Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 3, 2016, Pages 964-966

  Barreto Luis, Amalia ^a,b   Pino Yanes, Maria ^a,c   Corrales, Almudena ^a,c   Campo, Paloma ^d   Callero, Ariel ^a   Acosta Herrera, Marialbert ^a,c,e   Cumplido, José ^e   Ma, Shwu Fan ^f   Martinez Tadeo, Juan ^a   Villar, Jesús ^c,e   Garcia, Joe G N ^g   Carrillo, Teresa ^e   Carracedo, Ángel ^h   Blanca, Miguel ^d   Flores, Carlos ^a,b,c  

^a HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^e HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^f UNIVERSITY OF CHICAGO   (United States)

^g UNIVERSITY OF ARIZONA   (United States)

^h UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADAM METALLOPEPTIDASE WITH THROMBOSPONDIN TYPE 1 MOTIF 9; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; CHOLESTEROL; DEOXYRIBONUCLEASE I; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 33; METALLOPROTEINASE; PROTEOGLYCAN; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS9 PROTEIN; ADAMTS9 PROTEIN, HUMAN;

AGE RELATED MACULAR DEGENERATION; AIRWAY REMODELING; ASTHMA; DISEASE SEVERITY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HERITABILITY; HUMAN; LETTER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; CASE CONTROL STUDY; CAUCASIAN; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS;

ADAM PROTEINS; ADAMTS9 PROTEIN; ASTHMA; CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; SPAIN;

EID: 84973548046     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.09.051     Document Type: Article

References (13)

1. D.A. Meyers, E.R. Bleecker, J.W. Holloway, and S.T. Holgate Asthma genetics and personalised medicine Lancet Respir Med 2 2014 405 415
2. M.F. Moffatt, I.G. Gut, F. Demenais, D.P. Strachan, E. Bouzigon, S. Heath, and et al. A large-scale, consortium-based genomewide association study of asthma N Engl J Med 363 2010 1211 1221
3. D.G. Torgerson, E.J. Ampleford, G.Y. Chiu, W.J. Gauderman, C.R. Gignoux, P.E. Graves, and et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations Nat Genet 43 2011 887 892
4. K. Nihlberg, A. Andersson-Sjoland, E. Tufvesson, J.S. Erjefalt, L. Bjermer, and G. Westergren-Thorsson Altered matrix production in the distal airways of individuals with asthma Thorax 65 2010 670 676
5. M. Weitoft, C. Andersson, A. Andersson-Sjoland, E. Tufvesson, L. Bjermer, J. Erjefalt, and et al. Controlled and uncontrolled asthma display distinct alveolar tissue matrix compositions Respir Res 15 2014 67
6. G. Chiappara, R. Gagliardo, A. Siena, M.R. Bonsignore, J. Bousquet, G. Bonsignore, and et al. Airway remodelling in the pathogenesis of asthma Curr Opin Allergy Clin Immunol 1 2001 85 93
7. I.M. Heid, A.U. Jackson, J.C. Randall, T.W. Winkler, L. Qi, V. Steinthorsdottir, and et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution Nat Genet 42 2010 949 960
8. L.G. Fritsche, W. Chen, M. Schu, B.L. Yaspan, Y. Yu, G. Thorleifsson, and et al. Seven new loci associated with age-related macular degeneration Nat Genet 45 2013 433 439
9. C.T. Liu, K.L. Monda, K.C. Taylor, L. Lange, E.W. Demerath, W. Palmas, and et al. Genome-wide association of body fat distribution in African ancestry populations suggests new loci PLoS Genet 9 2013 e1003681
10. M.A. Ferreira, M.C. Matheson, C.S. Tang, R. Granell, W. Ang, J. Hui, and et al. Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype J Allergy Clin Immunol 133 2014 1564 1571
11. C. Dong, L. Tang, Z. Liu, S. Bu, Q. Liu, Q. Wang, and et al. Landscape of the relationship between type 2 diabetes and coronary heart disease through an integrated gene network analysis Gene 539 2014 30 36
12. C.M. Visness, S.J. London, J.L. Daniels, J.S. Kaufman, K.B. Yeatts, A.M. Siega-Riz, and et al. Association of childhood obesity with atopic and nonatopic asthma: results from the National Health and Nutrition Examination Survey 1999-2006 J Asthma 47 2010 822 829
13. B. Al-Shawwa, N. Al-Huniti, G. Titus, and M. Abu-Hasan Hypercholesterolemia is a potential risk factor for asthma J Asthma 43 2006 231 233