A comparison of the cost-effectiveness of treatment of prolonged acute convulsive epileptic seizures in children across Europe

Health Economics Review

Volumn 4, Issue 1, 2014, Pages 1-15

  Lee, Dawn C ^a   Gladwell, Daniel ^a   Hatswell, Anthony J ^a   Porter, Joshua ^a   Brereton, Nic ^a   Tate, Elaine ^a   Saunders, Alison L ^b  

^a BRESMED   (United Kingdom)

^b BioExcel   (United Kingdom)

Author keywords

BUCCOLAM; Cost utility modelling; Epilepsy; Health technology assessment

Indexed keywords

MIDAZOLAM;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL TRIAL (TOPIC); COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; ECONOMIC EVALUATION; EUROPE; HEALTH CARE COST; HUMAN; INFANT; MEDICAL DECISION MAKING; NEWBORN; PATIENT ASSESSMENT; PRIORITY JOURNAL; PROLONGED ACUTE CONVULSIVE EPILEPTIC SEIZURES; QUALITY OF LIFE; QUESTIONNAIRE; SEIZURE; SENSITIVITY ANALYSIS; TREATMENT OUTCOME; TREATMENT PLANNING;

EID: 84971207207     PISSN: None     EISSN: 21911991     Source Type: Journal    
DOI: 10.1186/s13561-014-0006-6     Document Type: Article

References (27)

1. ViroPharma Limited: BUCCOLAM 2.5 mg oromucosal solution: summary of product characteristics; 2011. www.medicines.org.uk/emc/medicine/25541/spc. Accessed 28 March 2014.
2. Forsgren L, Beghi E, Oun A, Sillanpaa M: The epidemiology of epilepsy in Europe - a systematic review. Eur J Neurol 2005, 12:245-253.
3. SEIN (WHO Collaborating Centre for Research, Training and Treatment in Epilepsy), W.H., and the ILAE/IBE/WHO Global Campaign Against Epilepsy: EPILEPSY IN THE WHO EUROPEAN REGION: Fostering Epilepsy Care in Europe.; 2010. www.ibe_epilepsy.org/downloads/EURO Report 160510.pdf. Accessed 28 March 2014.
4. World Health Organization: Epilepsy: Fact Sheet No999; 2012. www.who.int/mediacentre/factsheets/fs999/en/index.html. Accessed 28 March 2014.
5. Sander JW: The use of antiepileptic drugs-principles and practice. Epilepsia 2004, 45(Suppl 6):28-34.
6. Klimach VJ: The community use of rescue medication for prolonged epileptic seizures in children. Seizure 2009, 18:343-346.
7. Pellock JM: Overview: definitions and classifications of seizure emergencies. J Child Neurol 2007, 22:9S-13S.
8. Anderson M: Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability. Patient Prefer Adher 2013, 7:27-34.
9. Scott RC, Besag FM, Neville BG: Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet 1999, 353:623-626.
10. Camfield CS, Camfield PR, Smith E, Dooley JM: Home use of rectal diazepam to prevent status epilepticus in children with convulsive disorders. J Child Neurol 1989, 4:125-126.
11. O'Dell C, Shinnar S, Ballaban-Gil KR, Hornick M, Sigalova M, Kang H, Moshe SL: Rectal diazepam gel in the home management of seizures in children. Pediatr Neurol 2005, 33:166-172.
12. Riechmann J, Strzelczyk A, Reeses JP, Boor R, Langner C, Neubauer BA, Obermann B, Philippi H, Rochel M, Seeger J, et al: Direct Costs of Epilepsy among Children and Adolescents in Germany. Interlaken, Switzerland: 8 Dreiländertagung der Deutschen und Österreichischen Gesellschaften für Epileptologie sowie der Schweizerischen Liga gegen Epilepsie; 2013.
13. Arzimanoglou A, Lagae L, Cross JH, Beghi E, Mifsud J, Bennett C, Schmidt D, Wait S, Harvey G: The administration of rescue medication to children with prolonged acute convulsive seizures in a non-hospital setting: an exploratory survey of healthcare professionals' perspectives. Eur J Pediatr, 2014. Jan 3. [Epub ahead of print].
14. Wait S, Lagae L, Arzimanoglou A, Beghi E, Bennett C, Cross JH, Mifsud J, Schmidt D, Harvey G: The administration of rescue medication to children with prolonged acute convulsive seizures in the community: what happens in practice? Eur J Paediatr Neurol 2013, 17:14-23.
15. European Medicines Agency: Questions and Answers on the Paediatric Use Marketing Authorisation (PUMA); 2011. www.ema.europa.eu/docs/en_GB/document_library/Other/2011/09/WC500112071.pdf. Accessed 28 March 2014.
16. Lee D, Gladwell D, Batty AJ, Brereton N, Tate E: The cost effectiveness of licensed oromucosal midazolam (Buccolam®) for the treatment of children experiencing acute epileptic seizures: an approach when trial evidence is limited. Pediatr Drugs 2013, 15:151-162.
17. Conroy S, Choonara I, Impicciatore P, Mohn A, Arnell H, Rane A, Knoeppel C, Seyberth H, Pandolfini C, Raffaelli MP, et al: Survey of unlicensed and off label drug use in paediatric wards in European countries. European Network for Drug Investigation in Children. BMJ 2000, 320:79-82.
18. McIntyre J, Robertson S, Norris E, Appleton R, Whitehouse WP, Phillips B, Martland T, Berry K, Collier J, Smith S, Choonara I: Safety and efficacy of buccal midazolam versus rectal diazepam for emergency treatment of seizures in children: a randomised controlled trial. Lancet 2005, 366:205-210.
19. Hsu CC, Sandford BA: The Delphi technique: making sense of consensus. Pract Assess Res Eval 2007, 12:1-8.
20. Information Services Division NHS National Services Scotland: Scottish Drug Tariff May 2013 Section 7S; 2013. www.isdscotland.org/Health-Topics/ Prescribing-and-Medicines/Scottish-Drug-Tariff/Drugs-and-Preparations-with-Tariff-Prices.asp. Accessed March 28 2014.
21. NHS Business Services Authority NHS: NHS Electronic Drug Tariff: Part IIIB (May 2013); www.ppa.org.uk/edt/May_2013/mindex.htm. Accessed 28 March 2014.
22. Pharmaceutical Services Negotiating Committee: Unlicensed specials and imports; 2013. www.psnc.org.uk/publications_download.php/285/Unlicensed_specials_and_imports_FAQs.pdf. Accessed 13 February 2014.
23. Stephens RJ, Hopwood P, Girling DJ, Machin D: Randomized trials with quality of life endpoints: are doctors' ratings of patients' physical symptoms interchangeable with patients' self-ratings? Qual Life Res 1997, 6:225-236.
24. Morrow AM, Hayen A, Quine S, Scheinberg A, Craig JC: A comparison of doctors', parents' and children's reports of health states and health-related quality of life in children with chronic conditions. Child: Care, Health Dev 2012, 38:186-195.
25. Hladschik-Kermer B, Kierner KA, Heck U, Miksovsky A, Reiter B, Zoidl H, Medicus E, Masel EK, Watzke HH: Patients and staff perceptions of cancer patients' quality of life. Eur J Oncol Nurs 2013, 17:70-74.
26. Group EQ: EuroQol - a new facility for the measurement of health-related quality of life. Health Policy 1990, 16:199-208.
27. Pugliatti M, Beghi E, Forsgren L, Ekman M, Sobocki P: Estimating the cost of epilepsy in Europe: a review with economic modeling. Epilepsia 2007, 48:2224-2233.