Value of SATB2 immunostaining in the distinction between small intestinal and colorectal adenocarcinomas

Journal of Clinical Pathology

Volumn 69, Issue 12, 2016, Pages 1046-1050

  Kim, Christopher J ^a   Baruch Oren, Tamar ^a   Lin, Fan ^b   Fan, Xuemo ^c   Yang, Ximing J ^d   Wang, Hanlin L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GEISINGER MEDICAL CENTER   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

COLORECTAL CANCER; IMMUNOCYTOCHEMISTRY; SMALL INTESTINE

Indexed keywords

DNA BINDING PROTEIN; SPECIAL AT RICH SEQUENCE BINDING PROTEIN 2; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG; CYTOKERATIN 20; KRT20 PROTEIN, HUMAN; MATRIX ATTACHMENT REGION BINDING PROTEIN; SATB2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; COLORECTAL CARCINOMA; COMPARATIVE STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINAL ADENOCARCINOMA; SMALL INTESTINE CARCINOMA; TUMOR CELL; ADENOCARCINOMA; CLASSIFICATION; COLORECTAL TUMOR; INTESTINE; INTESTINE TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; VERY ELDERLY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL NEOPLASMS; INTESTINES; KERATIN-20; MALE; MATRIX ATTACHMENT REGION BINDING PROTEINS; MIDDLE AGED; TRANSCRIPTION FACTORS;

EID: 84973334021     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2015-203588     Document Type: Article

References (17)

1. Halfdanarson TR, McWilliams RR, Donohue JH, et al. A single-institution experience with 491 cases of small bowel adenocarcinoma. Am J Surg 2010; 199: 797-803
2. Overman MJ, Hu CY, Kopetz S, et al. A population-based comparison of adenocarcinoma of the large and small intestine: insights into a rare disease. Ann Surg Oncol 2012; 19: 1439-45
3. Estrella JS, Wu TT, Rashid A, et al. Mucosal colonization by metastatic carcinoma in the gastrointestinal tract: a potential mimic of primary Neoplasia. Am J Surg Pathol 2011; 35: 563-72
4. Zhang MQ, Lin F, Hui P, et al. Expression of mucins, SIMA, villin, and CDX2 in small-intestinal adenocarcinoma. Am J Clin Pathol 2007; 128: 808-16
5. Chen ZM, Wang HL. Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine. Am J Surg Pathol 2004; 28: 1352-9
6. Mac MT, Chung F, Lin F, et al. Expression of hepatocyte antigen in small intestinal epithelium and adenocarcinoma. Am J Clin Pathol 2009; 132: 80-5
7. Chen ZME, Ritter JH, Wang HL. Differential expression of alpha-methylacyl coenzyme A racemase in adenocarcinomas of the small and large intestines. Am J Surg Pathol 2005; 29: 890-6
8. Bayrak R, Haltas H, Yenidunya S. The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody. Diagn Pathol 2012; 7: 9
9. Bayrak R, Yenidünya S, Haltas H. Cytokeratin 7 and cytokeratin 20 expression in colorectal adenocarcinomas. Pathol Res Pract 2011; 207: 156-60
10. Hernandez BY, Frierson HF, Moskaluk CA, et al. CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray. Hum Pathol 2005; 36: 275-81
11. Magnusson K, de Wit M, Brennan DJ, et al. SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas. Am J Surg Pathol 2011; 35: 937-48
12. Lin F, Shi J, Zhu S, et al. Cadherin-17 and SATB2 are sensitive and specific immunomarkers for medullary carcinoma of the large intestine. Arch Pathol Lab Med 2014; 138: 1015-26
13. Dragomir A, de Wit M, Johansson C, et al. The role of SATB2 as a diagnostic marker for tumors of colorectal origin: results of a pathology-based clinical prospective study. Am J Clin Pathol 2014; 141: 630-8
14. Wang S, Zhou J, Wang XY, et al. Down-regulated expression of SATB2 is associated with metastasis and poor prognosis in colorectal cancer. J Pathol 2009; 219: 114-22
15. Eberhard J, Gaber A, Wangefjord S, et al. A cohort study of the prognostic and treatment predictive value of SATB2 expression in colorectal cancer. Br J Cancer 2012; 106: 931-8
16. Overman MJ, Pozadzides J, Kopetz S, et al. Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. Br J Cancer 2010; 102: 144-50
17. Whitcomb E, Liu X, Xiao SY. Crohn enteritis-Associated small bowel adenocarcinomas exhibit gastric differentiation. Hum Pathol 2014; 45: 359-67