-
1
-
-
1542376929
-
Glutathione metabolism and its implications for health
-
Wu G, Fang YZ, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health. J Nutr 134:489-492
-
(2004)
J Nutr
, vol.134
, pp. 489-492
-
-
Wu, G.1
Fang, Y.Z.2
Yang, S.3
Lupton, J.R.4
Turner, N.D.5
-
2
-
-
0030576641
-
Differential distribution of free and bound glutathione and cyst(e) ine in human blood
-
Mills BJ, Lang CA (1996) Differential distribution of free and bound glutathione and cyst(e) ine in human blood. Biochem Pharmacol 52:401-406
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 401-406
-
-
Mills, B.J.1
Lang, C.A.2
-
3
-
-
65549092679
-
Oxidation of the albumin thiol to sulfenic acid and its implications in the intravascular compartment
-
Turell L, Carballal S, Botti H, Radi R, Alvarez B (2009) Oxidation of the albumin thiol to sulfenic acid and its implications in the intravascular compartment. Braz J Med Biol Res 42:305-311
-
(2009)
Braz J Med Biol Res
, vol.42
, pp. 305-311
-
-
Turell, L.1
Carballal, S.2
Botti, H.3
Radi, R.4
Alvarez, B.5
-
4
-
-
0001691160
-
A spectrophotometiic method for studying the rates of reaction of disulfides with protein thiol groups applied to bovine serum albumin
-
Wilson JM, Wu D, Motiu-DeGrood R, Hupe DJ (1980) A spectrophotometiic method for studying the rates of reaction of disulfides with protein thiol groups applied to bovine serum albumin. J Am Chem Soc 102:359-363
-
(1980)
J Am Chem Soc
, vol.102
, pp. 359-363
-
-
Wilson, J.M.1
Wu, D.2
Motiu-DeGrood, R.3
Hupe, D.J.4
-
5
-
-
41549159471
-
The human PDI family: Versatility packed into a single fold
-
Appenzeller-Herzog C, Ellgaard L (2008) The human PDI family: versatility packed into a single fold. Biochim Biophys Acta 1783:535-548
-
(2008)
Biochim Biophys Acta
, vol.1783
, pp. 535-548
-
-
Appenzeller-Herzog, C.1
Ellgaard, L.2
-
6
-
-
0036566039
-
Endolysosomal proteolysis and its regulation
-
Pillay CS, Elliott E, Dennison C (2002) Endolysosomal proteolysis and its regulation. Biochem J363:417-429
-
(2002)
Biochem
, vol.J363
, pp. 417-429
-
-
Pillay, C.S.1
Elliott, E.2
Dennison, C.3
-
7
-
-
34249019920
-
Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
-
Ciechanover A (2006) Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Hematol Am Soc Hematol Educ Prog 1-12:505-506
-
(2006)
Hematol Am Soc Hematol Educ Prog
, vol.1-12
, pp. 505-506
-
-
Ciechanover, A.1
-
8
-
-
64949125849
-
Antibody-cytotoxic agent conjugates: Preparation and characterization
-
Singh R, Erickson HK (2009) Antibody-cytotoxic agent conjugates: preparation and characterization. Methods Mol Biol 525:445-467, xiv
-
(2009)
Methods Mol Biol
, vol.525
-
-
Singh, R.1
Erickson, H.K.2
-
9
-
-
77957590621
-
Engineered thio-trastuzumab- DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer
-
Junutula JR, Flagella KM, Graham RA, Parsons KL, Ha E, Raab H, Bhakta S, Nguyen T, Dugger DL, Li G, Mai E, Lewis Phillips GD, Hiraragi H, Fuji RN, Tibbitts J, Vandlen R, Spencer SD, Scheller RH, Polakis P, Sliwkowski MX (2010) Engineered thio-trastuzumab- DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer. Clin Cancer Res 16:4769-4778
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4769-4778
-
-
Junutula, J.R.1
Flagella, K.M.2
Graham, R.A.3
Parsons, K.L.4
Ha, E.5
Raab, H.6
Bhakta, S.7
Nguyen, T.8
Dugger, D.L.9
Li, G.10
Mai, E.11
Lewis Phillips, G.D.12
Hiraragi, H.13
Fuji, R.N.14
Tibbitts, J.15
Vandlen, R.16
Spencer, S.D.17
Scheller, R.H.18
Polakis, P.19
Sliwkowski, M.X.20
more..
