Hepatobiliary secretion kinetics of conjugated bile acids measured in pigs by 11C-cholylsarcosine PET

Journal of Nuclear Medicine

Volumn 57, Issue 6, 2016, Pages 961-966

  Sørensen, Michael ^a   Munk, Ole Lajord ^a   Ørntoft, Nikolaj W ^a   Frisch, Kim ^a   Andersen, Kasper Jarlhelt ^a   Mortensen, Frank Viborg ^a   Alstrup, Aage Kristian Olsen ^a   Ott, Peter ^a   Hofmann, Alan F ^b   Keiding, Susanne ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Bile salt export pump; Functional molecular imaging; Hepatic excretory function; In vivo liver kinetics; Intrahepatic cholestasis

Indexed keywords

BILE ACID CONJUGATE; CARBON CHOLYLSARCOSINE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; CHOLIC ACID DERIVATIVE; CHOLYLSARCOSINE; SARCOSINE;

ANIMAL EXPERIMENT; ARTERIAL VENOUS BLOOD; ARTICLE; CHOLESTASIS; COMPARTMENT MODEL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG HALF LIFE; DRUG TRANSPORT; FEMALE; HEMOLYMPHATIC SYSTEM; HEPATIC VENOUS BLOOD; HEPATOBILIARY SYSTEM; IN VIVO STUDY; LIPID TRANSPORT; LIVER BLOOD FLOW; LIVER PERFUSION; NONHUMAN; PIG; PORTAL VEIN BLOOD; PRIORITY JOURNAL; PROCESS DEVELOPMENT; VALIDATION PROCESS; ANALOGS AND DERIVATIVES; ANIMAL; DIAGNOSTIC IMAGING; KINETICS; LIVER; METABOLISM; POSITRON EMISSION TOMOGRAPHY; SECRETION (PROCESS);

ANIMALS; BILIARY TRACT; CHOLIC ACIDS; FEMALE; KINETICS; LIVER; POSITRON-EMISSION TOMOGRAPHY; SARCOSINE; SWINE;

EID: 84973651866     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.115.171579     Document Type: Article

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