambers, M.M. Eilert, C. Ellis, N.A. Elshourbagy, A.S. Goetz, D.T. Minnick, P.R. Murdock, H.R. Sauls Jr., U. Shabon, L.D. Spinage, J.C. Strum, P.G. Szekeres, K.B. Tan, J.M. Way, D.M. Ignar, S. Wilson, and A.I. Muir The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids J. Biol. Chem. 278 13 2003 11303 11311
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.13
, pp. 11303-11311
-
-
Briscoe, C.P.1
Tadayyon, M.2
Andrews, J.L.3
Benson, W.G.4
Chambers, J.K.5
Eilert, M.M.6
Ellis, C.7
Elshourbagy, N.A.8
Goetz, A.S.9
Minnick, D.T.10
Murdock, P.R.11
Sauls, H.R.12
Shabon, U.13
Spinage, L.D.14
Strum, J.C.15
Szekeres, P.G.16
Tan, K.B.17
Way, J.M.18
Ignar, D.M.19
Wilson, S.20
Muir, A.I.21
more..
-
109
-
-
84880964021
-
The fatty acid receptor FFA1/GPR40 a decade later: How much do we know?
-
A.D. Mancini, and V. Poitout The fatty acid receptor FFA1/GPR40 a decade later: how much do we know? Trends Endocrinol. Metab. 24 8 2013 398 407
-
(2013)
Trends Endocrinol. Metab.
, vol.24
, Issue.8
, pp. 398-407
-
-
Mancini, A.D.1
Poitout, V.2
-
110
-
-
67049100849
-
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
-
D. Gras, P. Chanez, V. Urbach, I. Vachier, P. Godard, and C. Bonnans Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor Am. J. Physiol. Lung Cell. Mol. Physiol. 296 6 2009 L970 978
-
(2009)
Am. J. Physiol. Lung Cell. Mol. Physiol.
, vol.296
, Issue.6
, pp. L970-978
-
-
Gras, D.1
Chanez, P.2
Urbach, V.3
Vachier, I.4
Godard, P.5
Bonnans, C.6
-
111
-
-
84973865850
-
GPR40 agonists for the treatment of type 2 diabetes mellitus: Benefits and challenges
-
S. Mohammad GPR40 agonists for the treatment of type 2 diabetes mellitus: benefits and challenges Curr. Drug Targets 2015
-
(2015)
Curr. Drug Targets
-
-
Mohammad, S.1
-
112
-
-
0037434991
-
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
-
Y. Itoh, Y. Kawamata, M. Harada, M. Kobayashi, R. Fujii, S. Fukusumi, K. Ogi, M. Hosoya, Y. Tanaka, H. Uejima, H. Tanaka, M. Maruyama, R. Satoh, S. Okubo, H. Kizawa, H. Komatsu, F. Matsumura, Y. Noguchi, T. Shinohara, S. Hinuma, Y. Fujisawa, and M. Fujino Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Nature 422 6928 2003 173 176
-
(2003)
Nature
, vol.422
, Issue.6928
, pp. 173-176
-
-
Itoh, Y.1
Kawamata, Y.2
Harada, M.3
Kobayashi, M.4
Fujii, R.5
Fukusumi, S.6
Ogi, K.7
Hosoya, M.8
Tanaka, Y.9
Uejima, H.10
Tanaka, H.11
Maruyama, M.12
Satoh, R.13
Okubo, S.14
Kizawa, H.15
Komatsu, H.16
Matsumura, F.17
Noguchi, Y.18
Shinohara, T.19
Hinuma, S.20
Fujisawa, Y.21
Fujino, M.22
more..
-
113
-
-
20944433543
-
Receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
-
P. Steneberg, N. Rubins, R. Bartoov-Shifman, M.D. Walker, H. Edlund, and F.F.A. The receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse Cell Metab. 1 4 2005 245 258
-
(2005)
Cell Metab.