-
10
-
-
56449129810
-
Targeting HER2-positive breast cancer with trastuzumab- DM1, an antibody-cytotoxic drug conjugate
-
Lewis Phillips GD, Li G, Dugger DL, Crocker LM, Parsons KL, Mai E, Blattler WA, Lambert JM, Chari RV, Lutz RJ, Wong WL, Jacobson FS, Koeppen H, Schwall RH, Kenkare-Mitra SR, Spencer SD, Sliwkowski MX (2008) Targeting HER2-positive breast cancer with trastuzumab- DM1, an antibody-cytotoxic drug conjugate. Cancer Res 68:9280-9290
-
(2008)
Cancer Res
, vol.68
, pp. 9280-9290
-
-
Lewis Phillips, G.D.1
Li, G.2
Dugger, D.L.3
Crocker, L.M.4
Parsons, K.L.5
Mai, E.6
Blattler, W.A.7
Lambert, J.M.8
Chari, R.V.9
Lutz, R.J.10
Wong, W.L.11
Jacobson, F.S.12
Koeppen, H.13
Schwall, R.H.14
Kenkare-Mitra, S.R.15
Spencer, S.D.16
Sliwkowski, M.X.17
-
11
-
-
58149161759
-
Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker
-
Oflazoglu E, Stone IJ, Gordon K, Wood CG, Repasky EA, Grewal IS, Law CL, Gerber HP (2008) Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker. Clin Cancer Res 14:6171-6180
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6171-6180
-
-
Oflazoglu, E.1
Stone, I.J.2
Gordon, K.3
Wood, C.G.4
Repasky, E.A.5
Grewal, I.S.6
Law, C.L.7
Gerber, H.P.8
-
12
-
-
33645500289
-
Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
-
Erickson HK, Park PU, Widdison WC, Kovtun YV, Garrett LM, Hoffman K, Lutz RJ, Goldmacher VS, Blattler WA (2006) Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res 66:4426-4433
-
(2006)
Cancer Res
, vol.66
, pp. 4426-4433
-
-
Erickson, H.K.1
Park, P.U.2
Widdison, W.C.3
Kovtun, Y.V.4
Garrett, L.M.5
Hoffman, K.6
Lutz, R.J.7
Goldmacher, V.S.8
Blattler, W.A.9
-
13
-
-
77950224905
-
Antibody-maytansinoid conjugates designed to bypass multidrug resistance
-
Kovtun YV, Audette CA, Mayo MF, Jones GE, Doherty H, Maloney EK, Erickson HK, Sun X, Wilhelm S, Ab O, Lai KC, Widdison WC, Kellogg B, Johnson H, Pinkas J, Lutz RJ, Singh R, Goldmacher VS, Chari RV (2010) Antibody-maytansinoid conjugates designed to bypass multidrug resistance. Cancer Res 70:2528-2537
-
(2010)
Cancer Res
, vol.70
, pp. 2528-2537
-
-
Kovtun, Y.V.1
Audette, C.A.2
Mayo, M.F.3
Jones, G.E.4
Doherty, H.5
Maloney, E.K.6
Erickson, H.K.7
Sun, X.8
Wilhelm, S.9
Ab, O.10
Lai, K.C.11
Widdison, W.C.12
Kellogg, B.13
Johnson, H.14
Pinkas, J.15
Lutz, R.J.16
Singh, R.17
Goldmacher, V.S.18
Chari, R.V.19
-
14
-
-
31544441685
-
Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: Effects of linker technology on efficacy and toxicity
-
Doronina SO, Mendelsohn BA, Bovee TD, Cerveny CG, Alley SC, Meyer DL, Oflazoglu E, Toki BE, Sanderson RJ, Zabinski RF, Wahl AF, Senter PD (2006) Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem 17:114-124
-
(2006)
Bioconjug Chem
, vol.17
, pp. 114-124
-
-
Doronina, S.O.1
Mendelsohn, B.A.2
Bovee, T.D.3
Cerveny, C.G.4
Alley, S.C.5
Meyer, D.L.6
Oflazoglu, E.7
Toki, B.E.8
Sanderson, R.J.9
Zabinski, R.F.10
Wahl, A.F.11
Senter, P.D.12
-
15
-
-
79955022475
-
Disulfide-linked antibody-maytansinoid conjugates: Optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage
-
Kellogg BA, Garrett L, Kovtun Y, Lai KC, Leece B, Miller M, Payne G, Steeves R, Whiteman KR, Widdison W, Xie H, Singh R, Chari RV, Lambert JM, Lutz RJ (2011) Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage. Bioconjug Chem 22:717-727
-
(2011)
Bioconjug Chem
, vol.22
, pp. 717-727
