"Universal Flu Vaccine": Can NK Cell-mediated ADCC Tip the Scales?

EBioMedicine

Volumn 8, Issue , 2016, Pages 18-19

  Hassane, Maya ^a,b   Paget, Christophe ^a  

^a UNIV LILLE   (France)

^b LEBANESE UNIVERSITY   (Lebanon)

Author keywords

ADCC; Influenza; NK cells; Vaccine

Indexed keywords

INFLUENZA VACCINE;

AMINO ACID SEQUENCE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; B LYMPHOCYTE; CELL ACTIVATION; HUMAN; IMMUNE RESPONSE; NATURAL KILLER CELL; NOTE; OPSONIZATION; PRIORITY JOURNAL; PUBLIC HEALTH;

EID: 84973161309     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2016.05.042     Document Type: Note

References (8)

1. Eggink D., Goff P.H., Palese P. Guiding the immune response against influenza virus hemagglutinin toward the conserved stalk domain by hyperglycosylation of the globular head domain. J. Virol. 2014, 88(1):699-704.
2. Gerdil C. The annual production cycle for influenza vaccine. Vaccine 2003, 21(16):1776-1779.
3. Jegaskanda S., Reading P.C., Kent S.J. Influenza-specific antibody-dependent cellular cytotoxicity: toward a universal influenza vaccine. J. Immunol. 2014, 193(2):469-475.
4. Krammer F., Palese P. Advances in the development of influenza virus vaccines. Nat. Rev. Drug Discov. 2015, 14(3):167-182.
5. Madhavi V., Kent S.J., Stratov I. HIV-specific antibody-dependent cellular cytotoxicity: a novel vaccine modality. Expert. Rev. Clin. Immunol. 2012, 8(8):767-774.
6. Palese P. Influenza: old and new threats. Nat. Med. 2004, 10(12 Suppl):S82-S87.
7. Summary analysis of 2014 survey of National Influenza Centres in the WHO Global Influenza Surveillance and Response System Releve epidemiologique hebdomadaire/Section d'hygiene du Secretariat de la Societe des Nations = Weekly Epidemiological Record/Health Section of the Secretariat of the League of Nations 2014, 89(34):369-376.
8. Vanderven H.A., Ana-Sosa-Batiz F., Jegaskanda S., Rockman S., Laurie K., Barr I., Chen W., Wines B., Hogarth P.M., Lambe T., Gilbert S.C., Parsons M.S., Kent S.J. What lies beneath: antibody dependent natural killer cell activation by antibodies to internal influenza virus proteins. EBioMedicine 2016, 8:280-293.