, vol.1
, Issue.4
, pp. 245-258
-
-
Steneberg, P.1
Rubins, N.2
Bartoov-Shifman, R.3
Walker, M.D.4
Edlund, H.5
The, F.F.A.6
-
114
-
-
65549114432
-
Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice
-
K. Nagasumi, R. Esaki, K. Iwachidow, Y. Yasuhara, K. Ogi, H. Tanaka, M. Nakata, T. Yano, K. Shimakawa, S. Taketomi, K. Takeuchi, H. Odaka, and Y. Kaisho Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice Diabetes 58 5 2009 1067 1076
-
(2009)
Diabetes
, vol.58
, Issue.5
, pp. 1067-1076
-
-
Nagasumi, K.1
Esaki, R.2
Iwachidow, K.3
Yasuhara, Y.4
Ogi, K.5
Tanaka, H.6
Nakata, M.7
Yano, T.8
Shimakawa, K.9
Taketomi, S.10
Takeuchi, K.11
Odaka, H.12
Kaisho, Y.13
-
115
-
-
33745607930
-
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: Identification of agonist and antagonist small molecules
-
C.P. Briscoe, A.J. Peat, S.C. McKeown, D.F. Corbett, A.S. Goetz, T.R. Littleton, D.C. McCoy, T.P. Kenakin, J.L. Andrews, C. Ammala, J.A. Fornwald, D.M. Ignar, and S. Jenkinson Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules Br. J. Pharmacol. 148 5 2006 619 628
-
(2006)
Br. J. Pharmacol.
, vol.148
, Issue.5
, pp. 619-628
-
-
Briscoe, C.P.1
Peat, A.J.2
McKeown, S.C.3
Corbett, D.F.4
Goetz, A.S.5
Littleton, T.R.6
McCoy, D.C.7
Kenakin, T.P.8
Andrews, J.L.9
Ammala, C.10
Fornwald, J.A.11
Ignar, D.M.12
Jenkinson, S.13
-
116
-
-
51649104136
-
Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization
-
R. Vettor, M. Granzotto, D. De Stefani, E. Trevellin, M. Rossato, M.G. Farina, G. Milan, C. Pilon, A. Nigro, G. Federspil, R. Vigneri, L. Vitiello, R. Rizzuto, R. Baratta, and L. Frittitta Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization J. Clin. Endocrinol. Metab. 93 9 2008 3541 3550
-
(2008)
J. Clin. Endocrinol. Metab.
, vol.93
, Issue.9
, pp. 3541-3550
-
-
Vettor, R.1
Granzotto, M.2
De Stefani, D.3
Trevellin, E.4
Rossato, M.5
Farina, M.G.6
Milan, G.7
Pilon, C.8
Nigro, A.9
Federspil, G.10
Vigneri, R.11
Vitiello, L.12
Rizzuto, R.13
Baratta, R.14
Frittitta, L.15
-
117
-
-
84889083042
-
Modulating GPR40: Therapeutic promise and potential in diabetes
-
V. Poitout, and D.C. Lin Modulating GPR40: therapeutic promise and potential in diabetes Drug Discov. Today 18 23-24 2013 1301 1308
-
(2013)
Drug Discov. Today
, vol.18
, Issue.23-24
, pp. 1301-1308
-
-
Poitout, V.1
Lin, D.C.2
-
118
-
-
84867290314
-
A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents
-
J. Luo, G. Swaminath, S.P. Brown, J. Zhang, Q. Guo, M. Chen, K. Nguyen, T. Tran, L. Miao, P.J. Dransfield, M. Vimolratana, J.B. Houze, S. Wong, M. Toteva, B. Shan, F. Li, R. Zhuang, and D.C. Lin A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents PLoS One 7 10 2012 e46300