-
-
Kellogg, B.A.1
Garrett, L.2
Kovtun, Y.3
Lai, K.C.4
Leece, B.5
Miller, M.6
Payne, G.7
Steeves, R.8
Whiteman, K.R.9
Widdison, W.10
Xie, H.11
Singh, R.12
Chari, R.V.13
Lambert, J.M.14
Lutz, R.J.15
-
16
-
-
33644787435
-
Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen
-
Kovtun YV, Audette CA, Ye Y, Xie H, Ruberti MF, Phinney SJ, Leece BA, Chittenden T, Blattler WA, Goldmacher VS (2006) Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res 66:3214-3221
-
(2006)
Cancer Res
, vol.66
, pp. 3214-3221
-
-
Kovtun, Y.V.1
Audette, C.A.2
Ye, Y.3
Xie, H.4
Ruberti, M.F.5
Phinney, S.J.6
Leece, B.A.7
Chittenden, T.8
Blattler, W.A.9
Goldmacher, V.S.10
-
17
-
-
74949139946
-
Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates
-
Erickson HK, Widdison WC, Mayo MF, Whiteman K, Audette C, Wilhelm SD, Singh R (2010) Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. Bioconjug Chem 21:84-92
-
(2010)
Bioconjug Chem
, vol.21
, pp. 84-92
-
-
Erickson, H.K.1
Widdison, W.C.2
Mayo, M.F.3
Whiteman, K.4
Audette, C.5
Wilhelm, S.D.6
Singh, R.7
-
18
-
-
34250707392
-
Alphav integrin-targeted immunoconjugates regress established human tumors in xenograft models
-
Chen Q, Millar HJ, McCabe FL, Manning CD, Steeves R, Lai K, Kellogg B, Lutz RJ, Trikha M, Nakada MT, Anderson GM (2007) Alphav integrin-targeted immunoconjugates regress established human tumors in xenograft models. Clin Cancer Res 13:3689-3695
-
(2007)
Clin Cancer Res
, vol.13
, pp. 3689-3695
-
-
Chen, Q.1
Millar, H.J.2
McCabe, F.L.3
Manning, C.D.4
Steeves, R.5
Lai, K.6
Kellogg, B.7
Lutz, R.J.8
Trikha, M.9
Nakada, M.T.10
Anderson, G.M.11
-
19
-
-
10744222473
-
Development of potent monoclonal antibody auristatin conjugates for cancer therapy
-
Doronina SO, Toki BE, Torgov MY, Mendelsohn BA, Cerveny CG, Chace DF, DeBlanc RL, Gearing RP, Bovee TD, Siegall CB, Francisco JA, Wahl AF, Meyer DL, Senter PD (2003) Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat Biotechnol 21:778-784
-
(2003)
Nat Biotechnol
, vol.21
, pp. 778-784
-
-
Doronina, S.O.1
Toki, B.E.2
Torgov, M.Y.3
Mendelsohn, B.A.4
Cerveny, C.G.5
Chace, D.F.6
DeBlanc, R.L.7
Gearing, R.P.8
Bovee, T.D.9
Siegall, C.B.10
Francisco, J.A.11
Wahl, A.F.12
Meyer, D.L.13
Senter, P.D.14
-
20
-
-
76049122850
-
Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate
-
Okeley NM, Miyamoto JB, Zhang X, Sanderson RJ, Benjamin DR, Sievers EL, Senter PD, Alley SC (2010) Intracellular activation of SGN-35, a potent anti-CD30 antibody-drug conjugate. Clin Cancer Res 16:888-897
-
(2010)
Clin Cancer Res
, vol.16
, pp. 888-897
-
-
Okeley, N.M.1
Miyamoto, J.B.2
Zhang, X.3
Sanderson, R.J.4
Benjamin, D.R.5
Sievers, E.L.6
Senter, P.D.7
Alley, S.C.8
-
21
-
-
70350494468
-
Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
-
Dornan D, Bennett F, Chen Y, Dennis M, Eaton D, Elkins K, French D, Go MA, Jack A, Junutula JR, Koeppen H, Lau J, McBride J, Rawstron A, Shi X, Yu N, Yu SF, Yue P, Zheng B, Ebens A, Polson AG (2009) Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma. Blood 114:2721-2729
-
(2009)
Blood
, vol.114
, pp. 2721-2729
-
-
Dornan, D.1
Bennett, F.2
Chen, Y.3
Dennis, M.4
Eaton, D.5
Elkins, K.6
French, D.7
Go, M.A.8
Jack, A.9
Junutula, J.R.10
Koeppen, H.11
Lau, J.12
McBride, J.13
Rawstron, A.14
Shi, X.15
Yu, N.16
Yu, S.F.17
Yue, P.18
Zheng, B.19
Ebens, A.20
Polson, A.G.21
more..
