Diagnosing acute HIV infection at point of care: A retrospective analysis of the sensitivity and specificity of a fourth-generation point-of-care test for detection of HIV core protein p24

Sexually Transmitted Infections

Volumn 93, Issue 2, 2017, Pages 100-101

  Fitzgerald, Naomi ^a   Cross, Maria ^a   O'Shea, Siobhan ^a   Fox, Julie ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

ANTIGEN DETECTION; DIAGNOSIS; HIV; HIV TESTING; PRIMARY HIV INFECTION

Indexed keywords

ANTIGEN P24; GAG PROTEIN; DIAGNOSTIC KIT; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

ACUTE HIV INFECTION; ANTIGEN DETECTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HIV TEST; HUMAN; POINT OF CARE TESTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; RANDOMIZED CONTROLLED TRIAL; RETROSPECTIVE STUDY; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; BLOOD; DIAGNOSTIC KIT; ENZYME IMMUNOASSAY; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; MASS SCREENING; PROCEDURES; UNITED KINGDOM;

HIV ANTIBODIES; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOENZYME TECHNIQUES; MASS SCREENING; POINT-OF-CARE TESTING; REAGENT KITS, DIAGNOSTIC; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; UNITED KINGDOM;

EID: 84973375184     PISSN: 13684973     EISSN: 14723263     Source Type: Journal    
DOI: 10.1136/sextrans-2015-052491     Document Type: Article

References (10)

1. Branson BM, Stekler JD. Detection of acute HIV infection: we can't close the window. J Infect Dis 2012;205:521-4.
2. Public Health England. HIV in the United Kingdom:2014 Report. https://www. gov. uk/government/uploads/system/uploads/attachment-data/file/401662/2014-PHE- HIV-annual-report-draft-Final-07-01-2015. pdf
3. Pilcher CD, Tien HC, Eron JJ, et al. Brief but efficient: Acute HIV infection and the sexual transmission of HIV. J Infect Dis 2004;189:1785-92.
4. Hollingsworth TD, Anderson RM, Fraser C. HIV-1 transmission, by stage of infection. J Infect Dis 2008;198:687-93.
5. Hocqueloux L, Prazuck T, Avettand-Fenoel V, et al. Long-term immunovirologic control following antiretroviral therapy interruption in patients treated at the time of primary HIV-1 infection. AIDS 2010;24:1598-601.
6. Rosenberg ES, Altfeld M, Poon SH, et al. Immune control of HIV-1 after early treatment of acute infection. Nature 2000;407:523-6.
7. Jones CB, Kuldanek K, Muir D, et al. Clinical evaluation of the Determine HIV-1/2 Ag/Ab Combo test. J Infect Dis 2012;206:1947-9.
8. Le T, Wright EJ, Smith DM, et al. Enhanced CD4+ T-cell recovery with earlier HIV-1 antiretroviral therapy. N Engl J Med 2013;368:218-30.
9. Rosenberg NE, Kamanga G, Phiri S, et al. Detection of acute HIV infection: A field evaluation of the Determine® HIV-1/2 Ag/Ab Combo test. J Infect Dis 2012;205:528-34.
10. Fox J, Dunn H, O'shea S. Low rates of p24 antigen detection using a fourth-generation point of care HIV test. Sex Transm Infect 2011;87:178-9.