-
(2012)
PLoS One
, vol.7
, Issue.10
, pp. e46300
-
-
Luo, J.1
Swaminath, G.2
Brown, S.P.3
Zhang, J.4
Guo, Q.5
Chen, M.6
Nguyen, K.7
Tran, T.8
Miao, L.9
Dransfield, P.J.10
Vimolratana, M.11
Houze, J.B.12
Wong, S.13
Toteva, M.14
Shan, B.15
Li, F.16
Zhuang, R.17
Lin, D.C.18
-
119
-
-
58149100292
-
Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease
-
H. Lan, L.M. Hoos, L. Liu, G. Tetzloff, W. Hu, S.J. Abbondanzo, G. Vassileva, E.L. Gustafson, J.A. Hedrick, and H.R. Davis Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease Diabetes 57 11 2008 2999 3006
-
(2008)
Diabetes
, vol.57
, Issue.11
, pp. 2999-3006
-
-
Lan, H.1
Hoos, L.M.2
Liu, L.3
Tetzloff, G.4
Hu, W.5
Abbondanzo, S.J.6
Vassileva, G.7
Gustafson, E.L.8
Hedrick, J.A.9
Davis, H.R.10
-
120
-
-
0033105510
-
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
-
H.E. Xu, M.H. Lambert, V.G. Montana, D.J. Parks, S.G. Blanchard, P.J. Brown, D.D. Sternbach, J.M. Lehmann, G.B. Wisely, T.M. Willson, S.A. Kliewer, and M.V. Milburn Molecular recognition of fatty acids by peroxisome proliferator-activated receptors Mol. Cell 3 3 1999 397 403
-
(1999)
Mol. Cell
, vol.3
, Issue.3
, pp. 397-403
-
-
Xu, H.E.1
Lambert, M.H.2
Montana, V.G.3
Parks, D.J.4
Blanchard, S.G.5
Brown, P.J.6
Sternbach, D.D.7
Lehmann, J.M.8
Wisely, G.B.9
Willson, T.M.10
Kliewer, S.A.11
Milburn, M.V.12
-
121
-
-
0037423719
-
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
-
K. Kotarsky, N.E. Nilsson, E. Flodgren, C. Owman, and B. Olde A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs Biochem. Biophys. Res. Commun. 301 2 2003 406 410
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.301
, Issue.2
, pp. 406-410
-
-
Kotarsky, K.1
Nilsson, N.E.2
Flodgren, E.3
Owman, C.4
Olde, B.5
-
122
-
-
67650533801
-
The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1
-
N.J. Smith, L.A. Stoddart, N.M. Devine, L. Jenkins, and G. Milligan The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1 J. Biol. Chem. 284 26 2009 17527 17539
-
(2009)
J. Biol. Chem.
, vol.284
, Issue.26
, pp. 17527-17539
-
-
Smith, N.J.1
Stoddart, L.A.2
Devine, N.M.3
Jenkins, L.4
Milligan, G.5
-
123
-
-
84907203364
-
A novel non-agonist peroxisome proliferator-activated receptor gamma (PPARgamma) ligand UHC1 blocks PPAR gamma phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity
-
S.S. Choi, E.S. Kim, M. Koh, S.J. Lee, D. Lim, Y.R. Yang, H.J. Jang, K.A. Seo, S.H. Min, I.H. Lee, S.B. Park, P.G. Suh, and J.H. Choi A novel non-agonist peroxisome proliferator-activated receptor gamma (PPARgamma) ligand UHC1 blocks PPAR gamma phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity J. Biol. Chem. 289 38 2014 26618 26629
-
(2014)