-
22
-
-
10744229449
-
Antibody-targeted chemotherapy with CMC-544: A CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies
-
DiJoseph JF, Armellino DC, Boghaert ER, Khandke K, Dougher MM, Sridharan L, Kunz A, Hamann PR, Gorovits B, Udata C, Moran JK, Popplewell AG, Stephens S, Frost P, Damle NK (2004) Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies. Blood 103:1807-1814
-
(2004)
Blood
, vol.103
, pp. 1807-1814
-
-
DiJoseph, J.F.1
Armellino, D.C.2
Boghaert, E.R.3
Khandke, K.4
Dougher, M.M.5
Sridharan, L.6
Kunz, A.7
Hamann, P.R.8
Gorovits, B.9
Udata, C.10
Moran, J.K.11
Popplewell, A.G.12
Stephens, S.13
Frost, P.14
Damle, N.K.15
-
23
-
-
34848917110
-
CD74: A new candidate target for the immunotherapy of B-cell neoplasms
-
Stein R, Mattes MJ, Cardillo TM, Hansen HJ, Chang CH, Burton J, Govindan S, Goldenberg DM (2007) CD74: a new candidate target for the immunotherapy of B-cell neoplasms. Clin Cancer Res 13:5556s-5563s
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5556s-5563s
-
-
Stein, R.1
Mattes, M.J.2
Cardillo, T.M.3
Hansen, H.J.4
Chang, C.H.5
Burton, J.6
Govindan, S.7
Goldenberg, D.M.8
-
24
-
-
33644777526
-
In vivo behaviour of antibody-drug conjugates for the targeted treatment of cancer
-
Xie H, Blattler WA (2006) In vivo behaviour of antibody-drug conjugates for the targeted treatment of cancer. Expert Opin Biol Ther 6:281-291
-
(2006)
Expert Opin Biol Ther
, vol.6
, pp. 281-291
-
-
Xie, H.1
Blattler, W.A.2
-
26
-
-
0018958580
-
Elastase-type proteases on the surface of human blood monocytes: Possible role in amyloid formation
-
Lavie G, Zucker-Franklin D, Franklin EC (1980) Elastase-type proteases on the surface of human blood monocytes: possible role in amyloid formation. J Immunol 125:175-180
-
(1980)
J Immunol
, vol.125
, pp. 175-180
-
-
Lavie, G.1
Zucker-Franklin, D.2
Franklin, E.C.3
-
27
-
-
37249026703
-
Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004
-
Ciechanover A (2007) Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. Ann N Y Acad Sci 1116:1-28
-
(2007)
Ann N Y Acad Sci
, vol.1116
, pp. 1-28
-
-
Ciechanover, A.1
-
28
-
-
0024232289
-
Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: Significance of elevated interstitial pressure
-
Jain RK, Baxter LT (1988) Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res 48:7022-7032
-
(1988)
Cancer Res
, vol.48
, pp. 7022-7032
-
-
Jain, R.K.1
Baxter, L.T.2
-
29
-
-
79952516871
-
Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
-
Ciechanover A (2010) Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Medicina (Buenos Aires) 70:105-119
-
(2010)
Medicina (Buenos Aires)
, vol.70
, pp. 105-119
-
-
Ciechanover, A.1
-
30
-
-
77954031486
-
Phase I study of trastuzumab- DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer
-
Krop IE, Beeram M, Modi S, Jones SF, Holden SN, Yu W, Girish S, Tibbitts J, Yi JH, Sliwkowski MX, Jacobson F, Lutzker SG, Burris HA (2010) Phase I study of trastuzumab- DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol 28:2698-2704
-
(2010)
J Clin Oncol
, vol.28
, pp. 2698-2704
-
-
Krop, I.E.1
Beeram, M.2
Modi, S.3
Jones, S.F.4
Holden, S.N.5
Yu, W.6
Girish, S.7
Tibbitts, J.8
