Two-year, prospective, multicenter study of the use of dexamethasone intravitreal implant for treatment of macular edema secondary to retinal vein occlusion in the clinical setting in France

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 254, Issue 12, 2016, Pages 2307-2318

  Korobelnik, Jean François ^a,b,c   Kodjikian, Laurent ^d   Delcourt, Cécile ^b,c   Gualino, Vincent ^e   Leaback, Richard ^f   Pinchinat, Sybil ^g   Velard, Marie Eve ^f  

^a BORDEAUX UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c INSERM U657   (France)

^d CROIX ROUSSE HOSPITAL   (France)

^e Honoré Cave Clinic   (France)

^f ALLERGAN PLC   (United States)

^g Axonal Biostatem   (France)

Author keywords

Dexamethasone; Intravitreal; Macular edema; Observational; Prospective; Retinal vein occlusion

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; DEXAMETHASONE; RANIBIZUMAB; DRUG IMPLANT; GLUCOCORTICOID;

ADULT; AGED; ARTICLE; BEST CORRECTED VISUAL ACUITY; BRANCH RETINAL VEIN OCCLUSION; CATARACT; CENTRAL RETINA VEIN OCCLUSION; CLINICAL PRACTICE; CONTROLLED STUDY; CORTICAL CATARACT; DISEASE COURSE; DRUG EFFICACY; DRUG SAFETY; DRUG USE; ENDOPHTHALMITIS; FEMALE; FOLLOW UP; FRANCE; GLAUCOMA; HOSPITAL PATIENT; HUMAN; INCIDENCE; INTRAOCULAR PRESSURE; INTRAOCULAR PRESSURE ABNORMALITY; INTRAVITREAL IMPLANT; LONGITUDINAL STUDY; LOW LEVEL LASER THERAPY; MACULAR EDEMA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SUBCAPSULAR CATARACT; CLINICAL TRIAL; COMPLICATION; DRUG IMPLANT; INTRAVITREAL DRUG ADMINISTRATION; MIDDLE AGED; OPTICAL COHERENCE TOMOGRAPHY; RETINAL VEIN OCCLUSION; TIME FACTOR; TREATMENT OUTCOME; VERY ELDERLY; VISUAL ACUITY;

ADULT; AGED; AGED, 80 AND OVER; DEXAMETHASONE; DRUG IMPLANTS; FEMALE; FOLLOW-UP STUDIES; FRANCE; GLUCOCORTICOIDS; HUMANS; INTRAVITREAL INJECTIONS; MACULAR EDEMA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; QUALITY OF LIFE; RETINAL VEIN OCCLUSION; TIME FACTORS; TOMOGRAPHY, OPTICAL COHERENCE; TREATMENT OUTCOME; VISUAL ACUITY;

EID: 84973637660     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-016-3394-y     Document Type: Article

References (17)