J. Biol. Chem.
, vol.289
, Issue.38
, pp. 26618-26629
-
-
Choi, S.S.1
Kim, E.S.2
Koh, M.3
Lee, S.J.4
Lim, D.5
Yang, Y.R.6
Jang, H.J.7
Seo, K.A.8
Min, S.H.9
Lee, I.H.10
Park, S.B.11
Suh, P.G.12
Choi, J.H.13
-
124
-
-
84864976082
-
GQ-16, a novel peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, promotes insulin sensitization without weight gain
-
A.A. Amato, S. Rajagopalan, J.Z. Lin, B.M. Carvalho, A.C. Figueira, J. Lu, S.D. Ayers, M. Mottin, R.L. Silveira, P.C. Souza, R.H. Mourao, M.J. Saad, M. Togashi, L.A. Simeoni, D.S. Abdalla, M.S. Skaf, I. Polikparpov, M.C. Lima, S.L. Galdino, R.G. Brennan, J.D. Baxter, I.R. Pitta, P. Webb, K.J. Phillips, and F.A. Neves GQ-16, a novel peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, promotes insulin sensitization without weight gain J. Biol. Chem. 287 33 2012 28169 28179
-
(2012)
J. Biol. Chem.
, vol.287
, Issue.33
, pp. 28169-28179
-
-
Amato, A.A.1
Rajagopalan, S.2
Lin, J.Z.3
Carvalho, B.M.4
Figueira, A.C.5
Lu, J.6
Ayers, S.D.7
Mottin, M.8
Silveira, R.L.9
Souza, P.C.10
Mourao, R.H.11
Saad, M.J.12
Togashi, M.13
Simeoni, L.A.14
Abdalla, D.S.15
Skaf, M.S.16
Polikparpov, I.17
Lima, M.C.18
Galdino, S.L.19
Brennan, R.G.20
Baxter, J.D.21
Pitta, I.R.22
Webb, P.23
Phillips, K.J.24
Neves, F.A.25
more..
-
125
-
-
84863609091
-
Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism
-
A. Mieczkowska, M.F. Basle, D. Chappard, and G. Mabilleau Thiazolidinediones induce osteocyte apoptosis by a G protein-coupled receptor 40-dependent mechanism J. Biol. Chem. 287 28 2012 23517 23526
-
(2012)
J. Biol. Chem.
, vol.287
, Issue.28
, pp. 23517-23526
-
-
Mieczkowska, A.1
Basle, M.F.2
Chappard, D.3
Mabilleau, G.4
-
126
-
-
84874781809
-
The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation
-
F. Wauquier, C. Philippe, L. Leotoing, S. Mercier, M.J. Davicco, P. Lebecque, J. Guicheux, P. Pilet, E. Miot-Noirault, V. Poitout, T. Alquier, V. Coxam, and Y. Wittrant The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation J. Biol. Chem. 288 9 2013 6542 6551
-
(2013)
J. Biol. Chem.
, vol.288
, Issue.9
, pp. 6542-6551
-
-
Wauquier, F.1
Philippe, C.2
Leotoing, L.3
Mercier, S.4
Davicco, M.J.5
Lebecque, P.6
Guicheux, J.7
Pilet, P.8
Miot-Noirault, E.9
Poitout, V.10
Alquier, T.11
Coxam, V.12
Wittrant, Y.13
-
127
-
-
84939235405
-
G protein-coupled receptor 40 (GPR40) and peroxisome proliferator-activated receptor gamma (PPARgamma): An integrated two-receptor signaling pathway
-
S. Wang, K.S. Awad, J.M. Elinoff, E.J. Dougherty, G.A. Ferreyra, J.Y. Wang, R. Cai, J. Sun, A. Ptasinska, and R.L. Danner G protein-coupled receptor 40 (GPR40) and peroxisome proliferator-activated receptor gamma (PPARgamma): An integrated two-receptor signaling pathway J. Biol. Chem. 290 32 2015 19544 19557
-
(2015)
J. Biol. Chem.
, vol.290
, Issue.32
, pp. 19544-19557
-
-
Wang, S.1
Awad, K.S.2
Elinoff, J.M.3
Dougherty, E.J.4
Ferreyra, G.A.5
Wang, J.Y.6
Cai, R.7
Sun, J.8
Ptasinska, A.9
Danner, R.L.10
-
128
-
-
33750036728
-
12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism
-
12,14-prostaglandin J2 induces renal epithelial cell death through NF-kappaB-dependent and MAPK-independent mechanism Toxicol. Appl. Pharmacol. 216 3 2006 426 435
-
(2006)
Toxicol. Appl. Pharmacol.
