Investigator-Reported Bleeding Versus Post Hoc Adjudication of Bleeding: Lessons From the CHAMPION PHOENIX Trial

Journal of the American College of Cardiology

Volumn 67, Issue 5, 2016, Pages 596-598

  Jatene, Tannas ^a   Harrington, Robert A ^a   Stone, Gregg W ^a   Steg, Ph Gabriel ^a   Gibson, C Michael ^a   Hamm, Christian W ^a   Price, Matthew J ^a   Prats, Jayne ^a   Deliargyris, Efthymios N ^a   Mahaffey, Kenneth W ^a   White, Harvey D ^a   Bhatt, Deepak L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CANGRELOR; CLOPIDOGREL; HEMOGLOBIN; ADENOSINE PHOSPHATE; PURINERGIC P2Y RECEPTOR ANTAGONIST;

BLEEDING; CLINICAL TRIAL (TOPIC); DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; HUMAN; LETTER; NON ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STABLE ANGINA PECTORIS; TREATMENT OUTCOME; ANALOGS AND DERIVATIVES; CHEMICALLY INDUCED; METHODOLOGY; MYOCARDIAL INFARCTION; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); STATISTICS AND NUMERICAL DATA;

ADENOSINE MONOPHOSPHATE; HEMORRHAGE; HUMANS; MYOCARDIAL INFARCTION; PERCUTANEOUS CORONARY INTERVENTION; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN;

EID: 84973460174     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.11.027     Document Type: Letter

References (5)

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2. 2 Granger, C.B., Vogel, V., Cummings, S.R., et al. Do we need to adjudicate major clinical events?. Clin Trials 5 (2008), 56–60.
3. 3 Mahaffey, K.W., Held, C., Wojdyla, D.M., et al., for the PLATO Investigators. Ticagrelor effects on myocardial infarction and the impact of event adjudication in the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol 63 (2014), 1493–1499.
4. 4 Pogue, J., Walter, S.D., Yusuf, S., Evaluating the benefit of event adjudication of cardiovascular outcomes in large simple RCTs. Clin Trials 6 (2009), 239–251.
5. 5 Arnold, D.M., Lauzier, F., Rabbat, C., et al. Adjudication of bleeding outcomes in an international thromboprophylaxis trial in critical illness. Thromb Res 131 (2013), 204–209.