Yi, J.H.9
Sliwkowski, M.X.10
Jacobson, F.11
Lutzker, S.G.12
Burris, H.A.13
-
31
-
-
41149160183
-
Contribution of linker stability to the activities of anticancer immunoconjugates
-
Alley SC, Benjamin DR, Jeffrey SC, Okeley NM, Meyer DL, Sanderson RJ, Senter PD (2008) Contribution of linker stability to the activities of anticancer immunoconjugates. Bioconjug Chem 19:759-765
-
(2008)
Bioconjug Chem
, vol.19
, pp. 759-765
-
-
Alley, S.C.1
Benjamin, D.R.2
Jeffrey, S.C.3
Okeley, N.M.4
Meyer, D.L.5
Sanderson, R.J.6
Senter, P.D.7
-
32
-
-
80052937158
-
A novel pathway for maytansinoid release from thioether linked antibody-drug conjugates (ADCs) under oxidative conditions
-
Fishkin N, Maloney EK, Chari RV, Singh R (2011) A novel pathway for maytansinoid release from thioether linked antibody-drug conjugates (ADCs) under oxidative conditions. Chem Commun (Camb) 47:10752-10754
-
(2011)
Chem Commun (Camb)
, vol.47
, pp. 10752-10754
-
-
Fishkin, N.1
Maloney, E.K.2
Chari, R.V.3
Singh, R.4
-
33
-
-
12244295755
-
In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immuno- conjugate
-
Sanderson RJ, Hering MA, James SF, Sun MM, Doronina SO, Siadak AW, Senter PD, Wahl AF (2005) In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immuno- conjugate. Clin Cancer Res 11:843-852
-
(2005)
Clin Cancer Res
, vol.11
, pp. 843-852
-
-
Sanderson, R.J.1
Hering, M.A.2
James, S.F.3
Sun, M.M.4
Doronina, S.O.5
Siadak, A.W.6
Senter, P.D.7
Wahl, A.F.8
-
34
-
-
21244469077
-
Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry
-
Lazar AC, Wang L, Blattler WA, Amphlett G, Lambert JM, Zhang W (2005) Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry. Rapid Commun Mass Spectrom 19:1806-1814
-
(2005)
Rapid Commun Mass Spectrom
, vol.19
, pp. 1806-1814
-
-
Lazar, A.C.1
Wang, L.2
Blattler, W.A.3
Amphlett, G.4
Lambert, J.M.5
Zhang, W.6
-
35
-
-
6044223544
-
Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate
-
Hamblett KJ, Senter PD, Chace DF, Sun MM, Lenox J, Cerveny CG, Kissler KM, Bernhardt SX, Kopcha AK, Zabinski RF, Meyer DL, Francisco JA (2004) Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate. Clin Cancer Res 10:7063-7070
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7063-7070
-
-
Hamblett, K.J.1
Senter, P.D.2
Chace, D.F.3
Sun, M.M.4
Lenox, J.5
Cerveny, C.G.6
Kissler, K.M.7
Bernhardt, S.X.8
Kopcha, A.K.9
Zabinski, R.F.10
Meyer, D.L.11
Francisco, J.A.12
-
36
-
-
67449119398
-
The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo
-
Ikeda H, Hideshima T, Fulciniti M, Lutz RJ, Yasui H, Okawa Y, Kiziltepe T, Vallet S, Pozzi S, Santo L, Perrone G, Tai YT, Cirstea D, Raje NS, Uherek C, Dalken B, Aigner S, Osterroth F, Munshi N, Richardson P, Anderson KC (2009) The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. Clin Cancer Res 15:4028-4037
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4028-4037
-
-
Ikeda, H.1
Hideshima, T.2
Fulciniti, M.3
Lutz, R.J.4
Yasui, H.5
Okawa, Y.6
Kiziltepe, T.7
Vallet, S.8
Pozzi, S.9
Santo, L.10
Perrone, G.11
Tai, Y.T.12
Cirstea, D.13
Raje, N.S.14
Uherek, C.15
Dalken, B.16
Aigner, S.17
Osterroth, F.18
Munshi, N.19
Richardson, P.20
Anderson, K.C.21
more..