, vol.216
, Issue.3
, pp. 426-435
-
-
Kang, D.S.1
Kwon, C.H.2
Park, J.Y.3
Kim, J.H.4
Woo, J.S.5
Jung, J.S.6
Kim, Y.K.7
-
129
-
-
0035966105
-
15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells
-
K. Takeda, T. Ichiki, T. Tokunou, N. Iino, and A. Takeshita 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells J. Biol. Chem. 276 52 2001 48950 48955
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.52
, pp. 48950-48955
-
-
Takeda, K.1
Ichiki, T.2
Tokunou, T.3
Iino, N.4
Takeshita, A.5
-
130
-
-
0034805226
-
A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPAR gamma
-
W.A. Wilmer, C. Dixon, L. Lu, T. Hilbelink, and B.H. Rovin A cyclopentenone prostaglandin activates mesangial MAP kinase independently of PPAR gamma Biochem. Biophys. Res. Commun. 281 1 2001 57 62
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.281
, Issue.1
, pp. 57-62
-
-
Wilmer, W.A.1
Dixon, C.2
Lu, L.3
Hilbelink, T.4
Rovin, B.H.5
-
131
-
-
79952038944
-
15-Deoxy-Delta12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species
-
K. Kitz, W. Windischhofer, H.J. Leis, E. Huber, M. Kollroser, and E. Malle 15-Deoxy-Delta12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species Free Radic. Biol. Med. 50 7 2011 854 865
-
(2011)
Free Radic. Biol. Med.
, vol.50
, Issue.7
, pp. 854-865
-
-
Kitz, K.1
Windischhofer, W.2
Leis, H.J.3
Huber, E.4
Kollroser, M.5
Malle, E.6
-
132
-
-
80053131732
-
Antidiabetic actions of a non-agonist PPAR gamma ligand blocking Cdk5-mediated phosphorylation
-
J.H. Choi, A.S. Banks, T.M. Kamenecka, S.A. Busby, M.J. Chalmers, N. Kumar, D.S. Kuruvilla, Y. Shin, Y. He, J.B. Bruning, D.P. Marciano, M.D. Cameron, D. Laznik, M.J. Jurczak, S.C. Schurer, D. Vidovic, G.I. Shulman, B.M. Spiegelman, and P.R. Griffin Antidiabetic actions of a non-agonist PPAR gamma ligand blocking Cdk5-mediated phosphorylation Nature 477 7365 2011 477 481
-
(2011)
Nature
, vol.477
, Issue.7365
, pp. 477-481
-
-
Choi, J.H.1
Banks, A.S.2
Kamenecka, T.M.3
Busby, S.A.4
Chalmers, M.J.5
Kumar, N.6
Kuruvilla, D.S.7
Shin, Y.8
He, Y.9
Bruning, J.B.10
Marciano, D.P.11
Cameron, M.D.12
Laznik, D.13
Jurczak, M.J.14
Schurer, S.C.15
Vidovic, D.16
Shulman, G.I.17
Spiegelman, B.M.18
Griffin, P.R.19
-
133
-
-
38349192580
-
New drugs for the treatment of diabetes mellitus: Part I: Thiazolidinediones and their evolving cardiovascular implications
-
D.K. McGuire, and S.E. Inzucchi New drugs for the treatment of diabetes mellitus: part I: Thiazolidinediones and their evolving cardiovascular implications Circulation 117 3 2008 440 449
-
(2008)
Circulation
, vol.117
, Issue.3
, pp. 440-449
-
-
McGuire, D.K.1
Inzucchi, S.E.2
-
134
-
-
85027953305
-
Effect of exogenous surfactant on phosphatidylinositol 3-kinase-Akt pathway and peroxisome proliferator activated receptor-gamma during endotoxin induced acute respiratory distress syndrome
-
N. Mittal, and S.N. Sanyal Effect of exogenous surfactant on phosphatidylinositol 3-kinase-Akt pathway and peroxisome proliferator activated receptor-gamma during endotoxin induced acute respiratory distress syndrome Mol. Cell. Biochem. 361 1-2 2012 135 141
-
(2012)
Mol. Cell. Biochem.
