메뉴 건너뛰기




Volumn , Issue , 2013, Pages 117-135

Linker technology and impact of linker design on ADC properties

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84973319470     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-5456-4_7     Document Type: Chapter
Times cited : (7)

References (61)
  • 1
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu G, Fang YZ, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health. J Nutr 134:489-492
    • (2004) J Nutr , vol.134 , pp. 489-492
    • Wu, G.1    Fang, Y.Z.2    Yang, S.3    Lupton, J.R.4    Turner, N.D.5
  • 2
    • 0030576641 scopus 로고    scopus 로고
    • Differential distribution of free and bound glutathione and cyst(e) ine in human blood
    • Mills BJ, Lang CA (1996) Differential distribution of free and bound glutathione and cyst(e) ine in human blood. Biochem Pharmacol 52:401-406
    • (1996) Biochem Pharmacol , vol.52 , pp. 401-406
    • Mills, B.J.1    Lang, C.A.2
  • 3
    • 65549092679 scopus 로고    scopus 로고
    • Oxidation of the albumin thiol to sulfenic acid and its implications in the intravascular compartment
    • Turell L, Carballal S, Botti H, Radi R, Alvarez B (2009) Oxidation of the albumin thiol to sulfenic acid and its implications in the intravascular compartment. Braz J Med Biol Res 42:305-311
    • (2009) Braz J Med Biol Res , vol.42 , pp. 305-311
    • Turell, L.1    Carballal, S.2    Botti, H.3    Radi, R.4    Alvarez, B.5
  • 4
    • 0001691160 scopus 로고
    • A spectrophotometiic method for studying the rates of reaction of disulfides with protein thiol groups applied to bovine serum albumin
    • Wilson JM, Wu D, Motiu-DeGrood R, Hupe DJ (1980) A spectrophotometiic method for studying the rates of reaction of disulfides with protein thiol groups applied to bovine serum albumin. J Am Chem Soc 102:359-363
    • (1980) J Am Chem Soc , vol.102 , pp. 359-363
    • Wilson, J.M.1    Wu, D.2    Motiu-DeGrood, R.3    Hupe, D.J.4
  • 5
    • 41549159471 scopus 로고    scopus 로고
    • The human PDI family: Versatility packed into a single fold
    • Appenzeller-Herzog C, Ellgaard L (2008) The human PDI family: versatility packed into a single fold. Biochim Biophys Acta 1783:535-548
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 535-548
    • Appenzeller-Herzog, C.1    Ellgaard, L.2
  • 6
    • 0036566039 scopus 로고    scopus 로고
    • Endolysosomal proteolysis and its regulation
    • Pillay CS, Elliott E, Dennison C (2002) Endolysosomal proteolysis and its regulation. Biochem J363:417-429
    • (2002) Biochem , vol.J363 , pp. 417-429
    • Pillay, C.S.1    Elliott, E.2    Dennison, C.3
  • 7
    • 34249019920 scopus 로고    scopus 로고
    • Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
    • Ciechanover A (2006) Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Hematol Am Soc Hematol Educ Prog 1-12:505-506
    • (2006) Hematol Am Soc Hematol Educ Prog , vol.1-12 , pp. 505-506
    • Ciechanover, A.1
  • 8
    • 64949125849 scopus 로고    scopus 로고
    • Antibody-cytotoxic agent conjugates: Preparation and characterization
    • Singh R, Erickson HK (2009) Antibody-cytotoxic agent conjugates: preparation and characterization. Methods Mol Biol 525:445-467, xiv
    • (2009) Methods Mol Biol , vol.525
    • Singh, R.1    Erickson, H.K.2
  • 11
    • 58149161759 scopus 로고    scopus 로고
    • Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker
    • Oflazoglu E, Stone IJ, Gordon K, Wood CG, Repasky EA, Grewal IS, Law CL, Gerber HP (2008) Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker. Clin Cancer Res 14:6171-6180
    • (2008) Clin Cancer Res , vol.14 , pp. 6171-6180
    • Oflazoglu, E.1    Stone, I.J.2    Gordon, K.3    Wood, C.G.4    Repasky, E.A.5    Grewal, I.S.6    Law, C.L.7    Gerber, H.P.8