-
37
-
-
77958059151
-
Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability
-
Oroudjev E, Lopus M, Wilson L, Audette C, Provenzano C, Erickson H, Kovtun Y, Chari R, Jordan MA (2010) Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. Mol Cancer Ther 9:2700-2713
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2700-2713
-
-
Oroudjev, E.1
Lopus, M.2
Wilson, L.3
Audette, C.4
Provenzano, C.5
Erickson, H.6
Kovtun, Y.7
Chari, R.8
Jordan, M.A.9
-
38
-
-
9444260479
-
Biological impediments to monoclonal antibody-based cancer immunotherapy
-
Christiansen J, Rajasekaran AK (2004) Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol Cancer Ther 3:1493-1501
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 1493-1501
-
-
Christiansen, J.1
Rajasekaran, A.K.2
-
39
-
-
0022875861
-
Modulation of antigen expression in human tumor cell populations
-
Greiner JW (1986) Modulation of antigen expression in human tumor cell populations. Cancer Invest 4:239-256
-
(1986)
Cancer Invest
, vol.4
, pp. 239-256
-
-
Greiner, J.W.1
-
40
-
-
0035874887
-
High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules
-
Adams GP, Schier R, McCall AM, Simmons HH, Horak EM, Alpaugh RK, Marks JD, Weiner LM (2001) High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. Cancer Res 61:4750-4755
-
(2001)
Cancer Res
, vol.61
, pp. 4750-4755
-
-
Adams, G.P.1
Schier, R.2
McCall, A.M.3
Simmons, H.H.4
Horak, E.M.5
Alpaugh, R.K.6
Marks, J.D.7
Weiner, L.M.8
-
41
-
-
66249109940
-
Affinity and avidity in antibody-based tumor targeting
-
Rudnick SI, Adams GP (2009) Affinity and avidity in antibody-based tumor targeting. Cancer Biother Radiopharm 24:155-161
-
(2009)
Cancer Biother Radiopharm
, vol.24
, pp. 155-161
-
-
Rudnick, S.I.1
Adams, G.P.2
-
42
-
-
0029114671
-
Targeting cancer micrometastases with monoclonal antibodies: A binding-site barrier
-
Saga T, Neumann RD, Heya T, Sato J, Kinuya S, Le N, Paik CH, Weinstein JN (1995) Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier. Proc Natl Acad Sci USA 92:8999-9003
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8999-9003
-
-
Saga, T.1
Neumann, R.D.2
Heya, T.3
Sato, J.4
Kinuya, S.5
Le, N.6
Paik, C.H.7
Weinstein, J.N.8
-
43
-
-
0019515510
-
Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells
-
Drewinko B, Patchen M, Yang LY, Barlogie B (1981) Differential killing efficacy of twenty antitumor drugs on proliferating and nonproliferating human tumor cells. Cancer Res 41:2328-2333
-
(1981)
Cancer Res
, vol.41
, pp. 2328-2333
-
-
Drewinko, B.1
Patchen, M.2
Yang, L.Y.3
Barlogie, B.4
-
44
-
-
0018509644
-
Cell cycle phase-specific cytotoxicity of the antitumor agent maytansine
-
Rao PN, Freireich EJ, Smith ML, Loo TL (1979) Cell cycle phase-specific cytotoxicity of the antitumor agent maytansine. Cancer Res 39:3152-3155
-
(1979)
Cancer Res
, vol.39
, pp. 3152-3155
-
-
Rao, P.N.1
Freireich, E.J.2
Smith, M.L.3
Loo, T.L.4
-
45
-
-
33644775686
-
Targeting multidrug resistance in cancer
-
Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM (2006) Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5:219-234
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 219-234
-
-
Szakacs, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
Gottesman, M.M.5
-
46
-
-
20144375952
-
An anti-MUC1 antibody-calicheamicin conjugate for treatment of solid tumors. Choice of linker and overcoming drug resistance
-
Hamann PR, Hinman LM, Beyer CF, Greenberger LM, Lin C, Lindh D, Menendez AT, Wallace R, Durr FE, Upeslacis J (2005) An anti-MUC1 antibody-calicheamicin conjugate for treatment of solid tumors. Choice of linker and overcoming drug resistance. Bioconjug Chem 16:346-353
-
(2005)
Bioconjug Chem
, vol.16
, pp. 346-353
-
-
Hamann, P.R.1
Hinman, L.M.2
Beyer, C.F.3
Greenberger, L.M.4
Lin, C.5
Lindh, D.6
Menendez, A.T.7
Wallace, R.8
