The Incidence and Differential Seasonal Patterns of Plasmodium vivax Primary Infections and Relapses in a Cohort of Children in Papua New Guinea

PLoS Neglected Tropical Diseases

Volumn 10, Issue 5, 2016, Pages

  Ross, Amanda ^a,b   Koepfli, Cristian ^a,b,c   Schoepflin, Sonja ^a,b,h   Timinao, Lincoln ^d   Siba, Peter ^d   Smith, Thomas ^a,b   Mueller, Ivo ^c,e,f,g   Felger, Ingrid ^a,b   Tanner, Marcel ^a,b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^e CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^f UNIVERSITY OF MELBOURNE   (Australia)

^g INSTITUT PASTEUR   (France)

^h Roche Pharma Schweiz AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CAPILLARY ELECTROPHORESIS; CHILD; COHORT ANALYSIS; GENE FREQUENCY; GENOTYPE; GUINEA; HUMAN; INCIDENCE; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM VIVAX MALARIA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PREVALENCE; PRIMARY INFECTION; RECURRENCE RISK; SEASONAL VARIATION; SENSITIVITY ANALYSIS; GENETICS; INFANT; ISOLATION AND PURIFICATION; MALARIA, FALCIPARUM; MALARIA, VIVAX; PAPUA NEW GUINEA; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; RECURRENT DISEASE; SEASON;

CHILD, PRESCHOOL; COHORT STUDIES; HUMANS; INCIDENCE; INFANT; MALARIA, FALCIPARUM; MALARIA, VIVAX; PAPUA NEW GUINEA; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; RECURRENCE; SEASONS;

EID: 84971664197     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0004582     Document Type: Article

References (45)