, vol.361
, Issue.1-2
, pp. 135-141
-
-
Mittal, N.1
Sanyal, S.N.2
-
135
-
-
84926295655
-
Identification of a novel selective agonist of PPARgamma with no promotion of adipogenesis and less inhibition of osteoblastogenesis
-
C. Liu, T. Feng, N. Zhu, P. Liu, X. Han, M. Chen, X. Wang, N. Li, Y. Li, Y. Xu, and S. Si Identification of a novel selective agonist of PPARgamma with no promotion of adipogenesis and less inhibition of osteoblastogenesis Sci. Rep. 5 2015 9530
-
(2015)
Sci. Rep.
, vol.5
, pp. 9530
-
-
Liu, C.1
Feng, T.2
Zhu, N.3
Liu, P.4
Han, X.5
Chen, M.6
Wang, X.7
Li, N.8
Li, Y.9
Xu, Y.10
Si, S.11
-
136
-
-
84937484796
-
Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
-
W. Zheng, L. Qiu, R. Wang, X. Feng, Y. Han, Y. Zhu, D. Chen, Y. Liu, L. Jin, and Y. Li Selective targeting of PPAR gamma by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency Sci. Rep. 5 2015 12222
-
(2015)
Sci. Rep.
, vol.5
, pp. 12222
-
-
Zheng, W.1
Qiu, L.2
Wang, R.3
Feng, X.4
Han, Y.5
Zhu, Y.6
Chen, D.7
Liu, Y.8
Jin, L.9
Li, Y.10
-
137
-
-
74049162863
-
Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists
-
C. Zhou, C. Tang, E. Chang, M. Ge, S. Lin, E. Cline, C.P. Tan, Y. Feng, Y.P. Zhou, G.J. Eiermann, A. Petrov, G. Salituro, P. Meinke, R. Mosley, T.E. Akiyama, M. Einstein, S. Kumar, J. Berger, A.D. Howard, N. Thornberry, S.G. Mills, and L. Yang Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists Bioorg. Med. Chem. Lett. 20 3 2010 1298 1301
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.3
, pp. 1298-1301
-
-
Zhou, C.1
Tang, C.2
Chang, E.3
Ge, M.4
Lin, S.5
Cline, E.6
Tan, C.P.7
Feng, Y.8
Zhou, Y.P.9
Eiermann, G.J.10
Petrov, A.11
Salituro, G.12
Meinke, P.13
Mosley, R.14
Akiyama, T.E.15
Einstein, M.16
Kumar, S.17
Berger, J.18
Howard, A.D.19
Thornberry, N.20
Mills, S.G.21
Yang, L.22
more..
-
138
-
-
50949128408
-
Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice
-
C.P. Tan, Y. Feng, Y.P. Zhou, G.J. Eiermann, A. Petrov, C. Zhou, S. Lin, G. Salituro, P. Meinke, R. Mosley, T.E. Akiyama, M. Einstein, S. Kumar, J.P. Berger, S.G. Mills, N.A. Thornberry, L. Yang, and A.D. Howard Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice Diabetes 57 8 2008 2211 2219
-
(2008)
Diabetes
, vol.57
, Issue.8
, pp. 2211-2219
-
-
Tan, C.P.1
Feng, Y.2
Zhou, Y.P.3
Eiermann, G.J.4
Petrov, A.5
Zhou, C.6
Lin, S.7
Salituro, G.8
Meinke, P.9
Mosley, R.10
Akiyama, T.E.11
Einstein, M.12
Kumar, S.13
Berger, J.P.14
Mills, S.G.15
Thornberry, N.A.16
Yang, L.17
Howard, A.D.18
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