1. Rehak M, Wiedemann P (2010) Retinal vein thrombosis: pathogenesis and management. J Thromb Haemost 8:1886–1894. doi:10.1111/j.1538-7836.2010.03909.x
2. Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P, Kowalski JW, Nguyen H, Wong TY, International Eye Disease Consortium (2010) The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 117:313–319.e1. doi:10.1016/j.ophtha.2009.07.017
3. Awdeh RM, Elsing SH, Deramo VA, Stinnett S, Lee PP, Fekrat S (2010) Vision-related quality of life in persons with unilateral branch retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire. Br J Ophthalmol 94:319–323. doi:10.1136/bjo.2007.135913
4. Deramo VA, Cox TA, Syed AB, Lee PP, Fekrat S (2003) Vision-related quality of life in people with central retinal vein occlusion using the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol 121:1297–1302. doi:10.1001/archopht.121.9.1297
5. Adelman RA, Parnes AJ, Bopp S, Saad Othman I, Ducournau D, EVRS Macular Edema Study Group (2015) Strategy for the management of macular edema in retinal vein occlusion: the European Vitreo Retinal Society macular edema study. Biomed Res Int 2015:870987. doi:10.1155/2015/870987
6. Chang-Lin JE, Attar M, Acheampong AA, Robinson MR, Whitcup SM, Kuppermann BD, Welty D (2011) Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant. Invest Ophthalmol Vis Sci 52:80–86. doi:10.1167/iovs.10-5285
7. Haller JA, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J, Loewenstein A, Yoon YH, Jacques ML, Jiao J, Li XY, Whitcup SM, Ozurdex GENEVA Study Group (2010) Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology 117:1134–1146.e3. doi:10.1016/j.ophtha.2010.03.032
8. Haller JA, Bandello F, Belfort R Jr, Blumenkranz MS, Gillies M, Heier J, Loewenstein A, Yoon YH, Jiao J, Li XY, Whitcup SM, Ozurdex GENEVA Study Group (2011) Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results. Ophthalmology 118:2453–2460. doi:10.1016/j.ophtha.2011.05.014
9. Kuppermann BD, Haller JA, Bandello F, Loewenstein A, Jiao J, Li XY, Whitcup SM (2014) Onset and duration of visual acuity improvement after dexamethasone intravitreal implant in eyes with macular edema due to retinal vein occlusion. Retina 34:1743–1749. doi:10.1097/iae.0000000000000167
10. Mangione CM, Lee PP, Gutierrez PR, Spritzer K, Berry S, Hays RD (2001) Development of the 25-item National Eye Institute Visual Function Questionnaire. Arch Ophthalmol 119:1050–1058
11. Nordmann JP, Viala M, Sullivan K, Arnould B, Berdeaux G (2004) Psychometric validation of the National Eye Institute Visual Function Questionnaire - 25 (NEI VFQ-25) French version: in a population of patients treated for ocular hypertension and glaucoma. Pharmacoeconomics 22:197–206
12. Nordmann JP, Auzanneau N, Ricard S, Berdeaux G (2003) Vision related quality of life and topical glaucoma treatment side effects. Health Qual Life Outcomes 1:75. doi:10.1186/1477-7525-1-75
13. Yuzawa M, Fujita K, Wittrup-Jensen KU, Norenberg C, Zeitz O, Adachi K, Wang EC, Heier J, Kaiser P, Chong V, Korobelnik JF (2015) Improvement in vision-related function with intravitreal aflibercept: data from phase 3 studies in wet age-related macular degeneration. Ophthalmology 122:571–578. doi:10.1016/j.ophtha.2014.09.024
14. Yeh WS, Haller JA, Lanzetta P, Kuppermann BD, Wong TY, Mitchell P, Whitcup SM, Kowalski JW (2012) Effect of the duration of macular edema on clinical outcomes in retinal vein occlusion treated with dexamethasone intravitreal implant. Ophthalmology 119:1190–1198. doi:10.1016/j.ophtha.2011.12.028
15. Augustin AJ, Holz FG, Haritoglou C, Mayer WJ, Bopp S, Scheuerle AF, Maier M, Sekundo W, Sandner D, Shirlaw A, Hattenbach LO (2015) Retrospective, observational study in patients receiving a dexamethasone intravitreal implant 0.7 mg for macular oedema secondary to retinal vein occlusion. Ophthalmologica 233:18–26. doi:10.1159/000368840
16. Capone A Jr, Singer MA, Dodwell DG, Dreyer RF, Oh KT, Roth DB, Walt JG, Scott LC, Hollander DA (2014) Efficacy and safety of two or more dexamethasone intravitreal implant injections for treatment of macular edema related to retinal vein occlusion (SHASTA study). Retina 34:342–351. doi:10.1097/IAE.0b013e318297f842
17. Singer MA, Capone A Jr, Dugel PU, Dreyer RF, Dodwell DG, Roth DB, Shi R, Walt JG, Scott LC, Hollander DA, SHASTA Study Group (2015) Two or more dexamethasone intravitreal implants as monotherapy or in combination therapy for macular edema in retinal vein occlusion: subgroup analysis of a retrospective chart review study. BMC Ophthalmol 15:33. doi:10.1186/s12886-015-0018-y