Epileptic Prodromal Alzheimer's Disease, a Retrospective Study of 13 New Cases: Expanding the Spectrum of Alzheimer's Disease to an Epileptic Variant?

Journal of Alzheimer's Disease

Volumn 52, Issue 3, 2016, Pages 1125-1133

  Cretin, Benjamin ^a,b,c,d   Sellal, François ^b,e,f   Philippi, Nathalie ^a,b,c,d   Bousiges, Olivier ^a,b   Di Bitonto, Laure ^a,b,c,d   Martin Hunyadi, Catherine ^b   Blanc, Frederic ^a,b,c,d  

^a UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^b hôpitaux civils   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d Centre de Competences des Demences Rares des Hopitaux Universitaires de Strasbourg   (France)

^e Service de Neurologie   (France)

^f INSERM   (France)

Author keywords

Alzheimer's disease; mild cognitive impairment; partial seizures; temporal lobe epilepsy

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; ELECTROENCEPHALOGRAM; EPILEPSY; EPILEPTIC PRODROMAL ALZHEIMER DISEASE; FEMALE; HIPPOCAMPUS; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; ONSET AGE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TEMPORAL LOBE EPILEPSY; CEREBROSPINAL FLUID; COHORT ANALYSIS; COMPLICATION; DIAGNOSTIC IMAGING; DISEASE COURSE; ELECTROENCEPHALOGRAPHY; EPILEPSY, TEMPORAL LOBE; MENTAL HEALTH; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRODROMAL SYMPTOM;

AMYLOID BETA PROTEIN; ANTICONVULSIVE AGENT;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTICONVULSANTS; COHORT STUDIES; DISEASE PROGRESSION; ELECTROENCEPHALOGRAPHY; EPILEPSY, TEMPORAL LOBE; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PRODROMAL SYMPTOMS;

EID: 84971574811     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150096     Document Type: Article

References (14)

1. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA,Miller BL, Mucke L (2013) Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol 70, 1158-1166
2. Palop JJ, Mucke L (2009) Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 66, 435-440
3. Villemagne VL, Burnham S, Bourgeat P, Brown B, Ellis KA, Salvado O, Szoeke C,Macaulay SL, Martins R, Maruff P, Ames D, Rowe CC, Masters CL, Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group (2013) Amyloid deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study. Lancet Neurol 12, 357-367
4. Petersen RC, Parisi JE, Dickson DW, Johnson KA, Knopman DS, Boeve BF, Jicha GA, Ivnik RJ, Smith GE, Tangalos EG, Braak H, Kokmen E (2006) Neuropathologic features of amnestic mild cognitive impairment. Arch Neurol 63, 665-672
5. Cretin B, Blanc F, Gaultier C, Sellal F (2012) Epileptic amnesic syndrome revealing Alzheimer's disease. Epilepsy Res 102, 206-209
6. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, Emde Boas W, Engel J, French J, Glauser TA, Mathern GW, Moshé SL, Nordli D, Plouin P, Scheffer IE (2010) Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia 51, 676-685
7. Martin RC, Faught E, Richman J, Funkhouser E, Kim Y, Clements K, Pisu M (2014) Psychiatric and neurologic risk factors for incident cases of new-onset epilepsy in older adults: Data from U.S. Medicare beneficiaries. Epilepsia 55, 1120-1127
8. Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, WinbladB(2006) International Psychogeriatric Association Expert Conference on mild cognitive impairment. Lancet 367, 1262-1270
9. Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J (1992) Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: Diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 55, 967-972
10. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, Gamst A, Holtzman DM, Jagust WJ, Petersen RC, Snyder PJ, Carrillo MC, Thies B, PhelpsCH(2011) The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7, 270-279
11. Sauvée M, Didier Laurent G, Latarche C, Escanyé MC, Olivier JL, Malaplate-Armand C (2014) Additional use of A42/A40 ratio with cerebrospinal fluid biomarkers P-Tau and A42 increases the level of evidence of Alzheimer's disease pathophysiological process in routine practice. J Alzheimers Dis 41, 377-386
12. Blank L, Baxter S, Baird W, Reuber M (2013) Understanding referral patterns to an epilepsy clinic: Professional perceptions of factors influencing the referral of older adults. Seizure 22, 698-702
13. Pacagnella D, Lopes TM, Morita ME, Yasuda CL, Cappabianco FA, Bergo F, Balthazar ML, Coan AC, Cendes F (2014) Memory impairment is not necessarily related to seizure frequency in mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 55, 1197-1204
14. Vingerhoets G (2006) Cognitive effects of seizures. Seizure 15, 221-226