In utero exposure to valproate increases the risk of isolated cleft palate

Archives of Disease in Childhood: Fetal and Neonatal Edition

Volumn 101, Issue 3, 2016, Pages F207-F211

  Jackson, Adam ^a   Bromley, Rebecca ^b   Morrow, James ^c   Irwin, Beth ^c   Clayton Smith, Jill ^d  

^a BLACKPOOL VICTORIA HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c ROYAL VICTORIA HOSPITAL   (United Kingdom)

^d MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VALPROIC ACID; ANTICONVULSIVE AGENT;

ARTICLE; CLEFT PALATE; COUNSELING; EMBASE; GENETIC SERVICE; HUMAN; ISOLATED CLEFT PALATE; MAJOR CLINICAL STUDY; MEDLINE; META ANALYSIS (TOPIC); MONOTHERAPY; PATIENT REFERRAL; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; REGISTER; RISK ASSESSMENT; SYSTEMATIC REVIEW; TERATOGENESIS; WEB OF SCIENCE; CHEMICALLY INDUCED; FEMALE; FETOMATERNAL TRANSFUSION; GREAT BRITAIN; MALE; NEWBORN; PREGNANCY;

ANTICONVULSANTS; CLEFT PALATE; FEMALE; GREAT BRITAIN; HUMANS; INFANT, NEWBORN; MALE; MATERNAL-FETAL EXCHANGE; PREGNANCY; REGISTRIES; VALPROIC ACID;

EID: 84971501011     PISSN: 13592998     EISSN: 14682052     Source Type: Journal    
DOI: 10.1136/archdischild-2015-308278     Document Type: Article

References (33)

1. DiLiberti JH, Farndon PA, Dennis NR, et al. The fetal valproate syndrome. Am Med Genet 1984;19:473-81.
2. Tomson T, Battino D, Bonizzoni E, et al. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011;10:609-17.
3. Meador KJ, Baker GA, Browning N, et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol 2013;12:244-52.
4. Hernández-Díaz S, Smith CR, Shen A, et al. Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692-9.
5. Meador KJ, Baker GA, Finnell RH, et al. In utero antiepileptic drug exposure: fetal death and malformations. Neurology 2006;67:407-12.
6. Cassidy SB, Allanson JE. Management of genetic syndromes. John Wiley & Sons, 2010.
7. http://fetalvalproatesyndrome.com/ (accessed 13 May 2014).
8. http://rarediseases.info.nih.gov/gard/5447/fetal-valproate-syndrome/case/25731/case-questions (accessed 13 May 2014).
9. Meng L, Bian Z, Torensma R, et al. Biological mechanisms in palatogenesis and cleft palate. J Dent Res 2009;88:22-33.
10. Campbell E, Kennedy F, Russell A, et al. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol Neurosurg Psychiatry 2014;85:1029-34.
11. Sadler TW. Langman's medical embryology. Philadelphia, PA: Lippincott, 2000:366-75.
12. Stroustrup Smith A, Estroff JA, Barnewolt CE, et al. Prenatal diagnosis of cleft lip and cleft palate using MRI. AJR Am J Roentgenol 2004;183:229-35.
13. Offerdal K, Jebens N, Syvertsen T, et al. Prenatal ultrasound detection of facial clefts: a prospective study of 49314 deliveries in a non-selected population in Norway. Ultrasound Obstet Gynecol 2008;31:639-46.
14. Campbell S, Lees C, Moscoso G, et al. Ultrasound antenatal diagnosis of cleft palate by a new technique: the 3D 'reverse face' view. Ultrasound Obstet Gynecol 2007;25:12-18.
15. Martínez-Frías ML. Clinical manifestation of prenatal exposure to valproic acid using case reports and epidemiologic information. Am J Med Genet 1990;37:277-82.
16. Jentink J, Loane MA, Dolk H, et al., EUROCAT Antiepileptic Study Working Group. Valproic acid monotherapy in pregnancy and major congenital malformations. N Engl J Med 2010;362:2185-93.
17. Gilboa SM, Broussard CS, Devine OJ, et al. Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States. Am J Med Genet C Semin Med Genet 2011;157C:234-46.
18. Vajda FJ, O'Brien TJ, Graham JE, et al. Dose dependence of fetal malformations associated with valproate. Neurology 2013;81:999-1003.
19. Artama M, Auvinen A, Raudaskoski T, et al. Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 2005;64:1874-8.
20. Wide K, Winbladh B, Källén B. Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. Acta Paediatr 2004;93:174-6.
21. Samrén EB, van Duijn CM, Christiaens GC, et al. Antiepileptic drug regimens and major congenital abnormalities in the offspring. Ann Neurol 1999;46:739-46.
22. Samrén EB, van Duijn CM, Koch S, et al. Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy. Epilepsia 1997;38:981-90.
23. Clayton-Smith J, Donnai D. Fetal valproate syndrome. J Med Genet 1995;32:724-7.
24. Jackson A, Fryer A, Clowes V, et al. Ocular coloboma and foetal valproate syndrome: four further cases and a hypothesis for aetiology. Clin Dysmorphol 2014;23:74-5.
25. IPDTOC Working Group. Prevalence at birth of cleft lip with or without cleft palate: data from the International Perinatal Database of Typical Oral Clefts (IPDTOC). Cleft Palate Craniofac J 2011;48:66-81.
26. Calzolari E, Bianchi F, Rubini M, et al., EUROCAT WORKING GROUP. Epidemiology of Cleft Palate in Europe: implications for genetic research. Cleft Palate Craniofac J 2004;41:244-9.
27. Morrow JI, Hunt SJ, Russell AJ, et al. Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neuroseurg Psychiatry 2009;80:506-11.
28. Morrell MJ. Folic acid and epilepsy. Epilepsy Curr 2002;2:31-4.
29. Johnson CY, Little J. Folate intake, markers of folate status and oral clefts: is the evidence converging? Int J Epidemiol 2008;37:1041-58.
30. Göttlicher M, Minucci S, Zhu P, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001;20:6969-78.
31. Chuang CM, Chang CH, Wang HE, et al. Valproic acid downregulates RBP4 and elicits hypervitaminosis A-teratogenesis - a kinetic analysis on retinol/retinoic acid homeostatic system. PLoS One 2012;7:e43692.
32. Lammer EJ, Chen DT, Hoar RM, et al. Retinoic acid embryopathy. N Engl J Med 1985;313:837-41.
33. Brent RL. Environmental causes of human congenital malformations: the pediatrician's role in dealing with these complex clinical problems caused by a multiplicity of environmental and genetic factors. Pediatrics 2004;113(4 Suppl):957-68.