Durr, F.E.9
Upeslacis, J.10
-
47
-
-
18444411317
-
Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers
-
Matsui H, Takeshita A, Naito K, Shinjo K, Shigeno K, Maekawa M, Yamakawa Y, Tanimoto M, Kobayashi M, Ohnishi K, Ohno R (2002) Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug resistance modifiers. Leukemia 16:813-819
-
(2002)
Leukemia
, vol.16
, pp. 813-819
-
-
Matsui, H.1
Takeshita, A.2
Naito, K.3
Shinjo, K.4
Shigeno, K.5
Maekawa, M.6
Yamakawa, Y.7
Tanimoto, M.8
Kobayashi, M.9
Ohnishi, K.10
Ohno, R.11
-
48
-
-
0043240102
-
Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells
-
Walter RB, Raden BW, Hong TC, Flowers DA, Bernstein ID, Linenberger ML (2003) Multidrug resistance protein attenuates gemtuzumab ozogamicin-induced cytotoxicity in acute myeloid leukemia cells. Blood 102:1466-1473
-
(2003)
Blood
, vol.102
, pp. 1466-1473
-
-
Walter, R.B.1
Raden, B.W.2
Hong, T.C.3
Flowers, D.A.4
Bernstein, I.D.5
Linenberger, M.L.6
-
50
-
-
0028334791
-
V79 Chinese hamster lung cells resistant to the bis-alkylator bizelesin are multidrug-resistant
-
Butryn RK, Smith KS, Adams EG, Abraham I, Stackpole J, Sampson KE, Bhuyan BK (1994) V79 Chinese hamster lung cells resistant to the bis-alkylator bizelesin are multidrug-resistant. Cancer Chemother Pharmacol 34:44-50
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, pp. 44-50
-
-
Butryn, R.K.1
Smith, K.S.2
Adams, E.G.3
Abraham, I.4
Stackpole, J.5
Sampson, K.E.6
Bhuyan, B.K.7
-
51
-
-
0026589412
-
Resistance of CHO cells expressing P-glycoprotein to cyclopropylpyrroloindole (CPI) alkylating agents
-
Zsido TJ, Beerman TA, Meegan RL, Woynarowski JM, Baker RM (1992) Resistance of CHO cells expressing P-glycoprotein to cyclopropylpyrroloindole (CPI) alkylating agents. Biochem Pharmacol 43:1817-1822
-
(1992)
Biochem Pharmacol
, vol.43
, pp. 1817-1822
-
-
Zsido, T.J.1
Beerman, T.A.2
Meegan, R.L.3
Woynarowski, J.M.4
Baker, R.M.5
-
52
-
-
67650733509
-
P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients
-
Tang R, Cohen S, Perrot JY, Faussat AM, Zuany-Amorim C, Marjanovic Z, Morjani H, Fava F, Corre E, Legrand O, Marie JP (2009) P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer 9:199
-
(2009)
BMC Cancer
, vol.9
, pp. 199
-
-
Tang, R.1
Cohen, S.2
Perrot, J.Y.3
Faussat, A.M.4
Zuany-Amorim, C.5
Marjanovic, Z.6
Morjani, H.7
Fava, F.8
Corre, E.9
Legrand, O.10
Marie, J.P.11
-
53
-
-
32044453808
-
Recent progress in understanding the mechanism of P-glycoprotein- mediated drug efflux
-
Loo TW, Clarke DM (2005) Recent progress in understanding the mechanism of P-glycoprotein- mediated drug efflux. J Membr Biol 206:173-185
-
(2005)
J Membr Biol
, vol.206
, pp. 173-185
-
-
Loo, T.W.1
Clarke, D.M.2
-
54
-
-
85028500316
-
-
22nd EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics, Berlin, Germany
-
Kovtun Y, Jones G, Audette C, Mayo M, Leece B, Zhao R, Clancy L, Sun X, Chari R, Singh R (2010) 235. Negatively-charged sulfonate group in linker improves potency of antibody- maytansinoid conjugates against multidrug-resistant cancer cells. 22nd EORTC-NCI-AACR symposium on molecular targets and cancer therapeutics, Berlin, Germany
-
(2010)
235. Negatively-charged sulfonate group in linker improves potency of antibody- maytansinoid conjugates against multidrug-resistant cancer cells
-
-
Kovtun, Y.1
Jones, G.2
Audette, C.3
Mayo, M.4
Leece, B.5
Zhao, R.6
Clancy, L.7
Sun, X.8
Chari, R.9
Singh, R.10
-
55
-
-
77953376431
-
The pharmacokinetics and pharmacodynamics of IMGN242 (huC242-DM4) in patients with CanAg-expressing solid tumors
-
Qin A, Watermill J, Mastico RA, Lutz RJ, O'Keeffe J, Zildjian S, Mita AC, Phan AT, Tolcher AW (2008) The pharmacokinetics and pharmacodynamics of IMGN242 (huC242-DM4) in patients with CanAg-expressing solid tumors. ASCO Meet Abstr 26:3066
-
(2008)
ASCO Meet Abstr
, vol.26
