Fibroblast growth factor receptor 4: The missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy?

Kidney International

Volumn 89, Issue 1, 2016, Pages 7-9

  Wyatt, Christina M ^a   Drüeke, Tilman B ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR RECEPTOR 4; PHOSPHATE; PHOSPHOLIPASE C GAMMA; TRANSCRIPTION FACTOR NFAT; BETA GLUCURONIDASE; FGFR4 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR 3; KLOTHO PROTEIN; PHOSPHORUS;

ARTICLE; BLOOD VESSEL CALCIFICATION; CARDIAC MUSCLE CELL; CHRONIC KIDNEY DISEASE; CREATININE CLEARANCE; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME INHIBITION; GAIN OF FUNCTION MUTATION; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HYPERPHOSPHATEMIA; IN VITRO STUDY; IN VIVO STUDY; MORTALITY RISK; NEPHRECTOMY; NONHUMAN; PHOSPHATE BLOOD LEVEL; PHOSPHATE INTAKE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CHRONIC KIDNEY FAILURE; GENETICS; METABOLISM; MOUSE; RAT;

ANIMALS; FIBROBLAST GROWTH FACTOR 3; GLUCURONIDASE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; KIDNEY FAILURE, CHRONIC; MICE; PHOSPHORUS; RATS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4;

EID: 84973115759     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2015.11.012     Document Type: Note

References (10)

1. O.M. Gutierrez, M. Mannstadt, T. Isakova, and et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis N Engl J Med 359 2008 584 592
2. T. Isakova, H. Xie, W. Yang, and et al. Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease JAMA 305 2011 2432 2439
3. J. Kendrick, A.K. Cheung, J.S. Kaufman, and et al. FGF-23 associates with death, cardiovascular events, and initiation of chronic dialysis J Am Soc Nephrol 22 2011 1913 1922
4. B.D. Parker, L.J. Schurgers, V.M. Brandenburg, and et al. The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study Ann Intern Med 152 2010 640 648
5. J. Arnlov, A.C. Carlsson, J. Sundstrom, and et al. Higher fibroblast growth factor-23 increases the risk of all-cause and cardiovascular mortality in the community Kidney Int 83 2013 160 166
6. O.M. Gutierrez, J.L. Januzzi, T. Isakova, and et al. Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease Circulation 119 2009 2545 2552
7. C. Faul, A.P. Amaral, B. Oskouei, and et al. FGF23 induces left ventricular hypertrophy J Clin Invest 121 2011 4393 4408
8. V. Shalhoub, E.M. Shatzen, S.C. Ward, and et al. FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality J Clin Invest 122 2012 2543 2553
9. J.R. Stubbs, S. Liu, W. Tang, and et al. Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice J Am Soc Nephrol 18 2007 2116 2124
10. A. Grabner, A.P. Amaral, K. Schramm, and et al. Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy Cell Metab 22 2015 1 13