Intratumoral lymphatic vessel density as a predictor of progression-free and overall survival in locally advanced laryngeal/hypopharyngeal cancer

Head and Neck

Volumn 38, Issue , 2016, Pages E417-E420

  Hurst, Newton J ^a   Dominello, Michael ^a   Dyson, Gregory ^a   Jaratli, Hayan ^a   Sharma, Meenu ^a   Ahmed, Yasin K ^a   Melkane, Antoine E ^a   Rose, Christopher ^a   Jacobs, John ^a   Giorgadze, Tamar ^b   Kim, Harold ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

D2 40; immunohistochemistry; laryngeal hypopharyngeal cancer; lymphatic vessel density; prognosis

Indexed keywords

ANTINEOPLASTIC METAL COMPLEX;

ADJUVANT RADIOTHERAPY; ADULT; ADVANCED CANCER; AGED; CANCER ADJUVANT THERAPY; CANCER STAGING; CANCER SURVIVAL; COHORT ANALYSIS; CONFERENCE PAPER; FEMALE; HUMAN; HYPOPHARYNX CARCINOMA; IMMUNOHISTOCHEMISTRY; INTENSITY MODULATED RADIATION THERAPY; INTRATUMORAL LYMPHATIC VESSEL DENSITY; LARYNGECTOMY; LARYNX SQUAMOUS CELL CARCINOMA; LYMPHATIC PARAMETERS; MAJOR CLINICAL STUDY; MALE; ONCOLOGICAL PARAMETERS; OVERALL SURVIVAL; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; SURVIVAL PREDICTION; DISEASE FREE SURVIVAL; HYPOPHARYNX TUMOR; LARYNX TUMOR; LYMPH VESSEL; LYMPHANGIOGENESIS; MIDDLE AGED; PROGNOSIS;

ADULT; AGED; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; HYPOPHARYNGEAL NEOPLASMS; LARYNGEAL NEOPLASMS; LYMPHANGIOGENESIS; LYMPHATIC VESSELS; MALE; MIDDLE AGED; PROGNOSIS;

EID: 84973498453     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.24011     Document Type: Conference Paper

References (22)

1. Elsheikh MN, Mahfouz ME, Elsheikh E,. Level IIb lymph nodes metastasis in elective supraomohyoid neck dissection for oral cavity squamous cell carcinoma: a molecular-based study. Laryngoscope 2005; 115: 1636-1640.
2. Kowalski LP, Medina JE,. Nodal metastases: predictive factors. Otolaryngol Clin North Am 1998; 31: 621-637.
3. Lea J, Bachar G, Sawka AM, et al., Metastases to level IIb in squamous cell carcinoma of the oral cavity: a systematic review and meta-analysis. Head Neck 2010; 32: 184-190.
4. Lindberg R,. Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer 1972; 29: 1446-1449.
5. Shah JP,. Patterns of cervical lymph node metastasis from squamous carcinomas of the upper aerodigestive tract. Am J Surg 1990; 160: 405-409.
6. Bolzoni Villaret A, Barbieri D, Peretti G, et al., Angiogenesis and lymphangiogenesis in early-stage laryngeal carcinoma: prognostic implications. Head Neck 2013; 35: 1132-1137.
7. Franchi A, Gallo O, Massi D, Baroni G, Santucci M,. Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations. Cancer 2004; 101: 973-978.
8. Hinojar-Gutiérrez A, Fernández-Contreras ME, González-González R, et al., Intratumoral lymphatic vessels and VEGF-C expression are predictive factors of lymph node relapse in T1-T4 N0 laryngopharyngeal squamous cell carcinoma. Ann Surg Oncol 2007; 14: 248-257.
9. Kyzas PA, Geleff S, Batistatou A, Agnantis NJ, Stefanou D,. Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J Pathol 2005; 206: 170-177.
10. Lin JY, Li XY, Dong P, Nakashima T,. Prognostic value of lymphangiogenesis in supraglottic laryngeal carcinoma. J Laryngol Otol 2011; 125: 945-951.
11. Maula SM, Luukkaa M, Grénman R, Jackson D, Jalkanen S, Ristamäki R,. Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region. Cancer Res 2003; 63: 1920-1926.
12. Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG,. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer 2014; 14: 159-172.
13. van Netten JP, Cann SA, Maxwell CA, Finegan RP,. Lymphagenesis and cancer metastasis. Br J Cancer 1998; 78: 277-278.
14. Beasley NJ, Prevo R, Banerji S, et al., Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res 2002; 62: 1315-1320.
15. Audet N, Beasley NJ, MacMillan C, Jackson DG, Gullane PJ, Kamel-Reid S,. Lymphatic vessel density, nodal metastases, and prognosis in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 2005; 131: 1065-1070.
16. Frech S, Hörmann K, Riedel F, Götte K,. Lymphatic vessel density in correlation to lymph node metastasis in head and neck squamous cell carcinoma. Anticancer Res 2009; 29: 1675-1679.
17. Nathanson SD,. Insights into the mechanisms of lymph node metastasis. Cancer 2003; 98: 413-423.
18. Kahn HJ, Marks A,. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest 2002; 82: 1255-1257.
19. Paximadis P, Yoo G, Lin HS, et al., Concurrent chemoradiotherapy improves survival in patients with hypopharyngeal cancer. Int J Radiat Oncol Biol Phys 2012; 82: 1515-1521.
20. Mnejja M, Hammami B, Bougacha L, et al., Occult lymph node metastasis in laryngeal squamous cell carcinoma: therapeutic and prognostic impact. Eur Ann Otorhinolaryngol Head Neck Dis 2010; 127: 173-176.
21. Zhang Z, Helman JI, Li LJ,. Lymphangiogenesis, lymphatic endothelial cells and lymphatic metastasis in head and neck cancer-a review of mechanisms. Int J Oral Sci 2010; 2: 5-14.
22. Yu M, Liu L, Liang C, et al., Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: a meta-analysis of literature. Head Neck 2014; 36: 596-602.