1. Mendis K, Sina B, Marchesini P, Carter R, The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg2001;64 (1–2 Suppl):97–106. 11425182
2. Tijtra E, Anstey N, Sugiarto P, Wariker N, Kenangelem E, Karyana M, et al. Multi-drug resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia. PLoS Med2008;5:e127.
3. Genton B, D’Acremont V, Rare L, Baea K, Reeder J, Alpers M, et al. Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort from Papua New Guinea. PLoS Med2008;5:e127. doi: 10.1371/journal.pmed.005012718563961
4. White N, Determinants of relapse periodicity in Plasmodium vivax malaria. Malar J2011;11:297.
5. White NJ, Imwong M, Relapse. Adv Parasitol2012;80:113–50. doi: 10.1016/B978-0-12-397900-1.00002-523199487
6. Bretscher M, Maire N, Chitnis N, Felger I, Owusu-Agyei S, Smith T, The distribution of Plasmodium falciparum infection durations. Epidemics2011;3:109–18. doi: 10.1016/j.epidem.2011.03.00221624782
7. Felger I, Maire M, Bretscher M, Falk N, Tiaden A, Sama W, et al. The dynamics of natural Plasmodium falciparum infections. PLoS ONE2012;7:e45542. doi: 10.1371/journal.pone.004554223029082
8. Sama W, Owusu-Agyei S, Felger I, Vounatsou P, Smith T., An immigration-death model to estimate the duration of malaria infection when detectability of the parasite is imperfect. Stat Med2005;24:3269–88. 16143990
9. Sama W, Owusu-Agyei S, Felger I, Dietz K, Smith T, Age and seasonal variation in the transmission rates and detectibility of Plasmodium falciparum malaria. Parasitology2006;132:13–21. 16393349
10. Smith T, Felger I, Fraser-Hurt N, Beck H, Effect of insecticide-treated bed nets on the dynamics of multiple Plasmodium falciparum infections. Trans Roy Soc Trop Med Hyg1999;93 (suppl 3):53–7.
11. Smith T, Vounatsou P, Estimation of infection and recovery rates for highly polymorphic parasites when detectability is imperfect, using hidden Markov models. Stats Med22:1709–24.
12. Bright AT, Manary MJ, Tewhey R, Arango EM, Wang T, Schork NJ, et al. A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings. PLoS Negl Trop Dis2014;8:e2882. doi: 10.1371/journal.pntd.000288224901334
13. Lin E, Kiniboro B, Gray L, Dobbie S, Robinson L, Laumaea A, et al. Differential patterns of infection and disease with P falciparum and P vivax in young Papua New Guinean children. PLoS ONE2010;5:e9047. doi: 10.1371/journal.pone.000904720140220
14. Koepfli C, Colborn K, Lin E, Kiniboro B, Zimmerman P, Speed T, et al. A high force of Plasmodium vivax blood-stage infection drives the rapid natural acquisition of immunity in Papua New Guinean children. PLoS Negl Trop Dis2013;5:e2403.
15. Koepfli C, Schoepflin S, Bretscher M, Lin E, Kiniboro B, Zimmerman P, et al. How much remains undetected? Probability of molecular detection of human Plasmodia in the field. PLoS ONE2011;6:e19010. doi: 10.1371/journal.pone.001901021552561
16. Koepfli C, Ross A, Kiniboro B, Smith T, Zimmerman P, Siba P, et al. Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea. PLoS Negl Trop Dis2011;5:e1424. doi: 10.1371/journal.pntd.000142422206027
17. Schoepflin S, Valsangiacomo F, Lin E, Kiniboro B, Mueller I, Felger I, Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotyping. Malar J2009;8:250. doi: 10.1186/1475-2875-8-25019878560
18. McNamara D, Kasehagen L, Grimberg B, Cole-Tobian J, Collins W, Zimmerman P, Diagnosing infection levels of four human malaria parasite species by a polymerase chain reaction/ligase detection reactio flourescent microsphere-based assay. Am J Trop Med Hyg2006;74:413–21. 16525099
19. Ross A, Koepfli C, Li X, Schoepflin S, Siba P, Mueller I, et al. Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data. PLoS ONE2012;7:e42496. doi: 10.1371/journal.pone.004249622952595
20. Muench H, Catalytic models in epidemiology. Cambridge, Massachusetts: Harvard University Press; 1959.
21. Wampfler R, Hofmann N, Waltmann A, Betuela I, Silkey M, Siba P, et al. The effect of radical cure on the subsequent dynamics of Plasmodium vivax infections. In prep2016;
22. Bretscher MT, Maire N, Felger I, Owusu-Agyei S, Smith T., Asymptomatic Plasmodium falciparum infections may not be shortened by acquired immunity. Malar J2015;:294.
23. Battle K, Karhunen M, Bhatt S, Gething P, Howes R, Golding N, et al. Geographic variation in Plasmodium vivax relapse. Mal J2014;13:144.
24. Lover A, Coker R, Quantifying the effect of geographic location on epidemiology of Plasmodium vivax malaria. Emerg Inf Dis2013;19:1058–65.
25. Lover A, Zhao X, Gao Z, Coker R, Cook A, The distribution of incubation and relapse times in experimental human infection with the malaria parasite Plasmodium vivax. BMC Infect Dis2014;14:539. doi: 10.1186/1471-2334-14-53925280926
26. Coatney RG, Cooper WC, Young MD, Studies in human malaria XXX. A summary of 204 sporozoite-induced infections with the Chesson strain of Plasmodium vivax. J Nat Malar Soc1950;9:381–96.
27. WHO. WHO child growth standards. http://www.who.int/childgrowth/standards/en/
28. Mosteller R, Simplified calculation of body surface area. N Engl Med J1987;317:1098.
29. Nelder J, Mead R, A simplex method for function minimization. Comput. J1965;7:308–13.
30. O’Neill R, Algorithm AS 47: Function minimization using a simplex procedure. Appl Stat. 1971;20:338–45.
31. Venzon D, Moolgavkar S, A method for computing profile likelihood based confidence intervals. Appl Stats1988;37:87–94.
32. Patiwan Y, In all likelihood: statistical modelling and inference using likelihood. Oxford University Press; 2001.
33. Mueller I, Schoepflin S, Smith T, Benton K, Bretscher M, Lin E, et al. Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. Proc Natl Acad Sci USA2012;109:10030–5. doi: 10.1073/pnas.120084110922665809
34. White MT, Karl S, Battle KE, Hay SI, Mueller I, Ghani AC, Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission. eLife2014;:04692.
35. Adekunle AI, Pinkevych M, McGready R, Luxemburger C, White LJ, Nosten F, et al. Modeling the dynamics of Plasmodium vivax infection and hypnozoite reactivation in vivo. PLoS NTD2015;9:e0003595.
36. Betuela I, Rosanas-Urgell A, Kiniboro B, Stanisic D, Samol L, de Lazzari E, et al. Relapses contribute significantly to the risk of Plasmodium vivax infection and disease in Papua New Guinean children 1–5 years of age. J Inf Dis2012;206:1171–80.
37. Robinson L, Wampfler R, Betuela I, Karl S, White M, Li Wai Suen CSI, et al. Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model. PLoS Med2015;12:e1001891. doi: 10.1371/journal.pmed.100189126505753
38. Baird J, Real world therapies and the problem of vivax malaria. N Engl J Med2008;359:24.
39. Baird J, Hoffman SL, Primaquine therapy for malaria. Clin Inf Dis2004;39:1336–45.
40. Pybus BS, Marcsisin SR, Jin X, Deye G, Sousa JS, Li Q, et al. The metabolism of primaquine to its active metabolite is dependent on CYP 2D6. Malar J2012;12:212.
41. Douglas NM, Nosten F, Ashley EA, Phaiphun L, van Vugt M, Singhasivanon P, et al. Plasmodium vivax recurrence following falciparum and mixed species malaria: risk factors and effect of antimalarial kinetics. Clin Inf Dis2011;52:612–20.
42. Shanks GD, White NJ, The activation of vivax malaria hypnozoites by infectious disease. Lancet Inf Dis2013;13:900–6.
43. Smith T, Maire N, Dietz K, Killeen G, Vounatsou P, Molineaux L, et al. Relationship between the entomologic inoculation rate and the force of infection for Plasmodium falciparum malaria. Am J Trop Med Hyg2006;75 (2 Suppl):11–8. 16931811
44. Pulford J, Mueller I, Siba P, Hetzel M, Malaria case management in Papua New Guinea prior to the introduction of a revised treatment protocol. Malar J2012;11:157. doi: 10.1186/1475-2875-11-15722564504
45. Sama W, Dietz K, Smith T, Distribution of survival times of deliberate Plasmodium falciparum infections in tertiary syphilis patients. Trans Roy Soc Trop Med Hyg2006;100:811–6. 16451806