  • 24
    • 33644777526 scopus 로고    scopus 로고
    • In vivo behaviour of antibody-drug conjugates for the targeted treatment of cancer
    • Xie H, Blattler WA (2006) In vivo behaviour of antibody-drug conjugates for the targeted treatment of cancer. Expert Opin Biol Ther 6:281-291
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 281-291
    • Xie, H.1    Blattler, W.A.2
  • 26
    • 0018958580 scopus 로고
    • Elastase-type proteases on the surface of human blood monocytes: Possible role in amyloid formation
    • Lavie G, Zucker-Franklin D, Franklin EC (1980) Elastase-type proteases on the surface of human blood monocytes: possible role in amyloid formation. J Immunol 125:175-180
    • (1980) J Immunol , vol.125 , pp. 175-180
    • Lavie, G.1    Zucker-Franklin, D.2    Franklin, E.C.3
  • 27
    • 37249026703 scopus 로고    scopus 로고
    • Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004
    • Ciechanover A (2007) Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. Ann N Y Acad Sci 1116:1-28
    • (2007) Ann N Y Acad Sci , vol.1116 , pp. 1-28
    • Ciechanover, A.1
  • 28
    • 0024232289 scopus 로고
    • Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure
    • Jain RK, Baxter LT (1988) Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res 48:7022-7032
    • (1988) Cancer Res , vol.48 , pp. 7022-7032
    • Jain, R.K.1    Baxter, L.T.2
  • 29
    • 79952516871 scopus 로고    scopus 로고
    • Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
    • Ciechanover A (2010) Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Medicina (Buenos Aires) 70:105-119
    • (2010) Medicina (Buenos Aires) , vol.70 , pp. 105-119
    • Ciechanover, A.1
  • 32
    • 80052937158 scopus 로고    scopus 로고
    • A novel pathway for maytansinoid release from thioether linked antibody-drug conjugates (ADCs) under oxidative conditions
    • Fishkin N, Maloney EK, Chari RV, Singh R (2011) A novel pathway for maytansinoid release from thioether linked antibody-drug conjugates (ADCs) under oxidative conditions. Chem Commun (Camb) 47:10752-10754
    • (2011) Chem Commun (Camb) , vol.47 , pp. 10752-10754
    • Fishkin, N.1    Maloney, E.K.2    Chari, R.V.3    Singh, R.4
  • 34
    • 21244469077 scopus 로고    scopus 로고
    • Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry
    • Lazar AC, Wang L, Blattler WA, Amphlett G, Lambert JM, Zhang W (2005) Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry. Rapid Commun Mass Spectrom 19:1806-1814
    • (2005) Rapid Commun Mass Spectrom , vol.19 , pp. 1806-1814
    • Lazar, A.C.1    Wang, L.2    Blattler, W.A.3    Amphlett, G.4    Lambert, J.M.5    Zhang, W.6
  • 38
    • 9444260479 scopus 로고    scopus 로고
    • Biological impediments to monoclonal antibody-based cancer immunotherapy
    • Christiansen J, Rajasekaran AK (2004) Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol Cancer Ther 3:1493-1501
    • (2004) Mol Cancer Ther , vol.3 , pp. 1493-1501
    • Christiansen, J.1    Rajasekaran, A.K.2
  • 39
    • 0022875861 scopus 로고
    • Modulation of antigen expression in human tumor cell populations
    • Greiner JW (1986) Modulation of antigen expression in human tumor cell populations. Cancer Invest 4:239-256
    • (1986) Cancer Invest , vol.4 , pp. 239-256
    • Greiner, J.W.1
  • 41
    • 66249109940 scopus 로고    scopus 로고
    • Affinity and avidity in antibody-based tumor targeting
    • Rudnick SI, Adams GP (2009) Affinity and avidity in antibody-based tumor targeting. Cancer Biother Radiopharm 24:155-161
    • (2009) Cancer Biother Radiopharm , vol.24 , pp. 155-161
    • Rudnick, S.I.1    Adams, G.P.2
  • 43
    • 0019515510 scopus 로고
    • Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells
    • Drewinko B, Patchen M, Yang LY, Barlogie B (1981) Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells. Cancer Res 41:2328-2333
    • (1981) Cancer Res , vol.41 , pp. 2328-2333
    • Drewinko, B.1    Patchen, M.2    Yang, L.Y.3    Barlogie, B.4
  • 44
    • 0018509644 scopus 로고
    • Cell cycle phase-specific cytotoxicity of the antitumor agent maytansine
    • Rao PN, Freireich EJ, Smith ML, Loo TL (1979) Cell cycle phase-specific cytotoxicity of the antitumor agent maytansine. Cancer Res 39:3152-3155
    • (1979) Cancer Res , vol.39 , pp. 3152-3155
    • Rao, P.N.1    Freireich, E.J.2    Smith, M.L.3    Loo, T.L.4
  • 47
    • 18444411317 scopus 로고    scopus 로고
    • Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers
    • Matsui H, Takeshita A, Naito K, Shinjo K, Shigeno K, Maekawa M, Yamakawa Y, Tanimoto M, Kobayashi M, Ohnishi K, Ohno R (2002) Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers. Leukemia 16:813-819
    • (2002) Leukemia , vol.16 , pp. 813-819
    • Matsui, H.1    Takeshita, A.2    Naito, K.3    Shinjo, K.4    Shigeno, K.5    Maekawa, M.6    Yamakawa, Y.7    Tanimoto, M.8    Kobayashi, M.9    Ohnishi, K.10    Ohno, R.11
  • 48
    • 0043240102 scopus 로고    scopus 로고
    • Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells
    • Walter RB, Raden BW, Hong TC, Flowers DA, Bernstein ID, Linenberger ML (2003) Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells. Blood 102:1466-1473
    • (2003) Blood , vol.102 , pp. 1466-1473
    • Walter, R.B.1    Raden, B.W.2    Hong, T.C.3    Flowers, D.A.4    Bernstein, I.D.5    Linenberger, M.L.6
  • 51
    • 0026589412 scopus 로고
    • Resistance of CHO cells expressing P-glycoprotein to cyclopropylpyrroloindole (CPI) alkylating agents
    • Zsido TJ, Beerman TA, Meegan RL, Woynarowski JM, Baker RM (1992) Resistance of CHO cells expressing P-glycoprotein to cyclopropylpyrroloindole (CPI) alkylating agents. Biochem Pharmacol 43:1817-1822
    • (1992) Biochem Pharmacol , vol.43 , pp. 1817-1822
    • Zsido, T.J.1    Beerman, T.A.2    Meegan, R.L.3    Woynarowski, J.M.4    Baker, R.M.5
  • 52
    • 67650733509 scopus 로고    scopus 로고
    • P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients
    • Tang R, Cohen S, Perrot JY, Faussat AM, Zuany-Amorim C, Marjanovic Z, Morjani H, Fava F, Corre E, Legrand O, Marie JP (2009) P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer 9:199
    • (2009) BMC Cancer , vol.9 , pp. 199
    • Tang, R.1    Cohen, S.2    Perrot, J.Y.3    Faussat, A.M.4    Zuany-Amorim, C.5    Marjanovic, Z.6    Morjani, H.7    Fava, F.8    Corre, E.9    Legrand, O.10    Marie, J.P.11
  • 53
    • 32044453808 scopus 로고    scopus 로고
    • Recent progress in understanding the mechanism of P-glycoprotein- mediated drug efflux
    • Loo TW, Clarke DM (2005) Recent progress in understanding the mechanism of P-glycoprotein- mediated drug efflux. J Membr Biol 206:173-185
    • (2005) J Membr Biol , vol.206 , pp. 173-185
    • Loo, T.W.1    Clarke, D.M.2
  • 57
    • 1342287215 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice
    • Xie H, Audette C, Hoffee M, Lambert JM, Blattler WA (2004) Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice. J Pharmacol Exp Ther 308:1073-1082
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1073-1082
    • Xie, H.1    Audette, C.2    Hoffee, M.3    Lambert, J.M.4    Blattler, W.A.5
  • 61
    • 84952975583 scopus 로고    scopus 로고
    • Antibody-maytansinoid conjugates: A new strategy for the treatment of cancer
    • Lambert JM (2010) Antibody-maytansinoid conjugates: a new strategy for the treatment of cancer. Drugs of the future 35:471-480
    • (2010) Drugs of the future , vol.35 , pp. 471-480
    • Lambert, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.