, pp. 3066
-
-
Qin, A.1
Watermill, J.2
Mastico, R.A.3
Lutz, R.J.4
O'Keeffe, J.5
Zildjian, S.6
Mita, A.C.7
Phan, A.T.8
Tolcher, A.W.9
-
56
-
-
0037440038
-
Cantuzumab mertansine, a maytansinoid immu- noconjugate directed to the CanAg antigen: A phase I, pharmacokinetic, and biologic correlative study
-
Tolcher AW, Ochoa L, Hammond LA, Patnaik A, Edwards T, Takimoto C, Smith L, de Bono J, Schwartz G, Mays T, Jonak ZL, Johnson R, DeWitte M, Martino H, Audette C, Maes K, Chari RV, Lambert JM, Rowinsky EK (2003) Cantuzumab mertansine, a maytansinoid immu- noconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. J Clin Oncol 21:211-222
-
(2003)
J Clin Oncol
, vol.21
, pp. 211-222
-
-
Tolcher, A.W.1
Ochoa, L.2
Hammond, L.A.3
Patnaik, A.4
Edwards, T.5
Takimoto, C.6
Smith, L.7
de Bono, J.8
Schwartz, G.9
Mays, T.10
Jonak, Z.L.11
Johnson, R.12
DeWitte, M.13
Martino, H.14
Audette, C.15
Maes, K.16
Chari, R.V.17
Lambert, J.M.18
Rowinsky, E.K.19
-
57
-
-
1342287215
-
Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice
-
Xie H, Audette C, Hoffee M, Lambert JM, Blattler WA (2004) Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice. J Pharmacol Exp Ther 308:1073-1082
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 1073-1082
-
-
Xie, H.1
Audette, C.2
Hoffee, M.3
Lambert, J.M.4
Blattler, W.A.5
-
58
-
-
78650279693
-
Phase I multidose escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous (IV) infusion every 3 weeks to patients with relapsed/refractory B-Cell non-Hodgkin's lymphoma (NHL)
-
Younes A, Gordon L, Kim S, Romaguera J, Copeland AR, de Castro Farial S, Kwak L, Fayad L, Hagemeister F, Fanale M, Lambert J, Bagulho T, Morariu-Zamfir R (2009) Phase I multidose escalation study of the anti-CD19 maytansinoid immunoconjugate SAR3419 administered by intravenous (IV) infusion every 3 weeks to patients with relapsed/refractory B-Cell non-Hodgkin's lymphoma (NHL). ASH Annu Meet Abstr 114:585
-
(2009)
ASH Annu Meet Abstr
, vol.114
, pp. 585
-
-
Younes, A.1
Gordon, L.2
Kim, S.3
Romaguera, J.4
Copeland, A.R.5
de Castro Farial, S.6
Kwak, L.7
Fayad, L.8
Hagemeister, F.9
Fanale, M.10
Lambert, J.11
Bagulho, T.12
Morariu-Zamfir, R.13
-
59
-
-
84862162222
-
Phase I studies of AVE9633, an anti-CD33 antibody-maytansinoid conjugate, in adult patients with relapsed/refractory acute myeloid leukemia
-
Lapusan S, Vidriales MB, Thomas X, de Botton S, Vekhoff A, Tang R, Dumontet C, Morariu- Zamfir R, Lambert JM, Ozoux ML, Poncelet P, San Miguel JF, Legrand O, Deangelo DJ, Giles FJ, Marie JP (2012) Phase I studies of AVE9633, an anti-CD33 antibody-maytansinoid conjugate, in adult patients with relapsed/refractory acute myeloid leukemia. Invest New Drugs 30(3): 1121-1131
-
(2012)
Invest New Drugs
, vol.30
, Issue.3
, pp. 1121-1131
-
-
Lapusan, S.1
Vidriales, M.B.2
Thomas, X.3
de Botton, S.4
Vekhoff, A.5
Tang, R.6
Dumontet, C.7
Morariu-Zamfir, R.8
Lambert, J.M.9
Ozoux, M.L.10
Poncelet, P.11
San Miguel, J.F.12
Legrand, O.13
Deangelo, D.J.14
Giles, F.J.15
Marie, J.P.16
-
60
-
-
77955876581
-
A phase I dose-escalation study of IMGN388 in patients with solid tumors
-
Thompson DS, Patnaik A, Bendell JC, Papadopoulos K, Infante JR, Mastico RA, Johnson D, Qin A, O'Leary JJ, Tolcher AW (2010) A phase I dose-escalation study of IMGN388 in patients with solid tumors. ASCO Meet Abstr 28:3058
-
(2010)
ASCO Meet Abstr
, vol.28
, pp. 3058
-
-
Thompson, D.S.1
Patnaik, A.2
Bendell, J.C.3
Papadopoulos, K.4
Infante, J.R.5
Mastico, R.A.6
Johnson, D.7
Qin, A.8
O'Leary, J.J.9
Tolcher, A.W.10
-
61
-
-
84952975583
-
Antibody-maytansinoid conjugates: A new strategy for the treatment of cancer
-
Lambert JM (2010) Antibody-maytansinoid conjugates: a new strategy for the treatment of cancer. Drugs of the future 35:471-480
-
(2010)
Drugs of the future
, vol.35
, pp. 471-480
-
-
Lambert, J.M.1
|